CN109044897A - A kind of antibacterial anti hemorrhagic oral cavity nursing agent - Google Patents
A kind of antibacterial anti hemorrhagic oral cavity nursing agent Download PDFInfo
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- CN109044897A CN109044897A CN201711431648.4A CN201711431648A CN109044897A CN 109044897 A CN109044897 A CN 109044897A CN 201711431648 A CN201711431648 A CN 201711431648A CN 109044897 A CN109044897 A CN 109044897A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Abstract
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight: 3.0~4.5 parts of acrylic acid polymer；1.5~4.5 parts of sodium lauroyl sarcosine；1.5~3.5 parts of Cocoamidopropyl betaine；28~40 parts of moisturizer；0.2~0.5 part of sweetener；0.3~0.7 part of thickener；30~50 parts of rubbing agent；10~25 parts of deionized water；Mulberry leaf and 4.0~6.0 parts of mulberries extract；The rubbing agent is the compounding of longan seed powder and Herba Euphorbiae Humifusae powder.By the present invention in that longan seed powder and the rubbing agent of the compounding of Herba Euphorbiae Humifusae powder as oral cavity nursing agent is used both effectively to drive away tooth stain, it is avoided that the phenomenon that therefore friction leads to bleeding gums again, and without adding new hemostatic compositions, to reduce the production cost of oral cavity nursing agent.
Description
Technical field
The present invention relates to a kind of technical field of daily necessities more particularly to a kind of antibacterial anti hemorrhagic oral cavity nursing agents.
Background technique
Periodontal disease is common mouth disease, and symptom mainly has bleeding gums, swelling, pain.There is statistics to show, tooth
The main reason for all diseases are 35 years old or more crowd's absence of tooth, it is seen that the seriousness of periodontal disease.But since patient is not easy to examine
Feel, most people is not aware that oneself is suffered from this disease.Think to many human factor errors that people can just suffer from periodontal disease to old, it is practical
Upper 5 year old, children can suffer from gingivitis.
Periodontosis is not only to influence the health of tooth, also will affect the health of whole body.Periodontosis is to whole body health in recent years
Influence caused the concern of people.Bacterial component and bacterial product are easy to be diffused by oral pocket ulcer surface nearby or remote
Every organ, lead to or aggravate certain general diseases, such as coronary heart disease, low birth weight infant, diabetes, pulmonary infection disease hair
Hair tonic exhibition seriously endangers human health.It depends merely on stomatological hospital and drug therapy is to be unable to satisfy people to improve oral health water
Flat needs, with the use of the oral cavity nursing health products with prevention and treatment periodontal disease, periodontal disease is that gradually to be had
Effect prevention and control.
In order to preferably prevent and treat periodontal disease, many persons select and are added into rubbing agent in oral cavity nursing agent, but add
After entering rubbing agent, people's discovery gum when carrying out oral care using the oral cavity nursing agent with rubbing agent is easy bleeding, from
And it is be easy to cause infection, and in order to stop blooding, it still needs to be added into hemostatic compositions in oral cavity nursing agent, must will increase in this way
The production cost of oral cavity nursing agent.
Summary of the invention
It is an object of the invention to overcome the shortcomings of that above and defect proposes a kind of antibacterial anti hemorrhagic oral cavity nursing agent.
To achieve this purpose, the present invention adopts the following technical scheme:
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
3.0~4.5 parts of acrylic acid polymer；
1.5~4.5 parts of sodium lauroyl sarcosine；
1.5~3.5 parts of Cocoamidopropyl betaine；
28~40 parts of moisturizer；
0.2~0.5 part of sweetener；
0.3~0.7 part of thickener；
15~30 parts of rubbing agent；
10~25 parts of deionized water；
Mulberry leaf and 4.0~6.0 parts of mulberries extract；
The rubbing agent is the compounding of longan seed powder and Herba Euphorbiae Humifusae powder.
It preferably, further include 0.02-0.06 portions of preservatives.
Preferably, the preservative is the mixed of one or more of isothiazolinone, paraben esters, potassium sorbate
Close object.
Preferably, the moisturizer is that the one or more of them of propylene glycol, butanediol or glycine betaine compounds.
Preferably, the sweetener is the one or two of saccharin sodium or xylitol.
Preferably, the thickener be sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer it is one or more multiple
Match.
Preferably, longan seed powder, the size of Herba Euphorbiae Humifusae powder are 500-1000 mesh.If the powder used is crossed conference and is made
At laborious when brushing teeth, the inconvenience brushed teeth is caused；If too small, it is easy to remain in the gap of tooth in friction process, reduces
Friction, to reduce the ability of tooth stain expeling.And longan seed powder, Herba Euphorbiae Humifusae floury texture be not hard, not will cause tooth
Tooth damage.
The present invention has passed through adds the compounding of longan seed powder and Herba Euphorbiae Humifusae powder as rubbing agent in oral cavity nursing agent,
So that the oral cavity nursing agent obtained is quickly removed the dirt for being attached to dental surface, tooth jaundice or length is avoided to decay tooth, while by
In the effect of friction, gum is easy bleeding, and longan seed powder, humid euphorbia grass meal itself have effects that cooling blood and hemostasis, therefore make
Longan seed powder and the oral cavity nursing agent of the compounding of Herba Euphorbiae Humifusae powder as rubbing agent is used not only effectively to drive away tooth stain, but also can
The phenomenon that therefore friction leads to bleeding gums is avoided, and without adding new hemostatic compositions, to reduce oral cavity nursing agent
Production cost.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.
Embodiment 1
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
3.0 parts of acrylic acid polymer；
1.5 parts of sodium lauroyl sarcosine；
1.5 parts of Cocoamidopropyl betaine；
28 parts of glycine betaine；
0.2 part of saccharin sodium；
0.3 part of sodium carboxymethylcellulose；
Longan seed powder, Herba Euphorbiae Humifusae powder: additive amount is added by table 1；
Paraben esters 0.02；
Mulberry leaf and 4.0 parts of mulberries extract.
Table 1 is influence of the additive amount of rubbing agent to tooth stain ability is driven away
It can be obtained by table 1, after having used the rubbing agent of longan seed powder and Herba Euphorbiae Humifusae powder as compounding, drive away tooth stain
Ability enhance, and either can reach 91 for the expeling dirt ability of the tooth stain that has been aged 15 days or 30 days
More than, and it is optimal drive away soils be using longan seed powder and Herba Euphorbiae Humifusae powder compounding proportion be 2:1.
In order to test the effect of the present embodiment 1-1 to embodiment 1-3 obtains the hemostasis aspect of oral cavity nursing agent, mouse is carried out
Clinical hemostasis experiment mice clinical hemostasis experiment.
Clinical trial of stopping blooding uses blank lotion, Colgate-Palmolive toothpaste, Crest toothpaste, embodiment 1-1 into embodiment 1-3
Oral cavity nursing agent as examination object sample.
It is carried out using hemostasis observation method is damaged to mouse liver local woanded surface.Take kunming mice 108 of health, weight
18~22g, male and female dual-purpose.After anesthetized mice, liver is cut in left lobe of liver with operating scissors and is about 0.5cm, wide about 0.5cm, it is high about
0.5cm after the blood for wiping ejection, immediately in situation portion spreading object sample 0.5g to be tried, oppresses 1min with 200g counterweight, after 1min
Counterweight is removed, haemostatic effect is observed, until not bleeding.Such as still bleeding, adds to apply and pressurize after trying object sample, observed every 30s
Once, bleeding stopping period is recorded, is such as no more than 3min, being then denoted as can stop blooding；Such as fail to stop blooding more than 3min, is then denoted as and fails to stop
Blood, experimental result are shown in Table 2.
The clinical blood coagulation hemostasis experimental result of 2 mouse of table
| Try object sample | Experiment number | Bleeding stopping period |
| Blank lotion | 18 | > 3 |
| Colgate-Palmolive toothpaste | 18 | 2.65±0.22 |
| Crest toothpaste | 18 | 2.51±0.18 |
| The oral cavity nursing agent of embodiment 1-1 | 18 | 2.17±0.15 |
| The oral cavity nursing agent of embodiment 1-2 | 18 | 2.11±0.13 |
| The oral cavity nursing agent of embodiment 1-3 | 18 | 2.06±0.12 |
As shown in Table 2, the oral cavity nursing agent of embodiment 1-1 to embodiment 1-3 is to mouse liver local woanded surface bleeding due to trauma
There is apparent blood coagulation haemostatic effect.
Embodiment 2
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
4.5 parts of acrylic acid polymer；
3.5 parts of sodium lauroyl sarcosine；
3.5 parts of Cocoamidopropyl betaine；
30 parts of butanediol；
0.3 part of saccharin sodium；
0.7 part of hydroxyethyl cellulose；
17 parts of longan seed powder, 8 parts of Herba Euphorbiae Humifusae powder；
0.06 part of potassium sorbate；
20 parts of deionized water；
Mulberry leaf and 5.0 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 97/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 91/12 day.
Embodiment 3
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
3.5 parts of acrylic acid polymer；
4.5 parts of sodium lauroyl sarcosine；
2.5 parts of Cocoamidopropyl betaine；
32 parts of propylene glycol；
0.5 part of xylitol；
0.6 part of carbomer；
13.5 parts of longan seed powder, Herba Euphorbiae Humifusae powder 11.5；
0.04 part of isothiazolinone；
15 parts of deionized water；
Mulberry leaf and 6.0 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 97/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 92/11 day.
Embodiment 4
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
4 parts of acrylic acid polymer；
3 parts of sodium lauroyl sarcosine；
2.6 parts of Cocoamidopropyl betaine；
35 parts of glycine betaine；
0.3 part of saccharin sodium；
0.2 part of sodium carboxymethylcellulose, 0.2 part of hydroxyethyl cellulose, 0.3 part of carbomer；
8 parts of longan seed powder 11, Herba Euphorbiae Humifusae powder；
Paraben esters 0.25,0.15 part of potassium sorbate；
22 parts of deionized water；
Mulberry leaf and 4.2 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 96/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 92/19 day.
Embodiment 5
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
4.5 parts of acrylic acid polymer；
2.5 parts of sodium lauroyl sarcosine；
3.2 parts of Cocoamidopropyl betaine；
30 parts of butanediol；
0.4 part of xylitol；
0.4 part of sodium carboxymethylcellulose, 0.2 part of hydroxyethyl cellulose；
9 parts of longan seed powder, 7 parts of Herba Euphorbiae Humifusae powder；
0.02 part of isothiazolinone, 0.03 part of paraben esters；
14 parts of deionized water；
Mulberry leaf and 4.5 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 96/9 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 91/18 day.
Embodiment 6
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
3.5 parts of acrylic acid polymer；
4 parts of sodium lauroyl sarcosine；
2.8 parts of Cocoamidopropyl betaine；
38 parts of propylene glycol；
0.3 part of xylitol, 0.2 part of saccharin sodium；
0.1 part of sodium carboxymethylcellulose, 0.3 part of carbomer；
10 parts of longan seed powder, 11.5 parts of Herba Euphorbiae Humifusae powder；
0.05 part of isothiazolinone；
17.5 parts of deionized water；
Mulberry leaf and 5.5 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 97/9 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 91/13 day.
Embodiment 7
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
4.1 parts of acrylic acid polymer；
4.5 parts of sodium lauroyl sarcosine；
3.2 parts of Cocoamidopropyl betaine；
10 parts of propylene glycol, 21 parts of glycine betaine；
0.3 part of saccharin sodium；
0.25 part of hydroxyethyl cellulose, 0.35 part of carbomer；
11 parts of longan seed powder, 11 parts of Herba Euphorbiae Humifusae powder；
0.01 part of isothiazolinone, 0.01 part of potassium sorbate；
14.5 parts of deionized water；
Mulberry leaf and 4.8 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 97/7 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 92/12 day.
Embodiment 8
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
3.8 parts of acrylic acid polymer；
4.2 parts of sodium lauroyl sarcosine；
2.1 parts of Cocoamidopropyl betaine；
24 parts of butanediol, 10 parts of glycine betaine；
0.3 part of xylitol, 0.1 part of saccharin sodium；
0.55 part of hydroxyethyl cellulose；
9 parts of longan seed powder, 15 parts of Herba Euphorbiae Humifusae powder；
0.01 part of isothiazolinone, 0.02 part of paraben esters；
20.5 parts of deionized water；
Mulberry leaf and 5.8 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 97/10 day for the expeling ability of the tooth stain of ageing 15 days；For old
The expeling ability for changing 30 days tooth stains is 91/17 day.
Embodiment 9
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
3.2 parts of acrylic acid polymer；
1.8 parts of sodium lauroyl sarcosine；
2.7 parts of Cocoamidopropyl betaine；
Propylene glycol, butanediol or 28 parts of glycine betaine；
0.25 part of xylitol；
0.35 part of sodium carboxymethylcellulose；
8 parts of longan seed powder, 10 parts of Herba Euphorbiae Humifusae powder；
0.02 part of isothiazolinone, 0.01 part of paraben esters, 0.03 part of potassium sorbate；
15 parts of deionized water；
Mulberry leaf and 5.2 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 97/9 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 91/15 day.
Embodiment 10
A kind of antibacterial anti hemorrhagic oral cavity nursing agent, includes following components in parts by weight:
3.2 parts of acrylic acid polymer；
2.1 parts of sodium lauroyl sarcosine；
3.3 parts of Cocoamidopropyl betaine；
14 parts of propylene glycol, 23 parts of butanediol；
0.2 part of xylitol, 0.25 part of saccharin sodium；
0.5 part of carbomer；
12 parts of longan seed powder, 8 parts of Herba Euphorbiae Humifusae powder；
0.01 part of potassium sorbate, 0.02 part of isothiazolinone；
25 parts of deionized water；
Mulberry leaf and 4.6 parts of mulberries extract.
The oral cavity nursing agent of the present embodiment is 98/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of 30 days tooth stains is 92/12 day.
The technical principle of the invention is described above in combination with a specific embodiment.These descriptions are intended merely to explain of the invention
Principle, and shall not be construed in any way as a limitation of the scope of protection of the invention.Based on the explanation herein, the technology of this field
Personnel can associate with other specific embodiments of the invention without creative labor, these modes are fallen within
Within protection scope of the present invention.
Claims (7)
1. a kind of antibacterial anti hemorrhagic oral cavity nursing agent, which is characterized in that it includes following components in parts by weight:
3.0~4.5 parts of acrylic acid polymer；
1.5~4.5 parts of sodium lauroyl sarcosine；
1.5~3.5 parts of Cocoamidopropyl betaine；
28~40 parts of moisturizer；
0.2~0.5 part of sweetener；
0.3~0.7 part of thickener；
30~50 parts of rubbing agent；
10~25 parts of deionized water；
Mulberry leaf and 4.0~6.0 parts of mulberries extract；
The rubbing agent is the compounding of longan seed powder and Herba Euphorbiae Humifusae powder.
2. a kind of antibacterial anti hemorrhagic oral cavity nursing agent according to claim 1, it is characterised in that: it further includes 0.02-0.06
Part preservative.
3. a kind of antibacterial anti hemorrhagic oral cavity nursing agent according to claim 2, it is characterised in that: the preservative is isothiazole
The mixture of one or more of quinoline ketone, paraben esters, potassium sorbate.
4. a kind of antibacterial anti hemorrhagic oral cavity nursing agent according to claim 1, it is characterised in that: the moisturizer is the third two
The one or more of them of alcohol, butanediol or glycine betaine compounds.
5. a kind of antibacterial anti hemorrhagic oral cavity nursing agent according to claim 1, it is characterised in that: the sweetener is saccharin sodium
Or the one or two of xylitol.
6. a kind of antibacterial anti hemorrhagic oral cavity nursing agent according to claim 1, it is characterised in that: the thickener is carboxymethyl
One or more compoundings of sodium cellulosate, hydroxyethyl cellulose, carbomer.
7. a kind of antibacterial anti hemorrhagic oral cavity nursing agent according to claim 1, it is characterised in that: the longan seed powder,
The size at bright and beautiful grass meal end is 500-1000 mesh.
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| CN201711431648.4A CN109044897A (en) | 2017-12-26 | 2017-12-26 | A kind of antibacterial anti hemorrhagic oral cavity nursing agent |
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| CN201711431648.4A CN109044897A (en) | 2017-12-26 | 2017-12-26 | A kind of antibacterial anti hemorrhagic oral cavity nursing agent |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN101129298A (en) * | 2007-09-17 | 2008-02-27 | 江西诚志日化有限公司 | Pure toothpaste |
| CN102078270A (en) * | 2009-12-01 | 2011-06-01 | 牛庆军 | Toothpaste |
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
| CN105342912A (en) * | 2015-11-12 | 2016-02-24 | 施庚伟 | Traditional Chinese medicine toothpaste adopting grape seed matrix abrasive and preparation method of traditional Chinese medicine toothpaste |
| CN105769705A (en) * | 2016-04-23 | 2016-07-20 | 李大兴 | Mulberry leaf and mulberry fruit antibacterial toothpaste |
-
2017
- 2017-12-26 CN CN201711431648.4A patent/CN109044897A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN101129298A (en) * | 2007-09-17 | 2008-02-27 | 江西诚志日化有限公司 | Pure toothpaste |
| CN102078270A (en) * | 2009-12-01 | 2011-06-01 | 牛庆军 | Toothpaste |
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
| CN105342912A (en) * | 2015-11-12 | 2016-02-24 | 施庚伟 | Traditional Chinese medicine toothpaste adopting grape seed matrix abrasive and preparation method of traditional Chinese medicine toothpaste |
| CN105769705A (en) * | 2016-04-23 | 2016-07-20 | 李大兴 | Mulberry leaf and mulberry fruit antibacterial toothpaste |
Non-Patent Citations (2)
| Title |
|---|
| 熊辅信等: "《中药现代研究荟萃》", 31 May 2002, 云南科技出版社 * |
| 老中医养生堂编著: "《本草纲目中药草使用图鉴》", 30 April 2016, 福建科学技术出版社 * |
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Application publication date: 20181221 |