CN102503877A - Method for extracting astaxanthin - Google Patents
Method for extracting astaxanthin Download PDFInfo
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- CN102503877A CN102503877A CN2011103870690A CN201110387069A CN102503877A CN 102503877 A CN102503877 A CN 102503877A CN 2011103870690 A CN2011103870690 A CN 2011103870690A CN 201110387069 A CN201110387069 A CN 201110387069A CN 102503877 A CN102503877 A CN 102503877A
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- China
- Prior art keywords
- astaxanthin
- lixiviate
- extracting
- ethanolic soln
- hexane
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Abstract
The invention discloses a method for extracting astaxanthin, which includes the steps of firstly extracting in low-concentration ethanol liquor under the heating and stirring conditions, removing water-soluble compounds harmful to fish or other animals by means of filtering, then extracting from filter residues with mixed solvent consisting of dichloromethane and hexane, and obtaining astaxanthin extract containing about 7% of astaxanthin after distilling extract liquor. The method is simple in process, mild in reacting condition and easy to realize industrialized production. The astaxanthin produced by the method can be used for industries such as feed, food, cosmetics, drugs and the like.
Description
Technical field
The present invention relates to the process study of natural pigment, use technology of the present invention can from adonis amurensis, extract astaxanthin medicinal extract.
Background technology
Astaxanthin (astaxanthin) is a kind of carrotenoid, has extremely strong resistance of oxidation and biological tinting strength, has been widely used in many fields such as food, medicine, makeup, feed.Has higher using value at aspects such as prevention cardiovascular and cerebrovascular diseases, protection eyes and cns, ultraviolet radiation preventing, inhibition tumour, anti-inflammatory, relieving sports fatigues.
The production source of astaxanthin mainly is processing of aquatic products waste, Haematocoocus Pluvialls etc., and output is lower, has satisfied not the demand in market.
Summary of the invention
It is under-supply to the objective of the invention is to be directed against the market astaxanthin, and a kind of method of from natural phant-side gold small cup, extracting astaxanthin is provided.
Operational path of the present invention comprises: under heating condition; Remove water-soluble compound such as glycosides with ethanolic soln; After the filtration, add mixed solvent in the filter residue and under heating condition, extract continuous extraction 3-5 time; Till the extraction liquid lighter color, combining extraction liquid and distillation promptly get astaxanthin medicinal extract product.
Therefore, the invention provides a kind of is raw material with the adonis amurensis, and the method for astaxanthin medicinal extract is characterized in that this method may further comprise the steps:
(1) with ethanolic soln lixiviate side gold small cup dried flower particle, ethanolic soln and side gold small cup dried flower particulate envelope-bulk to weight ratio are 1.0～2.0 liters: 1 kilogram;
(2) filter, get filter residue, under 40～65 ℃ of conditions, add the mixed solvent lixiviate;
(3) filter, the extraction liquid distillation that obtains obtains containing the medicinal extract of astaxanthin.
According to the method for the invention, the lixiviate number of times is 3～5 times in the wherein said step (1), and each 1～3 hour, temperature was 40～70 ℃, and the concentration of ethanolic soln is 5-10%.
Mixed solvent is methylene dichloride and hexane in the said step (2), and the volume ratio of methylene dichloride and hexane is 1:1, and solid-liquid ratio is 1:3～6, and extraction temperature is 40-65 ℃, and the lixiviate number of times is 3～5 times, each 1～3 hour, can stir in the extraction process.
Distillation is carried out under-0.8～1.0MPa condition at 40-65 ℃ in the said step (3).
The invention provides a kind of method of extracting astaxanthin in the natural phant; At first adopt the lower concentration alcoholic solution to remove to fish or the deleterious water-soluble cpds of other animal; Use specific solvent to extract then, the astaxanthin extraction yield is high, can reach more than 95%; Methylene dichloride and hexane can be recycled, and the astaxanthin medicinal extract that obtains can further use column chromatography purification to obtain the high purity astaxanthin product.
The present invention is with low cost, and production technique is simple, and reaction conditions is gentle, is prone to realize suitability for industrialized production, and the shrimp of acquisition is blue or green
Plain product can be used for multiple fields such as food, medicine, makeup, healthcare products, feed.
Embodiment
Embodiment 1:
Take by weighing adonis amurensis dried flower particle 100 grams, add 5% ethanolic soln 200ml, insulation is 1 hour under 50 ℃ of conditions, repeats to extract 3 times.Add methylene dichloride and the hexane solution of 1:1 in the filter residue behind suction filtration, lixiviate is 3 times under 55 ℃ of conditions, get extraction liquid 60 ℃ ,-distill under the 0.8MPa condition, content astaxanthin is 7.02% in the gained medicinal extract.
Embodiment 2:
Take by weighing adonis amurensis dried flower particle 100 grams, add 5% ethanolic soln 150ml, insulation is 1.5 hours under 60 ℃ of conditions, repeats to extract 3 times.Add methylene dichloride and the hexane solution of 1:1 in the filter residue behind suction filtration, solid-liquid ratio is 1:3, and lixiviate is 3 times under 60 ℃ of conditions, get extraction liquid 50 ℃ ,-distill under the 1.0MPa condition, content astaxanthin is 7.3% in the gained medicinal extract.
Claims (4)
1. the process for extracting of an astaxanthin is characterized in that may further comprise the steps:
(1) with ethanolic soln lixiviate side gold small cup dried flower particle, ethanolic soln and side gold small cup dried flower particulate envelope-bulk to weight ratio are 1.0～2.0 liters: 1 kilogram;
(2) filter, get filter residue, under 40～65 ℃ of conditions, add the mixed solvent lixiviate;
(3) filter, the extraction liquid distillation that obtains obtains containing the medicinal extract of astaxanthin.
2. according to the method for claim 1, it is characterized in that the lixiviate number of times is 3～5 times in the said step (1), each 1～3 hour, temperature was 40～70 ℃, and the concentration of ethanolic soln is 5-10%.
3. according to the method for claim 1; It is characterized in that mixed solvent is methylene dichloride and hexane in the said step (2), the volume ratio of methylene dichloride and hexane is 1:1, and solid-liquid ratio is 1:3～6; Extraction temperature is 40-65 ℃; The lixiviate number of times is 3～5 times, each 1～3 hour, can stir in the extraction process.
4. according to the method for claim 1, it is characterized in that distillation is carried out under-0.8～1.0MPa condition at 40-65 ℃ in the said step (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103870690A CN102503877A (en) | 2011-11-29 | 2011-11-29 | Method for extracting astaxanthin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103870690A CN102503877A (en) | 2011-11-29 | 2011-11-29 | Method for extracting astaxanthin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102503877A true CN102503877A (en) | 2012-06-20 |
Family
ID=46216028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103870690A Pending CN102503877A (en) | 2011-11-29 | 2011-11-29 | Method for extracting astaxanthin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102503877A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104447464A (en) * | 2013-09-24 | 2015-03-25 | 浙江医药股份有限公司新昌制药厂 | Carotenoid compound derived from plant source and containing natural astaxanthin as well as preparation method and composition of carotenoid compound |
| CN105193638A (en) * | 2015-10-13 | 2015-12-30 | 云南中医学院 | Application of astaxanthin in toothpaste |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1472201A (en) * | 2003-06-07 | 2004-02-04 | 诸城莲春天然色素提纯有限公司 | Extraction of astaxanthin from plant |
-
2011
- 2011-11-29 CN CN2011103870690A patent/CN102503877A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1472201A (en) * | 2003-06-07 | 2004-02-04 | 诸城莲春天然色素提纯有限公司 | Extraction of astaxanthin from plant |
Non-Patent Citations (2)
| Title |
|---|
| 宋光泉，等: "天然虾青素的提取纯化及其应用", 《广东化工》, vol. 34, no. 11, 31 December 2007 (2007-12-31), pages 63 - 33 * |
| 陈晋明，等: "反相高效液相色谱法检测虾青素", 《化学分析计量》, vol. 15, no. 2, 31 December 2006 (2006-12-31), pages 27 - 29 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104447464A (en) * | 2013-09-24 | 2015-03-25 | 浙江医药股份有限公司新昌制药厂 | Carotenoid compound derived from plant source and containing natural astaxanthin as well as preparation method and composition of carotenoid compound |
| CN104447464B (en) * | 2013-09-24 | 2016-11-23 | 浙江医药股份有限公司新昌制药厂 | A kind of plant origin carotenoid compounds containing natural astaxanthin and preparation method thereof and compositions |
| CN105193638A (en) * | 2015-10-13 | 2015-12-30 | 云南中医学院 | Application of astaxanthin in toothpaste |
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Application publication date: 20120620 |