CN106377669A - 一种治疗女性闭经的药物及其制备方法 - Google Patents
一种治疗女性闭经的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗女性闭经的药物及其制备方法,其主要是由熟地黄、当归、山楂、瓜蒌、刘寄奴、益母草、鹿角霜、菟丝子、酸枣仁、鸡血藤、仙茅、地榆、泽兰、巴戟天、何首乌、瞿麦、鸡内金、桑椹、赤芍、牛膝、香附按一定重量配比制备而成,本发明药物具有补血和血,补肝益肾,祛风祛瘀,调经止痛,理气解郁的功能,用于治疗女性闭经见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗女性闭经的药物及其制备方法,属中药领域。
背景技术
女性闭经是指凡年龄已满18周岁而月经从未来潮者称原发性闭经,以往已有周期性月经而现在非生理性的停经已达到3个月或更长者称继发性闭经。闭经的原因众多,有生殖器官本身的各种原因和全身的诸多原因。中医则认为女性闭经与肝肾不足,气血虚弱,气滞血瘀,寒湿凝结,痰湿壅阻有关。由于西药治疗副作用大,因此人们对有效治疗女性闭经的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗女性闭经的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗女性闭经的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择熟地黄、当归、山楂、瓜蒌、刘寄奴、益母草、鹿角霜、菟丝子、酸枣仁、鸡血藤、仙茅、地榆、泽兰、巴戟天、何首乌、瞿麦、鸡内金、桑椹、天门冬、王不留行、党参、枸杞子、桂枝、泽泻、延胡索、赤芍、牛膝、香附、黄精、黄连、续断进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗女性闭经。其中选用熟地黄是因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用瓜蒌是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涤痰,宽胸散结,润燥滑肠的功能,治肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肠痈,大便秘结。选用刘寄奴是因为其性味苦,温,入心、脾经,有破血通经,敛疮消肿的功能,治经闭癥瘕,胸腹胀痛,产后血瘀,跌打损伤,金疮出血,痈毒焮肿。选用益母草是因为其性味辛苦,凉,入心包、肝经,有活血,祛瘀,调经,消水的功能,治月经不调,治漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用鹿角霜是因为其性味咸,温,入肝、肾经,有补虚,助阳的功能,治肾阳不足,腰脊酸痛,脾胃虚寒,呕吐,食少便溏,子宫虚冷,崩漏带下。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用酸枣仁是因为其性味甘,平,入心、脾、肝、胆经,有养肝,宁心,安神,敛汗的功能,治虚烦不眠,惊悸怔忡,烦渴,虚汗。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用仙茅是因为其性味辛,温,有毒,入肾、肝经,有温肾阳,壮筋骨的功能,治阳萎精冷,小便失禁,崩漏,心腹冷痛,腰脚冷痹,痈疽,瘰疬。选用地榆是因为其性味苦酸、寒。入肝、大肠经。凉血止血,清热解毒。治吐血,衄血,血痢,崩溃,肠风,痔漏,痈肿,湿疹,金疮,烧伤。选用泽兰是因为其性味苦辛,微温,入肝、脾经,有活血,行水的功能,治经闭,癥瘕,产后瘀滞腹痛,身面浮肿,跌扑损伤,金疮,痈肿。选用巴戟天是因为其性味辛甘,温,入肝、肾经,有补肾阳,壮筋骨,祛风湿的功能,治阳痿,少腹冷痛,小便不禁,子宫虚冷,风寒湿痹,腰膝酸痛。选用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用瞿麦是因为其性味苦,寒,入心、肾、小肠、膀胱经,有清热利水,破血通经的功能,治小便不通,淋病,水肿,经闭,痈肿,目赤障翳,浸淫疮毒。选用鸡内金是因为其性味甘,平,入脾、胃经,有治积滞,健脾胃的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。选用桑椹是因为其性味甘,寒,入肝、肾经,有补肝,益肾,熄风,滋液的功能,治肝肾阴亏,消渴,便秘,目暗,耳鸣,瘰疬,关节不利。选用天门冬是因为其性味甘苦,寒,入肺、肾经,有滋阴,润燥,清肺,降火的功能,治阴虚发热,咳嗽吐血,肺痿,肺痈,咽喉肿痛,消渴,便秘。选用王不留行是因为其性味苦平,入肝、胃经,有行血通经,催生下乳,消肿敛疮的功能,治妇女经闭,乳汁不通,难产,血淋,痈肿,金疮出血。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿的功能,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肢拘挛,痿痹。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用黄精是因为其性味甘平,入脾、肺、肾经,有补中益气,润心肺,强筋骨的功能,治虚损寒热,肺痨咳血,病后体虚食少,筋骨软弱,风湿疼痛,风癞癣疾。选用黄连是因为其性味苦,寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒,热盛心烦,痞满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿痛,火眼,口疮,痈疽疮毒,湿疹,汤火烫伤。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
熟地黄10-20克,当归10-20克,山楂15-25克,瓜蒌10-20克,刘寄奴10-15克,益母草10-20克,鹿角霜10-15克,菟丝子10-15克,酸枣仁10-20克,鸡血藤15-25克,仙茅10-15克,地榆10-20克,泽兰7-12克,巴戟天10-15克,何首乌10-15克,瞿麦10-15克,鸡内金5-15克,桑椹15-25克,天门冬10-20克,王不留行10-20克,党参10-15克,枸杞子5-15克,桂枝7-12克,泽泻5-15克,延胡索7-12克,赤芍10-20克,牛膝7-12克,香附3-9克,黄精10-15克,黄连3-9克,续断10-15克。
优选为:
熟地黄15克,当归15克,山楂20克,瓜蒌15克,刘寄奴12克,益母草15克,鹿角霜12克,菟丝子12克,酸枣仁15克,鸡血藤20克,仙茅12克,地榆15克,泽兰9克,巴戟天12克,何首乌12克,瞿麦12克,鸡内金10克,桑椹20克,天门冬15克,王不留行15克,党参12克,枸杞子10克,桂枝9克,泽泻10克,延胡索9克,赤芍15克,牛膝9克,香附6克,黄精12克,黄连6克,续断12克。
本发明药物的制备方法如下
一、备料
1、熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
2、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
3、山楂:拣净杂质,筛去核;
4、瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
5、刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
6、益母草:拣去杂质,洗净,润透,切段,晒干;
7、鹿角霜:拣去杂质,斫成小块;
8、菟丝子:过箩去净杂质,洗净,晒干;
9、酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将枣仁捞出,晒干;
10、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
11、仙茅:取净仙茅用黄酒拌匀,润透后,置锅内微炒至干,取出,晾干,每仙茅100斤,用黄酒10—20斤;
12、地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
13、泽兰:拣去杂质,除去残根,喷水稍润,切段晒干;
14、巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
15、何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
16、瞿麦:拣净杂质,除去残根,洗净,焖润,切段,晒干;
17、鸡内金:拣去杂质,漂净晒干;
18、桑椹:用水洗净,拣去杂质,摘除长柄,晒干;
19、天门冬:拣去杂质,水洗净,闷润至内外湿度均匀,切段、干燥;
20、王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
21、党参:洗净泥沙后润透去芦,切片或切段,晒干;
22、枸杞子:簸净杂质,摘去残留的梗和蒂;
23、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
24、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
25、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
26、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
27、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
28、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
29、黄精:洗净泥土,略润,切片,晒干;
30、黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
31、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑。
二、制备
1、将炮制后的熟地黄、当归、山楂、瓜蒌、刘寄奴、益母草、鹿角霜、菟丝子、酸枣仁、鸡血藤、仙茅、地榆、泽兰、巴戟天、何首乌、瞿麦、鸡内金、桑椹、天门冬、王不留行、党参、枸杞子、桂枝、泽泻、延胡索、赤芍、牛膝、香附、黄精、黄连、续断放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中益母草有活血,祛瘀,调经,消水的功能为君药;何首乌补肝,益肾,养血,祛风;当归有补血和血,调经止痛的功能,二者为臣药,三味药共同发挥补血和血,补肝益肾,祛瘀祛风,调经止痛的作用,治疗女性闭经效力全面,且以补血和血,补肝益肾,祛风祛瘀为主可治本,香附有理气解郁,止痛调经,治肝胃不和,气郁不舒,痰饮痞满,月经不调的功能为佐药,延胡索有活血,散瘀,理气,止痛的功能为使药,与余下诸药是治标。
本发明药物具有补血和血,补肝益肾,祛风祛瘀,调经止痛,理气解郁的功能,用于治疗女性闭经,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治女性闭经门诊患者共33例。
2、诊断标准
典型症状为体内一些内分泌腺的影响,如肾上腺,甲状腺,胰腺等功能紊乱。由于这些因素的影响,常常不来月经;头痛是常见症状,有时剧痛,眩晕,耳鸣,失眠,烦躁,多疑,喜怒无常和月经紊乱等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:女性闭经症状消失,体质恢复正常,痊愈;
好转:患者内分泌功能紊乱,头痛,月经紊乱的现象减轻,女性闭经症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗女性闭经患者33例,结果显效26例,显效率为78.79%,好转5例,好转率为15.15%,无效2例,总有效率为93.94%。
Claims (3)
1.一种治疗女性闭经的药物,其特征在于:它是由下列重量范围内的原料药制成:
熟地黄10-20克,当归10-20克,山楂15-25克,瓜蒌10-20克,刘寄奴10-15克,益母草10-20克,鹿角霜10-15克,菟丝子10-15克,酸枣仁10-20克,鸡血藤15-25克,仙茅10-15克,地榆10-20克,泽兰7-12克,巴戟天10-15克,何首乌10-15克,瞿麦10-15克,鸡内金5-15克,桑椹15-25克,天门冬10-20克,王不留行10-20克,党参10-15克,枸杞子5-15克,桂枝7-12克,泽泻5-15克,延胡索7-12克,赤芍10-20克,牛膝7-12克,香附3-9克,黄精10-15克,黄连3-9克,续断10-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
熟地黄15克,当归15克,山楂20克,瓜蒌15克,刘寄奴12克,益母草15克,鹿角霜12克,菟丝子12克,酸枣仁15克,鸡血藤20克,仙茅12克,地榆15克,泽兰9克,巴戟天12克,何首乌12克,瞿麦12克,鸡内金10克,桑椹20克,天门冬15克,王不留行15克,党参12克,枸杞子10克,桂枝9克,泽泻10克,延胡索9克,赤芍15克,牛膝9克,香附6克,黄精12克,黄连6克,续断12克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
(2)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(3)山楂:拣净杂质,筛去核;
(4)瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
(5)刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
(6)益母草:拣去杂质,洗净,润透,切段,晒干;
(7)鹿角霜:拣去杂质,斫成小块;
(8)菟丝子:过箩去净杂质,洗净,晒干;
(9)酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将枣仁捞出,晒干;
(10)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(11)仙茅:取净仙茅用黄酒拌匀,润透后,置锅内微炒至干,取出,晾干,每仙茅100斤,用黄酒10—20斤;
(12)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
(13)泽兰:拣去杂质,除去残根,喷水稍润,切段晒干;
(14)巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
(15)何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
(16)瞿麦:拣净杂质,除去残根,洗净,焖润,切段,晒干;
(17)鸡内金:拣去杂质,漂净晒干;
(18)桑椹:用水洗净,拣去杂质,摘除长柄,晒干;
(19)天门冬:拣去杂质,水洗净,闷润至内外湿度均匀,切段、干燥;
(20)王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
(21)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(22)枸杞子:簸净杂质,摘去残留的梗和蒂;
(23)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(24)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(25)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(26)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(27)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(28)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(29)黄精:洗净泥土,略润,切片,晒干;
(30)黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
(31)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(二)制备
(1)将炮制后的熟地黄、当归、山楂、瓜蒌、刘寄奴、益母草、鹿角霜、菟丝子、酸枣仁、鸡血藤、仙茅、地榆、泽兰、巴戟天、何首乌、瞿麦、鸡内金、桑椹、天门冬、王不留行、党参、枸杞子、桂枝、泽泻、延胡索、赤芍、牛膝、香附、黄精、黄连、续断放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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