CN104338083A - 一种治疗月经不调的药物及其制备方法 - Google Patents

一种治疗月经不调的药物及其制备方法 Download PDF

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CN104338083A
CN104338083A CN201410609688.3A CN201410609688A CN104338083A CN 104338083 A CN104338083 A CN 104338083A CN 201410609688 A CN201410609688 A CN 201410609688A CN 104338083 A CN104338083 A CN 104338083A
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薛学明
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薛学明
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Abstract

本发明公开了一种治疗月经不调的药物及其制备方法,它主要是由莪术、川芎、乳香、郁金、丹参、益母草、红花、水蛭、虻虫、王不留行、牛膝、刘寄奴、延胡索、姜黄按一定重量配比制备而成,本发明药物具有活血调经,逐瘀通经,凉血破积的功能,用于治疗月经不调疗效好,治愈后不复发,无毒副作用。

Description

一种治疗月经不调的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗月经不调的药物及其制备方法,属中药领域。 技术背景
[0002] 月经不调也称月经失调,是妇科常见疾病,表现为月经周期或出血量的异常,可伴 月经前、经期时的腹痛及全身症状。病因可能是器质性病变或是功能失常。基本表现为经 期提前,经期延迟,经期延长,月经中期出血等症状。目前,西药治疗月经不调效果不佳,且 长期服用西药有较多副作用,因此,人们对快速有效治疗月经不调的中药存在很大的需求。
发明内容
[0003] 目前还没有发现关于治疗月经不调的中药的有关报道,本发明人经过反复的研究 试验和验证,终于找到了有效治疗月经不调的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种能够有效治疗月经不调的组合药物。
[0005] 本发明的另一个目的就是提供了该组合药物的制备方法。
[0006] 本发明药物是选用莪术、川芎、乳香、郁金、丹参、益母草、红花、水蛭、虻虫、王不留 行、牛膝、刘寄奴、延胡索、姜黄、三棱、鸡血藤、泽兰、凌霄花、苏木、藿香、厚朴、虎杖、山药、 甘草、白术、百合、枸杞子、桑椹、黑芝麻、饴糖、龙眼肉、阿胶、白芍药物进行组合的,将这些 药物组合使得各药物功效产生协同作用,从而能够有效治疗月经不调的复发。其中选用莪 术是因为其性味辛、苦、温。归肝、脾经。行气破血,消积止痛。用于癥瘕痞块,瘀血经闭, 食积胀痛,跌打肿痛,早期宫颈癌。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁, 祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块 痛,痈疽疮疡。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功 能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用郁金是因为其 性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热 病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用丹参是因为其性味苦,微温,入心、肝 经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下, 癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用益母草是因为其性味辛苦,凉, 入心包、肝经,有活血,祛瘀,调经,消水的功能,治月经不调,治漏难产,胞衣不下,产后血 晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用红花是因为其性味辛,温,入心、肝经, 有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌 扑损伤。选用水蛭是因为其性味咸苦,平,有毒,入肝、膀胱经,有破血,逐瘀,通经的功能, 治蓄血,癥瘕,积聚,妇女经闭,干血成痨,跌扑损伤,目赤痛,云翳。选用虻虫是因为其性味 苦,凉,有毒,入肝经,有逐瘀,破积,通经的功能,治癥瘕,积聚,少腹蓄血,血滞经闭,扑损瘀 血。选用王不留行是因为其性味苦平,入肝、胃经,有行血通经,催生下乳,消肿敛疮的功能, 治妇女经闭,乳汁不通,难产,血淋,痈肿,金疮出血。选用牛膝是因为其性味甘苦酸,平,入 肝、肾经,生用散瘀血,消痈肿,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉 痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肥拘挛,痿痹。选用刘寄奴是因为 其性味苦,温,入心、脾经,有破血通经,敛疮消肿的功能,治经闭癥瘕,胸腹胀痛,产后血瘀, 跌打损伤,金疮出血,痈毒掀肿。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散 瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损 伤。选用姜黄是因为其性味辛苦,温,入脾、肝经,有破血,行气,通经,止痛的功能,治心腹痞 满胀痛,臂痛,癥瘕,妇女血瘀经闭,产后瘀停腹痛,跌扑损伤,痈肿。选用三棱是因为其性味 苦辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁 下胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用鸡血藤是因为其性味苦甘,温,入 心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用泽兰是因为其性味 苦辛,微温,入肝、脾经,有活血,行水的功能,治经闭,癥瘕,产后瘀滞腹痛,身面浮肿,跌扑 损伤,金疮,痈肿。选用凌霄花是因为其性味酸,寒,入肝经,有凉血去瘀的功能,治血滞经 闭,癥瘕,血热风痒,酒齄鼻。选用苏木是因为其性味甘、咸、平,有行血,破瘀,消肿,止痛的 功能,治妇人血气心腹痛,经闭,产后瘀血,胀痛喘急,痢疾,破伤风。选用藿香是因为其性味 辛,微温,入肺、脾、胃经,有快气,和中,辟秽,祛湿的功能,治感冒暑湿,寒热,头痛,胸脘痞 闷,呕吐泄泻,疟疾,痢疾,口臭。用厚朴是因为其性味苦辛,温,入脾、胃、大肠经,有温中,下 气,燥湿,消痰的功能,治胸腹痞满胀痛,反胃、呕吐,宿食不消,痰饮喘咳,寒湿泻痢。选用虎 杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊 带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用山药 是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚 劳咳嗽,消渴,遗精、带下,小便频数。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓 急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心 t季,惊痈,生用治咽喉肿痛,消化性溃瘍,痈疽疮瘍,解药毒及食物中毒。选用白术是因为其 性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少 气,虚胀,泄泻,痰饮,水肿,黄疸,湿搏,小便不利,头晕,自汗,胎气不安。选用百合是因为其 性味甘微苦,平,入心、肺经,有润肺止咳,清心安神的功能,治肺痨久嗽,咳唾痰血,热病后 余热未清,虚烦惊悸,神志恍惚,脚气浮肿。选用枸杞子是因为其性味甘,平,有滋肾,润肺, 补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用 桑椹是因为其性味甘,寒,入肝、肾经,有补肝,益肾,熄风,滋液的功能,治肝肾阴亏,消渴, 便秘,目暗,耳鸣,瘰疬,关节不利。选用黑芝麻,异名胡麻仁,其性味甘,平,归肝、肾、大肠 经,有补肝肾,益精血,润肠燥的功能,治头昏眼花,耳鸣耳聋,须发早白,病后脱发,肠燥便 秘。选用饴糖是因为其性味甘,温,入脾、胃、肺经,有缓中,补虚,生津,润燥的功能,治劳倦 伤脾,里急腹痛,肺燥咳嗽,吐血,口渴,咽痛,便秘。选用龙眼肉是因为其性味甘,温,入心、 脾经,有益心脾,补气血,安神的功能,治虚功羸弱,失眠,健忘,惊悸,怔仲。选用阿胶是因为 其性味甘平,入肺、肝、肾经,有滋阴补血,安胎的功能,治血虚,虚劳咳嗽,吐血、衄血、便血, 妇女月经不调,崩中,治漏。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中 止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏, 带下。
[0007] 本发明选用丹参为君药,姜黄、刘寄奴为臣药,泽兰为佐药,甘草为使药,共同制成 治疗月经不调的方剂。
[0008] 本发明组合的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好疗效 莪术 10-20克 川芎 10-20克 乳香 10-20克 郁金 13-19克 丹参 15-21克 益母草 25-35克 红花 10-20克 水蛭 6-10克 虻虫 5-10克 王不留行10-20克 牛膝 10-20克 刘寄奴 10-20克 延胡索 10-20克 姜黄 10-20克 三棱 10-20克 鸡血藤 10-20克 泽兰 10-20克 凌霄花 10-20克 苏木 10-20克 藿香 10-20克 厚朴 10-20克 虎杖 10-20克 山药 10-20克 甘草 10-20克 白术 10-20克 百合 30-40克 枸杞子 10-20克 桑椹 10-20克 黑芝麻 10-20克 饴糖 50-80克 龙眼肉 10-20克 阿胶 10-20克 白芍 10-20克 优选用量为: 莪术 15克 川芎 15克 乳香 15克 郁金 16克 丹参 18克 益母草 30克 红花 15克 水蛭 8克 虻虫 6克 王不留行15克 牛膝 15克 刘寄奴 15克 延胡索 15克 姜黄 15克 三棱 15克 鸡血藤 15克 泽兰 15克 凌霄花 15克 苏木 15克 藿香 15克 厚朴 15克 虎杖 15克 山药 15克 甘草 15克 白术 15克 百合 30克 枸杞子 15克 桑椹 15克 黑芝麻 15克 饴糖 60克 龙眼肉 15克 阿胶 15克 白芍 15克 本发明药物的制备方法如下 一、备料 1、 莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去 碎屑; 2、 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; 3、 乳香:拣去砂子杂质; 4、 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; 5、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晒干; 6、 益母草:拣去杂质,洗净,润透,切段,晒干; 7、 红花:拣净杂质,除去茎叶、蒂头,晒干; 8、 水蛭:洗净,闷软,切段,晒干; 9、 虻虫:拣净杂质,除去翅、足,用文火微炒用; 10、 王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉; 11、 牛膝:拣去杂质,洗净,润软,去芦,切段,晒干; 12、 刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干; 13、 延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎; 14、 姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干; 15、 三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干; 16、 鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干; 17、 泽兰:拣去杂质,除去残根,喷水稍润,切段晒干; 18、 凌霄花:7-9月间采收,择晴天摘下刚开放的花朵,晒干; 19、 苏木:取原药材,锯成短段,再劈成碎片或镑片; 20、 藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后 与叶和匀; 21、 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; 22、 虎杖:取原药材,除去杂质,洗净,干燥,劈碎; 23、 山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干; 24、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; 25、 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; 26、 百合:拣去杂质、黑瓣,簸去灰屑; 27、 枸杞子:簸净杂质,摘去残留的梗和蒂; 28、 桑椹:用水洗净,拣去杂质,摘除长柄,晒干; 29、 黑芝麻:取原药材,除去杂质,筛去碎屑; 30、 饴糖:按量提取; 31、 龙眼肉:取原药材,除去杂质; 32、 阿胶:捣碎用; 33、 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀, 切片,干燥。
[0009] 二、制备 1、将所述重量的莪术、川芎、乳香、郁金、丹参、益母草、红花、水蛭、虻虫、王不留行、牛 膝、刘寄奴、延胡索、姜黄、三棱、鸡血藤、泽兰、凌霄花、苏木、藿香、厚朴、虎杖、山药、甘草、 白术、百合、枸杞子、桑椹、黑芝麻、龙眼肉、白芍药物加8倍量水进行浸泡,浸泡120分钟后, 武火煎煮沸腾10分钟,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入 容器内。
[0010] 2、第二次加水6倍量,武火煎煮沸腾,加入阿胶,再用文火煎煮10分钟,过滤得第 二次煎煮液。
[0011] 3、将两次煎煮液混合,再将烊化的饴糖冲入汤药中混合即得,将煎煮液分为4剂 服用。
[0012] 本发明药物具有活血调经,逐瘀通经,凉血破积的功效,用于治疗月经不调,疗程 短、见效快、治愈后不复发、无毒副作用。
具体实施方式
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括了本 发明药物的动物毒性试验报告和临床观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告 取家兔30只,雌雄兼用,体重2. 0 - 2. 5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天2次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物治疗月经不调的临床观察资料 1、一般资料 收治门诊患者共36例。
[0016] 2、诊断标准 临床表现 (1)功能失调性子宫出血 指内外生殖器无明显器质性病变,而由内分泌调节系统失调所引起的子宫异常出血。 是月经失调中最常见的一种,常见于青春期及更年期。分为排卵性和无排卵性两类,约85% 病例属无排卵性出血。
[0017] (2)闭经 是妇科疾病中常见的症状,可以由各种不同的原因引起。通常将闭经分为原发性和继 发性两种。凡年过18岁仍未行经者称为原发性闭经;在月经初潮以后,正常绝经以前的任 何时间内(妊娠或哺乳期除外),月经闭止超过6个月者称为继发性闭经。
[0018] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚饭后各服1次,7天为一个疗程, 连续服用2个疗程。
[0019] 4、疗效评定标准 显效:月经不调症状消失,体质恢复正常; 好转:月经不调症状明显好转,体质逐步恢复; 无效:达不到好转标准者。
[0020] 5、治疗结果(见下表)
Figure CN104338083AD00081
在上述的治疗中,用本发明药物治疗月经不调患者36例,结果显效33例,显效率为 91. 67%,好转2例,好转率为5. 55%,无效1例,总有效率为97. 22%。

Claims (3)

1. 一种治疗月经不调的药物,其特征在于:它是由下列重量范围内的原料药制成: 莪术10-20克川芎10-20克乳香10-20克 郁金13-19克丹参15-21克益母草25-35克 红花10-20克 水蛭6-10克虻虫5-10克 王不留行 10-20克牛膝10-20克刘寄奴10-20克 延胡索10-20克 姜黄10-20克 三棱10-20克 鸡血藤10-20克 泽兰10-20克 凌霄花10-20克 苏木10-20克藿香10-20克厚朴10-20克 虎杖10-20克 山药10-20克 甘草10-20克 白术10-20克百合30-40克 枸杞子10-20克 桑椹10-20克 黑芝麻10-20克饴糖50-80克 龙眼肉10-20克阿胶10-20克 白芍10-20克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 莪术15克川芎15克乳香15克 郁金16克丹参18克益母草30克 红花15克 水蛭8克 虻虫6克 王不留行 15克牛膝15克刘寄奴15克 延胡索15克 姜黄15克 三棱15克 鸡血藤15克 泽兰15克 凌霄花15克 苏木15克藿香15克厚朴15克 虎杖15克山药15克甘草15克 白术15克百合30克枸杞子15克 桑椹15克 黑芝麻15克 饴糖60克 龙眼肉15克阿胶15克 白芍15克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去 碎屑; (2) 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; (3) 乳香:拣去砂子杂质; (4) 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; (5) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晒干; (6) 益母草:拣去杂质,洗净,润透,切段,晒干; (7) 红花:拣净杂质,除去茎叶、蒂头,晒干; (8) 水蛭:洗净,闷软,切段,晒干; (9) 虻虫:拣净杂质,除去翅、足,用文火微炒用; (10) 王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉; (11) 牛膝:拣去杂质,洗净,润软,去芦,切段,晒干; (12) 刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干; (13) 延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎; (14) 姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干; (15) 三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干; (16) 鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干; (17) 泽兰:拣去杂质,除去残根,喷水稍润,切段晒干; (18) 凌霄花:7-9月间采收,择晴天摘下刚开放的花朵,晒干; (19) 苏木:取原药材,锯成短段,再劈成碎片或镑片; (20) 藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后 与叶和匀; (21) 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; (22) 虎杖:取原药材,除去杂质,洗净,干燥,劈碎; (23) 山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干; (24) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; (25) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (26) 百合:拣去杂质、黑瓣,簸去灰屑; (27) 枸杞子:簸净杂质,摘去残留的梗和蒂; (28) 桑椹:用水洗净,拣去杂质,摘除长柄,晒干; (29) 黑芝麻:取原药材,除去杂质,筛去碎屑; (30) 饴糖:按量提取; (31) 龙眼肉:取原药材,除去杂质; (32) 阿胶:捣碎用; (33) 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀, 切片,干燥; (二)制备 (1) 将所述重量的莪术、川芎、乳香、郁金、丹参、益母草、红花、水蛭、虻虫、王不留行、牛 膝、刘寄奴、延胡索、姜黄、三棱、鸡血藤、泽兰、凌霄花、苏木、藿香、厚朴、虎杖、山药、甘草、 白术、百合、枸杞子、桑椹、黑芝麻、龙眼肉、白芍药物加8倍量水进行浸泡,浸泡120分钟后, 武火煎煮沸腾10分钟,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入 容器内; (2) 第二次加水6倍量,武火煎煮沸腾,加入阿胶,再用文火煎煮10分钟,过滤得第二次 煎煮液; (3) 将两次煎煮液混合,再将烊化的饴糖冲入汤药中混合即得。
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CN105362824A (zh) * 2015-10-25 2016-03-02 薛学明 一种治疗慢性肝炎的药物及其制备方法
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CN105497775A (zh) * 2015-10-26 2016-04-20 薛学明 一种治疗骨折的药物及其制备方法
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CN104758500A (zh) * 2015-03-11 2015-07-08 雷少华 一种针对行血破瘀消肿止痛的中药
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