CN106220724A - 人成纤维细胞生长因子21重组蛋白及其制备方法和应用 - Google Patents
人成纤维细胞生长因子21重组蛋白及其制备方法和应用 Download PDFInfo
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- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Proteomics, Peptides & Aminoacids (AREA)
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Cited By (11)
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CN107012150A (zh) * | 2017-05-12 | 2017-08-04 | 温州医科大学 | 重组人成纤维细胞生长因子‑16的克隆、表达和应用及其生物学活性的测定方法 |
CN107050429A (zh) * | 2017-04-01 | 2017-08-18 | 温州市生物医药协同创新中心 | 人成纤维生长因子21在制备用于治疗脑卒中药物中的应用 |
CN107987151A (zh) * | 2018-01-17 | 2018-05-04 | 吉林省农业科学院 | 一种叶绿体表达的成纤维细胞生长因子21蛋白及其制备方法 |
CN109453367A (zh) * | 2018-11-08 | 2019-03-12 | 温州医科大学 | 成纤维细胞生长因子21在急性肝损伤回肠粘膜损伤中的应用 |
CN109942716A (zh) * | 2019-04-08 | 2019-06-28 | 河南师范大学 | 一种用于治疗代谢疾病的瘦素融合蛋白及其制备方法和应用 |
CN111420030A (zh) * | 2020-05-12 | 2020-07-17 | 江南大学 | Fgf21在制备用于治疗结直肠癌药物中的应用 |
CN113227126A (zh) * | 2018-11-26 | 2021-08-06 | 巴塞罗那自治大学 | 成纤维细胞生长因子21(fgf21)基因治疗 |
CN113717269A (zh) * | 2021-08-31 | 2021-11-30 | 赣江中药创新中心 | 一种重组的变体fgf21蛋白及其制备方法和应用 |
WO2022097914A1 (ko) * | 2020-11-03 | 2022-05-12 | 주식회사 도어코코리아 | 에프지에프21의 열탄력성을 이용한 에프지에프21 생산 방법 |
CN115286705A (zh) * | 2021-12-30 | 2022-11-04 | 长江大学 | 一种黄鳝成纤维细胞因子21重组蛋白及其制备方法和应用 |
CN117187255A (zh) * | 2023-11-07 | 2023-12-08 | 北京大学第三医院(北京大学第三临床医学院) | 编码FGF18或rhFGF18的mRNA及其在骨关节炎治疗中的应用 |
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CN107050429A (zh) * | 2017-04-01 | 2017-08-18 | 温州市生物医药协同创新中心 | 人成纤维生长因子21在制备用于治疗脑卒中药物中的应用 |
CN107012150A (zh) * | 2017-05-12 | 2017-08-04 | 温州医科大学 | 重组人成纤维细胞生长因子‑16的克隆、表达和应用及其生物学活性的测定方法 |
CN107987151A (zh) * | 2018-01-17 | 2018-05-04 | 吉林省农业科学院 | 一种叶绿体表达的成纤维细胞生长因子21蛋白及其制备方法 |
CN109453367A (zh) * | 2018-11-08 | 2019-03-12 | 温州医科大学 | 成纤维细胞生长因子21在急性肝损伤回肠粘膜损伤中的应用 |
CN113227126A (zh) * | 2018-11-26 | 2021-08-06 | 巴塞罗那自治大学 | 成纤维细胞生长因子21(fgf21)基因治疗 |
CN109942716A (zh) * | 2019-04-08 | 2019-06-28 | 河南师范大学 | 一种用于治疗代谢疾病的瘦素融合蛋白及其制备方法和应用 |
CN109942716B (zh) * | 2019-04-08 | 2023-05-12 | 河南师范大学 | 一种用于治疗代谢疾病的瘦素融合蛋白及其制备方法和应用 |
CN111420030A (zh) * | 2020-05-12 | 2020-07-17 | 江南大学 | Fgf21在制备用于治疗结直肠癌药物中的应用 |
WO2021227493A1 (zh) * | 2020-05-12 | 2021-11-18 | 江南大学 | Fgf21在制备用于治疗结直肠癌药物中的应用 |
WO2022097914A1 (ko) * | 2020-11-03 | 2022-05-12 | 주식회사 도어코코리아 | 에프지에프21의 열탄력성을 이용한 에프지에프21 생산 방법 |
CN113717269A (zh) * | 2021-08-31 | 2021-11-30 | 赣江中药创新中心 | 一种重组的变体fgf21蛋白及其制备方法和应用 |
CN115286705A (zh) * | 2021-12-30 | 2022-11-04 | 长江大学 | 一种黄鳝成纤维细胞因子21重组蛋白及其制备方法和应用 |
CN115286705B (zh) * | 2021-12-30 | 2024-05-10 | 长江大学 | 一种黄鳝成纤维细胞因子21重组蛋白及其制备方法和应用 |
CN117187255A (zh) * | 2023-11-07 | 2023-12-08 | 北京大学第三医院(北京大学第三临床医学院) | 编码FGF18或rhFGF18的mRNA及其在骨关节炎治疗中的应用 |
CN117187255B (zh) * | 2023-11-07 | 2024-01-30 | 北京大学第三医院(北京大学第三临床医学院) | 编码FGF18或rhFGF18的mRNA及其在骨关节炎治疗中的应用 |
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