CN106176502A - There is skin care compositions and the application thereof of anti-blue light effect - Google Patents

There is skin care compositions and the application thereof of anti-blue light effect Download PDF

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Publication number
CN106176502A
CN106176502A CN201610807477.XA CN201610807477A CN106176502A CN 106176502 A CN106176502 A CN 106176502A CN 201610807477 A CN201610807477 A CN 201610807477A CN 106176502 A CN106176502 A CN 106176502A
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skin care
extract
blue light
care compositions
light effect
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胡喜芬
钟烈明
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Guangdong Chuangmei Anti-aging Research Co., Ltd.
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Foshan Qianru Cosmetics Co Ltd
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Priority to CN201610807477.XA priority Critical patent/CN106176502A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • A61K8/355Quinones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/895Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/927Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84Products or compounds obtained by lyophilisation, freeze-drying

Abstract

The invention discloses a kind of skin care compositions with anti-blue light effect, the described skin care compositions with anti-blue light effect mainly contains Flos Tagetis Erectae (TAGETES ERECTA) flower extract 0.1 5 parts, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 0.1 5 parts, both share has synergitic eye protection effect, can well solve the eye problems caused because of LED blue ray radiation.

Description

There is skin care compositions and the application thereof of anti-blue light effect
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of skin care compositions with anti-blue light effect and Application.
Background technology
Along with people's concern for health and the understanding for photo bio radiation effect, with our daily life breath manner of breathing The attention rate of the photo bio radiation safety of the illuminating product closed remains high always.The whole world substantial amounts of photobiology, medical research Showing, modern lighting source has effect inconsistent with human body biological characteristics, discordant, constitutes new to the health of the mankind Threaten.Child myopia, visual deterioration, night vision be poor, insomnia, fat, hormone declines, reproductive function goes down, breast carcinoma, de- Send out, depression etc., all have substantial connection with " light ".Meanwhile, LED illumination product is by the capital of property and government subsidy The dual promotion of policy,
So that its energy-saving and environmental protection, life-span length, volume be little etc., feature is developed rapidly, and progressively initially enters room lighting.At this Under background, people have reached unprecedented height for the concern of the photo bio radiation effect of LED illuminating product with attention.
Research shows, blue light arrives as ingredient indispensable in white light LEDs, the crystalline lens that can penetrate human eye Reach retina, and cause photochemistry to damage retina.All more than 20J cm-2Blue ray radiation, obvious optical fundus can be caused Change.The most immature human lens is the highest for the transmitance of shortwave spectral radiance, is the several times of adult human eye, short The blue light of ripple reaches retina more easily by the crystalline lens of this type of people, thus can accelerate the oxidation of macula retinae district cell. Although adult's crystalline lens has relatively low transmitance to blue light, but long-time exposure still results in retina under blue light Degenerative change, form photic retinitis.According to statistics, computer, a large amount of uses of mobile phone, people every day is facing to LED screen The time of curtain, the problem such as eyestrain that blue light causes, ocular injury, black eye, eye wrinkle-removing annoying people day by day more than 6 hours ?.
In view of the blue light injury to human body, especially eyes, the skin care item with anti-blue light need having good market Seek potentiality.Form protecting film after human body surface as the skin care item such as eye mask, eye cream put on, both can nutrition skin care, the most permissible Opposing blue light injury, facilitates consumer to use.But, the most not yet there is the relevant skin-protection product resisting blue light injury.Therefore, There is provided a kind of skin care item with anti-blue light effect the most necessary.
Summary of the invention
Embodiment of the present invention technical problem to be solved is, it is provided that a kind of skincare composition with anti-blue light effect Thing.
Concrete technical scheme is as follows:
First aspect, embodiments provides a kind of skin care compositions with anti-blue light effect, including following mass parts Component: Flos Tagetis Erectae (TAGETES ERECTA) flower extract 0.1-5 part, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 0.1-5 part.Wherein in some embodiments, of the present invention have anti-blue light effect Skin care compositions, including the component of following mass parts: Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5 parts, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5 parts.
Further, as preferably, the skin care compositions with anti-blue light effect of the present invention can also be containing such as The component of lower mass parts: Fructus Lycii (LYCIUM CHINENSE) berry extract 0.1-3 part, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) Root extract 0.1-3 part.Wherein in some embodiments, the skin care compositions with anti-blue light effect of the present invention, bag Include the component of following mass parts: Fructus Lycii (LYCIUM CHINENSE) berry extract 1.5 parts, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 1.5 parts.
Further, as preferably, the skin care compositions with anti-blue light effect of the present invention can also contain The component of following mass parts: Borneolum Syntheticum 0.01-0.1 part, ubiquinone 0.01-0.5 part.
Second aspect, the skin care compositions with anti-blue light effect of the present invention has the effect of anti-blue light, adds Substrate that skin care item are conventional or carrier, can be made into cream, emulsion, essence, eye mask, facial film, astringent, cosmetic water etc. and make up Product.
The embodiment of the present invention additionally provides a kind of eye cream, including each component of following weight/mass percentage composition: the poly-diformazan of ring five Radical siloxane 5-20%, polydimethylsiloxane/vinyl dimethione cross linked polymer 10-20%, polydimethylsiloxanes Alkane 5-20%, double-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane 1-2%, Cera Flava 0.5-2%, poly-second two Alcohol-8 5-10%, butanediol 5-15%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 0.1-0.3%, second Thiazolinyl polydimethylsiloxane/polymethyl siloxane silsesquioxane cross linked polymer 0.5-2%, sodium acrylate/acryloyl diformazan Base Taurate Copolymer 0.05-0.15%, 2-Methylpentadecane 0.15-0.6%, Polyoxyethylene Sorbitan Monooleate 0.05-0.15%, arginine 0.1-0.3%, above-mentioned there is the skin care compositions 0.2-10% of anti-blue light effect, water surplus.
The third aspect, the embodiment of the present invention additionally provides the preparation of a kind of Flos Tagetis Erectae (TAGETES ERECTA) flower extract Technique, specifically comprises the following steps that
(1) pulverize: the flower of Flos Tagetis Erectae be dry, pulverize, cross 50-100 eye mesh screen and sieve to obtain plant powder;
(2) enzymolysis: weigh the water that weight is plant powder 1-2 times, adds cellulase in water, makes the enzyme of water cellulase Vigor, at 1000-3000U/mL, is then sprayed onto on plant powder, and stirring moistening is uniform, is incubated 45-55 DEG C, and enzymolysis 1-3 is little Time, it is thus achieved that enzymolysis powder;
(3) extract: weigh No. 15 cosmetics-stage white mineral oils that weight portion is plant powder 20-30 times, join in enzymolysis powder, It is heated to 45-55 DEG C, under insulated and stirred, is ultrasonic Treatment 3-5 minute of 10-20KHZ every 20-30 minute open frequency, Lixiviating solution is obtained after ultrasonic Treatment 1-3 time;
(4) filter: by lixiviating solution first with 50-100 mesh filter-cloth filtering, the most again with 500-1000 mesh filter-cloth filtering, it is thus achieved that filtrate And filtering residue, by centrifugal for filtrate discard to precipitate i.e. obtain extract.
Compared with prior art, the method have the advantages that
1, the present invention is through the substantial amounts of experiment of inventor and research, finds that Flos Tagetis Erectae (TAGETES ERECTA) flower extract can be direct Absorbing ectogenic blue light, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract absorbs endogenic free radical, The protection each confluent monolayer cells of retina is complete, improves damaged cell, and both share has synergitic eye protection effect, can well solve because of The eye problems that LED blue ray radiation causes;The optic cell that photic damage is caused by Fructus Lycii (LYCIUM CHINENSE) berry extract Apoptosis has improvement result, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract can effectively protect retinal tissue ultra micro to tie Structure, both share, and enhance composition product to the reparation of the damage that endogenic blue light causes and prevention ability, can promote group Eye protection effect of compound;Borneolum Syntheticum has the effect of refrigerant improving eyesight, and ubiquinone has strong oxidation resistance, slow down aging, strengthens and lives Power, share the eye protection effect that can promote anti-blue light skin care compositions further.
2, the eye cream obtained by the present invention compounds through effective ratio science and forms, salubrious non-greasy, and spreadability is good, absorbs Hurry up, there is good use sense.
3, Flos Tagetis Erectae (TAGETES ERECTA) the flower extract activity obtained by present invention process is higher, and technique is simple Easy.
Hereinafter part material involved in the present invention is carried out brief introduction:
Flos Tagetis Erectae (TAGETES ERECTA) flower extract, the extract of the flower of Compositae plants of tagetes species Flos Tagetis Erectae.Flos Tagetis Erectae (TAGETES ERECTA) flower extract contains abundant phylloxanthin, has a direct Absorption to blue light, additionally it or one Plant antioxidant, the free radical that blue light causes can be absorbed.
Narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract, Ericaceae genus vaccinium plant narrow leaf Pericarpium Citri tangerinae The extract of mature fruit.Narrow leaf Pericarpium Citri tangerinae, has another name called blue berry, originates in America, extensively cultivates on the ground such as Northeast China, Xinjiang.Blue The certain kind of berries, because rich in polyphenols such as anthocyanin, having higher non-oxidizability, can be effectively improved photic damage rat retina thin The SOD (superoxide dismutase) of born of the same parents, GSH-Px(glutathion peroxidase) active and total protein content, significantly reduce MDA(malonaldehyde) content.Additionally, found by pathologic examination, Anthocyanin from Blueberry can protect each confluent monolayer cells of retina Completely, improve damaged cell, and increase outer nuclear layer thickness.
Fructus Lycii (LYCIUM CHINENSE) berry extract, the extract of the mature fruit of Solanaceae Lycium Fructus Lycii.This Fructus Lycii described in invention includes the Fructus Lycii kind that lycium barbarum, Lycium ruthenicum Murr. etc. are different.Having been reported that, photic damage is drawn by wolfberry fruit extract The optic cell apoptosis risen has obvious improvement result.
Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract, the extract of the root of Lamiaceae Salvia platymiscium Radix Salviae Miltiorrhizae. Having been reported that, Radix Salviae Miltiorrhizae can significantly reduce the content of retinal tissue MDA after illumination, it is to avoid SOD falls sharply, and effectively protects view Membrane tissue ultrastructure.
Borneolum Syntheticum, is obtained through steam distillation recrystallization by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf, for The crystalline solid off-white color of translucent, lamellar block like Flos Mume lobe or powder is to light taupe brown, and gas delicate fragrance, taste is refrigerant." Xin Xiuben Grass ": " main trusted subordinate's pathogen, rheumatism is gathered, deaf, and conjunctival congestion skin nebula is gone in improving eyesight.”
Ubiquinone, has another name called coenzyme Q10, is a kind of fat-soluble antioxidant, and energy human activin cell and the nutrition of cellular energy have Improve body immunity, strengthen the functions such as antioxidation, slow down aging and enhancing human activity.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below Step ground describes in detail.But embodiments of the present invention are not limited to this, for the technological parameter indicated the most especially or condition, can refer to Routine techniques is carried out.
Embodiment 1
The preparation technology of a kind of Flos Tagetis Erectae (TAGETES ERECTA) flower extract, specifically comprises the following steps that
(1) pulverize: the flower of 10kg Flos Tagetis Erectae be dry, pulverize, cross 50 eye mesh screens and sieve to obtain plant powder;
(2) enzymolysis: weigh 20kg water, in water add cellulase, make the enzyme activity of water cellulase at 1000U/mL, so After be sprayed onto on plant powder, stirring moistening is uniform, is incubated 55 DEG C, enzymolysis 1 hour, it is thus achieved that enzymolysis powder;
(3) extract: weigh 300kg15 cosmetics-stage white mineral oil, join in enzymolysis powder, be heated to 45 DEG C, insulated and stirred Under, every the ultrasonic Treatment that 30 minutes open frequency are 10KHZ 5 minutes, after ultrasonic Treatment 1 time, obtain lixiviating solution;
(4) filter: by lixiviating solution first with 100 mesh filter-cloth filterings, the most again with 500 mesh filter-cloth filterings, it is thus achieved that filtrate and filtering residue, will Filtrate is centrifuged to discard to precipitate and i.e. obtains extract.
Embodiment 2
The preparation technology of a kind of Flos Tagetis Erectae (TAGETES ERECTA) flower extract, specifically comprises the following steps that
(1) pulverize: the flower of 10kg Flos Tagetis Erectae be dry, pulverize, cross 100 eye mesh screens and sieve to obtain plant powder;
(2) enzymolysis: weigh 10kg water, in water add cellulase, make the enzyme activity of water cellulase at 3000U/mL, so After be sprayed onto on plant powder, stirring moistening is uniform, is incubated 45 DEG C, enzymolysis 3 hours, it is thus achieved that enzymolysis powder;
(3) extract: weigh 200kg15 cosmetics-stage white mineral oil, join in enzymolysis powder, be heated to 55 DEG C, insulated and stirred Under, every the ultrasonic Treatment that 20 minutes open frequency are 20KHZ 3 minutes, after ultrasonic Treatment 3 times, obtain lixiviating solution;
(4) filter: by lixiviating solution first with 50 mesh filter-cloth filterings, the most again with 1000 mesh filter-cloth filterings, it is thus achieved that filtrate and filtering residue, will Filtrate is centrifuged to discard to precipitate and i.e. obtains extract.
Embodiment 3
The preparation technology of a kind of Flos Tagetis Erectae (TAGETES ERECTA) flower extract, specifically comprises the following steps that
(1) pulverize: the flower of 10kg Flos Tagetis Erectae be dry, pulverize, cross 100 eye mesh screens and sieve to obtain plant powder;
(2) enzymolysis: weigh 15kg water, in water add cellulase, make the enzyme activity of water cellulase at 2000U/mL, so After be sprayed onto on plant powder, stirring moistening is uniform, is incubated 50 DEG C, enzymolysis 2 hours, it is thus achieved that enzymolysis powder;
(3) extract: weigh 250kg15 cosmetics-stage white mineral oil, join in enzymolysis powder, be heated to 50 DEG C, insulated and stirred Under, every the ultrasonic Treatment that 25 minutes open frequency are 15KHZ 4 minutes, after ultrasonic Treatment 2 times, obtain lixiviating solution;
(4) filter: by lixiviating solution first with 50 mesh filter-cloth filterings, the most again with 1000 mesh filter-cloth filterings, it is thus achieved that filtrate and filtering residue, will Filtrate is centrifuged to discard to precipitate and i.e. obtains extract.
Embodiment 4
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 5%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 20%, polydimethylsiloxane 5%, double-PEG/PPG-16/16 PEG/PPG- 16/16 polydimethylsiloxane 2%, Cera Flava 0.5%, PEG-8 10%, butanediol 5%, acrylic acid (ester) class/C10-30 Alkylol acrylamide acid esters cross linked polymer 0.3%, vinyldimethicone/polymethyl siloxane silsesquioxane crosslinking is poly- Compound 0.5%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.15%, 2-Methylpentadecane 0.15%, Polyoxyethylene Sorbitan Monooleate 0.15%, arginine 0.3%, Flos Tagetis Erectae (TAGETES ERECTA) flower extract 5% of embodiment 1 preparation, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 0.1%, water surplus.
Embodiment 5
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 20%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 10%, polydimethylsiloxane 20%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1%, Cera Flava 2%, PEG-8 5%, butanediol 15%, acrylic acid (ester) class/C10-30 Alkylol acrylamide acid esters cross linked polymer 0.1%, vinyldimethicone/polymethyl siloxane silsesquioxane crosslinking is poly- Compound 2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.05%, 2-Methylpentadecane 0.6%, Polyoxyethylene Sorbitan Monooleate 0.05%, arginine 0.1%, Flos Tagetis Erectae (TAGETES ERECTA) flower extract 0.1% of embodiment 2 preparation, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 5%, water surplus.
Embodiment 6
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% of ester-80 0.1%, arginine 0.2%, embodiment 3 preparation, narrow leaf are more Fructus Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, water surplus.
Embodiment 7
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% prepared by ester-80 0.1%, arginine 0.2%, embodiment 3, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, Fructus Lycii (LYCIUM CHINENSE) berry extract 0.1%, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 3%, water surplus.
Embodiment 8
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% of ester-80 0.1%, arginine 0.2%, embodiment 3 preparation, narrow leaf are more Fructus Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, Fructus Lycii (LYCIUM CHINENSE) berry extract 3%, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 0.1%, water surplus.
Embodiment 9
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% prepared by ester-80 0.1%, arginine 0.2%, embodiment 3, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, Fructus Lycii (LYCIUM CHINENSE) berry extract 1.5%, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 1.5%, Borneolum Syntheticum 0.01%, ubiquinone 0.5%, water surplus.
Embodiment 10
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% prepared by ester-80 0.1%, arginine 0.2%, embodiment 3, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, Fructus Lycii (LYCIUM CHINENSE) berry extract 1.5%, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 1.5%, Borneolum Syntheticum 0.1%, ubiquinone 0.01%, water surplus.
Comparative example 1
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Ester-80 0.1%, arginine 0.2%, water surplus.
Comparative example 2
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Ester-80 0.1%, arginine 0.2%, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, water surplus.
Comparative example 3
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate More than Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% of ester-80 0.1%, arginine 0.2%, embodiment 3 preparation, water Amount.
Comparative example 4
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% of ester-80 0.1%, arginine 0.2%, embodiment 3 preparation, narrow leaf are more More than Fructus Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, Fructus Lycii (LYCIUM CHINENSE) berry extract 5%, water Amount.
Comparative example 5
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5% of ester-80 0.1%, arginine 0.2%, embodiment 3 preparation, narrow leaf are more Fructus Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 5%, Water surplus.
Comparative example 6
A kind of eye cream, including each component of following weight/mass percentage composition: ring five polydimethylsiloxane 15%, polydimethylsiloxanes Alkane/vinyl dimethione cross linked polymer 15%, polydimethylsiloxane 12%, double-PEG/PPG-16/16 PEG/ PPG-16/16 polydimethylsiloxane 1.5%, Cera Flava 1.2%, PEG-8 7%, butanediol 10%, acrylic acid (ester) class/ C10-30 alkylol acrylamide acid esters cross linked polymer 0.2%, vinyldimethicone/polymethyl siloxane silsesquioxane Cross linked polymer 1.2%, sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.1%, 2-Methylpentadecane 0.3%, polysorbate Ester-80 0.1%, arginine 0.2%, commercially available Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5%, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5%, water surplus.
Embodiment 11
The eye cream of embodiment 4-10 and comparative example 1-6 is carried out efficacy assessments.Concrete method of testing is as follows: each experimental group is all chosen 10 every days facing to the LED screen time more than 6 hours and because of LED blue ray radiation cause eyestrain, ocular injury, black eye, The volunteer of the problems such as eye wrinkle-removing, age 20-50 year;Using method: the most each use 1 time, 2 weeks the most on probation, takes pictures and deposits Shelves.Evaluation methodology: contrast the 0th day and the 2nd week photo inquire volunteer, wherein eyestrain, ocular injury, black eye, eye wrinkle The problems such as stricture of vagina are to being obviously improved as effective;The problems such as eyestrain, ocular injury, black eye, eye wrinkle-removing are eased and no longer increase Add is effective;The problems such as eyestrain, ocular injury, black eye, eye wrinkle-removing do not improve for invalid.Concrete test result is such as Table 1.
Table 1 eye cream test recording table
Effective Effectively Invalid
Embodiment 4 2 4 4
Embodiment 5 2 5 3
Embodiment 6 3 4 3
Embodiment 7 6 3 1
Embodiment 8 7 2 1
Embodiment 9 9 1 0
Embodiment 10 8 2 0
Comparative example 1 0 4 6
Comparative example 2 0 5 5
Comparative example 3 0 6 4
Comparative example 4 3 4 3
Comparative example 5 3 5 2
Comparative example 6 2 2 6
Shown that by contrast experiment the result of table 1 is visible:
Embodiment 4-10 is visible with the contrast of comparative example 1-5, and eye cream prepared by the present invention has good eye protection effect, can efficient solution The eye problems certainly caused because of LED blue ray radiation;
Embodiment 4-5 is visible with the contrast of comparative example 1-3, Flos Tagetis Erectae (TAGETES ERECTA) flower extract, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract share has synergitic eye protection effect, can well solve because of LED blue light The eye problems that radiation causes;
Embodiment 7-8 contrasts visible with comparative example 4-5, embodiment 4-6, Fructus Lycii (LYCIUM CHINENSE) berry extract, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract share has synergism, can promote eye protection effect of anti-blue light compositions;
Embodiment 9-10 is visible with the contrast of embodiment 7-8, and Borneolum Syntheticum, ubiquinone share the eye protection that can promote anti-blue light compositions further Effect;
Embodiment 6 and comparative example 6 contrast visible, Flos Tagetis Erectae (TAGETES ERECTA) flower extract obtained by present invention process Activity is higher, and eye protection effect is preferable.
The above, be only presently preferred embodiments of the present invention, and the present invention not does any pro forma restriction, therefore All contents without departing from technical solution of the present invention, any simply repair made for any of the above embodiments according to the technical spirit of the present invention Change, equivalent variations and modification, all still fall within the range of technical solution of the present invention.

Claims (8)

1. a skin care compositions with anti-blue light effect, it is characterised in that described skin care compositions includes following quality The component of part: Flos Tagetis Erectae (TAGETES ERECTA) flower extract 0.1-5 part, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 0.1-5 part.
The skin care compositions with anti-blue light effect the most according to claim 1, it is characterised in that described skincare composition Thing includes the component of following mass parts: Flos Tagetis Erectae (TAGETES ERECTA) flower extract 2.5 parts, narrow leaf Pericarpium Citri tangerinae (VACCINIUM ANGUSTIFOLIUM) berry extract 2.5 parts.
The skin care compositions with anti-blue light effect the most according to claim 1, it is characterised in that described has anti-indigo plant The skin care compositions of light effect is possibly together with the component of following mass parts: Fructus Lycii (LYCIUM CHINENSE) berry extract 0.1-3 Part, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 0.1-3 part.
The skin care compositions with anti-blue light effect the most according to claim 3, it is characterised in that described has anti-indigo plant The skin care compositions of light effect is possibly together with the component of following mass parts: Fructus Lycii (LYCIUM CHINENSE) berry extract 1.5 parts, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) root extract 1.5 parts.
5. according to the skin care compositions with anti-blue light effect described in claim 1 or 3, it is characterised in that described has The skin care compositions of anti-blue light effect is possibly together with the component of following mass parts: Borneolum Syntheticum 0.01-0.1 part, ubiquinone 0.01-0.5 part.
6. the application in skin-protection product of the skin care compositions with anti-blue light effect described in any one of claim 1-5.
7. one kind is used for eye cream, it is characterised in that described eye cream includes each component of following weight/mass percentage composition: the poly-diformazan of ring five Radical siloxane 5-20%, polydimethylsiloxane/vinyl dimethione cross linked polymer 10-20%, polydimethylsiloxanes Alkane 5-20%, double-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane 1-2%, Cera Flava 0.5-2%, poly-second two Alcohol-8 5-10%, butanediol 5-15%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 0.1-0.3%, second Thiazolinyl polydimethylsiloxane/polymethyl siloxane silsesquioxane cross linked polymer 0.5-2%, sodium acrylate/acryloyl diformazan Base Taurate Copolymer 0.05-0.15%, 2-Methylpentadecane 0.15-0.6%, Polyoxyethylene Sorbitan Monooleate 0.05-0.15%, arginine Described in 0.1-0.3%, any one of claim 1-5, there is the skin care compositions 0.2-10% of anti-blue light effect, water surplus.
8. a preparation technology for Flos Tagetis Erectae (TAGETES ERECTA) flower extract described in claim 1 or 2, its feature exists In, specifically comprise the following steps that
(1) pulverize: the flower of Flos Tagetis Erectae be dry, pulverize, cross 50-100 eye mesh screen and sieve to obtain plant powder;
(2) enzymolysis: weigh the water that weight is plant powder 1-2 times, adds cellulase in water, makes the enzyme of water cellulase Vigor, at 1000-3000U/mL, is then sprayed onto on plant powder, and stirring moistening is uniform, is incubated 45-55 DEG C, and enzymolysis 1-3 is little Time, it is thus achieved that enzymolysis powder;
(3) extract: weigh No. 15 cosmetics-stage white mineral oils that weight portion is plant powder 20-30 times, join in enzymolysis powder, It is heated to 45-55 DEG C, under insulated and stirred, is ultrasonic Treatment 3-5 minute of 10-20KHZ every 20-30 minute open frequency, Lixiviating solution is obtained after ultrasonic Treatment 1-3 time;
(4) filter: by lixiviating solution first with 50-100 mesh filter-cloth filtering, the most again with 500-1000 mesh filter-cloth filtering, it is thus achieved that filtrate And filtering residue, by centrifugal for filtrate discard to precipitate i.e. obtain extract.
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CN106727027A (en) * 2017-01-18 2017-05-31 韩后化妆品股份有限公司 Anti- blue light, anti-oxidant, the free based composition and use thereof in packaging of removing, skin care item and preparation method
CN106806255A (en) * 2017-02-11 2017-06-09 佛山市芊茹化妆品有限公司 A kind of antipollution mask
CN108669333A (en) * 2018-04-17 2018-10-19 佛山市雷米高动物营养保健科技有限公司 Except pet tear stains composition, except pet tear stains product and preparation method thereof
CN108836920A (en) * 2018-09-25 2018-11-20 广州好润生物科技有限公司 A kind of shortwave blue light protection component of plant origin and its preparation method and application
CN108836920B (en) * 2018-09-25 2020-12-18 广州天然国度生物科技有限公司 Plant-derived short-wave blue light protection composition and preparation method and application thereof
CN109172448A (en) * 2018-10-12 2019-01-11 广州市雅彩盛生物科技有限公司 A kind of skin care item and preparation method thereof with anti-blue light action
CN109288714A (en) * 2018-11-21 2019-02-01 广州若双化妆品有限公司 A kind of eye cream of blue ray radiation preventing and preparation method thereof
CN110403871A (en) * 2019-08-29 2019-11-05 北昊干细胞与再生医学研究院有限公司 It is a kind of to have effects that anti-blue light, the composition repaired and the preparation method and application thereof
CN110974765A (en) * 2020-01-15 2020-04-10 青岛思拓新源细胞医学有限公司 Natural whitening mask and preparation method and application thereof
CN110974765B (en) * 2020-01-15 2021-06-15 芭芭多芦荟生物科技研究(广州)院 Natural whitening mask and preparation method and application thereof
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CN111529417B (en) * 2020-06-08 2023-05-30 马应龙大健康有限公司 Repairing eye cream with blue light resisting effect and preparation method thereof
CN112807250A (en) * 2021-01-14 2021-05-18 丽水学院 Anti-aging eye cream with blue light prevention effect and preparation method thereof
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Application publication date: 20161207

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