CN109172448A - A kind of skin care item and preparation method thereof with anti-blue light action - Google Patents
A kind of skin care item and preparation method thereof with anti-blue light action Download PDFInfo
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- CN109172448A CN109172448A CN201811191769.0A CN201811191769A CN109172448A CN 109172448 A CN109172448 A CN 109172448A CN 201811191769 A CN201811191769 A CN 201811191769A CN 109172448 A CN109172448 A CN 109172448A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The present invention relates to a kind of skin care item with anti-blue light action, the skin care item contain prebiotics, mung bean seed fermentation liquid, water lock magnetite, carnosine, double nano Co-Q10, sunflower bud extract.The skin care item are applied on skin; and it is massaged; the activity of skin confluent monolayer cells can be increased; to enhance skin itself to the filter capacity of blue light, the generation of infrared ray IR blue light free radical is stopped, injury of the blue light to skin is reduced and prevent; prevent from being exposed to the loss for leading to skin density under sunlight; there is facilitation to the generation of skin collagen, skin elasticity can be maintained, it is old that protection skin reduces light decay.Sunflower bud extract has activation to peroxidase activated receptor (PPAR) simultaneously, PPAR has Anti-G value, it can guarantee sufficient amount of epithelial cells living to participate in re-forming and migrating for wound epidermis, therefore play the role of skin wound healing and anti-inflammatory.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of skin care item and preparation method thereof of anti-blue light action.
Background technique
Blue light, also referred to as high energy visible light (HEV) refer to wavelength between the light of 390 to 500 nm.Therefore, blue light
It can be penetrated than UVA and UVB light to the deeper inside of skin, and there is higher energy than IR light, that is,
Say that it causes the Potential feasibility of damage bigger skin.The demand of blue light is defendd increasingly to be incremented by recent years, the source of blue light
It is only no longer the digital screen from sunlight, smart phone, computer and TV, there are also LED lamps can also issue a large amount of indigo plants
Optical wavelength.Blue light is maximally efficient on inhibiting melatonin, this is merit attention the problem of, and melatonin is a kind of adjusting
The hormone of the circadian rhythm and pace of moving things is the natural clock of body.Therefore, screen equipment, especially before sleep, meeting are used too much
Lead to the change of sleep habit, the result is that sleep quality be deteriorated, therefore blue light ray in addition to upset sleep cycle, can also by with
Under type causes negative impact to skin: generating free radicals in skin, causes oxidative damage and cause the light decay of skin old;
The reparation of delaying skin barrier.
Injury in view of blue light to human body, especially eyes, it is extremely important that protection skin, which resists the adverse effect of blue light,
, the skin care item with anti-blue light will have the good market demand potential.Such as eye mask, eye cream skin care item is applied to human body table
Protective film is formed behind face, can not only be nourished and moisturized skin, but also can resist blue light injury, and consumer is facilitated to use.However, existing skill
Anti- blue light, skin care item effect that is anti-oxidant, removing free radical in art are not obvious, and are easy to appear such as skin allergy not
Good reaction.Therefore, obtaining a kind of anti-blue light significant effect, safety, good skin care item are current urgent problems to be solved.
Summary of the invention
In order to solve the above-mentioned problems in the prior art, for deficiency existing for contemporary skin care product, the present invention is to it
It is improved, obtains a kind of skin care item with anti-blue light action.The skin care item with anti-blue light action, by weight hundred
Divide than meter, including skin care item matrix 67.5-98.99%, prebiotics 0.1-3%, mung bean seed fermentation liquid 0.3-5%, water lock magnetite 0.3-
10%, carnosine 0.01-0.5%, double nano Co-Q10 0.2-2%;
The skin care item matrix is selected from one or more of following component: stearine/PEG-100 stearate, whale
Wax stearyl alcohol, cetearyl glucoside, tocopherol (vitamin E), caprylic/capric triglyceride, Butyrospermum parkii
(BUTYROSPERMUM PARKII) fruit rouge extract, olive (OLEA EUROPAEA) oily unsaponifiable matter, Tahiti cape jasmine
(GARDENIA TAHITENSIS) caul-fat, cetostearyl alcohol, dimethyl silicone polymer, cyclomethicone, oxybenzene first
Ester, Nipasol, carbomer, hydrolecithin, 1,3- propylene glycol, Sodium Hyaluronate, xanthan gum, panthenol, Phosphoric acid monohexadecyl ester
Potassium, EDTA-2Na, butanediol, arginine, dipotassium glycyrrhizinate, bisabolol, Phenoxyethanol/Sensiva SC50, glacial water;
The prebiotics are selected from chlorella (CHLORELLA VULGARIS) extract;
Further, sunflower bud extract is also contained in the skin care item;Preferably, the sunflower bud extract accounts for skin care
Product weight percent is 0.1-12%;
By mass percentage, the glacial water includes following ingredient: 40-60% water, 40-60% glycerol, 0.4-0.6% preservative;
The preservative be selected from one or both of potassium sorbate, sodium benzoate, preferably 0.2-0.3% potassium sorbate and
0.2-0.3% sodium benzoate;
Preferably, the skin care item with anti-blue light action by weight percentage, including following component:
A phase
Stearine, PEG-100 stearate 2.5%
Cetostearyl alcohol, cetearyl glucoside 3%
Tocopherol (vitamin E) 0.1%-1%
Caprylic/capric triglyceride 3%
Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge extract 1%-4%
Olive (OLEA EUROPAEA) oil unsaponifiable matter 0.5%-5%
Tahiti cape jasmine (GARDENIA TAHITENSIS) caul-fat 0.5%-8%
Cetostearyl alcohol 1.5%-3%
Dimethyl silicone polymer 1.5%
Cyclomethicone 3%
Methyl hydroxybenzoate 0.2%
Nipasol 0.1%
B phase
Carbomer 0.2%
Hydrolecithin 0.25%
1,3- propylene glycol 8%
Sodium Hyaluronate 0.05%-0.2%
Xanthan gum 0.15%
Panthenol 0.1%-4%
Phosphoric acid monohexadecyl ester potassium 0.3%
EDTA-2Na 0.05%
Glacial water adds to 100%
C phase
Butanediol 1.5%
Arginine 0.4%
Carnosine 0.01%-0.5%
Glacial water 3%
D phase
Sunflower bud extract 0.1%-12%
Chlorella (CHLORELLA VULGARIS) extract 0.1%-3%
Mung bean seed fermentation liquid 0.3%-5%
Water lock magnetite 0.3%-10%
Double nano Co-Q10 0.2%-2%
Dipotassium glycyrrhizinate 0.3%
Bisabolol 0.4%
Phenoxyethanol/Sensiva SC50 0.5%.
Skin care item of the present invention with anti-blue light action, preparation method include the following steps:
(1) each material of A phase component is accurately weighed in oily phase pot, and wherein Tahiti gardenia flower oil/cyclomethicone exists
It is added in emulsion pot before emulsification, is heated to 90 DEG C when opening stirring, 85 DEG C of heat preservation is spare after being completely dissolved completely;
(2) B phase each component raw material is accurately weighed, is added in emulsion pot;Wherein, 1,3-PD/Sodium Hyaluronate/xanthan gum,
Preparatory dispersion mixing stirs evenly, spare;Take the 30% of total amount glacial water carbomer immersion is uniformly dispersed in advance, it is spare;It opens and stirs
38 revs/min are mixed, homogeneous 2500 turns/3 minutes, after dispersion, stirring maintained revolving speed constant, it is heated to 95 DEG C while stirring,
Heat preservation 5 minutes spare;
(3) emulsification pot temperature is maintained at 85 DEG C, 200 mesh device of the A phase component filtering dissolved in advance is added in emulsion pot, tower
Uncommon gardenia flower oil/the cyclomethicone that mentions also is added in emulsion pot at this moment, opens 45 revs/min of stirring, and 3800 turns of homogeneous/
5 minutes, after homogeneous, vacuumize 0.1 degree of defoaming, after adjust stirring 45 revs/min, open cooling water and cool down while stirring;
(4) C phase materials are accurately weighed, carnosine is heated to and is uniformly dissolved with arginine rear spare, pot temperature to be emulsified is down to 60 DEG C
When, the C phase materials pre-processed are added in emulsion pot, 40 revs/min of adjustment stirring, after dispersion completely, continue cooling drop
Temperature;
(5) it is spare to accurately weigh each material of D phase, when pot temperature to be emulsified is down to 48 DEG C, D phase materials are all added, adjustment is stirred
35 revs/min are mixed, homogeneous 2000 turns/2 minutes, is dispersed with stirring to substantially uniformity, continues to cool;Pot temperature drop to be emulsified
When to 45 DEG C, feeding inspection, 200 mesh filter-cloth filterings discharge after passing the inspection.
One of present invention has the skin care item of anti-blue light action, and sunflower bud extract contained therein can increase skin
The activity of skin layers cell is stopped the generation of infrared ray IR blue light free radical, is subtracted to enhance skin itself to the filter capacity of blue light
Less and injury of the blue light to skin is prevented, prevents from being exposed to the loss for leading to skin density under sunlight, to skin collagen
Generation has facilitation, can maintain skin elasticity, it is old that protection skin reduces light decay.Sunflower bud extract is to peroxide simultaneously
Enzyme activition receptor (PPAR) has an activation, PPAR has Anti-G value, it is ensured that sufficient amount of epithelial cells living are joined
It re-forming and migrates with wound epidermis, there is skin wound healing and anti-inflammatory;
Further, chlorella (CHLORELLA VULGARIS) extract as prebiotics contained in the present invention, it
Best foods balanced nutritious needed for energy and skin can be provided for skin.Since there is the nutrition of growth factor to mend for it
Effect is filled, while the microbiologic population of balance and the microbiologic population of calm skin balance are with calm skin, can be supplemented
Skin vigor while restoring skin youth state, can supplement skin vigor, restore skin youth state, while reducing daylight and causing
Sunburn maintenance;
For mung bean seed fermentation liquid, just it is used for scytitis and trauma care in ancient times mung bean, and passes through cool fermentation technology
After, containing tannic acid rich in, the substances such as sterol and flavonoids, these ferment and produce it is low molecular activity at
Part, can preferably allow skin absorb to reach reparation, moisturizing, it is potent releive, outside anti-aging, it is main that skin is protected to make it
The scytitis induced from UV light;
Heretofore described water lock magnetite, the entitled carbohydrate isomer of INCI.Water lock magnetite is a kind of guarantor well
Humectant agent and emollients have and repair epidermal layer cells, promote skin moisturizing ability, the isomery manufactured via Measurement for Biochemistry
Change D- glucan, have and human keratinous layer similar in composed structure, using on the skin can in conjunction with epsilon-amino acid functional group,
It is firmly combined just as magnetite, it can the long-acting hydromagnetic field energy power for maintaining skin.Another group of water lock magnetite then plays strength water
Cooperation is used, and skin is prevented percutaneously to scatter and disappear (TEWL), and is absorbed water from external environment, and dynamic maintains skin water balance, plays long-acting guarantor
Wet effect;
The dipeptides that carnosine is then made of alanine and histidine.Aging tolemerase illustrates within 1973: the length of telomere with
The increase of frequency dividing cell and shorten, telomere length determines the service life of cell.And carnosine can delay the shortening of telomere, together
A kind of potent antioxidants of Shi Zuowei can inhibit oxidative damage, prevent glycosylation, carbonyl radical is effectively quenched
(RCS), terminal saccharification reaction product (cytotoxin) is reduced.The crosslinking of the macromoleculars such as collagen can be prevented simultaneously, inhibited
MMP-1 reduces the generation of wrinkle and protects Skin Cell from the damage of UVB;
It handles, is combined together with substances such as the natural VEs of vitamin C and poorly water-soluble, shape by special package conversion process
At stable uniform system double nano Co-Q10, make it have higher permeability and bioactivity, therefore it not only can be with
It protects skin resistance light decay old, promotes the resistance to oxidation of skin, wrinkle can also be reduced, promote the more raw rate of epidermis cell, change
The activity of kind grain wire body, Cucumber Extract;
Relative to the anti-blue light cosmetics that existing market occurs, the phenomenon that unobvious for its prevalent effects and easy allergy
Deng a kind of skin care item with anti-blue light action of the present invention, sunflower bud active matter is by carrying out to Organic Sunflower bud
Extraction purification and come, it is compared with the mature plant, and bud is containing more essential fatty acid, vitamin, minerals and a series of
Secondary plant metabolites matter.These compounds are not related to main metabolic processes, such as growth course;Their effect is to protect
Plant resistant disease, injury, pathogen, extreme ultraviolet light, pollutant are protected, and resists herbivore and (herbivore is come
Say have the plant seedlings of high nutritive value, the tender shoots of especially non-lignifying attracts very much).Thus they are adjustable
Gene performance can assign skin youthful vigor and really delay and resist skin caused by blue light harm to protect cellular matrix
Aging.
Preparation method of the invention is advanced, can retain the nutrition essence of various components, and production cost is low.
Detailed description of the invention
Fig. 1 be sunflower bud extract block IR induction MMP-1(metalloproteinases) excessive generation Inhibition test pair
According to table;
Fig. 2 is that sunflower bud extract protects the formation of horn cell to resist the blue light damage experiment table of comparisons;
Fig. 3 is the damage experiment table of comparisons that sunflower bud extract protection fibrocyte resists blue light;
Fig. 4 be carnosine inhibit IR induction MMP-1(metalloproteinases) expression experiment contrast table;
Fig. 5 is experiment contrast table of the chlorella extract to horn cell inflammatory reaction inhibiting effect.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The present invention provides a kind of skin care item with anti-blue light action, by weight percentage, including skin care item matrix
67.5-98.99%, prebiotics 0.1-3%, mung bean seed fermentation liquid 0.3-5%, water lock magnetite 0.3-10%, carnosine 0.01-0.5% are double
Nanometer Co-Q10 0.2-2%.
The skin care item matrix is selected from one or more of following component: stearine/PEG-100 stearic acid
Ester, cetostearyl alcohol, cetearyl glucoside, tocopherol, caprylic/capric triglyceride, Butyrospermum parkii fruit rouge extract, oil
Olive oil unsaponifiable matter, Tahiti gardenia flower oil, cetostearyl alcohol, dimethyl silicone polymer, cyclomethicone, oxybenzene
Methyl esters, Nipasol, carbomer, hydrolecithin, 1,3- propylene glycol, Sodium Hyaluronate, xanthan gum, panthenol, cetanol phosphoric acid
Ester potassium, EDTA-2Na, butanediol, arginine, dipotassium glycyrrhizinate, bisabolol, Phenoxyethanol/Sensiva SC50, glacial water.
Embodiment 1
A kind of skin care item with anti-blue light action, by weight percentage, including following component:
A phase
Stearine, PEG-100 stearate 2.5%
Cetostearyl alcohol, cetearyl glucoside 3%
Tocopherol (vitamin E) 0.1%
Caprylic/capric triglyceride 3%
Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge extract 1%
Olive (OLEA EUROPAEA) oil unsaponifiable matter 0.5%
Tahiti cape jasmine (GARDENIA TAHITENSIS) caul-fat 0.5%
Cetostearyl alcohol 1.5%
Dimethyl silicone polymer 1.5%
Cyclomethicone 3%
Methyl hydroxybenzoate 0.2%
Nipasol 0.1%
B phase
Carbomer 0.2%
Hydrolecithin 0.25%
1,3- propylene glycol 8%
Sodium Hyaluronate 0.05%
Xanthan gum 0.15%
Panthenol 0.1%
Phosphoric acid monohexadecyl ester potassium 0.3%
EDTA-2Na 0.05%
Glacial water adds to 100%
C phase
Butanediol 1.5%
Arginine 0.4%
Carnosine 0.01%
Glacial water 3%
D phase
Sunflower bud extract 0.1%
Chlorella (CHLORELLA VULGARIS) extract 0.1%
Mung bean seed fermentation liquid 0.3%
Water lock magnetite 0.3%
Double nano Co-Q10 0.2%
Dipotassium glycyrrhizinate 0.3%
Bisabolol 0.4%
Phenoxyethanol/Sensiva SC50 0.5%;
The skin care item with anti-blue light action, preparation method include the following steps:
(1) accurately weighing each material of A phase component, (Tahiti gardenia flower oil/cyclomethicone is emulsifying in oily phase pot
Before add in emulsion pot), while open stirring while be heated to 90 DEG C, wait be completely dissolved completely after heat preservation 85 DEG C it is spare;
(2) accurately weighing B phase each component raw material, (1,3-PD/Sodium Hyaluronate/xanthan gum, preparatory dispersion mixing stirring are equal
It is even, it is spare;Take the 30% of total amount glacial water carbomer immersion is uniformly dispersed in advance, spare) be added in emulsion pot, open stirring 38
Rev/min, homogeneous 2500 turns/3 minutes, after dispersion, stirring maintained revolving speed constant, was heated to 95 DEG C while stirring, heat preservation 5
Minute is spare;
(3) emulsification pot temperature is maintained at 85 DEG C, and (tower in emulsion pot is added in 200 mesh device of the A phase component filtering dissolved in advance
Uncommon gardenia flower oil/the cyclomethicone that mentions also is added in emulsion pot at this moment), open 45 revs/min of stirring, homogeneous 3800
Turn/5 minutes, after homogeneous, vacuumize 0.1 degree of defoaming, after adjust stir 45 revs/min, open cooling water and drop while stirring
Temperature;
(4) C phase materials are accurately weighed, carnosine is heated to and is uniformly dissolved with arginine rear spare, pot temperature to be emulsified is down to 60 DEG C
When, the C phase materials pre-processed are added in emulsion pot, 40 revs/min of adjustment stirring, after dispersion completely, continue cooling drop
Temperature;
(5) it is spare to accurately weigh each material of D phase, when pot temperature to be emulsified is down to 48 DEG C, D phase materials are all added, adjustment is stirred
35 revs/min are mixed, homogeneous 2000 turns/2 minutes, is dispersed with stirring to substantially uniformity, continues to cool;Pot temperature drop to be emulsified
When to 45 DEG C, feeding inspection, 200 mesh filter-cloth filterings discharge after passing the inspection.
Embodiment 2
A kind of skin care item with anti-blue light action, by weight percentage, including following component:
A phase
Stearine, PEG-100 stearate 2.5%
Cetostearyl alcohol, cetearyl glucoside 3%
Tocopherol (vitamin E) 1%
Caprylic/capric triglyceride 3%
Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge extract 4%
Olive (OLEA EUROPAEA) oil unsaponifiable matter 5%
Tahiti cape jasmine (GARDENIA TAHITENSIS) caul-fat 8%
Cetostearyl alcohol 3%
Dimethyl silicone polymer 1.5%
Cyclomethicone 3%
Methyl hydroxybenzoate 0.2%
Nipasol 0.1%
B phase
Carbomer 0.2%
Hydrolecithin 0.25%
1,3- propylene glycol 8%
Sodium Hyaluronate 0.2%
Xanthan gum 0.15%
Panthenol 4%
Phosphoric acid monohexadecyl ester potassium 0.3%
EDTA-2Na 0.05%
Glacial water adds to 100%
C phase
Butanediol 1.5%
Arginine 0.4%
Carnosine 0.5%
Glacial water 3%
D phase
Sunflower bud extract 12%
Chlorella (CHLORELLA VULGARIS) extract 3%
Mung bean seed fermentation liquid 5%
Water lock magnetite 10%
Double nano Co-Q10 2%
Dipotassium glycyrrhizinate 0.3%
Bisabolol 0.4%
Phenoxyethanol/Sensiva SC50 0.5%;
The skin care item with anti-blue light action, preparation method is the same as embodiment 1.
Embodiment 3
A kind of skin care item with anti-blue light action, by weight percentage, including following component:
A phase
Stearine, PEG-100 stearate 2.5%
Cetostearyl alcohol, cetearyl glucoside 3%
Tocopherol (vitamin E) 0.5%
Caprylic/capric triglyceride 3%
Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge extract 3%
Olive (OLEA EUROPAEA) oil unsaponifiable matter 4%
Tahiti cape jasmine (GARDENIA TAHITENSIS) caul-fat 5%
Cetostearyl alcohol 2.5%
Dimethyl silicone polymer 1.5%
Cyclomethicone 3%
Methyl hydroxybenzoate 0.2%
Nipasol 0.1%
B phase
Carbomer 0.2%
Hydrolecithin 0.25%
1,3- propylene glycol 8%
Sodium Hyaluronate 0.15%
Xanthan gum 0.15%
Panthenol 3%
Phosphoric acid monohexadecyl ester potassium 0.3%
EDTA-2Na 0.05%
Glacial water adds to 100%
C phase
Butanediol 1.5%
Arginine 0.4%
Carnosine 0.35%
Glacial water 3%
D phase
Sunflower bud extract 8%
Chlorella (CHLORELLA VULGARIS) extract 2.5%
Mung bean seed fermentation liquid 4.5%
Water lock magnetite 7%
Double nano Co-Q10 1.5%
Dipotassium glycyrrhizinate 0.3%
Bisabolol 0.4%
Phenoxyethanol/Sensiva SC50 0.5%;
The skin care item with anti-blue light action, preparation method is the same as embodiment 1.
Embodiment 4
One of present invention contain with anti-blue light action skin care item, compared with the existing technology in other anti-blue light skin cares resist
It is more preferable with maintenance effect, it is illustrated by experiment below:
1. the MMP-1(metalloproteinases that sunflower bud extract induces IR) excessively generate Inhibition test
According to Fig. 1, the ability of sunflower bud extract protection skin collagen is to be induced by measuring it infrared ray
MMP-1(matrix metalloproteinase) release influence depending on.This enzyme participates in the decomposition of I collagen type.Addition is (real
Test group) or do not add (control group) 0.1% sunflower bud extract (infraGuard is sunflower bud extract in Fig. 1),
Or positive control (dexamethasone), normal human's corium fabric mother cell is handled.Then IR(654 J/cm is irradiated
2), MMP-1 gene is analyzed using RT-qPCR.The results show that the irradiation of IR make MMP-1 gene expression be substantially increased (+
267%), and sunflower bud extract is proved to be able to suppress the MMP-1 release of IR induction, this shows skin collagen
It is protected.Using sunflower bud extract, even if carrying out IR irradiation, fibroblast will not generate more MMP-1.
Sunflower bud extract is to horn cell and fibrocyte Protection
In the addition %/0.01% of 0.1 %/0.05 sunflower bud extract to normal human epidermal keratinocyte
Or normal human body corium fabric mother cell carries out pretreatment 24 hours, then using HEV to cell culture medium irradiation 2
Hour (48.2 J/cm2,420-500 nm).Immediately using active chalcogen in fluorescence detector measurement cell after blue light illumination
(ROS) quantity.
As a result as shown in Figures 2 and 3, under the concentration of sunflower bud extract addition 0.05 % and 0.1 %, shone through blue light
ROS yield significantly reduces in the keratinocyte penetrated;Meanwhile sunflower bud extract addition 0.01%, 0.05 % and
Under the concentration of 0.1 %, ROS yield is also significantly reduced in the fibroblast through irradiating.It can be seen that sunflower bud extract
Help to prevent the formation of free radical under blue light illumination.
The MMP-1(metalloproteinases that carnosine induces IR) expression inhibiting experiment
Primary human's dermal fibroblast is cultivated, is divided into six groups, number is followed successively by 1-6;Group 1-3 does not use IR to handle,
Group 4-6 is handled using IR.For a group 1-3, wherein group 1 is blank group, it is 0.0001% He that group 2 and group 3, which are separately added into concentration,
0.001% carnosine;For a group 4-6, wherein group 4 is blank group, it is 0.0001% and 0.001% that group 5 and group 6, which are separately added into concentration,
Carnosine.MMP-1 gene is analyzed by using RT-qPCR, as a result as shown in figure 4, not in the group 1-3 using IR processing,
Obviously expressing does not occur in MMP-1;In the group 4-6 induced through IR, MMP-1 expression quantity is dramatically increased, and by the way that carnosine is added, then
The target of MMP-1 can effectively be inhibited relative to blank group, and the inhibiting effect is in concentration dependent, wherein relative to group 4, group
5 and group 6 in MMP-1 inhibiting rate be respectively 28% and 69%.
Inhibition test of the chlorella extract to horn cell inflammatory reaction
People's epidermal keratinocyte is cultivated in vitro, cultivated cell is divided into 3 groups, and wherein blank group with no treatment, is organized in 1
It is the lipopeptid for activating TLR2 that Pam 3CSK4(Pam 3CSK4, which is added), the Pam 3CSK4 that equivalent is added in 2 is organized, is added simultaneously
Enter the chlorella extract that concentration is 1%;After for 24 hours, the inflammatory conditions of horn cell are detected.The inflammatory conditions pass through to IL-6's
Secretory volume carries out detection and is judged, wherein IL-6 is pro-inflammatory cellular cerebroysin, right by toll sample receptor (mainly TLR2)
The reaction that microbiologic population is unbalance is activated.As a result as shown in figure 5, the addition of chlorella extract can to significantly inhibit cutin thin
The generation of born of the same parents' inflammatory reaction, to play the role of significantly releiving to skin.
The present invention does not use traditional deionized water as solvent, completely with glacial water come generation compared with existing cosmetics
It replaces, and minerals contained in glacial water and microelement have multiple benefit to skin, possess balanced potassium/na ratio,
And it is similar with the water content of natural skin, the isobaric environment of skin cell can be maintained to prevent TEWL(transepidermal water loss), and increase
Add the water holding moisturizing degree of skin.We select Organic Sunflower bud as the source of active matter simultaneously, are because planting with maturation
Object is compared, and sprout contains the essential fatty acid of higher concentration, vitamin and mineral.In addition, sprout also contains a series of time
Raw metabolin, can protect plant to resist disease, injury, pathogen, extremely strong sunray and pollutant.And containing organic to day
Certain herbaceous plants with big flowers bud extract is proved that the normal function of mitochondria can be protected, under the influence of ambient pressure and aging, to maintenance line grain
Body energy production has significant help.And immunity can be enhanced in carnosine contained in inventive formulation, and reduces inflammation, energy
Wound healing is effectively facilitated, protects the damage of radiation, and resist syndrome after radiation, while can be with effective protection glucose
The oxidation of damage and protein prevents glycosylation and resulting slowly damaging skin aging, with other compounds
It after compounding, can not only prevent and the damage from infrared ray to skin, can also widely protect the skin from ultraviolet light
Damage, thus the inaccessiable protective effect of conventional ultra-violet absorbent of having extended.Therefore, the present invention is a kind of contains anti-blue light action
Sunflower bud extract cream skin care item, can be more preferable, safer, the all-round photoprotection effect of more comprehensive offer.
Claims (8)
1. a kind of skin care item with anti-blue light action, which is characterized in that by weight percentage, including skin care item matrix
67.5-98.99%, prebiotics 0.1-3%, mung bean seed fermentation liquid 0.3-5%, water lock magnetite 0.3-10%, carnosine 0.01-0.5% are double
Nanometer Co-Q10 0.2-2%.
2. the skin care item according to claim 1 with anti-blue light action, which is characterized in that the skin care item matrix is selected from
One or more of following component: stearine/PEG-100 stearate, cetostearyl alcohol, cetearyl glucose
Glycosides, tocopherol, caprylic/capric triglyceride, Butyrospermum parkii fruit rouge extract, olive oil unsaponifiable matter, Tahiti gardenia
Oil, cetostearyl alcohol, dimethyl silicone polymer, cyclomethicone, methyl hydroxybenzoate, Nipasol, carbomer, hydrogenation ovum
Phosphatide, 1,3- propylene glycol, Sodium Hyaluronate, xanthan gum, panthenol, Phosphoric acid monohexadecyl ester potassium, EDTA-2Na, butanediol, arginine,
Dipotassium glycyrrhizinate, bisabolol, Phenoxyethanol/Sensiva SC50, glacial water.
3. the skin care item according to claim 1 with anti-blue light action, which is characterized in that the prebiotics are selected from bead
Algae extract.
4. the skin care item according to claim 1 with anti-blue light action, which is characterized in that also contain in the skin care item
Sunflower bud extract.
5. the skin care item according to claim 5 with anti-blue light action, which is characterized in that the sunflower bud extract
Accounting for skin care item weight percent is 0.1-12%.
6. the skin care item according to claim 1 with anti-blue light action, which is characterized in that including following component:
A phase:
Stearine, PEG-100 stearate 2.5%
Cetostearyl alcohol, cetearyl glucoside 3%
Tocopherol 0.1%-1%
Caprylic/capric triglyceride 3%
Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge extract 1%-4%
Olive (OLEA EUROPAEA) oil unsaponifiable matter 0.5%-5%
Tahiti cape jasmine (GARDENIA TAHITENSIS) caul-fat 0.5%-8%
Cetostearyl alcohol 1.5%-3%
Dimethyl silicone polymer 1.5%
Cyclomethicone 3%
Methyl hydroxybenzoate 0.2%
Nipasol 0.1%
B phase:
Carbomer 0.2%
Hydrolecithin 0.25%
1,3- propylene glycol 8%
Sodium Hyaluronate 0.05%-0.2%
Xanthan gum 0.15%
Panthenol 0.1%-4%
Phosphoric acid monohexadecyl ester potassium 0.3%
EDTA-2Na 0.05%
Glacial water adds to 100%
C phase:
Butanediol 1.5%
Arginine 0.4%
Carnosine 0.01%-0.5%
Glacial water 3%
D phase:
Sunflower bud extract 0.1%-12%
Chlorella (CHLORELLA VULGARIS) extract 0.1%-3%
Mung bean seed fermentation liquid 0.3%-5%
Water lock magnetite 0.3%-10%
Double nano Co-Q10 0.2%-2%
Dipotassium glycyrrhizinate 0.3%
Bisabolol 0.4%
Phenoxyethanol/Sensiva SC50 0.5%.
7. the skin care item according to claim 6 with anti-blue light action, which is characterized in that preparation method includes as follows
Step:
(1) each material of A phase component is accurately weighed in oily phase pot, and wherein Tahiti gardenia flower oil/cyclomethicone exists
It is added in emulsion pot before emulsification, is heated to 90 DEG C when opening stirring, 85 DEG C of heat preservation is spare after being completely dissolved completely;
(2) B phase each component raw material is accurately weighed, is added in emulsion pot;Wherein: 1,3-PD/Sodium Hyaluronate/xanthan gum,
Preparatory dispersion mixing stirs evenly, spare;Take the 30% of total amount glacial water carbomer immersion is uniformly dispersed in advance, it is spare;It opens and stirs
38 revs/min are mixed, homogeneous 2500 turns/3 minutes, after dispersion, stirring maintained revolving speed constant, it is heated to 95 DEG C while stirring,
Heat preservation 5 minutes spare;
(3) emulsification pot temperature is maintained at 85 DEG C, 200 mesh device of the A phase component filtering dissolved in advance is added in emulsion pot, tower
Uncommon gardenia flower oil/the cyclomethicone that mentions also is added in emulsion pot at this moment, opens 45 revs/min of stirring, and 3800 turns of homogeneous/
5 minutes, after homogeneous, vacuumize 0.1 degree of defoaming, after adjust stirring 45 revs/min, open cooling water and cool down while stirring;
(4) C phase materials are accurately weighed, carnosine is heated to and is uniformly dissolved with arginine rear spare, pot temperature to be emulsified is down to 60 DEG C
When, the C phase materials pre-processed are added in emulsion pot, 40 revs/min of adjustment stirring, after dispersion completely, continue cooling drop
Temperature;
(5) it is spare to accurately weigh each material of D phase, when pot temperature to be emulsified is down to 48 DEG C, D phase materials are all added, adjustment is stirred
35 revs/min are mixed, homogeneous 2000 turns/2 minutes, is dispersed with stirring to substantially uniformity, continues to cool;Pot temperature drop to be emulsified
When to 45 DEG C, feeding inspection, 200 mesh filter-cloth filterings discharge after passing the inspection.
8. the method for preparing the skin care item according to claim 6 with anti-blue light action, which is characterized in that including as follows
Step:
(1) each material of A phase component is accurately weighed in oily phase pot, and Tahiti gardenia flower oil/cyclomethicone is emulsifying
Before add in emulsion pot, while open stirring while be heated to 90 DEG C, wait be completely dissolved completely after heat preservation 85 DEG C it is spare;
(2) B phase each component raw material is accurately weighed, in which: 1,3-PD/Sodium Hyaluronate/xanthan gum, preparatory dispersion mixing are stirred
It mixes uniformly, it is spare;Take the 30% of total amount glacial water carbomer immersion is uniformly dispersed in advance, it is spare;It is added in emulsion pot, opens and stir
38 revs/min are mixed, homogeneous 2500 turns/3 minutes, after dispersion, stirring maintained revolving speed constant, it is heated to 95 DEG C while stirring,
Heat preservation 5 minutes spare;
(3) emulsification pot temperature is maintained at 85 DEG C, 200 mesh device of the A phase component filtering dissolved in advance is added in emulsion pot, tower
Uncommon gardenia flower oil/the cyclomethicone that mentions also is added in emulsion pot at this moment, opens 45 revs/min of stirring, and 3800 turns of homogeneous/
5 minutes, after homogeneous, vacuumize 0.1 degree of defoaming, after adjust stirring 45 revs/min, open cooling water and cool down while stirring;
(4) C phase materials are accurately weighed, carnosine is heated to and is uniformly dissolved with arginine rear spare, pot temperature to be emulsified is down to 60 DEG C
When, the C phase materials pre-processed are added in emulsion pot, 40 revs/min of adjustment stirring, after dispersion completely, continue cooling drop
Temperature;
(5) it is spare to accurately weigh each material of D phase, when pot temperature to be emulsified is down to 48 DEG C, D phase materials are all added, adjustment is stirred
35 revs/min are mixed, homogeneous 2000 turns/2 minutes, is dispersed with stirring to substantially uniformity, continues to cool;Pot temperature drop to be emulsified
When to 45 DEG C, feeding inspection, 200 mesh filter-cloth filterings discharge after passing the inspection.
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CN110025542A (en) * | 2019-06-01 | 2019-07-19 | 古裕聪 | A kind of skin-care product additive and preparation method thereof with anti-blue light |
CN111773161A (en) * | 2020-06-16 | 2020-10-16 | 广州优理氏生物科技有限公司 | Prebiotic composition and preparation method and application thereof |
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WO2021104777A1 (en) * | 2019-11-26 | 2021-06-03 | Beiersdorf Ag | Active substance combinations of ubiquinol and one or more emulsifiers from the group of phosphates and sulfates, and cosmetic or dermatological preparations containing such active substance combinations |
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CN114073658A (en) * | 2021-11-23 | 2022-02-22 | 湖北省麦诗特生物科技有限公司 | Essence composition containing liposome capable of resisting photoaging damage and preparation method thereof |
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