CN1060841A - 喹唑啉衍生物及其制备方法 - Google Patents

喹唑啉衍生物及其制备方法 Download PDF

Info

Publication number
CN1060841A
CN1060841A CN91109920A CN91109920A CN1060841A CN 1060841 A CN1060841 A CN 1060841A CN 91109920 A CN91109920 A CN 91109920A CN 91109920 A CN91109920 A CN 91109920A CN 1060841 A CN1060841 A CN 1060841A
Authority
CN
China
Prior art keywords
compound
amino
nitro
salt
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN91109920A
Other languages
English (en)
Chinese (zh)
Inventor
岛崎宪彦
山崎齐
矢田部巧
田中洋和
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909022306A external-priority patent/GB9022306D0/en
Priority claimed from GB919118337A external-priority patent/GB9118337D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CN1060841A publication Critical patent/CN1060841A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN91109920A 1990-10-15 1991-10-14 喹唑啉衍生物及其制备方法 Pending CN1060841A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9022306.6 1990-10-15
GB909022306A GB9022306D0 (en) 1990-10-15 1990-10-15 Quinazoline derivatives and their preparation
GB919118337A GB9118337D0 (en) 1991-08-27 1991-08-27 Quinazoline derivatives and their preparation
GB9118337.6 1991-08-27

Publications (1)

Publication Number Publication Date
CN1060841A true CN1060841A (zh) 1992-05-06

Family

ID=26297803

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91109920A Pending CN1060841A (zh) 1990-10-15 1991-10-14 喹唑啉衍生物及其制备方法

Country Status (13)

Country Link
US (1) US5304560A (enExample)
EP (1) EP0481342A1 (enExample)
JP (1) JP3164119B2 (enExample)
KR (1) KR920008031A (enExample)
CN (1) CN1060841A (enExample)
AU (1) AU648110B2 (enExample)
CA (1) CA2053475A1 (enExample)
FI (1) FI914826A7 (enExample)
HU (1) HUT59390A (enExample)
IE (1) IE913473A1 (enExample)
NO (1) NO914036L (enExample)
PT (1) PT99227B (enExample)
TW (1) TW201308B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786483A (zh) * 2011-05-19 2012-11-21 复旦大学 4-（4-苯基哌嗪基）喹唑啉类衍生物的药用用途
CN102807531A (zh) * 2005-04-11 2012-12-05 诺瓦提斯公司 1h-喹唑啉-2,4-二酮及其作为ampa-受体配体的用途

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69021855T2 (de) * 1990-01-02 1996-02-29 Fujisawa Pharmaceutical Co Quinazolinderivate und ihre Herstellung.
US5994542A (en) * 1995-11-14 1999-11-30 Sumitomo Chemical Company, Limited Process for producing 1-substituted tetrahydroquinazolines
US6413724B1 (en) 1996-10-28 2002-07-02 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US6025371A (en) * 1996-10-28 2000-02-15 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US6133275A (en) * 1998-05-06 2000-10-17 Abbott Laboratories 3-phenylpyrrolidine alpha-1 adrenergic compounds
US6599910B1 (en) * 1998-08-20 2003-07-29 Smithkline Beecham Corporation Substituted triazole compounds
EP1114035B1 (en) 1998-08-21 2006-05-17 Daiichi Asubio Pharma Co., Ltd. Quinazoline derivatives and pharmaceutical applications thereof
US6521630B1 (en) 1999-08-31 2003-02-18 Pfizer Inc. Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof
DE60023025T2 (de) 1999-11-23 2006-07-13 Smithkline Beecham Corp. 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
AU1783201A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
JP2003514899A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
EP1248624A4 (en) * 1999-11-23 2003-01-22 Smithkline Beecham Corp 3,4-DIHYDRO- (1H) -CHIRAZOLINE-2-ONES AND THE USE THEREOF AS CSBP / P38 KINASE INHIBITORS
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
AU3413601A (en) * 2000-02-22 2001-09-03 Daiichi Asubio Pharma Co., Ltd. Preventive or therapeutic drugs for dermatitises containing chymase inhibitors as the active ingredient
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
IL155367A0 (en) * 2000-10-23 2003-12-23 Smithkline Beecham Corp NOVEL 2,4,8-TRISUBSTITUTED-8h-PYRIDO[2,3,-d]PYRIMIDIN-7-ONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, PROCESSES FOR THE PREPARATION THEREOF, AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR TREATING CSBP/p38 KINASE MEDIATED DISEASES
BR0309053A (pt) * 2002-04-19 2005-02-22 Smithkline Beecham Corp Compostos
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
US7855207B2 (en) 2003-11-20 2010-12-21 Janssen Pharmaceutica, Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors
SG150534A1 (en) * 2003-11-20 2009-03-30 Janssen Pharmaceutica Nv 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp- ribose) polymerase inhibitors
UA89618C2 (ru) * 2003-12-05 2010-02-25 Янссен Фармацевтика Н.В. 6-замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли(адф-рибоза)полимеразы
SG154432A1 (en) * 2004-06-30 2009-08-28 Janssen Pharmaceutica Nv Quinazolinedione derivatives as parp inhibitors
CA2569826C (en) 2004-06-30 2013-07-16 Janssen Pharmaceutica N.V. Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
WO2006003147A1 (en) * 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
JP2008535822A (ja) * 2005-03-25 2008-09-04 グラクソ グループ リミテッド 新規化合物
JP2008537937A (ja) * 2005-03-25 2008-10-02 グラクソ グループ リミテッド ピリド［２，３−ｄ］ピリミジン−７−オンおよび３，４−ジヒドロピリミド［４，５−ｄ］ピリミジン−２（１Ｈ）−オン誘導体の製造方法
PE20100737A1 (es) * 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
PE20100741A1 (es) * 2005-03-25 2010-11-25 Glaxo Group Ltd COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38
ES2381446T3 (es) 2007-03-08 2012-05-28 Janssen Pharmaceutica, N.V. Derivado de quinolinona como inhibidores de PARP y TANK
EP2215075B1 (en) * 2007-10-26 2013-12-11 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp inhibitors
AU2009228945B2 (en) * 2008-03-27 2013-05-02 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
HRP20150139T1 (hr) 2008-03-27 2015-05-22 Janssen Pharmaceutica N.V. Tetrahidrofenanthridinoni i tetrahidrociklopentakinolinoni kao inhibitori parp i polimerizacije tubulina
EP3332645A1 (de) 2016-12-12 2018-06-13 Bayer Cropscience AG Verwendung substituierter pyrimidindione oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress
EP4141009A1 (de) * 2021-08-30 2023-03-01 Saltigo GmbH Verfahren zur herstellung von mischungen enthaltend 2 (2 hydroxyethyl)-piperidinyl-carbamidsäure-sek.-butylester

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274194A (en) * 1963-03-29 1966-09-20 Miles Lab Quinazolinedione derivatives
US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
US4522945A (en) * 1979-10-12 1985-06-11 Janssen Pharmaceutica N.V. (Piperidinylalkyl) quinazoline derivatives
JPS5948777B2 (ja) * 1980-07-07 1984-11-28 株式会社クボタ 厚形瓦の製造方法
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
US4716161A (en) * 1984-04-17 1987-12-29 Mitsubishi Chemical Industries Limited Phenylpiperazine derivatives and their acid addition salts
US4711883A (en) * 1985-09-30 1987-12-08 Ortho Pharmaceutical Corporation Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102807531A (zh) * 2005-04-11 2012-12-05 诺瓦提斯公司 1h-喹唑啉-2,4-二酮及其作为ampa-受体配体的用途
CN102786483A (zh) * 2011-05-19 2012-11-21 复旦大学 4-（4-苯基哌嗪基）喹唑啉类衍生物的药用用途
CN102786483B (zh) * 2011-05-19 2016-03-30 复旦大学 4-（4-苯基哌嗪基）喹唑啉类衍生物的药用用途

Also Published As

Publication number Publication date
HUT59390A (en) 1992-05-28
AU8580091A (en) 1992-04-16
FI914826L (fi) 1992-04-16
FI914826A7 (fi) 1992-04-16
CA2053475A1 (en) 1992-04-16
FI914826A0 (fi) 1991-10-14
HU913243D0 (en) 1992-01-28
JP3164119B2 (ja) 2001-05-08
AU648110B2 (en) 1994-04-14
PT99227A (pt) 1992-09-30
NO914036D0 (no) 1991-10-14
US5304560A (en) 1994-04-19
IE913473A1 (en) 1992-04-22
JPH04261170A (ja) 1992-09-17
NO914036L (no) 1992-04-21
EP0481342A1 (en) 1992-04-22
PT99227B (pt) 1999-04-30
TW201308B (enExample) 1993-03-01
KR920008031A (ko) 1992-05-27

Similar Documents

Publication Publication Date Title
CN1060841A (zh) 喹唑啉衍生物及其制备方法
CN1193025C (zh) 新的1,3－二氢－2h－吲哚－2－酮衍生物,它们的制备方法以及含有它们的药物组合物
CN1310907C (zh) 杂环化合物和以其为有效成分的抗肿瘤药
CN1072220C (zh) 作为神经激肽受体拮抗剂的1－苯甲酰基－2－(吲哚基－3－烷基)－哌嗪衍生物
CN1144791C (zh) 三唑化合物及其作为多巴胺d3配体的应用
CN1279023C (zh) 吲哚－3－硫衍生物
CN1293076C (zh) 过氧化物酶体增殖剂应答性受体δ的活化剂
CN1058969C (zh) 新的取代胍衍生物,其制备方法和其药物用途
CN1286822C (zh) 嘧啶酮化合物
CN1114598C (zh) 芳族化合物和含有它们的药物组合物
CN1149214C (zh) 三唑并衍生物和含有它们作为有效组分的趋化因子抑制剂
CN1150165C (zh) 用于治疗中枢神经系统紊乱的1-芳基磺酰基-2-芳基-吡咯烷衍生物
CN1079464A (zh) 治疗包括胆碱能功能降低的病症有价值的吲哚酮和吲哚二酮的衍生物的制备方法
CN1478080A (zh) 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物
CN1090846A (zh) 嘧啶类化合物和其药用盐的制备方法
CN1072219C (zh) 二氮杂䓬酮、其生产和用途
CN1087086A (zh) 噻唑基乙烯基苯基衍生物
CN1246315C (zh) 氨基烷基苯甲酰基－苯并呋喃或苯并噻吩类，它们的制备方法与含有它们的组合物
CN1653062A (zh) 作为nmda受体阻断剂的(咪唑－1－基－甲基)－哒嗪
CN1960984A (zh) 作为mglu5受体拮抗剂的吡啶－4－基－乙炔基－咪唑和吡唑
CN1111622A (zh) 丙烯酸衍生物
CN1250542C (zh) 具有抗肿瘤活性的2－(1h－吲哚－3－基)－2－氧代－乙酰胺
CN1035817C (zh) 三唑基取代的叔胺化合物及其盐的制备方法
CN1085896A (zh) 血管紧张素ii拮抗剂咪唑衍生物，它们的制备及其治疗用途
CN1802367A (zh) 作为谷氨酸受体拮抗剂的咪唑衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication