CN106061977B - 1,2-二氢-3h-吡咯并[1,2-c]咪唑-3-酮衍生物及其作为抗菌剂的用途 - Google Patents

1,2-二氢-3h-吡咯并[1,2-c]咪唑-3-酮衍生物及其作为抗菌剂的用途 Download PDF

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Publication number
CN106061977B
CN106061977B CN201580011865.0A CN201580011865A CN106061977B CN 106061977 B CN106061977 B CN 106061977B CN 201580011865 A CN201580011865 A CN 201580011865A CN 106061977 B CN106061977 B CN 106061977B
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CN
China
Prior art keywords
methyl
hydroxy
oxo
methylsulfonyl
pyrrolo
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Expired - Fee Related
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CN201580011865.0A
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English (en)
Chinese (zh)
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CN106061977A (zh
Inventor
盖尔·沙普
吉恩-克里斯多夫·高文
菲利普·潘乔德
吉恩-卢克·施佩克林
吉恩-菲利普·苏里韦特
克莉丝汀·施米特
阿泽利·米雷
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Aidu West Pharmaceutical Co Ltd
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Actelion Pharmaceuticals Ltd
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Publication of CN106061977A publication Critical patent/CN106061977A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580011865.0A 2014-03-04 2015-03-03 1,2-二氢-3h-吡咯并[1,2-c]咪唑-3-酮衍生物及其作为抗菌剂的用途 Expired - Fee Related CN106061977B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157636.3 2014-03-04
EP14157636 2014-03-04
PCT/EP2015/054358 WO2015132228A1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Publications (2)

Publication Number Publication Date
CN106061977A CN106061977A (zh) 2016-10-26
CN106061977B true CN106061977B (zh) 2018-10-26

Family

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Family Applications (1)

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CN201580011865.0A Expired - Fee Related CN106061977B (zh) 2014-03-04 2015-03-03 1,2-二氢-3h-吡咯并[1,2-c]咪唑-3-酮衍生物及其作为抗菌剂的用途

Country Status (31)

Country Link
US (1) US10106544B2 (enExample)
EP (1) EP3114126B1 (enExample)
JP (1) JP6516370B2 (enExample)
KR (1) KR20160127127A (enExample)
CN (1) CN106061977B (enExample)
AR (1) AR099612A1 (enExample)
AU (1) AU2015226250B2 (enExample)
BR (1) BR112016020278A8 (enExample)
CA (1) CA2938383A1 (enExample)
CL (1) CL2016002207A1 (enExample)
CY (1) CY1121362T1 (enExample)
DK (1) DK3114126T3 (enExample)
EA (1) EA030708B1 (enExample)
ES (1) ES2709382T3 (enExample)
HR (1) HRP20190013T1 (enExample)
HU (1) HUE042371T2 (enExample)
IL (1) IL247544A0 (enExample)
LT (1) LT3114126T (enExample)
MA (1) MA39707B1 (enExample)
MX (1) MX2016011380A (enExample)
PH (1) PH12016501699A1 (enExample)
PL (1) PL3114126T3 (enExample)
PT (1) PT3114126T (enExample)
SA (1) SA516371717B1 (enExample)
SG (1) SG11201607304WA (enExample)
SI (1) SI3114126T1 (enExample)
TR (1) TR201900393T4 (enExample)
TW (1) TW201542556A (enExample)
UA (1) UA118868C2 (enExample)
WO (1) WO2015132228A1 (enExample)
ZA (1) ZA201606794B (enExample)

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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
CA2933604A1 (en) 2013-12-19 2015-06-25 Actelion Pharmaceuticals Ltd Antibacterial 1h-indazole and 1h-indole derivatives
KR20170005105A (ko) 2014-05-16 2017-01-11 액테리온 파마슈티칼 리미티드 항균성 퀴나졸린-４(３ｈ)-온 유도체
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AU2016314963A1 (en) * 2015-08-28 2018-04-19 Idorsia Pharmaceuticals Ltd Antibacterial annulated pyrrolidin-2-one derivatives
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
EP4382527A4 (en) * 2021-08-05 2025-08-20 Zhejiang Hisun Pharm Co Ltd AROMATIC ACETYLENE DERIVATIVE, PROCESS FOR ITS PREPARATION AND USE

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WO2011045703A2 (en) * 2009-10-13 2011-04-21 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
WO2012137094A1 (en) * 2011-04-08 2012-10-11 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
CN103443079A (zh) * 2011-03-07 2013-12-11 辉瑞大药厂 可用作抗菌剂的氟吡啶酮衍生物
CN103492368A (zh) * 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物

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US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
BRPI0518984A2 (pt) 2004-12-10 2008-12-16 Univ Emory anÁlogos de nucleosÍdeo de ciclobutil substituÍdos em 2' e 3' para tratamento de infecÇÕes virais e proliferaÇço celular anormal
JP2008001635A (ja) 2006-06-22 2008-01-10 Toray Ind Inc グリシン誘導体及びその用途
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
MX2011010523A (es) 2009-04-06 2011-10-28 Daiichi Sankyo Co Ltd Compuesto ciclico que tiene grupo fenilo sustituido.
EP2432468A2 (en) 2009-05-20 2012-03-28 Ardea Biosciences, Inc. Methods of modulating uric acid levels
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JP5793766B2 (ja) 2009-12-16 2015-10-14 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
AR083760A1 (es) 2010-11-10 2013-03-20 Achaogen Inc Agentes antibacterianos y composiciones farmaceuticas
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WO2013170030A1 (en) 2012-05-09 2013-11-14 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) * 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
CA2933604A1 (en) 2013-12-19 2015-06-25 Actelion Pharmaceuticals Ltd Antibacterial 1h-indazole and 1h-indole derivatives
KR20170005105A (ko) 2014-05-16 2017-01-11 액테리온 파마슈티칼 리미티드 항균성 퀴나졸린-４(３ｈ)-온 유도체
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AU2016314963A1 (en) 2015-08-28 2018-04-19 Idorsia Pharmaceuticals Ltd Antibacterial annulated pyrrolidin-2-one derivatives
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
EP3386950A1 (en) 2015-12-08 2018-10-17 GlaxoSmithKline Intellectual Property Development Limited Substituted benzazinones as antibacterial compounds

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2011045703A2 (en) * 2009-10-13 2011-04-21 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
CN103443079A (zh) * 2011-03-07 2013-12-11 辉瑞大药厂 可用作抗菌剂的氟吡啶酮衍生物
WO2012137094A1 (en) * 2011-04-08 2012-10-11 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
CN103492368A (zh) * 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物

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Publication number Publication date
BR112016020278A8 (pt) 2017-12-26
JP6516370B2 (ja) 2019-05-22
EP3114126A1 (en) 2017-01-11
SG11201607304WA (en) 2016-09-29
EA201691775A1 (ru) 2017-03-31
US10106544B2 (en) 2018-10-23
UA118868C2 (uk) 2019-03-25
ES2709382T3 (es) 2019-04-16
CN106061977A (zh) 2016-10-26
AU2015226250B2 (en) 2018-12-13
LT3114126T (lt) 2018-12-27
JP2017508746A (ja) 2017-03-30
DK3114126T3 (en) 2019-02-25
EP3114126B1 (en) 2018-10-31
IL247544A0 (en) 2016-11-30
ZA201606794B (en) 2018-11-28
TR201900393T4 (tr) 2019-02-21
PL3114126T3 (pl) 2019-03-29
TW201542556A (zh) 2015-11-16
MA39707B1 (fr) 2019-01-31
EA030708B1 (ru) 2018-09-28
WO2015132228A1 (en) 2015-09-11
BR112016020278A2 (enExample) 2017-08-15
US20170107223A1 (en) 2017-04-20
HUE042371T2 (hu) 2019-06-28
CA2938383A1 (en) 2015-09-11
AR099612A1 (es) 2016-08-03
CY1121362T1 (el) 2020-05-29
SA516371717B1 (ar) 2018-10-25
PH12016501699A1 (en) 2016-10-03
SI3114126T1 (sl) 2019-01-31
MX2016011380A (es) 2016-12-07
KR20160127127A (ko) 2016-11-02
MA39707A (fr) 2017-01-11
PT3114126T (pt) 2019-02-06
HRP20190013T1 (hr) 2019-02-22
CL2016002207A1 (es) 2017-03-24
AU2015226250A1 (en) 2016-10-20

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Effective date of registration: 20171030

Address after: Swiss A Skei Weil

Applicant after: Aidu West Pharmaceutical Co. Ltd.

Address before: Swiss A Skei Weil

Applicant before: Actelion Pharmaceuticals Ltd.

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CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20181026

Termination date: 20210303