ZA201606794B - 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents - Google Patents

1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Info

Publication number
ZA201606794B
ZA201606794B ZA2016/06794A ZA201606794A ZA201606794B ZA 201606794 B ZA201606794 B ZA 201606794B ZA 2016/06794 A ZA2016/06794 A ZA 2016/06794A ZA 201606794 A ZA201606794 A ZA 201606794A ZA 201606794 B ZA201606794 B ZA 201606794B
Authority
ZA
South Africa
Prior art keywords
pyrrolo
imidazol
dihydro
derivatives
antibacterial agents
Prior art date
Application number
ZA2016/06794A
Other languages
English (en)
Inventor
Jean-Philippe Surivet
Jean-Luc Specklin
Philippe Panchaud
Jean-Christophe Gauvin
Gaelle Chapoux
Azely Mirre
Christine Schmitt
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of ZA201606794B publication Critical patent/ZA201606794B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA2016/06794A 2014-03-04 2016-10-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents ZA201606794B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04
PCT/EP2015/054358 WO2015132228A1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
ZA201606794B true ZA201606794B (en) 2018-11-28

Family

ID=50189621

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2016/06794A ZA201606794B (en) 2014-03-04 2016-10-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Country Status (31)

Country Link
US (1) US10106544B2 (enExample)
EP (1) EP3114126B1 (enExample)
JP (1) JP6516370B2 (enExample)
KR (1) KR20160127127A (enExample)
CN (1) CN106061977B (enExample)
AR (1) AR099612A1 (enExample)
AU (1) AU2015226250B2 (enExample)
BR (1) BR112016020278A8 (enExample)
CA (1) CA2938383A1 (enExample)
CL (1) CL2016002207A1 (enExample)
CY (1) CY1121362T1 (enExample)
DK (1) DK3114126T3 (enExample)
EA (1) EA030708B1 (enExample)
ES (1) ES2709382T3 (enExample)
HR (1) HRP20190013T1 (enExample)
HU (1) HUE042371T2 (enExample)
IL (1) IL247544A0 (enExample)
LT (1) LT3114126T (enExample)
MA (1) MA39707B1 (enExample)
MX (1) MX2016011380A (enExample)
PH (1) PH12016501699A1 (enExample)
PL (1) PL3114126T3 (enExample)
PT (1) PT3114126T (enExample)
SA (1) SA516371717B1 (enExample)
SG (1) SG11201607304WA (enExample)
SI (1) SI3114126T1 (enExample)
TR (1) TR201900393T4 (enExample)
TW (1) TW201542556A (enExample)
UA (1) UA118868C2 (enExample)
WO (1) WO2015132228A1 (enExample)
ZA (1) ZA201606794B (enExample)

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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
ES2687040T3 (es) 2014-05-16 2018-10-23 Idorsia Pharmaceuticals Ltd Derivados antibacterianos de quinazolin–4(3H)–ona
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
MX2018002479A (es) * 2015-08-28 2018-06-15 Idorsia Pharmaceuticals Ltd Derivados antibacterianos pirrolidin-2-ona anulados.
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
EP4382527A4 (en) * 2021-08-05 2025-08-20 Zhejiang Hisun Pharm Co Ltd AROMATIC ACETYLENE DERIVATIVE, PROCESS FOR ITS PREPARATION AND USE

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US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
AU2005313912A1 (en) 2004-12-10 2006-06-15 Emory University 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
JP2008001635A (ja) 2006-06-22 2008-01-10 Toray Ind Inc グリシン誘導体及びその用途
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
BRPI1013988A2 (pt) 2009-04-06 2016-04-05 Daiichi Sankyo Co Ltd composto, composição farmacêutica , e, uso de um composto ou um sal farmacologicamente aceitável do mesmo
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EP2488489A2 (en) * 2009-10-13 2012-08-22 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
JP5793766B2 (ja) 2009-12-16 2015-10-14 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
BR112013011693A2 (pt) 2010-11-10 2016-08-09 Achaogen Inc derivados de ácido hidroxâmico e seu uso no tratamento de infecções por bactérias
US8853213B2 (en) 2011-01-03 2014-10-07 Hanmi Pharm. Co., Ltd Bicyclic compound for modulating G protein-coupled receptors
JP5620020B2 (ja) * 2011-03-07 2014-11-05 ファイザー・インク 抗菌剤として有用なフルオロ−ピリジノン誘導体
SG193367A1 (en) 2011-04-08 2013-10-30 Pfizer Isoxazole derivatives useful as antibacterial agents
CN103492368A (zh) * 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物
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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
ES2687040T3 (es) 2014-05-16 2018-10-23 Idorsia Pharmaceuticals Ltd Derivados antibacterianos de quinazolin–4(3H)–ona
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
MX2018002479A (es) 2015-08-28 2018-06-15 Idorsia Pharmaceuticals Ltd Derivados antibacterianos pirrolidin-2-ona anulados.
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
RU2018124788A (ru) 2015-12-08 2020-01-15 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Замещенные бензазиноны в качестве антибактериальных соединений

Also Published As

Publication number Publication date
TW201542556A (zh) 2015-11-16
AR099612A1 (es) 2016-08-03
DK3114126T3 (en) 2019-02-25
BR112016020278A8 (pt) 2017-12-26
HRP20190013T1 (hr) 2019-02-22
KR20160127127A (ko) 2016-11-02
AU2015226250A1 (en) 2016-10-20
CL2016002207A1 (es) 2017-03-24
ES2709382T3 (es) 2019-04-16
CA2938383A1 (en) 2015-09-11
CN106061977B (zh) 2018-10-26
PT3114126T (pt) 2019-02-06
IL247544A0 (en) 2016-11-30
EA030708B1 (ru) 2018-09-28
US20170107223A1 (en) 2017-04-20
AU2015226250B2 (en) 2018-12-13
CY1121362T1 (el) 2020-05-29
JP2017508746A (ja) 2017-03-30
UA118868C2 (uk) 2019-03-25
SA516371717B1 (ar) 2018-10-25
HUE042371T2 (hu) 2019-06-28
US10106544B2 (en) 2018-10-23
MX2016011380A (es) 2016-12-07
LT3114126T (lt) 2018-12-27
MA39707A (fr) 2017-01-11
WO2015132228A1 (en) 2015-09-11
SG11201607304WA (en) 2016-09-29
PH12016501699A1 (en) 2016-10-03
PL3114126T3 (pl) 2019-03-29
EP3114126B1 (en) 2018-10-31
MA39707B1 (fr) 2019-01-31
TR201900393T4 (tr) 2019-02-21
EA201691775A1 (ru) 2017-03-31
BR112016020278A2 (enExample) 2017-08-15
SI3114126T1 (sl) 2019-01-31
EP3114126A1 (en) 2017-01-11
JP6516370B2 (ja) 2019-05-22
CN106061977A (zh) 2016-10-26

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