CN105998168A - Spray-dried granular medicinal slices prepared from freshly squeezed flos sophorae and preparation process thereof - Google Patents
Spray-dried granular medicinal slices prepared from freshly squeezed flos sophorae and preparation process thereof Download PDFInfo
- Publication number
- CN105998168A CN105998168A CN201610582900.0A CN201610582900A CN105998168A CN 105998168 A CN105998168 A CN 105998168A CN 201610582900 A CN201610582900 A CN 201610582900A CN 105998168 A CN105998168 A CN 105998168A
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- Prior art keywords
- flos sophorae
- spray
- squeezing
- medicinal
- medicine juice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
This invention discloses spray-dried granular medicinal slices prepared from freshly squeezed flos sophorae and a preparation process thereof. The process comprises the steps that after a flos sophorae medicinal material is harvested, cleaning, selection and drip washing are performed, the flos sophorae medicinal material is squeezed in a fresh state, and medicinal liquid is obtained through filtration; water is added to medicinal residues, and stirring, filtration and squeezing are performed; the obtained medicinal liquid is mixed and subjected to reduced-pressure concentration and spray drying, a spray-dried product is collected, the spray-dried product is smashed and mixed with the preliminarily squeezed medicinal liquid for granulation, and vacuum package is performed after granule organization. The flos sophorae granular medicinal slices prepared by means of the preparation process retains the polar and nonpolar effective components in the medicinal material to the most degree. The granular medicinal slices has good liquidity, is convenient for storage, transportation and dispensing, is controllable in quality and reliable in curative effect and has the important significance on guarantee of the clinical curative effect of traditional Chinese medicine. The preparation process has remarkable social significance and economic benefits in implementation and popularization.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Flos Sophorae decoction pieces.
Background technology
Chinese medicine Flos Sophorae is leguminous plant Chinese scholartreeSophora japonicaL. dry flower and alabastrum.This product only has removing heat from blood
Blood, effect of purging liver-fire, it is used for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, controlling of the headache disease such as dizziness
Treat.
The processing mode of conventional Flos Sophorae decoction pieces is: summer, the flowers are in blossom to put or gathers time alabastrum is formed, and is dried, then storage of packing
Fortune.This type of decoction pieces, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for that formula is adjusted
With guarantee its clinical efficacy, even to patient bring recessiveness harm.
At present, granule pieces market also having Flos Sophorae medical material to make after extracting is sold.The preparation of granule pieces
Journey, extracts not only time consumption and energy consumption, and because conventional substantial amounts of water does solvent, the nonpolar effective ingredient in medical material is difficult to be extracted
Out.Additionally, due to the Flos Sophorae medical material extracted also is to be dried and through long-time storage, therefore, the loss of effective ingredient
Also it is the biggest.In order to ensure clinical effective, the steady quality of Flos Sophorae medical material, a kind of novel Flos Sophorae decoction pieces and preparation technology thereof
Urgently develop.
Summary of the invention
The invention discloses " a kind of Flos Sophorae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof ".This technique can be
The polarity retained in Flos Sophorae medical material of limits and nonpolar effective ingredient, it is to avoid medical material is in the processing of existing decoction pieces and accumulating
The loss of the effective ingredient caused in journey and the decline of medical material quanlity, reduce the medical material pollution by mycete etc., to guaranteeing that Flos Sophorae is drunk
Steady quality and the clinical safety of sheet effectively have great importance.
To achieve these goals, the technical scheme is that
After Flos Sophorae is gathered, cleaning, washing, take advantage of fresh squeezing, collect and just squeeze medicine juice, the first squeezing medicine juice of retention 0.5% ~ 5% is standby, medicine
Slag adds the water of 1 ~ 5 times amount, stirs 5 ~ 30min, filter press filter pressing extracting juice, and remaining medicinal residues squeeze extracting juice again, merges remaining
First squeezing medicine juice and rear twice squeezing medicine juice, 60 ~ 120 mesh screen, obtain Flos Sophorae medicine juice.By the Flos Sophorae medicine juice that obtains in 40 ~ 75
It is evaporated to the concentrated solution that relative density is 1.02 ~ 1.15 under the conditions of DEG C, and this concentrated solution is spray-dried, intake air temperature
Being set as 90 ~ 140 DEG C, air outlet temperature is 80 ~ 110 DEG C, collects desciccate, crosses 60 ~ 100 mesh sieves after pulverizing.By above-mentioned Chinese scholartree
Flower spray drying powder, mixes with the first squeezing medicine juice retained, prepares soft material, pelletizes, and 50 ~ 80 DEG C are dried 4 ~ 8 hours, granulate, vacuum
Packaging.On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, decoction pieces manufacturer, the date of manufacture, main
The information such as component content, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and contraindication.The thin layer of Flos Sophorae is enclosed in Dai
Differentiate collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " identity card " of product.Additionally, in the packaging bag of product, be printed on two
Dimension code, can link the acquisition former plant photo of product, medical material photo, decoction pieces photo, character and microscopical identification by scanning special
The information such as levy.
The invention have benefit that:
The Flos Sophorae medical material of fresh collection, directly squeezes after cleaning washing, filters, concentrating under reduced pressure, is spray-dried, pelletizes, obtained
Granule pieces, the effective ingredient in medical material can be retained to greatest extent.This decoction pieces volume compares to tradition decoction pieces volume
Being greatly reduced, good fluidity, vacuum packaging so that prepared slice quality is more stable, beneficially accumulating and clinical adjustment, have very
Significantly social meaning and economic implications.
Detailed description of the invention
Embodiment 1
By the Flos Sophorae medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice, retain 1% weight
Just squeeze medicine juice separately to use.Gained medicinal residues add the tap water of 3 times amount, stir 20min, filter press squeezing extracting juice.Remaining medicinal residues
Extracting juice is squeezed again with squeezer.The above-mentioned remaining medicine juice that just squeezes is merged, by 100 eye mesh screen mistakes with follow-up twice squeezing medicine juice
Filter.Filtrate reduced in volume, temperature is set as 65 DEG C.When concentrating gained extractum relative density and being 1.05, it is spray-dried, air inlet
Temperature is 140 DEG C, and air outlet temperature is 100 DEG C, collects spray drying thing, low-temperature grinding, crosses 80 mesh sieves.By this spray drying powder with upper
The first squeezing medicine juice stating retention mixes soft material processed, pelletizes, and 75 DEG C are dried 6 hours, granulate, pack, and 1kg/ bag adds packed antioxidant
And desiccant, Vacuum Package, labeling.
Embodiment 2
By the Flos Sophorae medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice, retain 5% weight
Just squeeze medicine juice separately to use.Gained medicinal residues add the tap water of 5 times amount, stir 30min, filter press squeezing extracting juice.Remaining medicinal residues
Extracting juice is squeezed again with squeezer.The above-mentioned remaining medicine juice that just squeezes is merged, by 100 eye mesh screen mistakes with follow-up twice squeezing medicine juice
Filter.Filtrate reduced in volume, temperature is set as 70 DEG C.When concentrating gained extractum relative density and being 1.10, it is spray-dried, air inlet
Temperature is 120 DEG C, and air outlet temperature is 90 DEG C, collects spray drying thing, low-temperature grinding, crosses 80 mesh sieves.By this spray drying powder with upper
The first squeezing medicine juice stating retention mixes soft material processed, pelletizes, and 70 DEG C are dried 8 hours, granulate, pack, and 1kg/ bag adds packed antioxidant
And desiccant, Vacuum Package, labeling.
Above example, is only the technological thought that this invention is described, it is impossible to limit protection scope of the present invention whereby all
It is the technological thought proposed according to the present invention, any change done on the basis of technical scheme, each fall within present invention protection
Within the scope of.
Claims (3)
1. a Flos Sophorae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof, it is characterised in that: after Flos Sophorae is gathered, clean,
Washing, takes advantage of fresh squeezing, collects and just squeezes medicine juice, and the first squeezing medicine juice of retention 0.5% ~ 5% is standby, and medicinal residues add the water of 1 ~ 5 times amount, stirring
5 ~ 30min, filter press filter pressing extracting juice, remaining medicinal residues squeeze extracting juice again, merge remaining just squeezing medicine juice and rear twice squeezing
Medicine juice, 60 ~ 120 mesh screen, obtain Flos Sophorae medicine juice.
A kind of Flos Sophorae fresh squeezing spray-dried granules decoction pieces the most according to claim 1 and preparation technology thereof, it is characterised in that:
The Flos Sophorae medicine juice obtained in claim 1 is evaporated to the concentration that relative density is 1.02 ~ 1.15 under the conditions of 40 ~ 75 DEG C
Liquid, and this concentrated solution is spray-dried, intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects dry
Dry product, crosses 60 ~ 100 mesh sieves after pulverizing.
A kind of Flos Sophorae fresh squeezing spray-dried granules decoction pieces the most according to claim 1 and preparation technology thereof, it is characterised in that:
By the Flos Sophorae spray drying powder in claim 2, mix with the first squeezing medicine juice retained in claim 1, prepare soft material, pelletize,
50 ~ 80 DEG C are dried 4 ~ 8 hours, and granulate is vacuum-packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582900.0A CN105998168A (en) | 2016-07-23 | 2016-07-23 | Spray-dried granular medicinal slices prepared from freshly squeezed flos sophorae and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582900.0A CN105998168A (en) | 2016-07-23 | 2016-07-23 | Spray-dried granular medicinal slices prepared from freshly squeezed flos sophorae and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105998168A true CN105998168A (en) | 2016-10-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610582900.0A Pending CN105998168A (en) | 2016-07-23 | 2016-07-23 | Spray-dried granular medicinal slices prepared from freshly squeezed flos sophorae and preparation process thereof |
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| Country | Link |
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| CN (1) | CN105998168A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213186A (en) * | 2017-06-20 | 2017-09-29 | 徐漫 | A kind of acalypha copperleaf is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107375381A (en) * | 2017-08-25 | 2017-11-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of tussilago |
| CN110772484A (en) * | 2019-11-12 | 2020-02-11 | 安徽协和成制药有限公司 | Fried sophora flower formula particle and preparation method and quality standard detection method thereof |
| CN114832028A (en) * | 2022-05-07 | 2022-08-02 | 湖南省中医药研究院 | Method for increasing rutin content in flos sophorae formula particles and preparation method of flos sophorae formula particles |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287858A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried granular decoction piece and preparation technology thereof |
-
2016
- 2016-07-23 CN CN201610582900.0A patent/CN105998168A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287858A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried granular decoction piece and preparation technology thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213186A (en) * | 2017-06-20 | 2017-09-29 | 徐漫 | A kind of acalypha copperleaf is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107375381A (en) * | 2017-08-25 | 2017-11-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of tussilago |
| CN110772484A (en) * | 2019-11-12 | 2020-02-11 | 安徽协和成制药有限公司 | Fried sophora flower formula particle and preparation method and quality standard detection method thereof |
| CN114832028A (en) * | 2022-05-07 | 2022-08-02 | 湖南省中医药研究院 | Method for increasing rutin content in flos sophorae formula particles and preparation method of flos sophorae formula particles |
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Application publication date: 20161012 |