CN105997967B - 用于治疗癌症的化合物和组合物 - Google Patents

用于治疗癌症的化合物和组合物 Download PDF

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CN105997967B
CN105997967B CN201610353298.3A CN201610353298A CN105997967B CN 105997967 B CN105997967 B CN 105997967B CN 201610353298 A CN201610353298 A CN 201610353298A CN 105997967 B CN105997967 B CN 105997967B
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cancer
formula
compound
mmol
compounds
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CN105997967A (zh
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L·加尼翁
B·格劳克斯
L·格尔茨
P·劳伦
C·彭尼
B·扎卡赖尔
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General Midike Pharmaceutical Co Ltd Smt
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201610353298.3A 2010-10-27 2011-10-26 用于治疗癌症的化合物和组合物 Expired - Fee Related CN105997967B (zh)

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US (2) US9114118B2 (https=)
EP (2) EP2632452B1 (https=)
JP (2) JP6007186B2 (https=)
KR (2) KR101943280B1 (https=)
CN (2) CN105997967B (https=)
AU (2) AU2011356583C1 (https=)
BR (1) BR112013010507A2 (https=)
CA (1) CA2816093C (https=)
CL (1) CL2013001152A1 (https=)
DK (2) DK3443957T3 (https=)
EA (2) EA030038B1 (https=)
ES (2) ES2837599T3 (https=)
IL (2) IL225599A (https=)
MX (2) MX365807B (https=)
MY (2) MY184343A (https=)
NZ (1) NZ610851A (https=)
PH (2) PH12013500766B1 (https=)
PL (2) PL3443957T3 (https=)
PT (2) PT2632452T (https=)
SG (2) SG189538A1 (https=)
TR (1) TR201819987T4 (https=)
TW (2) TWI578983B (https=)
WO (1) WO2012097427A1 (https=)
ZA (1) ZA201303035B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX365807B (es) * 2010-10-27 2019-06-14 Prometic Pharma Smt Ltd Compuestos y composiciones para el tratamiento del cáncer.
TWI742541B (zh) 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
LT4124339T (lt) 2014-03-06 2025-11-10 Vaisto įvedimo sistemos ir būdai šlapimo pūslės vėžiui gydyti gemcitabinu
RU2560702C1 (ru) * 2014-06-05 2015-08-20 Общество с ограниченной ответственностью "Научно-производственный центр "Амфион" (ООО "НПЦ "Амфион") Фармацевтическая композиция для применения в онкологии
ES2785317T3 (es) * 2014-10-10 2020-10-06 Liminal Biosciences Ltd Compuestos aromáticos sustituidos y composiciones farmacéuticas para la prevención y el tratamiento de la osteoporosis
DK3204000T3 (da) 2014-10-10 2020-04-06 Liminal Biosciences Ltd Phenylketoncarboxylatforbindelser og farmaceutiske sammensætninger til forebyggelse og behandling af osteoporose
KR20170072352A (ko) 2014-11-12 2017-06-26 프로메틱 파마 에스엠티 리미티드 조직 자가-회복 및 재생을 위한 치환된 방향족 화합물 및 약제학적 조성물
CN106267213A (zh) * 2015-05-27 2017-01-04 聊城市奥润生物医药科技有限公司 环二核苷酸cGAMP在治疗肿瘤联合用药中的应用
BR112020000832A2 (pt) 2017-07-25 2020-07-21 Taris Biomedical Llc métodos para tratar metástase tumoral
JOP20200124A1 (ar) 2017-11-08 2020-05-20 Taris Biomedical Llc طُرق لعلاج سرطان المثانة باستخدام جيمسيتابين وعلاج مدوامة لذلك
WO2020113340A1 (en) * 2018-12-05 2020-06-11 Liminal Biosciences Limited Use of sodium 2-(3-pentylphenyl)acetate in the treatment of alström syndrome
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
CN118903087A (zh) 2019-07-26 2024-11-08 埃斯佩尔维塔治疗股份有限公司 可用于预防或治疗疾病的官能化的长链烃一元和二元羧酸
JP2024512510A (ja) * 2020-10-06 2024-03-19 ファーマセウティーク・インジェニュー・インコーポレイテッド 置換芳香族化合物及びその医薬組成物
CA3209453A1 (en) 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives therof, and their use for the prevention or treatment of disease
CN114436822B (zh) * 2022-01-12 2024-04-16 厦门稀土材料研究所 一枝蒿酮酸和生物碱复盐及其制备方法和用途
EP4683624A1 (en) * 2023-03-22 2026-01-28 UTI Limited Partnership Hydroxyphenyl propanoate compounds for tumour immunotherapy, compositions and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
CN1612729A (zh) * 2001-11-20 2005-05-04 冬姆佩股份公司 2－芳基－丙酸及含有它们的药物组合物
CN102421742A (zh) * 2009-05-04 2012-04-18 普罗米蒂克生物科学公司 3-戊基苯乙酸的盐及其药物用途
CN102438975A (zh) * 2009-05-04 2012-05-02 普罗米蒂克生物科学公司 取代的芳香化合物及其药物用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0268907A3 (en) 1986-11-19 1990-03-21 Carl Richard Thornfeldt Treatment of disease conditions relating to hyperactive organelles
CN1169768C (zh) * 2002-04-26 2004-10-06 中国科学院上海有机化学研究所 （4－炔基）－芳香酮酸类化合物、合成方法及应用
US7863428B2 (en) * 2002-12-27 2011-01-04 Tibotec Bvba Fluorogenic enzyme substrates and methods of preparation
WO2005010202A2 (en) * 2003-07-16 2005-02-03 Ligand Pharmacueticals Incorporated PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS
WO2005009104A2 (en) * 2003-07-16 2005-02-03 Ligand Pharmacueticals Incorporated Benzoic and phenyl acetic acid derivatives as hnf-4 modulators
US8198328B2 (en) * 2004-01-21 2012-06-12 New York University Treatment of cancer using benzoic acid derivatives
US20100010002A1 (en) 2006-09-01 2010-01-14 Piramal Life Sciences Limited Anticancer use of caffeic acid and its derivatives
CN105233294A (zh) * 2007-02-08 2016-01-13 爱密斯菲尔科技公司 苯烷基羧酸输送剂
WO2009055932A1 (en) 2007-11-02 2009-05-07 Prometic Biosciences Inc. Substituted phenylpropionic acids as stimulators of hematopoiesis and erythropoiesis
CN101878028A (zh) * 2007-11-02 2010-11-03 普罗米蒂克生物科学公司 作为肾保护剂的中链长度脂肪酸和甘油酯
NZ586249A (en) * 2007-12-19 2012-05-25 Prometic Biosciences Inc A combination of medium-chain length fatty acids, salts or triglycerides, gemcitabine, and optionally erlotinib, for the treatment of pancreatic cancer
MX365807B (es) * 2010-10-27 2019-06-14 Prometic Pharma Smt Ltd Compuestos y composiciones para el tratamiento del cáncer.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
CN1612729A (zh) * 2001-11-20 2005-05-04 冬姆佩股份公司 2－芳基－丙酸及含有它们的药物组合物
CN102421742A (zh) * 2009-05-04 2012-04-18 普罗米蒂克生物科学公司 3-戊基苯乙酸的盐及其药物用途
CN102438975A (zh) * 2009-05-04 2012-05-02 普罗米蒂克生物科学公司 取代的芳香化合物及其药物用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Design of Noncompetitive Interleukin-8 Inhibitors Acting on CXCR1 and CXCR2;Alessio Moriconi等;《Journal of Medicinal Chemistry》;20070801;第50卷(第17期);第3984-4002页
Phenylacetic Acid as a Potential Therapeutic Agent for the Treatment of Human Cancer;AD STIMULANDUM;《Specialia》;19710715;第860-861页

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