CN1612729A - 2-芳基-丙酸及含有它们的药物组合物 - Google Patents
2-芳基-丙酸及含有它们的药物组合物 Download PDFInfo
- Publication number
- CN1612729A CN1612729A CNA028270290A CN02827029A CN1612729A CN 1612729 A CN1612729 A CN 1612729A CN A028270290 A CNA028270290 A CN A028270290A CN 02827029 A CN02827029 A CN 02827029A CN 1612729 A CN1612729 A CN 1612729A
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- China
- Prior art keywords
- phenylpropionic acid
- phenyl
- acid
- sulfonyloxy
- sulfonamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
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- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract
Description
实施例 | 名称 | 抑制百分比(C=10-6M) |
5 | (R,S)2-[3’-異丙基苯基]丙酸 | 51±12 |
10 | (R)2-[3’-異丙基苯基]丙酸 | 43±18 |
14 | (S)2-[3’-異丙基苯基]丙酸 | 50±9 |
7 | (R,S),(R,S)2-[3’-(α-甲基-苯甲基)苯基]丙酸 | 54±4 |
16 | (R,S),(R,S)2-[3’-(α-羥基-乙基)苯基]丙酸 | 57±6 |
18 | (R,S)2-[(2′-(2″,6″-二氯苯基)氨基]苯基丙酸 | 52±3 |
19 | (R)2-[(2′-(2″,6″-二氯苯基)氨基]苯基丙酸 | 46±14 |
20 | (S)2-[(2′-(2″,6″-二氯苯基)氨基]苯基丙酸 | 50±7 |
6 | (R,S)2-[3’-(α-乙基-丙基)苯基]丙酸 | 58±2 |
22 | (R,S)2-[(2′-(2″,6″-二氯)苯氧基)苯基]丙酸 | 41±9 |
CXCR1和CXCR2受体的生物活性数据(抑制百分比) | |||
实施例 | 名称 | IL-8(c=10-8M) | GRO-α(c=10-8M) |
24 | (R)2-(4’-苯磺酰氨基)苯基丙酸 | 49±11 | 33±11 |
25 | (R)2-(4’-甲烷磺酰氨基)苯基丙酸 | 25±7 | 32±5 |
26 | (R)2-[4’-(2”-丙烷)磺酰氨基]苯基丙酸 | 54±14 | 44±12 |
27 | (R)2-(4’-三氟甲烷磺酰氨基)苯基丙酸 | 8±10 | 40±14 |
28 | (R)2-(4’-苯甲基磺酰氨基)苯基丙酸 | 60±10 | 24±8 |
29 | (R)2-[4’-(2”-氯)苯磺酰氨基]苯基丙酸 | -2±10 | 66±10 |
30 | (R)2-[4’-(2”-乙基)苯磺酰氨基]苯基丙酸 | 44±14 | 80±10 |
31 | (R)2-(4’-氨基磺酰氨基)苯基丙酸 | 55±10 | 2±5 |
32 | (R)2-(4’-苯磺酰氧基)苯基丙酸 | 28±11 | 25±10 |
35 | (R)2-[4’-(2”-丙烷)磺酰氧基]苯基丙酸 | 49±8 | 46±6 |
34 | (R)2-(4’-三氟甲烷磺酰氧基)苯基丙酸 | 62±7 | 59±10 |
33 | (R)2-(4’-苯甲基磺酰氧基)苯基丙酸 | 59±11 | 25±11 |
36 | (R)2-[4’-(2”-氯)苯磺酰氧基]苯基丙酸 | 25±7 | 65±10 |
37 | (R)2-[4’-(2”-乙基)苯磺酰氧基]苯基丙酸 | 45±13 | 70±10 |
38 | (R)2-(4’-氨基磺酰氧基)苯基丙酸 | 65±10 | 5±7 |
40 | (R)2-(4’-三氟甲烷磺酰甲基)苯基丙酸 | 48±7 | 45±7 |
39 | (R)2-(4’-苯磺酰甲基)苯基丙酸 | 60±7 | 52±5 |
Claims (11)
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IT2001MI002434A ITMI20012434A1 (it) | 2001-11-20 | 2001-11-20 | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
EPMI2001A002434 | 2001-11-20 |
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US (1) | US8063242B2 (zh) |
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JP (1) | JP4549674B2 (zh) |
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AU (1) | AU2002352052B2 (zh) |
BR (1) | BRPI0214322B1 (zh) |
CA (1) | CA2465375C (zh) |
DE (1) | DE60234272D1 (zh) |
DK (2) | DK1455773T3 (zh) |
ES (2) | ES2333943T3 (zh) |
HK (1) | HK1075014A1 (zh) |
HU (1) | HU229077B1 (zh) |
IL (2) | IL161767A0 (zh) |
IT (1) | ITMI20012434A1 (zh) |
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NZ (1) | NZ532705A (zh) |
PL (1) | PL209745B1 (zh) |
PT (2) | PT1455773E (zh) |
RU (1) | RU2317075C2 (zh) |
SI (1) | SI1455773T1 (zh) |
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US7919250B2 (en) * | 2007-07-31 | 2011-04-05 | New York University | Diagnostic and treatment methods for characterizing bacterial microbiota in skin conditions |
EP2166006A1 (en) | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
EP2427416B1 (en) | 2009-05-04 | 2016-03-09 | Prometic Pharma Smt Limited | Substituted aromatic compounds and pharmaceutical uses thereof |
DE102011119821A1 (de) | 2011-12-01 | 2013-06-06 | Bundesdruckerei Gmbh | Elektrooptisches Sicherheitselement |
TWI742541B (zh) | 2013-03-15 | 2021-10-11 | 英商邊緣生物科技有限公司 | 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物 |
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CN112778167A (zh) * | 2019-11-01 | 2021-05-11 | 邵阳学院 | 一种快速制备n-苯磺酰基氨基酸酯类化合物的方法 |
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