CN105873937A - 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 - Google Patents

用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 Download PDF

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Publication number
CN105873937A
CN105873937A CN201480071722.4A CN201480071722A CN105873937A CN 105873937 A CN105873937 A CN 105873937A CN 201480071722 A CN201480071722 A CN 201480071722A CN 105873937 A CN105873937 A CN 105873937A
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Prior art keywords
salt
nicotinamide riboside
skin
weight
compound
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Pending
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CN201480071722.4A
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English (en)
Chinese (zh)
Inventor
安·德仁-路易斯
特洛伊·鲁尼穆斯
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Chromadex Inc
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Chromadex Inc
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Priority to CN201910027571.7A priority Critical patent/CN109985056A/zh
Publication of CN105873937A publication Critical patent/CN105873937A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Birds (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
CN201480071722.4A 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 Pending CN105873937A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910027571.7A CN109985056A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361897713P 2013-10-30 2013-10-30
US61/897,713 2013-10-30
PCT/US2014/063260 WO2015066382A1 (en) 2013-10-30 2014-10-30 Nicotinamide riboside compositions for topical use in treating skin conditions

Related Child Applications (1)

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CN201910027571.7A Division CN109985056A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物

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Publication Number Publication Date
CN105873937A true CN105873937A (zh) 2016-08-17

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CN201480071722.4A Pending CN105873937A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物
CN201910027571.7A Pending CN109985056A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物

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Country Status (12)

Country Link
US (2) US10688118B2 (enExample)
EP (1) EP3063163B1 (enExample)
JP (1) JP6509844B2 (enExample)
KR (3) KR20220098049A (enExample)
CN (2) CN105873937A (enExample)
AU (1) AU2014342185B2 (enExample)
CA (1) CA2928656C (enExample)
ES (1) ES2925879T3 (enExample)
MX (2) MX385305B (enExample)
NZ (1) NZ719328A (enExample)
WO (1) WO2015066382A1 (enExample)
ZA (1) ZA201603314B (enExample)

Cited By (7)

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CN110913864A (zh) * 2018-08-17 2020-03-24 邦泰生物工程(深圳)有限公司 一种稳定型烟酰胺核糖组合物及其制备方法
CN111166760A (zh) * 2019-12-17 2020-05-19 浙江安赛新材料科技有限公司 β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用
CN111246838A (zh) * 2017-10-06 2020-06-05 艾克斯奥巴德蒙公司 用于将活性成分递送至皮肤的套件
CN111454311A (zh) * 2020-04-03 2020-07-28 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
WO2021073426A1 (zh) * 2019-10-17 2021-04-22 泓博元生命科技（深圳）有限公司 Nadh 及其盐在制备皮肤色素抑制剂中的应用
CN114423771A (zh) * 2019-07-19 2022-04-29 生物合成股份公司 制备烟酰胺呋喃核糖苷盐的方法、烟酰胺呋喃核糖苷盐本身及其用途
CN114933621A (zh) * 2022-04-13 2022-08-23 深圳市迪克曼生物科技有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途

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CN106715455A (zh) 2014-06-06 2017-05-24 葛兰素史密斯克莱知识产权（第2 号）有限公司 烟酰胺核苷类似物及其药物组合物和用途
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WO2016144660A1 (en) 2015-03-09 2016-09-15 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
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US20160317419A1 (en) * 2015-05-01 2016-11-03 The Procter & Gamble Company Method of improving skin health and compositions therefor
US20160317418A1 (en) 2015-05-01 2016-11-03 The Procter & Gamble Company Method of improving the appearance of skin and compositions therefor
EP3288530A1 (en) 2015-05-01 2018-03-07 The Procter and Gamble Company Method of improving the appearance of skin and compositions therefor using nicotinamide riboside
AU2016274126A1 (en) 2015-06-10 2018-01-18 Elysium Health, Inc. Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders
US20180177703A1 (en) * 2015-06-25 2018-06-28 N.V. Perricone Llc Niacinamide Mononucleotide Formulations For Skin Aging
WO2017004102A1 (en) 2015-06-29 2017-01-05 The Procter & Gamble Company Multi-component skin care product comprising nicoinamide riboside in a multi-chambered container
WO2017004101A1 (en) 2015-06-29 2017-01-05 The Procter & Gamble Company Skin care compositions comprising particles with nicotinamide riboside and methods of using the same
US20160374918A1 (en) * 2015-06-29 2016-12-29 The Procter & Gamble Company Encapsulated skin care agent
CA3010730C (en) 2016-01-11 2021-02-16 The Procter & Gamble Company Method of treating a skin condition and compositions therefor
AU2017232930B2 (en) 2016-03-16 2021-03-25 ChromaDex Inc. B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
CA3021571C (en) * 2016-04-20 2023-01-03 ChromaDex Inc. Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as nad+increasing precursors
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US11337908B2 (en) 2016-12-21 2022-05-24 Conopco, Inc. Personal care compositions with cystine
CA3046037A1 (en) 2016-12-21 2018-06-28 Unilever Plc Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids
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EA038885B1 (ru) 2016-12-21 2021-11-02 ЮНИЛЕВЕР АйПи ХОЛДИНГС Б.В. Осветляющая кожу добавка для местного применения и композиция с аминокислотами и никотинамидными соединениями
RU2651047C1 (ru) * 2017-05-04 2018-04-18 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Лекарственная композиция цитопротекторного действия и способ ее получения
WO2018213715A1 (en) * 2017-05-18 2018-11-22 Elysium Health, Inc. Methods and compositions for improving sleep
US11286274B2 (en) 2017-06-19 2022-03-29 Mitopower Llc Nicotinamide riboside derivatives and their uses
US10660838B2 (en) 2017-06-23 2020-05-26 The Procter & Gamble Company Composition and method for improving the appearance of skin
CN111542312A (zh) * 2017-07-28 2020-08-14 老龄化控制中心股份公司 预防和逆转衰老方面的组合物和方法
WO2019054485A1 (ja) * 2017-09-14 2019-03-21 めぐみ 田中 老化防止剤及び老化防止方法
US11414407B2 (en) 2017-12-22 2022-08-16 Elysium Health, Inc. Crystalline forms of nicotinamide riboside chloride
EP3817717A1 (en) 2018-07-03 2021-05-12 The Procter & Gamble Company Method of treating a skin condition
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
KR102315139B1 (ko) 2019-12-17 2021-10-20 주식회사 휴메딕스 지방아민 컨쥬게이션된 니코틴아미드 리보사이드 유도체
CN111184732B (zh) * 2020-03-04 2023-09-08 武汉华纳联合药业有限公司 一种复合组合物制剂及其制备方法和皮肤炎症中的应用
FR3110410A1 (fr) * 2020-05-20 2021-11-26 Nuvamid Sa Compositions cosmétiques anti-âge comprenant de la NMN
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CN111632049A (zh) * 2020-06-09 2020-09-08 西北农林科技大学 一种通过综合矫正细胞活性氧簇代谢紊乱以缓解睾丸衰老损伤的复合配方
WO2022047182A1 (en) * 2020-08-28 2022-03-03 University Of Washington High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation
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CN111246838A (zh) * 2017-10-06 2020-06-05 艾克斯奥巴德蒙公司 用于将活性成分递送至皮肤的套件
CN111246838B (zh) * 2017-10-06 2024-01-26 艾克斯奥巴德蒙公司 用于将活性成分递送至皮肤的套件
CN110913864A (zh) * 2018-08-17 2020-03-24 邦泰生物工程(深圳)有限公司 一种稳定型烟酰胺核糖组合物及其制备方法
CN110913864B (zh) * 2018-08-17 2022-12-13 邦泰生物工程(深圳)有限公司 一种稳定型烟酰胺核糖组合物及其制备方法
US12344629B2 (en) 2019-07-19 2025-07-01 Biosynth Ag Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof
CN114423771A (zh) * 2019-07-19 2022-04-29 生物合成股份公司 制备烟酰胺呋喃核糖苷盐的方法、烟酰胺呋喃核糖苷盐本身及其用途
WO2021073426A1 (zh) * 2019-10-17 2021-04-22 泓博元生命科技（深圳）有限公司 Nadh 及其盐在制备皮肤色素抑制剂中的应用
CN111166760A (zh) * 2019-12-17 2020-05-19 浙江安赛新材料科技有限公司 β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
US11505570B2 (en) 2020-04-03 2022-11-22 Shenzhen Dieckmann Tech Co., Ltd Organic acid salt of nicotinamide riboside, composition including organic acid salt, and preparation methods of organic acid salt and composition
KR20220156642A (ko) * 2020-04-03 2022-11-25 썬전 디에크만 테크 컴퍼니 리미티드 니코틴아미드 리보사이드의 유기산염 및 이의 조성물 및 제조방법
AU2020440743B2 (en) * 2020-04-03 2024-02-15 Shenzhen Dieckmann Tech Co. Ltd Organic acid salt of nicotinamide riboside, composition thereof and preparation method therefor
WO2021196349A1 (zh) * 2020-04-03 2021-10-07 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
KR102591687B1 (ko) 2020-04-03 2023-10-20 썬전 디에크만 테크 컴퍼니 리미티드 니코틴아미드 리보사이드의 유기산염 및 이의 조성물 및 제조방법
CN111454311A (zh) * 2020-04-03 2020-07-28 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN114933621A (zh) * 2022-04-13 2022-08-23 深圳市迪克曼生物科技有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途
CN116621898A (zh) * 2022-04-13 2023-08-22 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途

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