JP6509844B2 - 皮膚症状の治療において局所使用されるニコチンアミドリボシド組成物 - Google Patents

皮膚症状の治療において局所使用されるニコチンアミドリボシド組成物 Download PDF

Info

Publication number
JP6509844B2
JP6509844B2 JP2016526337A JP2016526337A JP6509844B2 JP 6509844 B2 JP6509844 B2 JP 6509844B2 JP 2016526337 A JP2016526337 A JP 2016526337A JP 2016526337 A JP2016526337 A JP 2016526337A JP 6509844 B2 JP6509844 B2 JP 6509844B2
Authority
JP
Japan
Prior art keywords
composition
salt
skin
nicotinamide riboside
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016526337A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016538271A (ja
JP2016538271A5 (enExample
Inventor
デレン−ルイス，アン
ローンマス，トロイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chromadex Inc
Original Assignee
Chromadex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromadex Inc filed Critical Chromadex Inc
Publication of JP2016538271A publication Critical patent/JP2016538271A/ja
Publication of JP2016538271A5 publication Critical patent/JP2016538271A5/ja
Application granted granted Critical
Publication of JP6509844B2 publication Critical patent/JP6509844B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Birds (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
JP2016526337A 2013-10-30 2014-10-30 皮膚症状の治療において局所使用されるニコチンアミドリボシド組成物 Active JP6509844B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361897713P 2013-10-30 2013-10-30
US61/897,713 2013-10-30
PCT/US2014/063260 WO2015066382A1 (en) 2013-10-30 2014-10-30 Nicotinamide riboside compositions for topical use in treating skin conditions

Publications (3)

Publication Number Publication Date
JP2016538271A JP2016538271A (ja) 2016-12-08
JP2016538271A5 JP2016538271A5 (enExample) 2017-12-21
JP6509844B2 true JP6509844B2 (ja) 2019-05-08

Family

ID=53005146

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016526337A Active JP6509844B2 (ja) 2013-10-30 2014-10-30 皮膚症状の治療において局所使用されるニコチンアミドリボシド組成物

Country Status (12)

Country Link
US (2) US10688118B2 (enExample)
EP (1) EP3063163B1 (enExample)
JP (1) JP6509844B2 (enExample)
KR (3) KR20210107895A (enExample)
CN (2) CN109985056A (enExample)
AU (1) AU2014342185B2 (enExample)
CA (1) CA2928656C (enExample)
ES (1) ES2925879T3 (enExample)
MX (2) MX385305B (enExample)
NZ (1) NZ719328A (enExample)
WO (1) WO2015066382A1 (enExample)
ZA (1) ZA201603314B (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015186068A1 (en) * 2014-06-02 2015-12-10 Glaxosmithkline Intellectual Property (No.2) Limited Preparation and use of crystalline beta-d-nicotinamide riboside
RU2016149767A (ru) 2014-06-06 2018-07-16 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Аналоги никотинамидрибозида и фармацевтические композиции и их применение
CN106715454B (zh) 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
CA2978069C (en) 2015-03-09 2021-10-12 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
BR112017019696A2 (pt) * 2015-03-16 2018-09-04 ChromaDex Inc. composto e usos de um composto
EP3288531B1 (en) * 2015-05-01 2019-07-24 The Procter and Gamble Company Method of improving skin health and compositions therefor
JP2018515485A (ja) 2015-05-01 2018-06-14 ザ プロクター アンド ギャンブル カンパニー 皮膚の外観を改善する方法及びニコチンアミドリボシドを使用したそのための組成物
US20160317418A1 (en) 2015-05-01 2016-11-03 The Procter & Gamble Company Method of improving the appearance of skin and compositions therefor
US11426398B2 (en) * 2015-06-10 2022-08-30 Elysium Health, Inc. Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders
US20180177703A1 (en) * 2015-06-25 2018-06-28 N.V. Perricone Llc Niacinamide Mononucleotide Formulations For Skin Aging
US11013678B2 (en) 2015-06-29 2021-05-25 The Procter & Gamble Company Multi-component skin care product
US20160374908A1 (en) 2015-06-29 2016-12-29 The Procter & Gamble Company Skin care composition and methods of using the same
US20160374918A1 (en) * 2015-06-29 2016-12-29 The Procter & Gamble Company Encapsulated skin care agent
CN112315837B (zh) 2016-01-11 2021-12-03 宝洁公司 处理皮肤状况的方法以及用于其的组合物
US10000520B2 (en) 2016-03-16 2018-06-19 ChromaDex Inc. B-vitamin and amino acid conjugates ofnicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
MX393076B (es) * 2016-04-20 2025-03-24 Chromadex Inc Uso de derivados de ribósido de ácido nicotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores que incrementan nad+
RU2019108100A (ru) 2016-08-22 2020-09-22 Элизиум Хелт, Инк. Композиции никотинамид рибозида и птеростильбена и методы лечения нейродегенеративных заболеваний
EP3538099A4 (en) 2016-11-11 2020-06-17 The Queen's University of Belfast EFFICIENT AND SCALABLE SYNTHESIS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS OF THEM, ADENYLYDINUCLEOTIDE CONJUGATES THEREOF AND NEW-WAY CRYSTALS
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
EP3554285A4 (en) 2016-11-29 2021-01-20 University of Iowa Research Foundation USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring
PH12019501354B1 (en) 2016-12-21 2023-04-19 Unilever Ip Holdings B V Personal care compositions with cystine
CA3047495A1 (en) 2016-12-21 2018-06-28 Unilever Plc Topical skin lightening additive and composition with amino acids and nicotinamide compounds
EP3558243B1 (en) 2016-12-21 2022-10-05 Unilever IP Holdings B.V. Personal care compositions comprising poorly soluble compounds
WO2018113634A1 (en) 2016-12-21 2018-06-28 Unilever Plc Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids
RU2651047C1 (ru) * 2017-05-04 2018-04-18 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Лекарственная композиция цитопротекторного действия и способ ее получения
EP3624808A4 (en) * 2017-05-18 2021-03-03 Elysium Health, Inc. PROCEDURES AND COMPOSITIONS FOR IMPROVED SLEEP
EP3642214A2 (en) 2017-06-19 2020-04-29 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
EP3641725A1 (en) 2017-06-23 2020-04-29 The Procter and Gamble Company Composition and method for improving the appearance of skin
CA3108015A1 (en) * 2017-07-28 2019-01-31 Centers For Age Control, Inc. Compositions and methods for preventing and reversing aspects of aging
KR102852384B1 (ko) * 2017-09-14 2025-09-01 메구미 타나카 노화 방지제 및 노화 방지 방법
GB201716391D0 (en) * 2017-10-06 2017-11-22 Xobaderm Ltd Kit for delivery of an active compound into a biological barrier
US11414407B2 (en) 2017-12-22 2022-08-16 Elysium Health, Inc. Crystalline forms of nicotinamide riboside chloride
JP2021530447A (ja) 2018-07-03 2021-11-11 ザ プロクター アンド ギャンブル カンパニーThe Procter & Gamble Company 皮膚状態の治療方法
JP6887025B2 (ja) * 2018-08-17 2021-06-16 邦泰生物工程（深▲セン▼）有限公司 安定型ニコチンアミドリボシド組成物及びその調製方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
US11833167B2 (en) 2018-12-17 2023-12-05 Mitopower Llc Nicotinyl riboside compounds and their uses
CN119684381A (zh) * 2019-07-19 2025-03-25 生物合成股份公司 烟酰胺呋喃核糖苷盐的结晶形式以及包含其的营养补充剂和药物组合物
CN110638827A (zh) * 2019-10-17 2020-01-03 泓博元生命科技（深圳）有限公司 Nadh及其盐在制备皮肤色素抑制剂中的应用
KR102315139B1 (ko) 2019-12-17 2021-10-20 주식회사 휴메딕스 지방아민 컨쥬게이션된 니코틴아미드 리보사이드 유도체
CN111166760A (zh) * 2019-12-17 2020-05-19 浙江安赛新材料科技有限公司 β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用
CN111184732B (zh) * 2020-03-04 2023-09-08 武汉华纳联合药业有限公司 一种复合组合物制剂及其制备方法和皮肤炎症中的应用
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
FR3110410A1 (fr) * 2020-05-20 2021-11-26 Nuvamid Sa Compositions cosmétiques anti-âge comprenant de la NMN
EP4153323A1 (fr) * 2020-05-20 2023-03-29 Nuvamid SA Compositions cosmetiques anti-age comprenant du nmn
WO2021247496A1 (en) 2020-06-01 2021-12-09 The Procter & Gamble Company Method of improving penetration of a vitamin b3 compound into skin
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
CN111632049A (zh) * 2020-06-09 2020-09-08 西北农林科技大学 一种通过综合矫正细胞活性氧簇代谢紊乱以缓解睾丸衰老损伤的复合配方
WO2022047182A1 (en) * 2020-08-28 2022-03-03 University Of Washington High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation
EP4029496A1 (en) * 2021-01-18 2022-07-20 Universitat de València Pterostilbene and silibinin for preventing, ameliorating or reducing radiation-induced diseases
EP4281465A1 (en) * 2021-01-19 2023-11-29 Biosynth AG Method of making nicotinamide ribofuranoside salts by salt metathesis, the crystalline form of its tosylate salt and the co-crystallized form of its chloride:iodide salt
US12150461B2 (en) * 2021-05-04 2024-11-26 Sovida Solutions Ltd. Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof
CN114129509B (zh) * 2021-12-03 2023-12-01 药酚享科技(北京)有限公司 一种保湿性nmn亲水凝胶剂及其制备方法
CN116621898A (zh) * 2022-04-13 2023-08-22 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途
KR102784901B1 (ko) * 2022-06-23 2025-03-21 제너럴바이오(주) Nr, nmn 및 nad를 함유한 피부 주름 개선용 화장료 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03007314A (es) * 2001-02-22 2003-12-04 Unilever Nv Composicion para la piel para reducir aceites y grasa de la piel.
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
WO2005077091A2 (en) 2004-02-10 2005-08-25 Trustees Of Dartmouth College Nicotinamide riboside kinase compositions and methods for using the same
PT1755391E (pt) 2004-06-04 2016-02-03 Univ Washington Métodos e composições para o tratamento de neuropatias
WO2006105440A2 (en) 2005-03-30 2006-10-05 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside and analogues thereof
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
CN103055313A (zh) * 2005-07-07 2013-04-24 西特里斯药业公司 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物
CN101257897A (zh) * 2005-07-07 2008-09-03 西特里斯药业公司 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物
ES2670927T3 (es) * 2005-11-18 2018-06-04 Cornell Research Foundation, Inc. Composiciones de nicotinoil ribósido y métodos de uso
CN101631593B (zh) * 2007-03-12 2014-08-13 帝斯曼知识产权资产管理有限公司 化妆品组合物
US20090069444A1 (en) 2007-09-07 2009-03-12 The United States Of America, As Represented By Th E Secretary Of Agriculture Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration
US20130004463A1 (en) * 2010-01-06 2013-01-03 Kabushiki Kaisha Yakult Honsha Dna damage repair promoter for oral application, and elastase activity inhibitor for oral application

Also Published As

Publication number Publication date
ZA201603314B (en) 2017-09-27
JP2016538271A (ja) 2016-12-08
CA2928656C (en) 2020-07-28
US20160250241A1 (en) 2016-09-01
ES2925879T3 (es) 2022-10-20
CN109985056A (zh) 2019-07-09
US20200289536A1 (en) 2020-09-17
MX2021009652A (es) 2022-07-26
EP3063163B1 (en) 2022-08-10
MX394291B (es) 2025-03-24
US10688118B2 (en) 2020-06-23
US11033568B2 (en) 2021-06-15
KR20220098049A (ko) 2022-07-08
AU2014342185B2 (en) 2019-01-03
CN105873937A (zh) 2016-08-17
CA2928656A1 (en) 2015-05-07
KR20210107895A (ko) 2021-09-01
WO2015066382A1 (en) 2015-05-07
EP3063163A1 (en) 2016-09-07
EP3063163A4 (en) 2017-05-10
MX385305B (es) 2025-03-18
MX2016005574A (es) 2016-12-09
KR20160067195A (ko) 2016-06-13
NZ719328A (en) 2022-04-29

Similar Documents

Publication Publication Date Title
JP6509844B2 (ja) 皮膚症状の治療において局所使用されるニコチンアミドリボシド組成物
AU2014342185A1 (en) Nicotinamide riboside compositions for topical use in treating skin conditions
BR112014025469B1 (pt) Usos de lisado filtrado da bactéria probiótica lactobacillus rhamnosus gg atcc 53103 no reparo ou regeneração da barreira cutânea e no tratamento cosmético para aumentar a função de barreira cutânea
TW201210601A (en) Compounds and methods for skin repair
US8816065B2 (en) Pharmaceutical or cosmetic composition containing nicotinic acid adenine dinucleotide phosphate or derivative thereof
KR20100135703A (ko) 주름 억제용 조성물과 피부 외용 조성물
JP2017528505A (ja) 発毛増進、皮膚再生促進及び創傷治癒のための組成物及び方法
EP3302452A1 (en) Olivamine-induced improvement in endothelial cells viability and function
EP0535237A1 (en) Composition for relieving skin irritation and external preparation for percutaneous adminstration containing the same
ES2827253T3 (es) Preparación cutánea externa antienvejecimiento
JP5455248B2 (ja) 保湿作用を有する皮膚外用剤
RU2720993C2 (ru) Пирролидон-карбоновая кислота (рса) для офтальмологического применения
JP4931369B2 (ja) リポソームおよびそれを含む処置用の組成物
HK40011054A (en) Nicotinamide nucleoside composition for topical use in the treatment of dermatosis
US20230372437A1 (en) Compositions and methods for the treatment of hair loss and other conditions
US20140107223A1 (en) Topical ubiquinol supplement skin care compositions
US20230390291A1 (en) Treatment of skin disorders with compositions comprising an egfr inhibitor
JP7396585B2 (ja) Ｔｓｌｐ遺伝子発現抑制用、ｉｌ－３３遺伝子発現抑制用、又はフィラグリン産生促進用組成物
US20250114362A1 (en) Methods and compositions for treatment of cutaneous proliferative disorders and other skin conditions
RU2793250C2 (ru) Композиция и способы лечения патологических состояний кожи; использование света и гидрохлорида глюкозамина
JP2007153863A (ja) 毛髪改善外用剤
US20210346380A1 (en) Treatment of skin disorders with compositions comprising an egfr inhibitor
KR20120032009A (ko) 피부 수분 투과 기능 이상의 예방제 또는 치료제
PL203478B1 (pl) Zastosowanie pochodnych biguanidu i ich soli do wytwarzania leku do bliznowacenia

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171027

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171027

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181001

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181130

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190305

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190403

R150 Certificate of patent or registration of utility model

Ref document number: 6509844

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250