MX385305B - Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel. - Google Patents
Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel.Info
- Publication number
- MX385305B MX385305B MX2016005574A MX2016005574A MX385305B MX 385305 B MX385305 B MX 385305B MX 2016005574 A MX2016005574 A MX 2016005574A MX 2016005574 A MX2016005574 A MX 2016005574A MX 385305 B MX385305 B MX 385305B
- Authority
- MX
- Mexico
- Prior art keywords
- nicotinamide riboside
- treatment
- compositions
- skin conditions
- skin
- Prior art date
Links
- 235000020956 nicotinamide riboside Nutrition 0.000 title abstract 6
- 239000011618 nicotinamide riboside Substances 0.000 title abstract 6
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000000699 topical effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000037041 intracellular level Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Birds (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361897713P | 2013-10-30 | 2013-10-30 | |
| PCT/US2014/063260 WO2015066382A1 (en) | 2013-10-30 | 2014-10-30 | Nicotinamide riboside compositions for topical use in treating skin conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016005574A MX2016005574A (es) | 2016-12-09 |
| MX385305B true MX385305B (es) | 2025-03-18 |
Family
ID=53005146
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016005574A MX385305B (es) | 2013-10-30 | 2014-10-30 | Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel. |
| MX2021009652A MX394291B (es) | 2013-10-30 | 2014-10-30 | Composiciones de ribosido de nicotinamida para uso topico en el tratamiento de afecciones de la piel. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021009652A MX394291B (es) | 2013-10-30 | 2014-10-30 | Composiciones de ribosido de nicotinamida para uso topico en el tratamiento de afecciones de la piel. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10688118B2 (enExample) |
| EP (1) | EP3063163B1 (enExample) |
| JP (1) | JP6509844B2 (enExample) |
| KR (3) | KR20210107895A (enExample) |
| CN (2) | CN109985056A (enExample) |
| AU (1) | AU2014342185B2 (enExample) |
| CA (1) | CA2928656C (enExample) |
| ES (1) | ES2925879T3 (enExample) |
| MX (2) | MX385305B (enExample) |
| NZ (1) | NZ719328A (enExample) |
| WO (1) | WO2015066382A1 (enExample) |
| ZA (1) | ZA201603314B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015186068A1 (en) * | 2014-06-02 | 2015-12-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Preparation and use of crystalline beta-d-nicotinamide riboside |
| RU2016149767A (ru) | 2014-06-06 | 2018-07-16 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Аналоги никотинамидрибозида и фармацевтические композиции и их применение |
| CN106715454B (zh) | 2014-07-24 | 2020-06-16 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| CA2978069C (en) | 2015-03-09 | 2021-10-12 | W.R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| BR112017019696A2 (pt) * | 2015-03-16 | 2018-09-04 | ChromaDex Inc. | composto e usos de um composto |
| EP3288531B1 (en) * | 2015-05-01 | 2019-07-24 | The Procter and Gamble Company | Method of improving skin health and compositions therefor |
| JP2018515485A (ja) | 2015-05-01 | 2018-06-14 | ザ プロクター アンド ギャンブル カンパニー | 皮膚の外観を改善する方法及びニコチンアミドリボシドを使用したそのための組成物 |
| US20160317418A1 (en) | 2015-05-01 | 2016-11-03 | The Procter & Gamble Company | Method of improving the appearance of skin and compositions therefor |
| US11426398B2 (en) * | 2015-06-10 | 2022-08-30 | Elysium Health, Inc. | Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders |
| US20180177703A1 (en) * | 2015-06-25 | 2018-06-28 | N.V. Perricone Llc | Niacinamide Mononucleotide Formulations For Skin Aging |
| US11013678B2 (en) | 2015-06-29 | 2021-05-25 | The Procter & Gamble Company | Multi-component skin care product |
| US20160374908A1 (en) | 2015-06-29 | 2016-12-29 | The Procter & Gamble Company | Skin care composition and methods of using the same |
| US20160374918A1 (en) * | 2015-06-29 | 2016-12-29 | The Procter & Gamble Company | Encapsulated skin care agent |
| CN112315837B (zh) | 2016-01-11 | 2021-12-03 | 宝洁公司 | 处理皮肤状况的方法以及用于其的组合物 |
| US10000520B2 (en) | 2016-03-16 | 2018-06-19 | ChromaDex Inc. | B-vitamin and amino acid conjugates ofnicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| MX393076B (es) * | 2016-04-20 | 2025-03-24 | Chromadex Inc | Uso de derivados de ribósido de ácido nicotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores que incrementan nad+ |
| RU2019108100A (ru) | 2016-08-22 | 2020-09-22 | Элизиум Хелт, Инк. | Композиции никотинамид рибозида и птеростильбена и методы лечения нейродегенеративных заболеваний |
| EP3538099A4 (en) | 2016-11-11 | 2020-06-17 | The Queen's University of Belfast | EFFICIENT AND SCALABLE SYNTHESIS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS OF THEM, ADENYLYDINUCLEOTIDE CONJUGATES THEREOF AND NEW-WAY CRYSTALS |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| EP3554285A4 (en) | 2016-11-29 | 2021-01-20 | University of Iowa Research Foundation | USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring |
| PH12019501354B1 (en) | 2016-12-21 | 2023-04-19 | Unilever Ip Holdings B V | Personal care compositions with cystine |
| CA3047495A1 (en) | 2016-12-21 | 2018-06-28 | Unilever Plc | Topical skin lightening additive and composition with amino acids and nicotinamide compounds |
| EP3558243B1 (en) | 2016-12-21 | 2022-10-05 | Unilever IP Holdings B.V. | Personal care compositions comprising poorly soluble compounds |
| WO2018113634A1 (en) | 2016-12-21 | 2018-06-28 | Unilever Plc | Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids |
| RU2651047C1 (ru) * | 2017-05-04 | 2018-04-18 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Лекарственная композиция цитопротекторного действия и способ ее получения |
| EP3624808A4 (en) * | 2017-05-18 | 2021-03-03 | Elysium Health, Inc. | PROCEDURES AND COMPOSITIONS FOR IMPROVED SLEEP |
| EP3642214A2 (en) | 2017-06-19 | 2020-04-29 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| EP3641725A1 (en) | 2017-06-23 | 2020-04-29 | The Procter and Gamble Company | Composition and method for improving the appearance of skin |
| CA3108015A1 (en) * | 2017-07-28 | 2019-01-31 | Centers For Age Control, Inc. | Compositions and methods for preventing and reversing aspects of aging |
| KR102852384B1 (ko) * | 2017-09-14 | 2025-09-01 | 메구미 타나카 | 노화 방지제 및 노화 방지 방법 |
| GB201716391D0 (en) * | 2017-10-06 | 2017-11-22 | Xobaderm Ltd | Kit for delivery of an active compound into a biological barrier |
| US11414407B2 (en) | 2017-12-22 | 2022-08-16 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
| JP2021530447A (ja) | 2018-07-03 | 2021-11-11 | ザ プロクター アンド ギャンブル カンパニーThe Procter & Gamble Company | 皮膚状態の治療方法 |
| JP6887025B2 (ja) * | 2018-08-17 | 2021-06-16 | 邦泰生物工程（深▲セン▼）有限公司 | 安定型ニコチンアミドリボシド組成物及びその調製方法 |
| KR102060374B1 (ko) * | 2018-12-14 | 2019-12-30 | 주식회사 휴메딕스 | 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| US11833167B2 (en) | 2018-12-17 | 2023-12-05 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| CN119684381A (zh) * | 2019-07-19 | 2025-03-25 | 生物合成股份公司 | 烟酰胺呋喃核糖苷盐的结晶形式以及包含其的营养补充剂和药物组合物 |
| CN110638827A (zh) * | 2019-10-17 | 2020-01-03 | 泓博元生命科技（深圳）有限公司 | Nadh及其盐在制备皮肤色素抑制剂中的应用 |
| KR102315139B1 (ko) | 2019-12-17 | 2021-10-20 | 주식회사 휴메딕스 | 지방아민 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| CN111166760A (zh) * | 2019-12-17 | 2020-05-19 | 浙江安赛新材料科技有限公司 | β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用 |
| CN111184732B (zh) * | 2020-03-04 | 2023-09-08 | 武汉华纳联合药业有限公司 | 一种复合组合物制剂及其制备方法和皮肤炎症中的应用 |
| CN111454311B (zh) * | 2020-04-03 | 2021-10-19 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其组合物与制备方法 |
| FR3110410A1 (fr) * | 2020-05-20 | 2021-11-26 | Nuvamid Sa | Compositions cosmétiques anti-âge comprenant de la NMN |
| EP4153323A1 (fr) * | 2020-05-20 | 2023-03-29 | Nuvamid SA | Compositions cosmetiques anti-age comprenant du nmn |
| WO2021247496A1 (en) | 2020-06-01 | 2021-12-09 | The Procter & Gamble Company | Method of improving penetration of a vitamin b3 compound into skin |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN111632049A (zh) * | 2020-06-09 | 2020-09-08 | 西北农林科技大学 | 一种通过综合矫正细胞活性氧簇代谢紊乱以缓解睾丸衰老损伤的复合配方 |
| WO2022047182A1 (en) * | 2020-08-28 | 2022-03-03 | University Of Washington | High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation |
| EP4029496A1 (en) * | 2021-01-18 | 2022-07-20 | Universitat de València | Pterostilbene and silibinin for preventing, ameliorating or reducing radiation-induced diseases |
| EP4281465A1 (en) * | 2021-01-19 | 2023-11-29 | Biosynth AG | Method of making nicotinamide ribofuranoside salts by salt metathesis, the crystalline form of its tosylate salt and the co-crystallized form of its chloride:iodide salt |
| US12150461B2 (en) * | 2021-05-04 | 2024-11-26 | Sovida Solutions Ltd. | Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof |
| CN114129509B (zh) * | 2021-12-03 | 2023-12-01 | 药酚享科技(北京)有限公司 | 一种保湿性nmn亲水凝胶剂及其制备方法 |
| CN116621898A (zh) * | 2022-04-13 | 2023-08-22 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途 |
| KR102784901B1 (ko) * | 2022-06-23 | 2025-03-21 | 제너럴바이오(주) | Nr, nmn 및 nad를 함유한 피부 주름 개선용 화장료 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03007314A (es) * | 2001-02-22 | 2003-12-04 | Unilever Nv | Composicion para la piel para reducir aceites y grasa de la piel. |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| WO2005077091A2 (en) | 2004-02-10 | 2005-08-25 | Trustees Of Dartmouth College | Nicotinamide riboside kinase compositions and methods for using the same |
| PT1755391E (pt) | 2004-06-04 | 2016-02-03 | Univ Washington | Métodos e composições para o tratamento de neuropatias |
| WO2006105440A2 (en) | 2005-03-30 | 2006-10-05 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| CN103055313A (zh) * | 2005-07-07 | 2013-04-24 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
| CN101257897A (zh) * | 2005-07-07 | 2008-09-03 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
| ES2670927T3 (es) * | 2005-11-18 | 2018-06-04 | Cornell Research Foundation, Inc. | Composiciones de nicotinoil ribósido y métodos de uso |
| CN101631593B (zh) * | 2007-03-12 | 2014-08-13 | 帝斯曼知识产权资产管理有限公司 | 化妆品组合物 |
| US20090069444A1 (en) | 2007-09-07 | 2009-03-12 | The United States Of America, As Represented By Th E Secretary Of Agriculture | Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration |
| US20130004463A1 (en) * | 2010-01-06 | 2013-01-03 | Kabushiki Kaisha Yakult Honsha | Dna damage repair promoter for oral application, and elastase activity inhibitor for oral application |
-
2014
- 2014-10-30 KR KR1020217026414A patent/KR20210107895A/ko not_active Ceased
- 2014-10-30 ES ES14857903T patent/ES2925879T3/es active Active
- 2014-10-30 US US15/033,285 patent/US10688118B2/en active Active
- 2014-10-30 KR KR1020167014302A patent/KR20160067195A/ko not_active Ceased
- 2014-10-30 JP JP2016526337A patent/JP6509844B2/ja active Active
- 2014-10-30 NZ NZ719328A patent/NZ719328A/en unknown
- 2014-10-30 KR KR1020227022241A patent/KR20220098049A/ko not_active Ceased
- 2014-10-30 WO PCT/US2014/063260 patent/WO2015066382A1/en not_active Ceased
- 2014-10-30 MX MX2016005574A patent/MX385305B/es unknown
- 2014-10-30 CA CA2928656A patent/CA2928656C/en active Active
- 2014-10-30 CN CN201910027571.7A patent/CN109985056A/zh active Pending
- 2014-10-30 EP EP14857903.0A patent/EP3063163B1/en active Active
- 2014-10-30 MX MX2021009652A patent/MX394291B/es unknown
- 2014-10-30 CN CN201480071722.4A patent/CN105873937A/zh active Pending
- 2014-10-30 AU AU2014342185A patent/AU2014342185B2/en active Active
-
2016
- 2016-05-16 ZA ZA2016/03314A patent/ZA201603314B/en unknown
-
2020
- 2020-06-03 US US16/891,824 patent/US11033568B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201603314B (en) | 2017-09-27 |
| JP2016538271A (ja) | 2016-12-08 |
| CA2928656C (en) | 2020-07-28 |
| US20160250241A1 (en) | 2016-09-01 |
| ES2925879T3 (es) | 2022-10-20 |
| CN109985056A (zh) | 2019-07-09 |
| US20200289536A1 (en) | 2020-09-17 |
| MX2021009652A (es) | 2022-07-26 |
| EP3063163B1 (en) | 2022-08-10 |
| JP6509844B2 (ja) | 2019-05-08 |
| MX394291B (es) | 2025-03-24 |
| US10688118B2 (en) | 2020-06-23 |
| US11033568B2 (en) | 2021-06-15 |
| KR20220098049A (ko) | 2022-07-08 |
| AU2014342185B2 (en) | 2019-01-03 |
| CN105873937A (zh) | 2016-08-17 |
| CA2928656A1 (en) | 2015-05-07 |
| KR20210107895A (ko) | 2021-09-01 |
| WO2015066382A1 (en) | 2015-05-07 |
| EP3063163A1 (en) | 2016-09-07 |
| EP3063163A4 (en) | 2017-05-10 |
| MX2016005574A (es) | 2016-12-09 |
| KR20160067195A (ko) | 2016-06-13 |
| NZ719328A (en) | 2022-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX385305B (es) | Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel. | |
| BR112017019696A2 (pt) | composto e usos de um composto | |
| BR112014006455A2 (pt) | alquilamidotiazóis, preparações cosméticas ou dermatológicas com um teor de um ou vários alquilamidotiazóis e uso de um ou vários alquilamidotiazóis | |
| EA201890435A1 (ru) | Производные никотинамидмононуклеотида и их применение | |
| MX394252B (es) | Tratamiento del cancer usando combinaciones de inhibidores de erk y raf | |
| CL2016000544A1 (es) | Composición cosmética que comprende 0,0001 a 10% en peso de extracto de guacatonga (casearia sylvestris) y 0,00005 a 10% en peso de extracto de aroeira (schinus terebinthifolius raddi) ambos respecto al peso total de la composición; uso de la composición en la prevención y/o tratamiento de los signos de envejicimiento de la piel; metodo para prevenir y/o tratar los signos de envejecimiento de la piel. | |
| ES2572211T3 (es) | Regeneración de músculo esquelético utilizando células madre mesenquimales | |
| BR112016000335A8 (pt) | método de tratamento da rosácea papulopustular, de tratamento de lesões inflamatórias da rosácea papulopustular e uso de uma composição farmacêutica | |
| BR112015006790A2 (pt) | composição de cetoprofeno tópico | |
| BRPI0919020B8 (pt) | uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris | |
| RU2014150505A (ru) | Способ идентификации лигандов рецептора ahr, которые обладают терапевтической себосупрессивной активностью, и указанные лиганды | |
| BR112014003071A2 (pt) | tratamento de doença vascular periférica com o uso de células derivadas do tecido do cordão umbilical | |
| WO2012116990A3 (en) | Novel use | |
| AR083651A1 (es) | Composiciones de brimonidina en gel y metodos de uso | |
| CO6660486A2 (es) | Composición tópica famacéutica o cosmética útil para el tratamiento de enfermedades o condiciones que cursan con un déficit de la maduración de la envoltura córnea | |
| MX385999B (es) | Composiciones y métodos para tratamiento de la piel. | |
| MX349854B (es) | Composiciones antitranspirantes y metodo para reducir la transpiracion. | |
| BR112012023747A2 (pt) | compostos de adenosina e seu uso | |
| BR112015002041A2 (pt) | formulação transdérmica contendo inibidores de cox | |
| UY34009A (es) | ?uso de receptor de a2b adenosina para tratar la insuficiencia cardíaca y la arritmia en pacientes posinfarto de miocardio?. | |
| AR097216A1 (es) | Composición para el tratamiento contra el envejecimiento de la piel | |
| CR20130488A (es) | Derivados de tieno [2,3-d]pirimidina y su uso para tratar arritmia | |
| ES2554110T3 (es) | Utilización de polisacáridos sulfatados como agente anticaspa | |
| CO6602160A2 (es) | Terapia de b12 oral | |
| AR094035A1 (es) | Estimulantes del colageno y su uso en el tratamiento de la piel |