CN105829349B - 肽嵌合抗原受体t细胞开关和其用途 - Google Patents
肽嵌合抗原受体t细胞开关和其用途 Download PDFInfo
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- CN105829349B CN105829349B CN201480066872.6A CN201480066872A CN105829349B CN 105829349 B CN105829349 B CN 105829349B CN 201480066872 A CN201480066872 A CN 201480066872A CN 105829349 B CN105829349 B CN 105829349B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
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Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891347P | 2013-10-15 | 2013-10-15 | |
| US61/891,347 | 2013-10-15 | ||
| US201361895704P | 2013-10-25 | 2013-10-25 | |
| US61/895,704 | 2013-10-25 | ||
| US201462009054P | 2014-06-06 | 2014-06-06 | |
| US62/009,054 | 2014-06-06 | ||
| US201462030526P | 2014-07-29 | 2014-07-29 | |
| US201462030514P | 2014-07-29 | 2014-07-29 | |
| US62/030,514 | 2014-07-29 | ||
| US62/030,526 | 2014-07-29 | ||
| PCT/US2014/060684 WO2015057834A1 (en) | 2013-10-15 | 2014-10-15 | Peptidic chimeric antigen receptor t cell switches and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105829349A CN105829349A (zh) | 2016-08-03 |
| CN105829349B true CN105829349B (zh) | 2023-02-03 |
Family
ID=52828649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480066872.6A Active CN105829349B (zh) | 2013-10-15 | 2014-10-15 | 肽嵌合抗原受体t细胞开关和其用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9624276B2 (https=) |
| EP (1) | EP3057994B1 (https=) |
| JP (2) | JP6734774B2 (https=) |
| KR (1) | KR102339240B1 (https=) |
| CN (1) | CN105829349B (https=) |
| AU (2) | AU2014337367B2 (https=) |
| CA (1) | CA2927543C (https=) |
| ES (1) | ES2845924T3 (https=) |
| WO (1) | WO2015057834A1 (https=) |
Families Citing this family (185)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| JP6375289B2 (ja) | 2012-04-05 | 2018-08-15 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫刺激組成物およびその使用方法 |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CN115028735A (zh) | 2013-05-03 | 2022-09-09 | 俄亥俄州创新基金会 | Cs1-特异性嵌合抗原受体工程化的免疫效应细胞 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| EP3057991B8 (en) * | 2013-10-15 | 2019-09-04 | The Scripps Research Institute | Chimeric antigen receptor t cell switches and uses thereof |
| KR102339240B1 (ko) | 2013-10-15 | 2021-12-15 | 더 스크립스 리서치 인스티튜트 | 펩타이드 키메라 항원 수용체 t 세포 스위치 및 이의 용도 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
| CN107530424A (zh) | 2015-02-20 | 2018-01-02 | 俄亥俄州国家创新基金会 | 针对nkg2d和肿瘤相关抗原的二价抗体 |
| WO2016149254A1 (en) | 2015-03-17 | 2016-09-22 | Chimera Bioengineering, Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
| WO2016154621A1 (en) * | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| AU2016246457B2 (en) | 2015-04-06 | 2020-10-15 | Cytoimmune Therapeutics, Inc. | EGFR-directed car therapy for glioblastoma |
| WO2016168773A2 (en) * | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| WO2017027422A1 (en) | 2015-08-07 | 2017-02-16 | Alexo Therapeutics Inc. | Constructs having a sirp-alpha domain or variant thereof |
| CA2999037A1 (en) | 2015-09-23 | 2017-03-30 | Cytoimmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
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| AU2020207804A1 (en) | 2020-08-06 |
| US20230355728A1 (en) | 2023-11-09 |
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| EP3057994B1 (en) | 2020-09-23 |
| CA2927543A1 (en) | 2015-04-23 |
| KR102339240B1 (ko) | 2021-12-15 |
| US20170246270A1 (en) | 2017-08-31 |
| AU2014337367B2 (en) | 2020-04-30 |
| US20200197497A1 (en) | 2020-06-25 |
| JP6734774B2 (ja) | 2020-08-05 |
| EP3057994A1 (en) | 2016-08-24 |
| US20150307564A1 (en) | 2015-10-29 |
| CN105829349A (zh) | 2016-08-03 |
| CA2927543C (en) | 2021-07-20 |
| WO2015057834A1 (en) | 2015-04-23 |
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