CN105814072A - 一种五环三萜结构修饰化合物及其制备方法和应用 - Google Patents

一种五环三萜结构修饰化合物及其制备方法和应用 Download PDF

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CN105814072A
CN105814072A CN201480065401.3A CN201480065401A CN105814072A CN 105814072 A CN105814072 A CN 105814072A CN 201480065401 A CN201480065401 A CN 201480065401A CN 105814072 A CN105814072 A CN 105814072A
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formula
pharmaceutically acceptable
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CN105814072B (zh
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王宏林
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Suzhou Botany Biomedical Co ltd
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Suzhou Botany Biomedical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种五环三萜结构修饰化合物及其制备方法和应用，本发明的化合物能够有效地治疗银屑病。并且，本发明的化合物能选择性抑制TH1和TH17细胞的体外分化，从而可应用于治疗TH1和TH17介导的自身免疫性疾病。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201480065401.3A 2013-11-30 2014-11-18 一种五环三萜结构修饰化合物及其制备方法和应用 Active CN105814072B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2013106233142 2013-11-30
CN201310623314.2A CN104672293B (zh) 2013-11-30 2013-11-30 一种五环三萜结构修饰化合物及其制备方法和应用
PCT/CN2014/091371 WO2015078321A1 (zh) 2013-11-30 2014-11-18 一种五环三萜结构修饰化合物及其制备方法和应用

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CN105814072A true CN105814072A (zh) 2016-07-27
CN105814072B CN105814072B (zh) 2018-08-24

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CN201480065401.3A Active CN105814072B (zh) 2013-11-30 2014-11-18 一种五环三萜结构修饰化合物及其制备方法和应用

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US (1) US9725482B2 (zh)
EP (1) EP3075739B1 (zh)
JP (1) JP6289659B2 (zh)
CN (2) CN104672293B (zh)
DK (1) DK3075739T3 (zh)
WO (1) WO2015078321A1 (zh)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
CN104672293B (zh) * 2013-11-30 2017-01-18 苏州博创园生物医药科技有限公司 一种五环三萜结构修饰化合物及其制备方法和应用
CN106674323B (zh) * 2015-11-05 2019-10-22 苏州博创园生物医药科技有限公司 具有acc1蛋白调控作用的五环三萜类化合物及其用途
CN108358990B (zh) * 2017-01-26 2021-04-20 苏州博创园生物医药科技有限公司 一种具有抗菌活性的五环三萜类化合物
CN110818767B (zh) * 2018-08-13 2022-06-07 江苏博创园生物医药科技有限公司 3-O-环己甲酰基-11-羰基-β-乳香酸或其类似物的制备及纯化方法
WO2022228352A1 (zh) * 2021-04-25 2022-11-03 江苏博创园生物医药科技有限公司 一种五环三萜类化合物结晶及其制备方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN101724004A (zh) * 2008-10-22 2010-06-09 王宏林 一种抗牛皮癣纯天然新药(11-羰基-β-乙酰乳香酸)

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WO2002085921A2 (de) * 2001-03-01 2002-10-31 Johann Jauch Einfaches verfahren zur synthese von boswelliasäuren und derivaten davon
KR100496776B1 (ko) 2001-06-21 2005-06-22 삼성토탈 주식회사 에틸렌 중합 및 공중합용 촉매
US20030199581A1 (en) 2002-03-13 2003-10-23 Seligson Allen L. Boswellin compositions enhanced with 3-beta-acetyl-11-keto-beta-boswellic acid ("AKBA") industrial manufacture and uses
US8748598B2 (en) * 2004-06-18 2014-06-10 Laila Nutraceuticals Analogs of 3-O-acetyl-11-keto-beta-boswellic acid
GB0604899D0 (en) * 2006-03-10 2006-04-19 York Pharma Plc Derivatives of 18-glycyrrhetinic acid
CN101775058B (zh) * 2009-01-08 2012-07-18 凌沛学 一种从乳香中提取的11-羰基-β-乙酰乳香酸及其衍生物的药物制剂的制备和应用
CN104672293B (zh) * 2013-11-30 2017-01-18 苏州博创园生物医药科技有限公司 一种五环三萜结构修饰化合物及其制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101724004A (zh) * 2008-10-22 2010-06-09 王宏林 一种抗牛皮癣纯天然新药(11-羰基-β-乙酰乳香酸)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AJAY KUMAR ET AL.: "Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Also Published As

Publication number Publication date
US9725482B2 (en) 2017-08-08
JP6289659B2 (ja) 2018-03-07
JP2016538346A (ja) 2016-12-08
US20170002039A1 (en) 2017-01-05
EP3075739B1 (en) 2018-10-17
CN105814072B (zh) 2018-08-24
EP3075739A4 (en) 2017-08-02
CN104672293B (zh) 2017-01-18
WO2015078321A1 (zh) 2015-06-04
CN104672293A (zh) 2015-06-03
DK3075739T3 (en) 2018-12-03
EP3075739A1 (en) 2016-10-05

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