CN105725190A - Functional nutrient food for improving joints - Google Patents
Functional nutrient food for improving joints Download PDFInfo
- Publication number
- CN105725190A CN105725190A CN201610086052.4A CN201610086052A CN105725190A CN 105725190 A CN105725190 A CN 105725190A CN 201610086052 A CN201610086052 A CN 201610086052A CN 105725190 A CN105725190 A CN 105725190A
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- CN
- China
- Prior art keywords
- joint
- powder
- vitis viniferae
- functional nutrient
- weight
- Prior art date
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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Abstract
The invention provides a functional nutrient food for improving joints.The functional nutrient food is prepared from, by weight, 10-80 parts of soybean flour, 10-80 parts of black soybean flour, 5-30 parts of chitosan oligosaccharide, 1-20 parts of collagen powder, 1-20 parts of II-type collagen, 0.1-16 parts of grape seed extract and 5-12 parts of vitamins C; according to the requirement of the dosage form, the functional nutrient food can further comprise, by weight, 10-80 parts of maltodextrin.According to the functional nutrient food, the synergistic effects of multiple nutrient substances are synthetically used; the effects of active ingredients are improved with the specific preparing method; the functional nutrient food has the remarkable treating effect and the remarkable curative effect on various bone-and-joint diseases and younger bone-and-joint diseases such as joints and tendon injuries caused by long-time sport injuries, and has the obvious improvement effect on relative lumbar-spinal-cord and joint-pain-and-swelling diseases and the like caused by female premenstrual syndromes.
Description
Technical field
The present invention relates to a kind of nutraceutical, be specifically related to the functional nutrient food of a kind of joint-improving.
Background technology
Diverse bone types joint disease, including degenerative osteoarthritis, bursitis, synovitis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, bone
Matter hypertrophy, rheumatic arthritis, rheumatoid arthritis, femur head necrosis etc., ill basic reason is not that skeleton occurs
Pathological changes, modern medicine study finds, old complaint is that the forfeiture to joint protective capability such as cartilage " joint protection system ".
The generation of diverse bone types joint disease often starts from that the lesions of synovium contributed, cartilage be impaired or degeneration；Take some antiinflammatory class, amcinonide
The cartilage injury that thing is caused also is one of main reason of many joint disease.Due to synovium of joint, the damage of cartilage and
The disappearance of knuckle synovia, causes joint skeleton to lack the protection of necessity, to such an extent as to human body one is movable, and the skeleton of joint is for want of
Directly there is violent rigid friction in necessary " cartilage protection ", and causes patient articular's pain, swelling, deformation, bony spur hypertrophy
Etc. multiple symptom.Even more important, if human synovial organ immune disorder, joint inevitable for want of necessary " immunoprotection "
And cause the intrusion of extraneous inflammatory factor, ultimately result in the generation of diverse bone types joint disease.
Osteoporosis, is one group of osteopathia causing of many reasons, and osseous tissue has a normal calcification, calcium salt and substrate in normally than
Example, the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosises, the minimizing of osseous tissue
Increase caused mainly due to bone absorption.With skeleton pain, it is prone to fracture and is characterized.
II type is mainly produced by chondrocyte, is present in the tissues such as skeleton, joint, tendon more.Vitamin C can promote collagen egg
White synthesis, prevents it from aoxidizing, containing having protection skin moisture, the effect of whitening wrinkle removing.Antioxidant composition Semen Vitis viniferae extract,
Vitamin E protection collagen protein and elastic fiber are not degraded, and help to rebuild skin histology.These superpower antioxidants are made jointly
With, resist the injury of free radical and other nuisances, the most effectively protect collagen structure.
In Semen Vitis viniferae extract, main component procyanidin has stronger antioxidation, using the teaching of the invention it is possible to provide body immunity.Crease-resistant
Effect: the crease-resistant effect of procyanidin can safeguard the synthesis of collagen based on it；Suppression elastoser；Assist body protective collagen
Albumen and the elasticity improving skin；Improve the healthy cycle of skin.Thus avoid or reduce the generation of wrinkle.Scientific practice confirms,
Procyanidin, together with collagen binder, can make skin rejuvenation, health, cell dynamic, can recover its extensibility and
Elasticity, helps body to damage from solar radiation, improve the elasticity of the junctions such as joint, improve blood circulation etc..And for containing fibre
The protein of dimension structure has good protective effect.Heart protective agent: procyanidin not only helps to recover skin elasticity, and
Joint, tremulous pulse and other tissue (such as heart) is helped to maintain normal function.Allergy inflammation: procyanidin also suppresses histamine to produce
Raw, thus can reduce inflammation, help tremulous pulse to resist the impact of those mutagens causing cardiovascular diseases, such as, allergy, gas
Breathe heavily, bronchitis, Hay Fever, rheumatoid arteritis, sports injuries, pressure ulcers etc..Athlete appreciates anthocyanidin very much, because of
For procyanidin make joint flexibly, the collagen protein can repaired in connective tissue, and alleviate edema.Also have been reported that, former flower
Blue or green element improves the arthritis of many people.
Semen sojae atricolor, has another name called crow bean, includes rich in protein, several mineral materials and trace element.The traditional Chinese medical science is thought, its sweet in the mouth, property
Flat, nontoxic.There are heat clearing away of inducing sweat, the suppressing the hyperactive liver that nourishes blood, Bu Shen Zhuang the moon, effect of qi-restoratives hair color.Li Shizhen (1518-1593 A.D.) is said: " Semen sojae atricolor enters kidney merit
Many, thus can harness the river, relieving distension, the therapeutic method to keep the adverse QI flowing downwards, control wind heat and promoting blood circulation and detoxication." protein content of Semen sojae atricolor is up to 36 percent
To 40, be equivalent to two times of meat content, three times of egg, the twelvefold of milk.18 kinds of amino acid contents of Semen sojae atricolor are rich
The necessary eight kinds of amino acid contents of richness, particularly human body, the high-grade protein standard that relatively U.S. FDA specifies is the highest.Semen sojae atricolor contains
1 19 oils and fats, wherein unsaturated fatty acid 80 percent, absorbance height grows by more than 95, except meeting human body
Outside demand to fat, also has the effect reducing Blood Cholesterol.Cholesterol is the arch-criminal of many Senile disease, and
Semen sojae atricolor does not contains cholesterol, containing only a kind of phytosterol, has suppression absorption of human body cholesterol, reduces blood cholesterol level
Effect.For old people, can vessel softening, skin care slow down aging, particularly to hypertension, heart disease, liver,
The Senile disease such as arteriosclerosis benefit.
Summary of the invention
The present invention seeks to the auxotrophy existed for prior art, comprehensively utilize multiple nutrients material compatibility, it is provided that Yi Zhongzhen
Diverse bone types joint disease and osteoporosis are effectively prevented the functional nutrient food with maintenance.
To achieve these goals, the present invention is by the following technical solutions:
The functional nutrient food of a kind of joint-improving, is prepared from by the raw material of following parts by weight: Semen sojae atricolor powder 10-80, black
Semen Glycines powder 10-80, oligochitosan 5-30, collagen protein powder 1-20, typeⅡ Collagen 1-20, Semen Vitis viniferae extract 0.1-16,
Vitamin C 5-12.
Described functional nutrient food is according to dosage form needs, it is also possible to include the adjuvant of following parts by weight: maltodextrin 10-80.
Preferably, the functional nutrient food of described joint-improving, the raw material of following parts by weight it is prepared from: Semen sojae atricolor powder
15-40, black bean powder 25-60, oligochitosan 10-20, collagen protein powder 5-10, typeⅡ Collagen 5-15, Semen Vitis viniferae extract
5-12, vitamin C 6-10；According to dosage form needs, it is also possible to include the adjuvant of following parts by weight: maltodextrin 15-50.
Preferably, the preparation method of described Semen Vitis viniferae extract is as follows: is pulverized by Semen Vitis viniferae and is placed on equipped with 0.3-0.5% bicarbonate
In sodium solution, regulation pH value is 7-8, is warming up to 40-50 DEG C, adds the mixed enzyme of Semen Vitis viniferae quality 2-8%, stirs,
Enzymolysis 40-70min, carries out high voltage pulse electric field processing during enzymolysis, electric field intensity 20-40kV/cm, burst length 400-500 μ s,
Pulse frequency 200-300Hz；The enzymolysis solution of above-mentioned process filters through 100-300 eye mesh screen, and filtrate is freeze-dried i.e. obtains Fructus Vitis viniferae
Seed extract；The quality group of described mixed enzyme becomes: amylase: pectase: cellulase=1:5-8:5-10.
The Proanthocyanidin from Grape-seed Extracts prepared by said method is more than 97%.
Preferably, the preparation method of described oligochitosan is as follows: cellulase: papain=3:1 is dissolved in pH5.2-5.6 acetic acid
Solution, temperature control 50-55 DEG C, mixed enzyme solution hydrolyzing chitosan 3-6h, hydrolyzed solution processes through enzyme denaturing, and vacuum lyophilization obtains
Oligochitosan.
Described typeⅡ Collagen extracts from Chick sternal cartilage and obtains.Currently preferred extracting method is as follows: the fresh pigeon chest of raw material
Cartilage slices, material-water ratio 1:3-8, it is 1.8-2.5 by acetic acid regulation material liquid pH, adds the pepsin of raw material weight 0.5%,
Room temperature 25 DEG C processes 2-8h, enzyme denaturing, filters, washing with alcohol, obtains the cartilage after remove impurity, low-temperature grinding under liquid nitrogen, adds solid
Shape thing weight 3-5 times water, adds 0.3% papain, regulates pH 6.3-6.8,55-60 DEG C, enzymolysis 1-3h；Enzymolysis solution
Separating through ion-exchange chromatography, lyophilization obtains high-purity II type collagen protein.
Described collagen protein powder, vitamin C etc. are commercial goods raw material.It is big that described Semen sojae atricolor powder or black bean powder are commercial goods
Bean or the size-reduced screening of Semen sojae atricolor obtain.
Functional nutrient food of the present invention is oral formulations, and described oral formulations can be tablet, granule, pill, dissipate
Agent, powder or capsule, preferred tablet or capsule, it is easy to preserve, the content of viable bacteria in instant edible, the most more conducively preparation
Stable with character.Described tablet can be sheet for oral administration, buccal tablet or chewable tablet etc..Described capsule can be hard capsule or flexible glue
Capsule.
Beneficial effect:
Product of the present invention comprehensive utilization multiple nutrients material synergism, improves active component effect, pin by specific preparation method
It is equal that osteoarthrosis various to old people and long-term motion damage " rejuvenation " osteoarthrosis such as the joint, the tendon injury that cause
There are notable treatment and curative effect.And the related symptoms such as the back causing women premenstrual syndrome, joint aches swelling also have
It is significantly improved.
Semen Vitis viniferae extract and vitamin C synergism.Procyanidin protection in Semen Vitis viniferae extract and stable vitamin c,
Contributing to absorption and the utilization of vitamin c, procyanidin also can strengthen ascorbic effect, extends vitamin C in human body
There is the time of effect.Semen Vitis viniferae extract and ascorbic combination accelerate decomposition and the eliminating of harmful cholesterol.Dimension is raw
Element C is again the nutriment that biochemical synthesis collagen protein is necessary, and procyanidin makes more vitamin C come into force, it means that dimension is raw
Element C can more easily go its all function (including that collagen protein produces).Semen Vitis viniferae extract assists, safeguards collagen
Albumen synergism, procyanidin, together with collagen binder, improves the elasticity of the junctions such as joint, improves blood circulation etc..
Product of the present invention can effectively reduce internal low density lipoprotein, LDL and content of triglyceride, reduces cholesterol levels.Britain transports
The summary that dynamic medical journal is delivered, has looked back 17 researchs, abnormal including 2612 tendon pain or muscle-tendon structure
Patient, finds that hypercholesterolemia increases tendon complication and pain.Minimum with pain degree compares, low density lipoprotein, LDL and glycerol
Three esters are the highest, and pain is the most serious.Tendon is injured, inflammation and other complication increase also with the increase of cholesterol levels.This
A little Notes of Key Datas, the cholesterol levels height in blood causes cholesterol in cell to be formed, suppresses tendon function, be similar to high gallbladder solid
The impact on arterial function of the alcohol level.
Detailed description of the invention
Below in conjunction with specific embodiment further describe the present invention, advantages of the present invention and feature will be with describe and apparent.
But these examples are only exemplary, the scope of the present invention is not constituted any restriction.Those skilled in the art should understand that
It is the details of technical solution of the present invention and form can be modified or replace lower without departing from the spirit and scope of the present invention,
But these amendments and replacement each fall within protection scope of the present invention.Method, composition and the consumption related in following embodiment, as
Without specified otherwise, conventional method the most known to those skilled in the art.
Embodiment 1
The functional nutrient food of a kind of joint-improving, is prepared from by the raw material of following parts by weight: Semen sojae atricolor powder 10, black bean powder
80, oligochitosan 5, collagen protein powder 1, typeⅡ Collagen 20, Semen Vitis viniferae extract 1, vitamin C 12；Also include with
The adjuvant of lower parts by weight: maltodextrin 80.
The preparation method of described Semen Vitis viniferae extract is as follows: is pulverized by Semen Vitis viniferae and is placed on equipped with in 0.3% sodium bicarbonate solution, adjusts
Joint pH value is 7, is warming up to 50 DEG C, adds the mixed enzyme of Semen Vitis viniferae quality 2%, stirs, enzymolysis 40min, during enzymolysis
Carry out high voltage pulse electric field processing, electric field intensity 20kV/cm, burst length 500 μ s, pulse frequency 300Hz；The enzyme of above-mentioned process
Solving liquid to filter through 120 eye mesh screens, filtrate is freeze-dried i.e. obtains Semen Vitis viniferae extract；The quality group of described mixed enzyme becomes: form sediment
Powder enzyme: pectase: cellulase=1:5:5.
The preparation method of described oligochitosan is as follows: cellulase: papain=3:1 is dissolved in pH 5.2 acetic acid solution, temperature control
50 DEG C, mixed enzyme solution hydrolyzing chitosan 6h, hydrolyzed solution processes through enzyme denaturing, and vacuum lyophilization obtains oligochitosan.
Described typeⅡ Collagen extracts from Chick sternal cartilage and obtains.Currently preferred extracting method is as follows: the fresh pigeon chest of raw material
Cartilage slices, material-water ratio 1:3, it is 1.8 by acetic acid regulation material liquid pH, adds the pepsin of raw material weight 0.5%, room temperature
25 DEG C process 2h, enzyme denaturing, filter, washing with alcohol, obtain the cartilage after remove impurity, and low-temperature grinding under liquid nitrogen adds solid content weight
Measure 3 times of water, add 0.3% papain, regulate pH 6.3,60 DEG C, enzymolysis 1h；Enzymolysis solution divides through ion-exchange chromatography
From, lyophilization obtains high-purity II type collagen protein.
Described collagen protein powder and vitamin C are commercial goods raw material.Described Semen sojae atricolor powder or black bean powder are commercial goods Semen sojae atricolor
Or the size-reduced screening of Semen sojae atricolor obtains.
The preparation method of above-mentioned nutraceutical is as follows: raw soybeans and Semen sojae atricolor are pulverized and sieved, then with the shell prepared by said method
Oligosaccharide, typeⅡ Collagen, Semen Vitis viniferae extract, and collagen protein powder, vitamin C and maltodextrin are mixed in proportion,
Pelletize, be dried, screening, tabletting, subpackage prepare tablet.
Embodiment 2
The functional nutrient food of a kind of joint-improving, is prepared from by the raw material of following parts by weight: Semen sojae atricolor powder 15, black bean powder
60, oligochitosan 10, collagen protein powder 10, typeⅡ Collagen 5, Semen Vitis viniferae extract 5, vitamin C 10；Also include with
The adjuvant of lower parts by weight: maltodextrin 15.
The preparation method of described Semen Vitis viniferae extract is as follows: is pulverized by Semen Vitis viniferae and is placed on equipped with in 0.4% sodium bicarbonate solution, adjusts
Joint pH value is 7.6, is warming up to 45 DEG C, adds the mixed enzyme of Semen Vitis viniferae quality 5%, stirs, enzymolysis 50min, the enzymolysis phase
Between carry out high voltage pulse electric field processing, electric field intensity 40kV/cm, burst length 500 μ s, pulse frequency 250Hz；Above-mentioned process
Enzymolysis solution filters through 200 eye mesh screens, and filtrate is freeze-dried i.e. obtains Semen Vitis viniferae extract；The quality group of described mixed enzyme becomes:
Amylase: pectase: cellulase=1:8:10.
The preparation method of described oligochitosan is as follows: cellulase: papain=3:1 is dissolved in pH 5.4 acetic acid solution, temperature control
50 DEG C, mixed enzyme solution hydrolyzing chitosan 4h, hydrolyzed solution processes through enzyme denaturing, and vacuum lyophilization obtains oligochitosan.
Described typeⅡ Collagen extracts from Chick sternal cartilage and obtains.Currently preferred extracting method is as follows: the fresh pigeon chest of raw material
Cartilage slices, material-water ratio 1:5, it is 2.2 by acetic acid regulation material liquid pH, adds the pepsin of raw material weight 0.5%, room temperature
25 DEG C process 5h, enzyme denaturing, filter, washing with alcohol, obtain the cartilage after remove impurity, and low-temperature grinding under liquid nitrogen adds solid content weight
Measure 4 times of water, add 0.3% papain, regulate pH 6.5,56 DEG C, enzymolysis 2h；Enzymolysis solution divides through ion-exchange chromatography
From, lyophilization obtains high-purity II type collagen protein.
Described collagen protein powder and vitamin C are commercial goods raw material.Described Semen sojae atricolor powder or black bean powder are commercial goods Semen sojae atricolor
Or the size-reduced screening of Semen sojae atricolor obtains.
The preparation method of above-mentioned nutraceutical is as follows: raw soybeans and Semen sojae atricolor are pulverized and sieved, then with the shell prepared by said method
Oligosaccharide, typeⅡ Collagen, Semen Vitis viniferae extract, and collagen protein powder, vitamin C and maltodextrin are mixed in proportion,
Filling capsule, polishing, subpackage prepare capsule product.
Embodiment 3
The functional nutrient food of a kind of joint-improving, is prepared from by the raw material of following parts by weight: Semen sojae atricolor powder 25, black bean powder
40, oligochitosan 15, collagen protein powder 5, typeⅡ Collagen 10, Semen Vitis viniferae extract 10, vitamin C 8；Also include with
The adjuvant of lower parts by weight: maltodextrin 35.
The preparation method of described Semen Vitis viniferae extract is as follows: is pulverized by Semen Vitis viniferae and is placed on equipped with in 0.5% sodium bicarbonate solution, adjusts
Joint pH value is 8, is warming up to 40 DEG C, adds the mixed enzyme of Semen Vitis viniferae quality 8%, stirs, enzymolysis 70min, during enzymolysis
Carry out high voltage pulse electric field processing, electric field intensity 40kV/cm, burst length 400 μ s, pulse frequency 200Hz；The enzyme of above-mentioned process
Solving liquid to filter through 300 eye mesh screens, filtrate is freeze-dried i.e. obtains Semen Vitis viniferae extract；The quality group of described mixed enzyme becomes: form sediment
Powder enzyme: pectase: cellulase=1:5:10.
The preparation method of described oligochitosan is as follows: cellulase: papain=3:1 is dissolved in pH 5.6 acetic acid solution, temperature control
55 DEG C, mixed enzyme solution hydrolyzing chitosan 3h, hydrolyzed solution processes through enzyme denaturing, and vacuum lyophilization obtains oligochitosan.
Described typeⅡ Collagen extracts from Chick sternal cartilage and obtains.Currently preferred extracting method is as follows: the fresh pigeon chest of raw material
Cartilage slices, material-water ratio 1:8, it is 2.5 by acetic acid regulation material liquid pH, adds the pepsin of raw material weight 0.5%, room temperature
25 DEG C process 8h, enzyme denaturing, filter, washing with alcohol, obtain the cartilage after remove impurity, and low-temperature grinding under liquid nitrogen adds solid content weight
Measure 5 times of water, add 0.3% papain, regulate pH 6.8,55 DEG C, enzymolysis 3h；Enzymolysis solution divides through ion-exchange chromatography
From, lyophilization obtains high-purity II type collagen protein.
Described collagen protein powder and vitamin C are commercial goods raw material.Described Semen sojae atricolor powder or black bean powder are commercial goods Semen sojae atricolor
Or the size-reduced screening of Semen sojae atricolor obtains.
The preparation method of above-mentioned nutraceutical is as follows: raw soybeans and Semen sojae atricolor are pulverized and sieved, then with the shell prepared by said method
Oligosaccharide, typeⅡ Collagen, Semen Vitis viniferae extract, and collagen protein powder, vitamin C and maltodextrin are mixed in proportion,
Pelletize, be dried, screening, tabletting, subpackage prepare tablet.
Embodiment 4
The functional nutrient food of a kind of joint-improving, is prepared from by the raw material of following parts by weight: Semen sojae atricolor powder 40, black bean powder
25, oligochitosan 20, collagen protein powder 7, typeⅡ Collagen 15, Semen Vitis viniferae extract 12, vitamin C 10；Also include
The adjuvant of following parts by weight: maltodextrin 50.
Described oligochitosan, Semen Vitis viniferae extract, typeⅡ Collagen preparation method substantially with embodiment 3.Described collagen protein
Powder and vitamin C are commercial goods raw material.Described Semen sojae atricolor powder or black bean powder are commercial goods Semen sojae atricolor or the size-reduced screening of Semen sojae atricolor
Obtain.
The preparation method of above-mentioned nutraceutical is as follows: raw soybeans and Semen sojae atricolor are pulverized and sieved, then with other various supplementary materials by than
Example mixes, pelletizes, is dried, granulate, and subpackage prepares granule product.
Embodiment 5
The functional nutrient food of a kind of joint-improving, is prepared from by the raw material of following parts by weight: Semen sojae atricolor powder 80, black bean powder
10, oligochitosan 30, collagen protein powder 20, typeⅡ Collagen 1, Semen Vitis viniferae extract 16, vitamin C 12；Also include
The adjuvant of following parts by weight: maltodextrin 60.
Described oligochitosan, Semen Vitis viniferae extract, typeⅡ Collagen preparation method substantially with embodiment 3.Described collagen protein
Powder and vitamin C are commercial goods raw material.Described Semen sojae atricolor powder or black bean powder are commercial goods Semen sojae atricolor or the size-reduced screening of Semen sojae atricolor
Obtain.
The preparation method of above-mentioned nutraceutical is as follows: raw soybeans and Semen sojae atricolor are pulverized and sieved, then with the shell prepared by said method
Oligosaccharide, typeⅡ Collagen, Semen Vitis viniferae extract, and collagen protein powder, vitamin C and maltodextrin are mixed in proportion,
Pelletize, be dried, screening, tabletting, subpackage prepare tablet.
Embodiment 6
Testing the eating effect of product of the present invention, verification test is divided into four groups, collects 150 volunteers, this
The amount of bright Products Show is 4.21-33.8g/d, and often group takes the embodiment of the present invention 3 product by same amount and number of times, even
Continue and take 30 days, statistical test result.
Concrete condition is as follows:
One group of experimenter 50, suffers from the bone such as osteoporosis in various degree, bone density low, rheumatic arthritis, gonarthritis
Joint disease, age 60-68 year.Take product of the present invention after 30 days, the above-mentioned disease person of significantly improving 42 people,
Improver 7 people, substantially without improver 1 people.
Two groups of experimenters 50, are the retired athlete of male, and arthralgia, tendon pain or muscle-tendon structure are abnormal
Patient, age 38-46 year.Take product of the present invention after 30 days, the above-mentioned disease person of significantly improving 36 people, make moderate progress
Person 12 people, substantially without improver 2 people.
Three groups of experimenters 50, age 25-35 women, suffer from more serious women premenstrual syndrome for a long time, including lumbago,
Joint aches, swelling etc..Take product of the present invention after 30 days, the above-mentioned disease person of significantly improving 38 people, the person of making moderate progress
9 people, substantially without improver 3 people.
Additionally, above-mentioned 150 experimenters have 68 to belong to hypercholesterolemia patient, take product of the present invention after 30 days, wherein
56 experimenter's cholesterol levels significantly reduce, and 12 experimenter's cholesterol levels decrease.
Above-mentioned alleged " improvement " situation is the form taking health check-up report to combine patient's readme, and " significantly " and " " is logical
Relatively divide according to improvement degree after crossing relatively.
Claims (9)
1. the functional nutrient food of a joint-improving, it is characterised in that be prepared from by the raw material of following parts by weight: Semen sojae atricolor powder
10-80, black bean powder 10-80, oligochitosan 5-30, collagen protein powder 1-20, typeⅡ Collagen 1-20, Semen Vitis viniferae extracts
Thing 0.1-16, vitamin C 5-12；According to dosage form needs, also include the adjuvant of following parts by weight: maltodextrin 10-80.
The functional nutrient food of a kind of joint-improving the most as claimed in claim 1, it is characterised in that former by following parts by weight
Material is prepared from: Semen sojae atricolor powder 15-40, black bean powder 25-60, oligochitosan 10-20, collagen protein powder 5-10, II Collagen Type VI
Albumen 5-15, Semen Vitis viniferae extract 5-12, vitamin C 6-10；According to dosage form needs, also include following parts by weight
Adjuvant: maltodextrin 15-50.
The functional nutrient food of a kind of joint-improving the most as claimed in claim 1, it is characterised in that described Semen Vitis viniferae extract
Preparation method is as follows: being pulverized by Semen Vitis viniferae and be placed on equipped with in 0.3-0.5% sodium bicarbonate solution, regulation pH value is 7-8,
Being warming up to 40-50 DEG C, add the mixed enzyme of Semen Vitis viniferae quality 2-8%, stir, enzymolysis 40-70min, during enzymolysis
Carry out high voltage pulse electric field processing, electric field intensity 20-40kV/cm, burst length 400-500 μ s, pulse frequency 200-300Hz；
The enzymolysis solution of above-mentioned process filters through 100-300 eye mesh screen, and filtrate is freeze-dried i.e. obtains Semen Vitis viniferae extract；Described mixing
The quality group of enzyme becomes: amylase: pectase: cellulase=1:5-8:5-10.
The functional nutrient food of a kind of joint-improving the most as claimed in claim 1, it is characterised in that the preparation side of described oligochitosan
Method is as follows: cellulase: papain=3:1 is dissolved in pH5.2-5.6 acetic acid solution, and temperature control 50-55 DEG C, mixed enzyme is molten
Liquid hydrolyzing chitosan 3-6h, hydrolyzed solution processes through enzyme denaturing, and vacuum lyophilization obtains oligochitosan.
The functional nutrient food of a kind of joint-improving the most as claimed in claim 1, it is characterised in that described typeⅡ Collagen from
Chick sternal cartilage extracts and obtains.
The functional nutrient food of a kind of joint-improving the most as claimed in claim 5, it is characterised in that described typeⅡ Collagen
Extracting method is as follows: the fresh Chick sternal cartilage of raw material is cut into slices, material-water ratio 1:3-8, is 1.8-2.5 by acetic acid regulation material liquid pH,
Adding the pepsin of raw material weight 0.5%, room temperature 25 DEG C processes 2-8h, enzyme denaturing, filters, washing with alcohol, obtains remove impurity
After cartilage, low-temperature grinding under liquid nitrogen, add solid content weight 3-5 times water, add 0.3% papain, regulate pH
6.3-6.8,55-60 DEG C, enzymolysis 1-3h；Enzymolysis solution separates through ion-exchange chromatography, and lyophilization obtains high-purity II type
Collagen protein.
7. the functional nutrient food of a kind of joint-improving as described in claim 1-6, it is characterised in that described functional nutrient is eaten
Product are oral formulations.
The functional nutrient food of a kind of joint-improving the most as claimed in claim 7, it is characterised in that described oral formulations be tablet,
Granule, pill, powder, powder or capsule.
9. the functional nutrient food of a kind of joint-improving as described in claim 1-6, it is characterised in that by following parts by weight
Raw material is prepared from: Semen sojae atricolor powder 25, black bean powder 40, oligochitosan 15, collagen protein powder 5, typeⅡ Collagen 10, Portugal
Grape seed extract 10, vitamin C 8；Also include the adjuvant of following parts by weight: maltodextrin 35；
The preparation method of described Semen Vitis viniferae extract is as follows: is pulverized by Semen Vitis viniferae and is placed on equipped with in 0.5% sodium bicarbonate solution, adjusts
Joint pH value is 8, is warming up to 40 DEG C, adds the mixed enzyme of Semen Vitis viniferae quality 8%, stirs, enzymolysis 70min, enzymolysis
Period carries out high voltage pulse electric field processing, electric field intensity 40kV/cm, burst length 400 μ s, pulse frequency 200Hz；Above-mentioned
The enzymolysis solution processed filters through 300 eye mesh screens, and filtrate is freeze-dried i.e. obtains Semen Vitis viniferae extract；The matter of described mixed enzyme
Amount consists of: amylase: pectase: cellulase=1:5:10；
The preparation method of described oligochitosan is as follows: cellulase: papain=3:1 is dissolved in pH 5.6 acetic acid solution, temperature control
55 DEG C, mixed enzyme solution hydrolyzing chitosan 3h, hydrolyzed solution processes through enzyme denaturing, and vacuum lyophilization obtains oligochitosan；
Described typeⅡ Collagen extracts from Chick sternal cartilage and obtains.Currently preferred extracting method is as follows: the fresh pigeon chest of raw material
Cartilage slices, material-water ratio 1:8, it is 2.5 by acetic acid regulation material liquid pH, adds the pepsin of raw material weight 0.5%, room
Temperature 25 DEG C processes 8h, enzyme denaturing, filters, washing with alcohol, obtains the cartilage after remove impurity, low-temperature grinding under liquid nitrogen, adds solid
5 times of water of shape thing weight, add 0.3% papain, regulate pH 6.8,55 DEG C, enzymolysis 3h；Enzymolysis solution is handed over through ion
Changing chromatography, lyophilization obtains high-purity II type collagen protein；
Described collagen protein powder and vitamin C are commercial goods raw material, and described Semen sojae atricolor powder or black bean powder are commercial goods Semen sojae atricolor
Or the size-reduced screening of Semen sojae atricolor obtains；
The preparation method of above-mentioned nutraceutical is as follows: raw soybeans and Semen sojae atricolor are pulverized and sieved, then with the shell prepared by said method
Oligosaccharide, typeⅡ Collagen, Semen Vitis viniferae extract, and collagen protein powder, vitamin C and maltodextrin mix in proportion
Close, pelletize, be dried, sieve, tabletting, subpackage prepare tablet.
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| CN201810892851.XA CN109043518A (en) | 2016-02-15 | 2016-02-15 | A kind of functional nutrient food improving bone and joint diseases symptom |
| CN201610086052.4A CN105725190B (en) | 2016-02-15 | 2016-02-15 | A kind of functional nutrient food of joint-improving |
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| CN201610086052.4A CN105725190B (en) | 2016-02-15 | 2016-02-15 | A kind of functional nutrient food of joint-improving |
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| CN106262817A (en) * | 2016-08-09 | 2017-01-04 | 江门多微生物科技有限公司 | A kind of nutraceutical being beneficial to desensitization and Mucous rehabilitation and maintenance |
| CN107348522A (en) * | 2017-08-14 | 2017-11-17 | 北京市营养源研究所 | A kind of alimentation composition for improving the elderly's kinematic system function and preparation method thereof |
| CN107691952A (en) * | 2017-08-22 | 2018-02-16 | 北京同仁堂健康药业股份有限公司 | A kind of resisting kinetic fatigue, the composition for promoting postexercise recovery and preparation method thereof |
| CN107669980A (en) * | 2017-10-10 | 2018-02-09 | 北京特食生物科技研究中心（有限合伙） | A kind of alimentation composition for improving bony articulation health and preparation method and application |
| CN108112997A (en) * | 2017-12-18 | 2018-06-05 | 北京康比特体育科技股份有限公司 | A kind of health-care food composition |
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| EP3806867A4 (en) * | 2018-07-16 | 2022-07-06 | Lonza Consumer Health Inc. | Collagen and cell matter supplement and method for administering same |
| CN111280447A (en) * | 2018-12-07 | 2020-06-16 | 解冰 | Composite nanometer preparation for treating and recovering bone joint function and preparation method thereof |
| CN110214947A (en) * | 2019-06-12 | 2019-09-10 | 宁波依萃健生物科技有限公司 | A kind of prevention and treatment osteoarthritis composition |
| CN112219958A (en) * | 2020-07-08 | 2021-01-15 | 许昌神飞航天生物科技有限公司 | Space navigation grade solid beverage for bone joint recuperation |
| WO2022160917A1 (en) * | 2021-01-28 | 2022-08-04 | 曲词 | Composite containing non-denaturing type ii collagen and chitosan oligosaccharide, and preparation method therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109043518A (en) | 2018-12-21 |
| CN105725190B (en) | 2018-09-25 |
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