CN102961744A - Composition used for moisturizing - Google Patents
Composition used for moisturizing Download PDFInfo
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- CN102961744A CN102961744A CN2012104827300A CN201210482730A CN102961744A CN 102961744 A CN102961744 A CN 102961744A CN 2012104827300 A CN2012104827300 A CN 2012104827300A CN 201210482730 A CN201210482730 A CN 201210482730A CN 102961744 A CN102961744 A CN 102961744A
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- moisture
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- keeping composition
- cellulase
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Abstract
The invention discloses a moisturizing composition, containing collagen, soybean extract, grape seed extract and vitamin E. Compared with the prior art, the composition has the advantages that collagen, soybean extract, grape seed extract and vitamin E are selected as main raw materials, nutrition required by organism can be supplemented, free radical can be eliminated, and the aims of moistening skin and improving skin moisture can be realized.
Description
Technical field
The invention belongs to the compositions for moisturizing.
Background technology
Skin is one of organ of human body maximum, and it is divided into epidermis, corium, subcutaneous tissue.Its mesocuticle is divided into horny layer, granular layer, spinous layer and basal layer; Corium is divided into collagen fiber, elastic fiber, blood capillary; Subcutaneous tissue is divided into fat deposit and loose knot hoof tissue, if untimely moisturizing can make xerosis cutis aging, thereby affects the normal function of human body.
Summary of the invention
Technical problem to be solved by this invention provides a kind of new moisture-keeping composition.
The technical scheme of technical solution problem of the present invention is: a kind of moisture-keeping composition, contain the material of following weight portion:
Described soybean extract prepares by the following method:
With the Semen sojae atricolor pulverizing, add entry and cellulase, 25-30 ℃ of reaction 12-24 hour, be warming up to again 90-100 ℃, reacted 2-5 hour, cool to room temperature filters, and heating is concentrated into 1-10 times (g/ml) that heating is concentrated into Semen sojae atricolor weight, gets final product; The weight ratio of Semen sojae atricolor, cellulase, water is 1:0.02-0.1:4-10.
Described cellulase is Trichoderma viride (Trichoderma viride) CGMCC 3.2942, contains 2 * 10 in every milliliters of liquid in its scale-up medium
7More than the individual active thalline.
Compositions added can to make medicine, health product, animal feed, the percentage by weight of compositions in medicine, health product, animal feed behind the adjuvant be 1-99%.
The dosage form of medicine is drop pill, tablet, capsule, soft capsule, granule, suspensoid, oral liquid, injectable powder, injection, transfusion.
Preferred dosage form is capsule.
Using method of the present invention is: every day 2 times, each 3.
Collagen protein is the protein that consists of human connective tissue, account for the human body total protein content 1/3rd more than, be the main protein composition of skin histology, content is up to more than 85%.Collagen protein not only provides the place of Nutrition and Metabolism for its peripheral cell, simultaneously also relevant with morphosis, growth metabolism and the cell movement of peripheral cell.
The existence of collagen protein and skin health degree, water-retaining property and elasticity etc. have close relationship.The growth of skin, reparation and nutrition all be unable to do without collagen protein, and it is the reinforcing bar framework of propping up skin histology.Concrete effect to skin is mainly reflected in: a large amount of existence of tropocollagen molecule outside hydrophilic group carboxyl and hydroxyl etc. make tropocollagen molecule very easily form hydrogen bond with water, so collagen protein have good water conservation performance of keeping humidity; It is rich in hydrophilic nature moisturizing factor, can keep the integrity of horny layer moisture content and fibre structure, improves the metabolism of skin living environment and promotion skin, and skin care reaches the purpose of improving skin moisture; Collagen protein can be filled between the dermal matrix layer, increases the toughness of collagen fiber and elastic fiber in the skin, thereby makes skin smooth, unfold; The affinity of collagen protein and surrounding tissue is good, can repair the damaged skin tissue, makes skin health beautiful.Therefore collagen protein can improve the moisture content of skin, keeps skin health.
Soybean extract is that bean cake extracts the material that obtains through special process, and composition is soybean isoflavone and other benefit materials.Soybean isoflavone has various health care functions, as improves skin quality, defying age, and it is uncomfortable to improve and alleviate menstrual period, climacteric, prevention of osteoporosis, antioxidation, replenishes skin moisture.
Semen Vitis viniferae extract is to extract from the seed of Fructus Vitis viniferae, and its composition is polyphenols, comprises free phenol and polymerized polyphenolic.The polymerized polyphenolic main component is procyanidin.Semen Vitis viniferae extract has multiple physiological function to the human body beneficial, has preferably health-care effect.In recent years, as a kind of functional adding ingredient of pure natural, Semen Vitis viniferae extract is widely used in the health food.
Various macromole damages in free radical accumulation can cause in the Skin Cell, the simultaneously pollution of surrounding, life are irregular etc. all can cause xerosis cutis aging, the aging easier drying of skin.Therefore replenish the composition with antioxidation, can improve skin aging, improve skin moisture.Procyanidin in the Semen Vitis viniferae extract has stronger antioxidant activity, and active oxygen is had very strong elimination ability.But the procyanidin enhancing body is organized the ability of Antioxidant Enzyme Systems, strengthens oxidation resistance, reduces the generation of lipid peroxide, oxidative damage is played a protective role, and protective effect is better than many other antioxidants.Procyanidin also can effectively be removed free radical in the very low situation of concentration, its activity is stronger than some other Natural antioxidant.Keeping another functional component of moisture of skin is hyaluronic acid, and the hyaluronic acid endonuclease capable hydrolysis hyaluronic acid mucopolysaccharide in the body reduces hyaluronic activity; Procyanidin also can be safeguarded the synthetic of collagen protein, suppresses elastoser, Collagenase, hyaluronidase, increases collagen protein, hyaluronic activity, improves the skin storage capacity, improves skin elasticity.
Vitamin E has another name called tocopherol, is one of fatsoluble vitamin.Vitamin E extensively is present in the germ oil and Semen sojae atricolor wet goods lipid of corn seed.It is one of topmost Natural antioxidant, has the various biological activity, is the healthy indispensable material of human life.
Radical reaction is the pathologic basis of numerous disease and damage, also is the major reason of accelerating body aging.The chemism of free radical is high, unstable, very easily produces new free radical with other material chain-reacts, and the protein in the body, lipid, saccharide and hereditary material nucleic acid are caused damage, and causes aging, the aging easier drying of skin of xerosis cutis.Under normal circumstances; the material that exists many defence radical damages in the body is antioxidant reductase and antioxidant; so that free radical constantly is eliminated in the body; be not subjected to radical damage with the protection body cell; but body is removed the function of free radical and is weakened along with the increase at age; so that the damage that free radical causes constantly accumulates, and accelerates the aging of body.Vitamin E can be by self being oxidized to the fertility quinone, with ROO
-Be converted into the inactive ROOH of chemical property, interrupt the chain reaction of lipid peroxidation, establishment fat
Vitamin E has " moistening " effect to the collagen fiber in the skin and elastic fiber, can strengthen capillary resistance, promote the blood circulation in the skin, makes skin obtain sufficient nutrition and moisture content.Take the roughness that vitamin E can improve skin, obviously improve the moisturizing degree of skin, improve the moisture content of skin.
The present invention is take collagen protein as main, collagen protein is the main protein composition of skin histology, the growth of skin, reparation and nutrition all be unable to do without collagen protein, collagen protein is rich in hydrophilic nature moisturizing factor, the integrity that can keep horny layer moisture content and fibre structure, improve the metabolism of skin living environment and promotion skin, reach the purpose of skin care; Collagen protein is filled between the dermal matrix layer, increases the toughness of collagen fiber and elastic fiber in the skin, thereby makes skin smooth, unfold; The affinity of collagen protein and surrounding tissue is good, can repair the damaged skin tissue, makes skin health beautiful.Collagen protein has the effect of additional skin moisture.Be aided with soybean extract, Semen Vitis viniferae extract, vitamin E, wherein the soybean isoflavone in the soybean extract and other active ingredient have the content that improves hydroxyproline in the skin, the effect that improves skin moisture; Semen Vitis viniferae extract can effectively be removed free radical, make collagen protein appropriately crosslinked, thereby procyanidin can suppress the activity of elastoser, Collagenase, hyaluronidase keeps skin delicate, smooth, improve skin moisture, procyanidin can reduce the vitamin E free radical and make vitamin E regeneration, thereby reduces the loss of vitamin E in the cell; Vitamin E makes and avoids peroxy oxygen destruction in cell membrane and the cell as a kind of powerful antioxidant, safeguards the normal function of epiderm skin, dermal tissue cell and collagen protein, reaches and improves the xerosis cutis state.Four kinds of material combinations are used and can improve preferably skin moisture without taboo.
The present invention is primary raw material by choosing collagen protein, soybean extract, Semen Vitis viniferae extract, vitamin E compared with prior art, can be that body replenishes needed nutrition, removes free radical, reaches skin care, improves the purpose of skin moisture
The specific embodiment
The present invention is described in detail below in conjunction with embodiment.
Collagen protein of the present invention is that Jiangxi can biochemical company limited production
Semen Vitis viniferae extract is that Shanxi Jiahe Plant Chemical Co., Ltd. produces.
Described soybean extract: by the following method preparation:
Semen sojae atricolor is pulverized, add entry and cellulase, 25-30 ℃ of reaction 24 hours, be warming up to 90-100 ℃ again, reacted 5 hours, cool to room temperature filters, and heating is concentrated into 5 times (g/ml) that heating is concentrated into Semen sojae atricolor weight, gets final product; The weight ratio of Semen sojae atricolor, cellulase, water is 1:0.1:10.
Described cellulase is Trichoderma viride (Trichoderma viride) CGMCC 3.2942, contains 2 * 10 in every milliliters of liquid in its scale-up medium
7More than the individual active thalline.
Embodiment 1:
Per 1000 (0.32g/ grain) capsules contain following material:
All the other are pharmaceutic adjuvant commonly used.
Embodiment 2:
Per 1000 (0.32g/ grain) capsules contain following material:
Embodiment 3:
Per 1000 (0.32g/ grain) capsules contain following material:
Embodiment 4:
The capsule that embodiment 1 is made, carry out the double blind random grouping with placebo, the experimenter selects the women of age 30-50 year, skin moisture＜=12, took medicine continuously 45 days, two groups of experimenters stop using other oral and relevant articles for use that keep skin moisture of external at duration of test, period in a medicine does not change dietary habit, and each measures once every test index when on-test and end.
Skin test: test forehead glabella skin moisture.
Namely under rest state, dip in distilled water with clean cotton balls and clean tested position, dry rear mensuration of carrying out moisture content in 15 minutes.
Its experimental result is as shown in table 1:
| Moisture content before the experiment | Moisture content after the experiment | |
| Embodiment 1 | 8.80 | 9.49 |
| Placebo | 8.87 | 8.96 |
Embodiment 1 compares with placebo before the test, no significant difference (P〉0.5).
Moisture content before and after the placebo test compares, no significant difference (P〉0.5).
Relatively, difference all has significance (P＜0.05) after testing after embodiment 1 test and before the test and with the comfort group.
Claims (6)
1. moisture-keeping composition, contain the material of following weight portion:
2. a kind of moisture-keeping composition according to claim 1, it is characterized in that: described soybean extract prepares by the following method:
With the Semen sojae atricolor pulverizing, add entry and cellulase, 25-30 ℃ of reaction 12-24 hour, be warming up to again 90-100 ℃, reacted 2-5 hour, cool to room temperature filters, and heating is concentrated into 1-10 times (g/ml) that heating is concentrated into Semen sojae atricolor weight, gets final product; The weight ratio of Semen sojae atricolor, cellulase, water is 1:0.02-0.1:4-10.
3. a kind of moisture-keeping composition according to claim 1, it is characterized in that: described cellulase is Trichoderma viride (Trichoderma viride) CGMCC 3.2942.
4. a kind of moisture-keeping composition according to claim 1 is characterized in that: compositions is added can to make medicine, health product, animal feed, the percentage by weight of compositions in medicine, health product, animal feed behind the adjuvant be 1-99%.
5. a kind of moisture-keeping composition according to claim 1, it is characterized in that: the dosage form of described medicine is drop pill, tablet, capsule, soft capsule, granule, suspensoid, oral liquid, injectable powder, injection, transfusion.
6. a kind of moisture-keeping composition according to claim 1 is characterized in that: preferred dosage form is capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104827300A CN102961744A (en) | 2012-11-23 | 2012-11-23 | Composition used for moisturizing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104827300A CN102961744A (en) | 2012-11-23 | 2012-11-23 | Composition used for moisturizing |
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| CN102961744A true CN102961744A (en) | 2013-03-13 |
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| CN2012104827300A Pending CN102961744A (en) | 2012-11-23 | 2012-11-23 | Composition used for moisturizing |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104432070A (en) * | 2014-12-22 | 2015-03-25 | 威海百合生物技术股份有限公司 | Health food for perfecting skin moisture |
| CN106072664A (en) * | 2016-06-24 | 2016-11-09 | 湖北丽生堂生物科技有限公司 | A kind of nutriment improving skin function |
| CN106490623A (en) * | 2016-10-28 | 2017-03-15 | 芜湖市诺康生物科技有限公司 | A kind of with the compositionss for improving moisture of skin function |
| CN107375158A (en) * | 2017-06-21 | 2017-11-24 | 佛山实瑞先导材料研究院（普通合伙） | A kind of NMF and its application |
| CN109043518A (en) * | 2016-02-15 | 2018-12-21 | 北京东方兴企食品工业技术有限公司 | A kind of functional nutrient food improving bone and joint diseases symptom |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361970A (en) * | 2008-09-28 | 2009-02-11 | 成都自豪药业有限公司 | Composition with beauty effect and health care efficacy and use thereof |
| CN102318822A (en) * | 2011-09-06 | 2012-01-18 | 宁波御坊堂生物科技有限公司 | Composite collagen capsule and preparation method thereof |
-
2012
- 2012-11-23 CN CN2012104827300A patent/CN102961744A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361970A (en) * | 2008-09-28 | 2009-02-11 | 成都自豪药业有限公司 | Composition with beauty effect and health care efficacy and use thereof |
| CN102318822A (en) * | 2011-09-06 | 2012-01-18 | 宁波御坊堂生物科技有限公司 | Composite collagen capsule and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104432070A (en) * | 2014-12-22 | 2015-03-25 | 威海百合生物技术股份有限公司 | Health food for perfecting skin moisture |
| CN109043518A (en) * | 2016-02-15 | 2018-12-21 | 北京东方兴企食品工业技术有限公司 | A kind of functional nutrient food improving bone and joint diseases symptom |
| CN106072664A (en) * | 2016-06-24 | 2016-11-09 | 湖北丽生堂生物科技有限公司 | A kind of nutriment improving skin function |
| CN106490623A (en) * | 2016-10-28 | 2017-03-15 | 芜湖市诺康生物科技有限公司 | A kind of with the compositionss for improving moisture of skin function |
| CN107375158A (en) * | 2017-06-21 | 2017-11-24 | 佛山实瑞先导材料研究院（普通合伙） | A kind of NMF and its application |
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Application publication date: 20130313 |