CN110214947A - A kind of prevention and treatment osteoarthritis composition - Google Patents
A kind of prevention and treatment osteoarthritis composition Download PDFInfo
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- CN110214947A CN110214947A CN201910506217.2A CN201910506217A CN110214947A CN 110214947 A CN110214947 A CN 110214947A CN 201910506217 A CN201910506217 A CN 201910506217A CN 110214947 A CN110214947 A CN 110214947A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of compositions, in particular to a kind of prevention and treatment osteoarthritis composition, belong to food technology field, composition includes the ingredient of following parts by weight: collagen: 50-150 parts, non denatured collagen: 5-40 parts, chitosan oligosaccharide: 20-80 parts, turmeric: 2-20 parts, other auxiliary materials: 70-700 parts, the ingredients such as collagen, chitosan oligosaccharide can also synergy reinforcing effect, and the finished product of different dosage forms is obtained by different preparation methods, expand the field of using.
Description
Technical field
The present invention relates to a kind of composition, in particular to a kind of prevention and treatment osteoarthritis composition belongs to food technology field.
Background technique
Bone is the pillar of life, has " living factory, constitution bank " support.People in life, bone will be born
Support, resistance to compression, tension, antitorque, bending resistance, anti-folding etc., arduous task！The health problem of bone mainly includes osteoporosis, bone
The types such as arthritis, cervical spondylosis, protrusion of lumber intervertebral disc, spur, caput femoris necrosis, wherein most outstanding is exactly osteoporosis and bone
Arthritis.
Arthritis (arthritis) refers to generation in human synovial and its surrounding tissue, by inflammation, infection, degeneration, wound
Or inflammatory disease caused by other factors, tens of kinds, predominantly degenerative osteoarthritis, rheumatic arthritis, class wind can be divided into
Wet arthritis etc..The arthritic in China has 100,000,000 or more, and number is being continuously increased.Clinical manifestation be joint it is red, swollen,
Heat, pain, dysfunction and joint deformity, serious person lead to joint deformity, influence patients ' life quality.According to statistics China 50 years old with
Half suffers from osteoarthritis in upper crowd, and 90% women and 80% male suffer from osteoarthritis in over-65s crowd.The illness in China
Rate is 0.34%~0.36%, and serious person's service life about shortens 10~15 years.
Different arthritis finally all characterized by cartilaginous tissue wears lesion, forms inflammation, therefore is alleviated and is treated and close
Section is scorching, requires to start in terms of inhibiting inflammation and repairing cartilaginous tissue two.
Summary of the invention
In view of the above problems, the present invention provides a kind of prevention and treatment osteoarthritis composition.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of prevention and treatment osteoarthritis composition, the composition include the ingredient of following parts by weight: collagen: 50-
150 parts, non denatured collagen: 5-40 parts, chitosan oligosaccharide: 20-80 parts, turmeric: 2-20 parts, other auxiliary materials: 70-700 parts.
The collagen that the present invention uses is typeⅡ Collagen, and only cartilaginous tissue does not provide typeⅡ Collagen, together
When also contain a large amount of chondroitin sulfate (> 30%).And chitosan oligosaccharide is unique positively charged cationic basic amine group in nature
Oligosaccharide is animal fiber element, contains natural Glucosamine.Chitosan oligosaccharide can promote the absorption of calcium, itself can promote
Into the absorption of Bones and joints nutriment, all there is certain complexing to the necessary metal ion of the bodies such as calcium ion, make calcium
Ion enters body therewith.Meanwhile chitosan oligosaccharide also improves the absorption environment of calcium ion, work along both lines, very good solution lacks
The problem of calcium.
Chondroitin sulfate (CS) is to be covalently attached a kind of glycosaminoglycan for forming proteoglycans on protein, divides extensively
It is distributed in the extracellular matrix and cell surface of animal tissue, plays many important physiological functions.Chondroitin sulfate is in medicine
Upper main application approach is to be used cooperatively as the drug for the treatment of joint disease with Glucosamine, has analgesic, promotes soft
The effect of osteanagenesis, can improve joint prob from basic.Chondroitin sulfate can also inhibit to destroy ferment (such as the glue of cartilage
Protoenzyme, elastoser and cathepsin), in case cartilage is decomposed or dissolves, or hardening.Chondroitin sulfate can also press down
The activity of COX-2 processed, to prevent Joint Inflammation.But chondroitin sulfate is currently health product raw material, it cannot be separately as food
Raw material uses, and it is legal raw-food material that this product, which is collagen, wherein the puritan filler chondroitin contained, therefore also belong to
Ingredient in kasher raw material, can be used.
Glucosamine is the substance synthesized in human body, is the important nutrient to form cartilage cell, is that healthy joint is soft
The natural tissues composition of bone.With advancing age, the shortage of the intracorporal Glucosamine of people is increasingly severe, and articular cartilage is not
It is disconnected to degenerate and wear.A large amount of medical researches show: Glucosamine can help to repair and safeguard cartilage, and cartilage can be stimulated thin
The growth of born of the same parents.When taking gucosamine, it is extremely important also to absorb chondroitin, because chondroitin can promote gucosamine to penetrate into pass
Section.It can more effectively be protected in conjunction with intake gucosamine and chondroitin, reverse damage and promote repairing articular cartilage and membrane bone,
So that osteosclerosis is reduced, allow bone that younger state is presented.But Glucosamine is currently health product raw material, cannot individually be made
For raw-food material use, it is legal raw-food material that this product, which is chitosan oligosaccharide, wherein therefore the native amino glucose contained also belongs to
Ingredient in kasher raw material, can be used.
The turmeric that the present invention uses is a kind of curcumin preparation of patent for phospholipid complexes of curcumin.Curcumin uses
Phosphatide complex technique by curcumin in conjunction with soybean lecithin after, the hydrolytic stability of curcumin can be significantly improved, and will
The oral absorption rate of curcumin chemical compounds improves nearly 30 times.Absorptivity about curcumin: 99% curcumin is with grape
The form of thuja acid appears in blood plasma, and remaining 1% is curcumin sulfuric ester and free curcumin.Compared with pure curcumin, phosphorus
Rouge compound prescription is remarkably improved the concentration of the curcumin in blood plasma (more than 20 times).And turmeric reduces the important of Osteoarthritis Index
Substance.
Rather than denatured collagen is non denatured typeⅡ Collagen, using the cartilage of birds as raw material, using patented technology
Low temperature extracts non denatured II collagen product that production does not destroy protein conformation.It completely possesses three spiral knot of collagen
Structure has the distinctive smell of collagen, and free from admixture has high bioactivity and safety, can promote articulation health,
It relieves pain, repairs injury gained in sports, improve kinematic dexterity.
Preferably, other described auxiliary materials include inulin, isomalt, microcrystalline cellulose, maltodextrin, stearic acid
One of magnesium is a variety of.The selection of auxiliary material will not only consider the compatibility between auxiliary material and major ingredient, while also will affect specific
Combination dosage form.
Preferably, the dosage form of the composition includes one or both of pressed candy, solid beverage.
Further preferably, the preparation method of the pressed candy includes after direct powder compression, wet granulation in tabletting
It is one or two kinds of；The preparation method of the solid beverage includes one or both of dry granulation, wet granulation.
Preferably, the direct powder compression specifically: by collagen, non denatured collagen, chitosan oligosaccharide, ginger
Huang, inulin, isomalt, microcrystalline cellulose, maltodextrin, magnesium stearate are added in mixing machine after powder processed uniformly respectively
Mixed powder is mixed to obtain, then mixed powder after tabletting, is packed into obtain pressed candy directly on tablet press machine.
Preferably, tabletting after the wet granulation specifically: by collagen, non denatured collagen, chitosan oligosaccharide, ginger
Be added in granulator and mix after Huang, inulin, isomalt, microcrystalline cellulose, maltodextrin powder, add solvent into
Solvent is added in row primary stirring after shutdown, discharge after secondary agitation and dry softwood, is sieved after particle is made in softwood, then
It carries out redrying, add magnesium stearate after whole grain, pressed candy is packed to obtain in tabletting after mixing.
Further preferably, the incorporation time is 5-15min.
Further preferably, the solvent includes one or both of water, ethyl alcohol.
Further preferably, after the shutdown, the elasticity of mixture need to be observed, is added according to the solvent that elasticity carries out again
Add.
Further preferably, the sieve mesh number of sieving is 16 mesh.
Further preferably, the redrying are as follows: wet granular is placed in stainless steel plate and is spread out, 55 in cyclic drying case
~60 DEG C of dryings.
Further preferably, the whole grain is carried out using 14 mesh screens.
Further preferably, the additive amount of the magnesium stearate is by mass percentage 0.5-5%.
Preferably, the dry granulation specifically: by collagen, non denatured collagen, chitosan oligosaccharide, turmeric, wheat
Bud dextrin is added to dry-pressing in granulator after mixing and pelletizes and be sieved, and packs to obtain solid beverage.
Further preferably, the particle of 60-20 mesh is obtained after the sieving.
Preferably, the wet granulation specifically: by collagen, non denatured collagen, chitosan oligosaccharide, turmeric, wheat
Bud dextrin, which is added in granulator, to be mixed, and is added solvent and is once stirred, and solvent is added after shutdown, is discharged after secondary agitation
And dry softwood, be sieved after particle is made in softwood, most afterwards through redrying, screening, pack to obtain solid beverage.
Further preferably, the incorporation time is 5-15min.
Further preferably, the solvent includes one or both of water, ethyl alcohol.
Further preferably, after the shutdown, the elasticity of mixture need to be observed, is added according to the solvent that elasticity carries out again
Add.
Further preferably, the sieve mesh number of sieving is 16 mesh.
Further preferably, the redrying are as follows: wet granular is placed in stainless steel plate and is spread out, 55 in cyclic drying case
~60 DEG C of dryings.
Further preferably, the screening obtains the particle of 80-20 mesh.
Application of the prevention and treatment osteoarthritis composition in food, prevention and treatment osteoarthritis composition can be made into pressed candy
The dosage form of one or both of fruit, solid beverage is applied in food.
Compared with other materials, the present invention has the advantage that
(1) collagen raw material of the invention, only cartilaginous tissue does not provide typeⅡ Collagen, while also containing a large amount of
Chondroitin sulfate, be used cooperatively with Glucosamine, have analgesic, promote regenerating bone or cartilage the effect of.
(2) chitosan oligosaccharide of the invention contains natural Glucosamine, and Glucosamine can help to repair and safeguard soft
Bone, and the growth of cartilage cell can be stimulated.
(3) non denatured collagen of the invention can promote articulation health, relieve pain, and repair injury gained in sports, improve
Kinematic dexterity.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described, but the present invention is simultaneously
It is not limited to these embodiments.
Table 1: the component and parts by weight of embodiment 1-7 prevention and treatment osteoarthritis composition
Table 2: the component and parts by weight of other auxiliary materials of embodiment 1-7
Pressed candy or solid beverage dosage form are prepared by the component and content of composition in table 1-2:
Pressed candy (direct powder compression):
Embodiment 1-7
Raw material is weighed respectively by the component and content of 1 embodiment 1-7 composition of table, by collagen, non denatured collagen egg
White, chitosan oligosaccharide, turmeric, inulin, isomalt, microcrystalline cellulose, maltodextrin, magnesium stearate are added to after powder processed respectively
Mixed powder is uniformly mixed to obtain in three-dimensional mixer, then mixed powder after tabletting, is packed into obtain pressed candy directly on tablet press machine.
Pressed candy (tabletting after wet granulation):
Embodiment 8
The component of object is closed by 1 example 1 group of table and content weighs raw material, collagen, non denatured collagen, shell is few
It is added in wet mixing pelletizer and mixes after sugar, turmeric, inulin, isomalt, microcrystalline cellulose, maltodextrin powder
10min, the ethyl alcohol for adding 75% are once stirred and are cut 5min, according to the second of particle elasticity addition 75% after shutdown
Alcohol, discharges after secondary agitation and dry softwood, and particle of uniform size is made through oscillating granulator in softwood and crosses 16 meshes,
Wet granular is placed in stainless steel plate again to spread out, 58 DEG C of dryings in cyclic drying case, with 14 mesh screen whole grains after drying, finally be added
Add 3% magnesium stearate, pressed candy is packed to obtain in tabletting after mixing.
Embodiment 9
Difference with embodiment 8 is only that the solvent that embodiment 9 is added when pelletizing is water.
Embodiment 10-11
Difference with embodiment 8 is only that the content for the magnesium stearate that embodiment 10-11 is finally added is respectively 0.5%
With 5%.
Solid beverage (dry granulation):
Embodiment 12
The component of object is closed by 1 example 1 group of table and content weighs raw material, collagen, non denatured collagen, shell is few
Sugar, turmeric, maltodextrin are added to dry-pressing in granulator after mixing and pelletize and cross 30 meshes, pack to obtain solid beverage.
Embodiment 13-14
Difference with embodiment 12 is only that the grit number of embodiment 13-14 is respectively 10 mesh and 60 mesh.
Solid beverage (wet granulation):
Embodiment 15
The component of object is closed by 1 example 1 group of table and content weighs raw material, collagen, non denatured collagen, shell is few
Sugar, turmeric, maltodextrin, which are added in wet mixing pelletizer, mixes 10min, adds suitable quantity of water and is once stirred and cut
5min is cut, suitable quantity of water is added according to particle elasticity after shutdown, is discharged after secondary agitation and dry softwood, by softwood through waving
Granulator is made particle of uniform size and crosses 16 meshes, then wet granular is placed in stainless steel plate and is spread out, in cyclic drying case
58 DEG C of dryings, sieve take 40 mesh particles, pack to obtain solid beverage.
Embodiment 16-17
Difference with embodiment 15 is only that it is respectively 20 mesh and 60 mesh that embodiment 16-17, which finally sieves the particle mesh number taken,.
Embodiment 18-19
Difference with embodiment 1 is only that, in embodiment 18-19 composition the number of collagen be respectively 49 parts and
151 parts.
Embodiment 20-21
Difference with embodiment 1 is only that the number of non denatured collagen is respectively 4 in embodiment 20-21 composition
Part and 41 parts.
Embodiment 22-23
Difference with embodiment 1 is only that the number of chitosan oligosaccharide is respectively 19 parts and 81 in embodiment 22-23 composition
Part.
Embodiment 24-25
Difference with embodiment 1 is only that the number of turmeric is respectively 1 part and 21 parts in embodiment 24-25 composition.
Comparative example 1
Difference with embodiment 1 is only that, collagen is free of in 1 composition component of comparative example.
Comparative example 2
Difference with embodiment 1 is only that, non denatured collagen is free of in 2 composition component of comparative example.
Comparative example 3
Difference with embodiment 1 is only that, chitosan oligosaccharide is free of in 3 composition component of comparative example.
Comparative example 4
Difference with embodiment 1 is only that, turmeric is free of in 4 composition component of comparative example.
The embodiment 1-25 and comparative example 1-4 finished product obtained is tested, its actual performance is tested, as a result such as 3 institute of table
Show:
Inclusion criteria: readme pain in knee osteoarthritis and discomfort, hepatic and renal function are normal.
Exclusion criteria: not having osteo-arthritic pain and discomfort, acute traumatic hemarthrosis of knee joint or inflammation, is diagnosed as secondary bone and closes
Section inflammation or severe osteoarthritic, take Glucosamine, chondroitin or other nutritional substances, may influence collagen to bone
Arthritis ache, because severe arthritis take analgesic or it is 6 months nearest in participate in other clinical researches.
Clinical evaluation: after patient takes 6 months, carrying out clinical evaluation according to feedback of the patient to effect,
It is divided into: without clinical efficacy, slight curative effect, general curative effect, obvious curative effects.
Table 3: finished product takes 6 months curative effects (number)
Although only listing the finished product prepared by the ingredient of table 1-2 embodiment 1-7, actual finished product in table 3
Preparation has also carried out the composition and content that including but not limited to above-described embodiment 1-7 is enumerated, since embodiment is numerous, herein no longer
It enumerates.
It is skilled to this field although present invention has been described in detail and some specific embodiments have been cited
For technical staff, as long as it is obvious for can making various changes or correct without departing from the spirit and scope of the present invention.
Claims (10)
1. a kind of prevention and treatment osteoarthritis composition, which is characterized in that the composition includes the ingredient of following parts by weight: collagen
Albumen: 50-150 parts, non denatured collagen: 5-40 parts, chitosan oligosaccharide: 20-80 parts, turmeric: 2-20 parts, other auxiliary materials: 70-
700 parts.
2. a kind of prevention and treatment osteoarthritis composition according to claim 1, which is characterized in that other described auxiliary materials include chrysanthemum
One of powder, isomalt, microcrystalline cellulose, maltodextrin, magnesium stearate are a variety of.
3. a kind of prevention and treatment osteoarthritis composition according to claim 1, which is characterized in that the dosage form packet of the composition
Include one or both of pressed candy, solid beverage.
4. a kind of prevention and treatment osteoarthritis composition according to claim 3, which is characterized in that the preparation of the pressed candy
Method includes one or both of tabletting after direct powder compression, wet granulation；The preparation method of the solid beverage includes
One or both of dry granulation, wet granulation.
5. a kind of prevention and treatment osteoarthritis composition according to claim 4, which is characterized in that the direct powder compression tool
Body are as follows: by collagen, non denatured collagen, chitosan oligosaccharide, turmeric, inulin, isomalt, microcrystalline cellulose, malt
Dextrin, magnesium stearate are added in mixing machine after powder processed uniformly mix to obtain mixed powder respectively, then by mixed powder directly in tablet press machine
After upper tabletting, pressed candy is packed to obtain.
6. a kind of prevention and treatment osteoarthritis composition according to claim 4, which is characterized in that tabletting after the wet granulation
Specifically: by collagen, non denatured collagen, chitosan oligosaccharide, turmeric, inulin, isomalt, microcrystalline cellulose, wheat
It is added in granulator and mixes after bud paste refined powder, add solvent and once stirred, solvent, secondary agitation are added after shutdown
Discharging and dry softwood afterwards, are sieved, then add magnesium stearate after carrying out redrying, whole grain after particle is made in softwood, mix
Pressed candy is packed to obtain in even rear tabletting.
7. a kind of prevention and treatment osteoarthritis composition according to claim 4, which is characterized in that the dry granulation is specific
Are as follows: it is added to dry-pressing in granulator after mixing collagen, non denatured collagen, chitosan oligosaccharide, turmeric, maltodextrin and pelletizes
And be sieved, pack to obtain solid beverage.
8. a kind of prevention and treatment osteoarthritis composition according to claim 4, which is characterized in that the wet granulation is specific
Are as follows: collagen, non denatured collagen, chitosan oligosaccharide, turmeric, maltodextrin are added in granulator and are mixed, is added molten
Agent is once stirred, and adds solvent after shutdown, is discharged after secondary agitation and dry softwood, and mistake after particle is made in softwood
Sieve, most afterwards through redrying, screening, pack to obtain solid beverage.
9. a kind of prevention and treatment osteoarthritis composition according to claim 6 or 8, which is characterized in that the solvent include water,
One or both of ethyl alcohol.
10. a kind of application of prevention and treatment osteoarthritis composition as described in claim 1 in food, which is characterized in that described
The dosage form that composition can be made into one or both of pressed candy, solid beverage is applied in food.
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