JP2011223965A - Foodstuff compound containing collagen - Google Patents
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本発明は、コラーゲンを含む食品化合物に関し、特に関節痛を緩和し、軟骨の生成を促進して骨の健康を改善する保健食品に係わる。 The present invention relates to a food compound containing collagen, and more particularly to a health food that alleviates joint pain and promotes cartilage formation to improve bone health.
正常で標準的な人体には206個の骨格がある。骨格は人体に対して二つの重要な機能を備えている。一つ目は固い骨格のフレームを提供してその他の身体組織を保護すること。二つ目は、固い梃子のシステムでそれが筋肉の力を用いて移動できることにある。そのため、骨格は人の活動メカニズムに於いて重要な鍵となる。一般的に、人の骨格の発展は、0〜0歳の骨格成長期、11〜20歳の黄金発育期、21〜35歳の鍵となる補充期及び35歳以上的骨質流失期となっている。それは人が中年に入ったところから骨格の健康についての意識を持ち始めた時、既に鍵となる補充期を過ぎていて骨質が流出する段階に進んでいることを表している。 A normal and normal human body has 206 skeletons. The skeleton has two important functions for the human body. The first is to provide a solid skeletal frame to protect other body tissues. The second is that it is a rigid insulator system that can be moved using muscle power. Therefore, the skeleton is an important key in human activity mechanisms. In general, human skeletal development consists of 0 to 0 years of skeletal growth, 11 to 20 years of golden growth, 21 to 35 years of key supplementation, and over 35 years of bone loss. Yes. It shows that when a person begins to have consciousness about skeletal health from the middle age, it has already passed the key replenishment period and is proceeding to the stage where bone quality flows out.
現在、よく見られる骨の疾病は関節炎であり、関節炎の原因はおよそ、軟骨の破壞、関節ライナー(滑液膜)、血管、腱、筋肉と靭帯の炎症、関節滑液内に発生した結晶、筋肉もしくは腱の萎縮もしくは短縮に依る関節の変形、皮膚の硬質化、内臓器官の傷害、関節活動能力の喪失及び筋力の衰えであり、上述の原因を総合的に見ると、適度な運動習慣の他に、関節炎を予防する最も良い方法は、骨質、関節軟骨及び関節液の主要成分を補充することである。 Currently, the most common bone disease is arthritis, and the causes of arthritis are roughly cartilage rupture, joint liner (synovial membrane), inflammation of blood vessels, tendons, muscles and ligaments, crystals formed in joint synovial fluid, Joint deformation due to muscle or tendon atrophy or shortening, stiffening of the skin, damage to internal organs, loss of joint activity ability and weakness of muscles. Besides, the best way to prevent arthritis is to supplement the main components of bone quality, articular cartilage and joint fluid.
公知技術の各種問題を鑑み、問題を解決するため、本発明者は、長年の研究開発及び実務経験に基づき、一種のコラーゲンを含む食品化合物を提供し、上述の欠点を改善する In order to solve the problems in view of various problems in the known technology, the present inventor provides a food compound containing a kind of collagen based on years of research and development and practical experience, and improves the above-mentioned drawbacks.
解決しようとする問題点は、骨の疾病の多くが関節炎であり、それは骨質、関節軟骨及び関節液の主要成分の補充が足りない点である。 The problem to be solved is that many of the bone diseases are arthritis, which is a lack of supplementation of the main components of bone quality, articular cartilage and joint fluid.
コラーゲンを含む食品化合物(Peptan Joint TM)，は、関節炎の改善に有効で、軟骨の生成を促進し、関節痛を緩和する。本発明は、別にコラーゲンを含む食品化合物を提供し、コラーゲン及びグルコサミンをその主成分として含み、グルコサミンとコラーゲンが相乗効果を発揮する。同時に本発明のコラーゲンを含む食品化合物は、散剤分包、ドリンク飲料、カプセルもしくは錠剤の形式で健康食品もしくは医薬化合物として使用することを最も主要な特徴とする。 A food compound containing collagen (Peptan Joint ™ ) is effective in improving arthritis, promotes cartilage formation, and relieves joint pain. The present invention separately provides a food compound containing collagen and contains collagen and glucosamine as its main components, and glucosamine and collagen exert a synergistic effect. At the same time, the food compound containing the collagen of the present invention is most characterized by being used as a health food or a pharmaceutical compound in the form of powder sachet, drink beverage, capsule or tablet.
本発明のコラーゲンを含む食品化合物は、以下の利点がある。
１．この食品化合物は、骨質、関節軟骨及び関節液の主要成分を補充することによって、人の骨格の健康を維持する。
２．この食品化合物は、グルコサミン、コンドロイチン硫酸もしくは鶏軟骨エキスを添加することで、コラーゲンと相乗効果をもたらし、新陳代謝を促進し、骨格細胞増生作用を加速する。
The food compound containing collagen of the present invention has the following advantages.
1. This food compound maintains human skeletal health by supplementing the main components of bone quality, articular cartilage and joint fluid.
2. By adding glucosamine, chondroitin sulfate or chicken cartilage extract, this food compound has a synergistic effect with collagen, promotes metabolism, and accelerates skeletal cell proliferation.
一種のコラーゲンを含む食品化合物を提供し、骨質、関節軟骨及び関節液の主要成分を補充することによって人の骨格の健康を維持することを本発明の目的とする。 It is an object of the present invention to provide a food compound containing a kind of collagen and maintain human skeletal health by supplementing the main components of bone quality, articular cartilage and joint fluid.
本発明の目的に基づき、一種のコラーゲンを含む食品化合物を提供し、重量百分濃度10%〜60%のコラーゲンを主要な有効成分として含む。そのうち、コラーゲンは、酸、アルカリもしくは酵素の加水分解処理を経て分子量が400〜4000ダルトン(Dalton)の間になる。 On the basis of the object of the present invention, a food compound containing a kind of collagen is provided, which contains 10% -60% collagen as a main active ingredient. Among them, collagen has a molecular weight of 400 to 4000 Dalton through hydrolysis of acid, alkali or enzyme.
本発明の上述の目的、特徴及び長所を更に明らかにするため、以下に本発明のコラーゲンを含む食品化合物の良好な実施例を挙げて説明する。 In order to further clarify the above-mentioned objects, features and advantages of the present invention, the following description will be made with reference to preferred examples of food compounds containing the collagen of the present invention.
本発明者は、研究と実験を経て、一種のコラーゲンを含む食品化合物を探し出した。多種のテストで表れたとおり、本発明の食品化合物は、関節炎を改善し、軟骨の生成を促進し、関節痛の緩和に極めて良好な効果があり、本発明が完成した。 The inventor searched for a food compound containing a kind of collagen through research and experiments. As shown in various tests, the food compound of the present invention improves arthritis, promotes cartilage formation, and has a very good effect on alleviating joint pain, thus completing the present invention.
本発明のコラーゲンを含む食品化合物の特徴には、コラーゲンを主成分とすることを含む。コラーゲンは、食品化合物全体の重量百分率10%〜60%を占める。一般に販売されているコラーゲンの分子量は約300,000ダルトン(Dalton)であるが、本発明中に述べるコラーゲンは、酸、アルカリもしくは酵素加水分解処理を経るため、分子量はわずかに400〜4000ダルトン(Dalton)の間で人体により吸収されやすい。コラーゲンは人体の主に支えるたんぱく質である。皮膚、骨格、関節軟骨内臟から血管まで等すべてにコラーゲンが含まれ、重要な役割を演じている。また人体の正常な骨格内には80%のコラーゲンが含まれ、その機能は主にカルシウム、リン、ミネラル等成分に付着し、その後骨質を構成する。関節等軟骨組織は主な成分がコラーゲンであり、運動時の筋骨に柔軟及び弾性を与え、適時にコラーゲンを補充することで、筋骨関節から発生する痛みやだるさ及び炎症を緩和する。第二型コラーゲンは、軟骨組織内だけに存在し、軟骨細胞の生成を促進し、骨の関節機能の保護を行う。正常軟骨関節の構成は、水分が最も多く、次に第二型コラーゲンと糖タンパク質となる。また軟骨は第二型コラーゲンと糖タンパク質が規則によってびっしりと一つに連なっているため、コラーゲンと糖タンパク質量が減少すると、構造が壊れ、軟骨が薄くなり、更には関節炎等の症状が表れる。 The food compound containing collagen according to the present invention includes collagen as a main component. Collagen accounts for 10% to 60% by weight of the total food compound. The molecular weight of collagen generally sold is about 300,000 Dalton, but the collagen described in the present invention is subjected to acid, alkali or enzyme hydrolysis treatment, so that the molecular weight is only 400-4000 Dalton. Are easily absorbed by the human body. Collagen is a protein that mainly supports the human body. Collagen is contained in everything from skin, skeleton, articular cartilage lining to blood vessels, and plays an important role. In addition, 80% collagen is contained in the normal skeleton of the human body, and its function adheres mainly to components such as calcium, phosphorus and minerals, and then constitutes bone quality. Collagen tissue such as joints is mainly composed of collagen, and gives softness and elasticity to musculoskeletal bones during exercise, and replenishes collagen in a timely manner, thereby relieving pain, dullness and inflammation generated from musculoskeletal joints. The second type collagen exists only in the cartilage tissue, promotes the production of chondrocytes, and protects the joint function of the bone. The structure of normal cartilage joints has the most water, followed by type 2 collagen and glycoprotein. In addition, since the type 2 collagen and glycoprotein are closely linked to each other by regulation, if the amount of collagen and glycoprotein decreases, the structure is broken, the cartilage becomes thin, and symptoms such as arthritis appear.
本発明のコラーゲンを含む食品化合物は、グルコサミン、コンドロイチン硫酸及び鶏軟骨エキスを含む。コラーゲンは、人体内の主要な支えるたんぱく質である。皮膚、骨格、関節軟骨、内臓から血管等まですべてにコラーゲンは含まれ、重要な役割を演じている。人体の正常骨格内には80%のコラーゲンが含まれ、その機能は主にカルシウム、リン、ミネラル等成分に粘着し、骨質を構成する。関節等軟骨組織は、主な成分がコラーゲンで、運動時に筋骨の柔軟及び彈性を保ち、適時にコラーゲンを補充することによって、筋骨関節に発生する痛みやだるさ炎症を緩和する。第二型コラーゲンは、ただ軟骨組織内だけに存在し、軟骨細胞の生成を促進して骨の関節機能を保護する。正常軟骨関節の構成は、水分が最も多く、次に第二型コラーゲンと糖タンパク質となる。また軟骨は第二型コラーゲンと糖タンパク質が規則によってびっしりと一つに連なっているため、コラーゲンと糖タンパク質量が減少すると、構造が壊れ、軟骨が薄くなり、更には関節炎等の症状が表れる。グルコサミンは、動物及び人体内の一種のアミノ糖で、体内で作られ、軟骨基質と結合組織の各所に存在し、股関節間の緩衝粘液の主要成分を構成し、軟骨細胞の最も重要な栄養素の一である。グルコサミンは人体に吸収されやすく、関節コンドロイチン硫酸及び関節液の重要成分の形成を促進し、骨関節の粘液弾性を高め、関節の退化、摩擦炎症、痛み、膨張変形を改善し、関節代謝の正常化を助け、関節の活動機能を改善し、骨密度と硬度を高める。コンドロイチン硫酸が関節の軟骨内に大量に集中すると、軟骨細胞が十分な水分を保ち、緩衝潤滑作用を達成する。また、軟骨が必要とするコラーゲンが作られることにより、流出した軟骨が新たになる。コンドロイチン硫酸にグルコサミンを加えると、相乗効果を発揮するため、グルコサミンとコンドロイチン硫酸の二種成分は併用し、骨関節の炎症を軽減するだけでなく、病例に依っては人を悩ます関節炎が治癒したと言う報告もある。鶏軟骨エキスはヒアルロン酸(Hyaluronic Acid)を含み、天然の多糖類で、主に関節液、軟骨、滑膜、靭帯内に存在し、含まれる量は年齢の増加に従って減少していく。ヒアルロン酸と関節附近の潤滑液は成分が似ていて、その作用は関節部位の水分を補充し、関節の潤滑液が流失して摩擦に依って傷つかないようにするが、医療機関では通常、関節部位に注射して補充している。服用する高分子量のヒアルロン酸は、スキンケアと、関節組織の健康を促進するのに、良好な効果を備える。 The food compound containing collagen of the present invention includes glucosamine, chondroitin sulfate and chicken cartilage extract. Collagen is the main supporting protein in the human body. Collagen is contained in everything from skin, skeleton, articular cartilage, viscera to blood vessels, and plays an important role. The normal skeleton of the human body contains 80% collagen, and its function mainly adheres to calcium, phosphorus, minerals, and other components to form bone quality. The main component of cartilage tissues such as joints is collagen, which keeps the musculoskelet's softness and inertia during exercise, and replenishes the collagen in a timely manner, thereby relieving pain and dull inflammation occurring in the musculoskeletal joint. The second type collagen is present only in the cartilage tissue and promotes the production of chondrocytes to protect the joint function of the bone. The structure of normal cartilage joints has the most water, followed by type 2 collagen and glycoprotein. In addition, since the type 2 collagen and glycoprotein are closely linked to each other by regulation, if the amount of collagen and glycoprotein decreases, the structure is broken, the cartilage becomes thin, and symptoms such as arthritis appear. Glucosamine is a type of amino sugar in animals and the human body, made in the body, present in various parts of the cartilage matrix and connective tissue, and constitutes the main component of buffer mucus between hip joints and is the most important nutrient of chondrocytes It is one. Glucosamine is easily absorbed by the human body, promotes the formation of joint chondroitin sulfate and important components of joint fluid, increases the mucoelasticity of bone joints, improves joint degeneration, friction inflammation, pain, swelling deformation, normal joint metabolism , Improve joint activity function, increase bone density and hardness. When chondroitin sulfate is concentrated in large amounts in the cartilage of the joint, the chondrocytes retain sufficient water and achieve a buffer lubrication action. In addition, the outflowing cartilage is renewed by producing the collagen required by the cartilage. When glucosamine is added to chondroitin sulfate, a synergistic effect is exerted. Therefore, glucosamine and chondroitin sulfate are used in combination to reduce inflammation of the bone and joint, and in some cases, arthritis that afflicts people is cured. There is also a report saying. Chicken cartilage extract contains hyaluronic acid and is a natural polysaccharide, mainly present in synovial fluid, cartilage, synovium, and ligaments, and the amount contained decreases with increasing age. Hyaluronic acid and the lubricant near the joint are similar in their components, and their action replenishes the joint area and prevents the joint lubricant from being washed away and damaged by friction. The joint site is injected and replenished. The high molecular weight hyaluronic acid taken has good effects in promoting skin care and joint tissue health.
本発明のコラーゲンを含む食品化合物は、混合した粉末で、混合した後の粉末を散剤分包にして使用する。骨格の健康を改善する保健散剤分包として用いる。混合した後の粉末は水に溶かして溶液にし、骨格の健康を改善する保健ドリンク飲料として用いる。平均して混合した後の粉末と乳糖、澱粉、麥芽糊等添加剤を混ぜて混合した後、加圧して錠剤にし、骨格の健康を改善する保健錠剤として用いる。混合した後の粉末充をカプセル内に入れ、骨格の健康を改善する保健カプセルとして用いる。そのうち、各剤型の骨格の健康を改善する保健食品は、すべて医薬化合物として使用することができる。 The food compound containing collagen of the present invention is a mixed powder, and the mixed powder is used as a powder sachet. Used as a health powder sachet to improve skeletal health. The powder after mixing is dissolved in water to form a solution, which is used as a health drink to improve the health of the skeleton. The powder after mixing on average and additives such as lactose, starch, and bud paste are mixed and mixed, and then pressed into tablets to be used as health tablets to improve the health of the skeleton. The powder filling after mixing is put in a capsule and used as a health capsule for improving skeletal health. Among them, all health foods that improve the health of the skeleton of each dosage form can be used as pharmaceutical compounds.
２歳成年ラット各１０匹を三組に作り、30ミリグラム入りコラーゲンを一組に、30ミリグラム入りグルコサミンを一組に、更に20ミリグラムのコラーゲンと10ミリグラムのグルコサミン混合物入りの餌を毎日それぞれに二週間与えたところ、二週間後の各組のラットの活動時間が栄養品を与える前と比べて大幅に増加した。更に、20ミリグラムのコラーゲンと10ミリグラムのグルコサミン混合物を与えた一組のラットたちは、毎日の運動時間が別の組のラットに比べて１．５倍以上に増えた。実験は、本発明のコラーゲンを含む食品化合物が明らかに関節炎の痛みを緩和し、骨格の健康を改善することを実証している。 Make two 10-year-old adult rats in triplicate, 30 mg of collagen in one set, 30 mg of glucosamine in one set, and 20 mg of collagen and 10 mg of glucosamine mixture each day. When given weekly, the activity time of each pair of rats after two weeks was significantly increased compared to before feeding the nutrients. In addition, one set of rats given 20 milligrams of collagen and 10 milligrams of glucosamine mixture increased daily exercise time more than 1.5 times compared to another set of rats. Experiments demonstrate that the food compounds containing collagen of the present invention clearly relieve arthritic pain and improve skeletal health.
三組各20名の関節炎患者に300ミリグラム入りコラーゲンカプセルを、また300ミリグラム入りグルコサミンのカプセルを、また200ミリグラム入りコラーゲンと100ミリグラムのグルコサミンのカプセルをそれぞれ、毎日一粒、四週間服用してもらった。300ミリグラム入りコラーゲンカプセルを服用した関節炎患者の30%が、関節痛が緩和したと感じ、300ミリグラム入りグルコサミンカプセルを服用した関節炎患者の50%が、関節痛が緩和したと感じ、また200ミリグラム入りコラーゲン及び100ミリグラム入りグルコサミンカプセルを服用した関節炎患者の85%が、関節痛が緩和したと感じており、実験は本発明のコラーゲンを含む食品化合物が関節痛を緩和し、骨格の健康を改善していることを実証している。 Each group of 20 arthritis patients received 300 milligrams of collagen capsules, 300 milligrams of glucosamine capsules, 200 milligrams of collagen and 100 milligrams of glucosamine capsules, one daily for four weeks. It was. 30% of arthritic patients who took 300 milligrams of collagen capsules felt that their joint pain had relieved, 50% of arthritic patients who took 300 milligrams of glucosamine capsules felt that their joint pain had relieved, and 200 milligrams 85% of arthritic patients taking collagen and 100 mg glucosamine capsules feel that joint pain has been alleviated, and experiments show that the food compound containing collagen of the present invention reduces joint pain and improves skeletal health. It has been proved that.
以上は例を挙げただけでありが、この領域に習熟した者には明らかである。本発明の技術思想の範囲内に於いて、多様な変形及び修飾ができる。該変形及び修飾は当然、請求範囲内に含まれる。 The above is just an example, but it is clear to those who are proficient in this area. Various modifications and modifications can be made within the scope of the technical idea of the present invention. Such variations and modifications are naturally within the scope of the claims.
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Claims (10)
重量百分濃度10%〜60%のコラーゲンを主な有効成分として含むことを特徴とするコラーゲンを含む食品化合物。 In food compounds containing collagen,
A food compound containing collagen, characterized by containing collagen having a weight percent concentration of 10% to 60% as a main active ingredient.
The food compound containing collagen according to claim 1, wherein the food compound containing collagen is used as a pharmaceutical compound.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101565159B1 (en) | 2014-01-23 | 2015-11-02 | (주)비아바이오텍 | Compositions for preventing or treating aging and arthritis |
| CN110214947A (en) * | 2019-06-12 | 2019-09-10 | 宁波依萃健生物科技有限公司 | A kind of prevention and treatment osteoarthritis composition |
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2010
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101565159B1 (en) | 2014-01-23 | 2015-11-02 | (주)비아바이오텍 | Compositions for preventing or treating aging and arthritis |
| CN110214947A (en) * | 2019-06-12 | 2019-09-10 | 宁波依萃健生物科技有限公司 | A kind of prevention and treatment osteoarthritis composition |
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