CN109567157A - A kind of composition and preparation method thereof for improving bony articulation health - Google Patents
A kind of composition and preparation method thereof for improving bony articulation health Download PDFInfo
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- CN109567157A CN109567157A CN201811236271.1A CN201811236271A CN109567157A CN 109567157 A CN109567157 A CN 109567157A CN 201811236271 A CN201811236271 A CN 201811236271A CN 109567157 A CN109567157 A CN 109567157A
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- 210000002950 fibroblast Anatomy 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000002478 hand joint Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
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- 238000011835 investigation Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000008376 long-term health Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 244000005700 microbiome Species 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 235000011576 oleuropein Nutrition 0.000 description 1
- RFWGABANNQMHMZ-CARRXEGNSA-N oleuropein Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)C(=CC)[C@H]1CC(=O)OCCc3ccc(O)c(O)c3 RFWGABANNQMHMZ-CARRXEGNSA-N 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
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- 230000003349 osteoarthritic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
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- 235000020636 oyster Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
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- 235000019509 white turmeric Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to a kind of compositions for improving bony articulation health, each component including following parts by weight, 1~6 part of non denatured typeⅡ Collagen, 10~50 parts of Cartilage collagen, 10~50 parts of Mussel Powder, 2~10 parts of olive fruit powder, 2~10 parts of turmeric, 30~50 parts, 10~40 parts of starch of sugar, 5~20 parts of microcrystalline cellulose, 1~5 part of magnesium stearate.The present invention is using raw materials such as non denatured typeⅡ Collagen, Cartilage collagen, Mussel Powder, olive fruit powder, turmerics, cartilage core nutrition can either be supplemented, cartilage lubricating fluid is promoted to generate, inflammatory factor caused by can inhibiting simultaneously because of cartilage loss, the effects of to alleviate arthralgia, to improving, osteoarthritis effect is significant.
Description
Technical field
The present invention relates to the healthy food fields improved with prevention bone and joint diseases, and in particular to one kind is for improving bone pass
Save the composition and preparation method thereof of health.
Background technique
Osteoarthropathy (osteoarthritis, OA) is a kind of clinically relatively common disease, including degeneration is closed
Save inflammation, bursal synovitis, synovitis, cervical spondylosis, lumbar vertebra disease, scapulohumeral periarthritis, osteoproliferation, rheumatic arthritis, rheumatoid arthritis,
Caput femoris necrosis etc..The basic reason of illness is not that lesion has occurred in bone, modern medical research has found that, old complaint is that soft
Forfeiture of the bone etc. " joint protection system " to joint protective capability.The generation of all kinds of bone and joint diseases often start from the lesions of synovium contributed,
Cartilage is impaired or is denaturalized, and taking cartilage damage caused by certain anti-inflammatory classes, hormone medicine is also many bone and joint diseases
One of main reason.Due to the missing of synovium of joint, the damage of cartilage and knuckle synovia, lead joint bone lack it is necessary
Protection, so that due to a lack of necessary " cartilage protection " violent rigid friction directly occurs for one activity of human body, the bone of joint,
And cause a variety of symptoms such as patient articular's pain, swelling, deformation, spur hyperplasia.Even more important, if human synovial organ is exempted from
Epidemic disease imbalance, joint necessarily cause the intrusion of extraneous inflammatory factor due to a lack of necessary " immunoprotection ", eventually lead to diverse bone types
The generation of joint disease.Bone and joint diseases disease incidence in mid-aged population is higher, with the aging trend of China human mortality, bone
Joint disease becomes us and has to face major issue, and bone and joint diseases directly affect the life matter of the elderly
Amount, and the therapeutic process of bone and joint diseases is a quite very long process, and the not only patient itself being in a bad way needs to hold
By ailing torment, also household can be caused to tie down.The pain and dysfunction of osteoarthropathy lead to the serious of disability
Property, quite even greater than cardio-cerebrovascular diseases.2000~2010 years are set to " Bones and joints 10 years " by the World Health Organization, will
2010~the year two thousand twenty is defined as second " Bones and joints 10 years ", it is seen that height weight of the bony articulation health by the World Health Organization
Depending on.
Improve bone and joint diseases health, it is necessary to start with from old complaint, the internal cause really fallen ill and bone and cartilage nutritional deficiency and
Nutrition and Metabolism disorder is related, and supplementing and keep osteotrophy always is the normal morphology structure of nutrition and reparation bone and Bones and joints,
Maintain complete physiological function, the important link of pre- preventing bone rarefaction, osteoproliferation and osteoarthritis.Supplement bone closes currently on the market
Section nutriment mainly has ammonia carbohydrate chondroitin sulfates health food, collagen and Chinese herbal and crude drugs preparations etc..Such as patent application
Number are as follows: 200910058056.1 disclose a kind of health-care food composition for promoting bone and bony articulation health, the composition battalion
Predominantly oyster, Hydrolyzed Collagen are formed point, mainly supplements Bones and joints nutritional ingredient, and collagen is hydrolytic collagen egg
It is white and limited to arthralgia and inflammation mitigation effect.Number of patent application discloses a kind of for changing for 201410463434.5
The important health care preparation of kind osteoarticular function, preparation face using Chinese yam, the rhizome of davallia, Morinda officinalis, Cortex Eucommiae, calcium carbonate as material combination
Bed experiments have shown that, the Chinese materia medica preparation to fracture, cartilage damage, osteoproliferation, rheumatoid, braking time too long caused by joint function
Energy obstacle has improvement and castering action well.This Chinese materia medica preparation is logical to mend three cokes, liver-nourishing kidney-boosting, dispel mainly from theory of traditional Chinese medical science
Wind dehumidifying, strengthening the muscles and bones, to promote function of joint, but can not supplement cartilage nutritional ingredient, cannot fundamentally improve bone
Joint disease；Application No. is 201610262529.X patent disclosure it is a kind of improve Bones and joints health care product and preparation method thereof,
Its effective component includes 10-40 parts of calcium carbonate, 15-40 parts of aminoglucose hydrochloride, 10-30 parts of chondroitin sulfate.This health care food
Product can supplement cartilage nutrition, increase the function of bone density, improve bony articulation health, but its primary raw material is health food original
Material, and the factor that cannot diminish inflammation very well.Therefore, the present invention is to supplement non denatured typeⅡ Collagen and Cartilage collagen
Based on typeⅡ Collagen, and the property ingredient characterized by non denatured typeⅡ Collagen, and add Mussel Powder, olive fruit powder, ginger
Yellow and sugar is auxiliary material, and exploitation improves the ordinary food of bony articulation health.Cartilage nutrition is fundamentally supplemented, Bones and joints lubrication is promoted
The generation of liquid, while the effect of promoting anti-inflammatory factors to generate substance is supplemented, to mitigate and eliminate the diseases such as bone and joint diseases distending pain
Shape fundamentally improves bony articulation health problem.
Summary of the invention
To overcome the shortcomings of existing technologies, the present invention provide it is a kind of improve bony articulation health composition and its preparation side
Method, the technical scheme is that
It is a kind of for improving the composition of bony articulation health, each component including following parts by weight, non denatured II Collagen Type VI
1~6 part of albumen, 10~50 parts of Cartilage collagen, 10~50 parts of Mussel Powder, 2~10 parts of olive fruit powder, 2~10 parts of turmeric, sugar
30~50 parts, 10~40 parts of starch, 5~20 parts of microcrystalline cellulose, 1~5 part of magnesium stearate.
4 parts of the non denatured typeⅡ Collagen, 30 parts of Cartilage collagen, 30 parts of Mussel Powder, 6 parts of olive fruit powder,
5 parts of turmeric, 40 parts, 25 parts of starch, 10 parts of microcrystalline cellulose, 3 parts of magnesium stearate of sugar.
The sugar is one of lactose, isomalt, xylitol or oligofructose.
A method of what is prepared is used to improve the composition of bony articulation health, comprising the following steps:
(1) each component is weighed according to the proportion of component, wherein protein content in non denatured typeⅡ Collagen used >=
10%, protein content >=30% in Cartilage collagen, protein content >=60% in Mussel Powder, hydroxytyrosol contains in olive fruit powder
Amount >=4.5%；Curcumin In Curcuma content >=95%；
(2) non denatured typeⅡ Collagen, olive fruit powder, turmeric are mixed, the sugar that 50% formulation weight part is added carries out
Artificial premix, forms premix；
(3) sequentially added in three-dimensional mixer Cartilage collagen, Mussel Powder, remaining 50% formulation weight part sugar with
And pre- mixed non denatured typeⅡ Collagen, olive fruit powder and turmeric premix in step (2)；Controlling mixing machine revolving speed is
10r/min, incorporation time 30-50min；
(4) composition being uniformly mixed in step (3) is transferred to wet granulator, 10% starch is added by formula rate
Slurry, and be granulated with 18 mesh screens, it is pumped into Fluidbedgranulatingdrier drying after granulation, selects grain with 18 mesh screens after drying, particle waits for
With；
(5) particle in step (4) is added to the 3d motion mixer with microcrystalline cellulose and magnesium stearate, control mixing
Machine revolving speed is 10r/min, incorporation time 30-50min；
(6) composition being uniformly mixed in step (5) is transferred to tablet press machine and carries out tabletting, adjust tablet press machine control parameter,
Control every slice weight 700mg；
(7) sheeted product in step (6) is coated；
(8) it after product after step (7) coating being carried out appearance and slice weight inspection, is dispensed with automatic packer.
The invention has the advantages that
Present invention property ingredient characterized by non denatured typeⅡ Collagen adds Cartilage collagen, Mussel Powder, olive fruit
Powder, turmeric, sugared auxiliary material exploitation improve bony articulation health product, and composite formula is same in supplement articular cartilage core nutritional ingredient
When, the symptoms such as anti-inflammatory, mitigation arthralgia can be played.Wherein non denatured typeⅡ Collagen, which can play, provides collagen and anti-inflammatory work
With；Cartilage collagen is to hydrolyze typeⅡ Collagen to can be used as joint matrix containing a large amount of chondroitin sulfates；Mussel Powder contains
There are a large amount of Glucosamines, glycosaminoglycan (GAG), minerals calcium and magnesium, Omega3 polyunsaturated fatty acid, forms cartilaginous element sulphur
Aching and limp ossein, hyaluronic acid, play it is anti-inflammatory, relieve pain, minerals are provided.Olive fruit powder and turmeric can play anti-inflammatory, anti-
Oxidation, plays the role of relieving pain, formula advantage is as follows:
Collagen: collagen is one of extracellular matrix important feature albumen, is synthesized by fibroblast, extensively
It is distributed in the tissue such as cartilage, bone, skin, hair, tendon forceps, blood vessel, accounts for the 25%-30% of body protein total amount, be human body
The protein that distribution is most wide, content is most plays a part of protecting body, support organ.In numerous collagen Related products,
It carefully analyzes, effective component can be summarized as two kinds: Hydrolyzed Collagen and typeⅡ Collagen.Wherein hydrolytic collagen egg
It is white to be related to many different sources, there are ox bone source, pigskin source, fish skin and scale source.II Collagen Type VI is mostly chicken cartilage source,
It is typeⅡ Collagen that cartilage, which removes 55%-65% except moisture, and the metabolism that typeⅡ Collagen participates in cartilage is outer, is also joined
It is related with the occurrence and development of certain diseases, such as osteoarthritis (OA), rheumatoid arthritis (RA).Medical college, Harvard University
Dr.David Trentham, which is studied, to be thought, " typeⅡ Collagen must be that non denatured (prototype) just has effects that ", non denatured II
Collagen type with low temperature extract without destroying molecular structure, keep the typeⅡ Collagen of very bioactivity, completely
Possess collagen helix structure.Non denatured typeⅡ Collagen is innovative health-care components, studies have shown that arthritic
For, non denatured typeⅡ Collagen is taken, can effectively slow down arthralgia and inflammation, stopping cartilage being closed by rotten, improvement is invaded
It saves flexibility, reparation and cartilage regeneration, promote Bones and joints long-term health.
Mussel Powder: mussel (Mytilus sp.) belongs to Mollusca (Mollusca) lamellibranchiata
(Lanellibranchia) Anisomyaria (Anisomyaria) mussel race (Mytilacea) Mytilidae (Mytidea) is a kind of wide
The general Bivalve aquatic products for being globally distributed various regions.Mussel is adaptable by force, disease is few, growth is rapid, yield is high, nutrition is rich
It is rich and be easy to the features such as cultivating.The nutritive value of mussel is very high, is rich in a variety of essential amino acids, polyunsaturated fatty acid, mineral
Matter and vitamin etc..In addition, it is there are also biologically active substances such as the distinctive succinic acid of shellfish, glyceric acid, glycine betaines, because
This is described as the laudatory titles such as " marine egg ", " East Sea madam " by people.Modern science research shows that mussel have anti-inflammatory, anticancer,
Anti-oxidant, antibacterial, decompression, anti-disease of cardiovascular system isoreactivity.Research has confirmed that New Zealand's Perna viridis has very strong
Anti-inflammatory activity, especially to some chronic inflammation class disease such as rheumatoid arthritis, osteoarthritis, asthma, inflammatory bowel disease
Etc. all showing certain curative effect.Epidemiological investigation the result shows that, New Zealand Maoris is local due to often eating
The disease incidence of a kind of Perna viridis, the relevant disease of inflammation is much lower compared with other areas.It is found unintentionally from the age in last century new
Since western orchid Perna viridis can improve arthritic's pain symptom and joint stiffness symptom, many scientists are to New Zealand bird with red feathers
The Anti-arthritic activity of emerald green mussel has carried out people's quantifier elimination and verifying, including animal experiment, human trial and in vitro test etc..
Clinical research also indicates that curative effect of the fat-soluble extract to rheumatic arthritis and osteoarthritis disorders of New Zealand's Perna viridis
Respectively up to 6 0% and 50% or so.Shellfish dry powder and mussel fat-soluble extract are to caused by rheumatic arthritis, osteoporosis
Arthralgia and section swelling have good relaxation effect.Bierert etc. has found dog feeding Green Lipped Mussel digested tankage, after 6 weeks, compares
According to group arthralgia, in terms of be obviously improved.The clinical researches such as Cho show mussel fat-soluble extract
To patients with osteoarthritis improve significantly illness effect, by 4 weeks and treatment in 8 weeks, there is 53% and 80% patient respectively
Illness mitigates, and function improves, and has no adverse reaction during treating.
Olive fruit powder: olive Oleaeuropaea L. is Oleaceae Olea aiphyllium, is world-renowned wood
This oil tree has more than 4,000 years cultivation histories.Research shows that olive have enhancing health of heart, anticancer, antibacterial, it is anti-inflammatory,
A variety of biologies such as anti-oxidant and pharmacological activity.Modern biotechnology analysis shows, active material mainly has olive more in olive
Phenol, flavonoids, secoiridoid (including oleuropein), biflavone etc..Experimental results demonstrate olive polyphenol extracts to have
Stronger free radical scavenging ability and higher antioxidant activity.It is some research shows that, oxidation can aggravate osteoporosis
Degree, and food of the resident of Mediterranean Region due to more eating olive oil component, developing osteoporosis rate are significantly lower than
Other areas, and average age of onset is later.It can promote the suction again of bone according to another cell factors such as document report TNF-α, IL-6
It receives, improves bone marrow microenvironment, olive polyphenol has the function of the activity for improving these cell factors and secretory volume, olive polyphenol pair
Ovariectomized rat bone density and calcium content of bone influence studies have shown that olive polyphenol can to dramatically increase ovariectomized rat femur close
Degree and calcium content of bone.In addition, there is preferable anti-inflammatory and analgesic effect simultaneously due to high-content polyphenol in olive fruit powder.To olive
Olive polyphenol mitigates bone joint pain investigation and shows to randomly select 100 patients from 300 people (containing rheumatoid arthritis and bone
Arthritic patient), health evaluating questionnaire is filled in front of testing.It is divided into two groups of A, B below, A group takes placebo, and B group is taken
HIDROX, 8 Zhou Houzai complete health evaluating questionnaire under physician guidance, the results showed that, after eating olive fruit powder, rheumatic is closed
Section is scorching and osteoarthritis has good improvement.Therefore, olive fruit powder can reduce the inflammation and swelling in joint, and support
The healing of damaged cartilage.All joint cases, such as pain, limitation of activity or tissue damage etc. tested, are all shown
Work is releived.The immune system for maintaining a balance is helped, and is proved in serious joint disease, such as chornic arthritis and Bones and joints
The case of the Conventional treatment regimens such as inflammation failure, situation of all being releived well.
Turmeric: turmeric is widely used in centuries as the traditional medicine of dual-purpose of drug and food in oriental countries, is daily
Common flavouring and natural pigment in life.Its main component with pharmacological action is curcumin, curcumin (cur
Cumin) be from Zingiber curcuma turmeric, Radix Curcumae, curcuma zedoary dry rhizome in extract a kind of natural activity it is low opposite
Molecular mass polyphenol compound.Recent study shows that curcumin has multiple pharmacological effect, such as anti-inflammatory, anti-oxidant, anti-swollen
Tumor adjusts the extensive pharmacological actions such as blood lipid, anticoagulant, anti-fibrosis, and toxicity is low, and adverse reaction is few.Curcumin, which has, inhibits more
The effect of kind inflammatory factor, being capable of a large amount of molecular targeted interactions relevant with to inflammation.It discloses at present, curcumin regulation is scorching
Disease reaction mainly by lowering the activity of COX-2, iNOS, lipoxidase, lowers Janus kinases and mitrogen-activated protein swashs
The expression of enzyme inhibits inflammatory cytokine, such as tumor necrosis factor (TNF)-α, interleukins (IL) -6, monocyte chemotactic
The generation of albumen etc..In recent years the study found that curcumin can improve the diseases such as pancreatitis, myocarditis, rheumatic arthritis
Symptom.Separately some researches show that the anti-inflammatory processing of curcumin can reduce systemic septicopyemia reaction symptom caused by various microorganisms.Turmeric
Usually by the substitute as NSAIDs.Results of in vitro studies confirms that curcumin can be used as diseases associated with inflammation (such as joint
It is scorching) natural material for the treatment of, curcumin is the potent inhibitor of human body cartilage cell PGE2, NO, IL -6 and IL-8 proinflammatory factor,
It can be by inhibiting cartilage matrix degrading enzyme to generate wholesome effect to cartilage degradation.
5.2 inventive principle
Skeleton is mainly made of collagen two parts of 2/3 calcium salt and 1/3, and articular cartilage is mainly by collagen
(59%), the composition such as proteoglycan (ammonia sugar) and cartilage cell.The middle-aged and the old's especially climacteric women, collagen, calcium, egg
White polysaccharide be lost be more than bon e formation speed, bone tissue becomes fragile, bone density rapid decrease, so as to cause osteoporosis,
Osteoproliferation and osteoarthritis, the degradation phenomenas such as performance of the osteoarthritis such as whole body bone joint pain, swelling, hyperplasia, modern times doctor
It learns and claims " bone declines "；That is " bone declines " is the reason of directly resulting in bone and bone and joint diseases.Both at home and abroad multiple studies have shown that,
During " bone declines " occurrence and development, the nutrition and metabolism of bone and cartilage play a significant role, the internal cause really fallen ill and bone and soft
Osteotrophy shortage is related with Nutrition and Metabolism disorder, supplements and keep osteotrophy to be nutrition and repair bone and Bones and joints just always
Normal morphosis maintains complete physiological function, the important link of pre- preventing bone rarefaction, osteoproliferation and osteoarthritis.Supplement bone
Articular cartilage core nutrition is conducive to the generation of joint lubrication liquid, adds anti-inflammatory Chinese traditional material, be conducive to anti-inflammatory factors and formed, mitigates
Osteoarthritic inflammation mitigates the symptoms such as arthralgia.
The composition for being used to improve bony articulation health of the invention, collagen sources are non denatured II Collagen Type VI egg
It is white, Cartilage collagen, and be typeⅡ Collagen, be conducive to supplement collagen in articular cartilage, cartilage matrix nutrition be provided,
It can play the role of anti-inflammatory, mitigation pain simultaneously；Wherein Mussel Powder contains a large amount of Glucosamines, glycosaminoglycan (GAG), mineral
Matter calcium and magnesium, Omega3 polyunsaturated fatty acid form cartilaginous element chondroitin sulfate, hyaluronic acid；Simultaneously can play it is anti-inflammatory,
It relieves pain, minerals is provided.Of the invention is used to improve the composition of bony articulation health, wherein playing anti-inflammatory, mitigation pain
The effect of left and right, substance was mainly turmeric, olive fruit powder.Turmeric, olive fruit powder play the role of inhibiting multiple inflammatory factors, reach
To anti-inflammatory, the effects of relieving pain.
The present invention uses the raw materials such as non denatured typeⅡ Collagen, Cartilage collagen, Mussel Powder, olive fruit powder, turmeric,
Can either supplement cartilage core nutrition, cartilage lubricating fluid is promoted to generate, at the same inflammation caused by can inhibiting because of cartilage loss because
The product of son, thus the effects of alleviating arthralgia.
Specific embodiment
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.Those skilled in the art
Member it should be understood that without departing from the spirit and scope of the invention can details to technical solution of the present invention and form into
Row modifications or substitutions, but these modifications and replacement are fallen within the protection scope of the present invention.
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
The specific raw material of 1 embodiment 1-5 of table forms
Embodiment 1:
(1) the non denatured typeⅡ Collagen 1kg of raw material, Cartilage collagen 50kg, Mussel Powder 35kg, olive fruit powder are taken
2kg, turmeric 8kg, lactose 45kg, starch 40kg, microcrystalline cellulose 20kg, magnesium stearate 5kg, non denatured II Collagen Type VI egg used
White middle protein content >=10%, protein content >=30% in Cartilage collagen, protein content >=60% in Mussel Powder, olive fruit
Hydroxytyrosol content >=4.5% in powder；Curcumin In Curcuma content >=95%, starch, microcrystalline cellulose, magnesium stearate are according to out
Factory's survey report is checked and accepted；
(2) by non denatured typeⅡ Collagen, olive fruit powder, turmeric mix, be added 50% formulation weight part lactose into
Pedestrian's work premix, forms premix；
(3) sequentially added in three-dimensional mixer Cartilage collagen, Mussel Powder, remaining 50% formulation weight part lactose
And pre- mixed non denatured typeⅡ Collagen, olive fruit powder and turmeric premix in step (2)；Controlling mixing machine revolving speed is
10r/min, incorporation time 30min；
(4) composition being uniformly mixed in step (3) is transferred to wet granulator, starch is made into 10% shallow lake with purified water
Slurry (is mixed, which is mass percent) with starch and water, and is granulated with 18 meshes.Boiling system is pumped into after granulation
Grain desiccant drying, selects grain with 18 meshes after drying, particle is stand-by；
(5) particle obtained by step (4) is added in three-dimensional mixer with microcrystalline cellulose and magnesium stearate and is uniformly mixed, controlled
Mixing machine revolving speed 10r/min processed, incorporation time 30min；
(6) composition being uniformly mixed in step (5) is transferred to tablet press machine and carries out tabletting, adjust tablet press machine control parameter,
Control every slice weight 700mg；
(7) sheeted product in step (6) is coated；
(8) it after product after step (7) coating being carried out appearance and slice weight inspection, is dispensed with automatic packer.
Embodiment 2:
(1) negated denatured II-type collagen 2kg, Cartilage collagen 40kg, Mussel Powder 40kg, olive fruit powder 8kg, ginger
Yellow 2kg, isomalt 45kg, starch 30kg, microcrystalline cellulose 15kg, magnesium stearate 4kg, non denatured II Collagen Type VI used
Protein content >=10% in albumen, protein content >=30% in Cartilage collagen, protein content >=60% in Mussel Powder, olive
Hydroxytyrosol content >=4.5% in fruit powder；Curcumin In Curcuma content >=95%；Starch, microcrystalline cellulose, magnesium stearate according to
Delivery Inspection Report is checked and accepted；
(2) non denatured typeⅡ Collagen, olive fruit powder, turmeric are mixed, the different malt of 50% formulation weight part is added
Ketose alcohol is manually premixed, and premix is formed；
(3) sequentially added in three-dimensional mixer Cartilage collagen, Mussel Powder, remaining 50% formulation weight part different wheat
Pre- mixed non denatured typeⅡ Collagen, olive fruit powder and turmeric premix in bud ketose alcohol and step (2)；Control mixing
Machine revolving speed is 10r/min, incorporation time 30min；
(4) composition being uniformly mixed in step (3) is transferred to wet granulator, starch is made into 10% shallow lake with purified water
Slurry, and be granulated with 18 meshes.It is pumped into the drying of boiling granulating desiccant after granulation, selects grain with 18 meshes after drying, particle is stand-by；
(5) particle obtained by step (4) is added in three-dimensional mixer with microcrystalline cellulose and magnesium stearate and is uniformly mixed, controlled
Mixing machine revolving speed 10r/min processed, incorporation time 30min；
(6) composition being uniformly mixed in step (5) is transferred to tablet press machine and carries out tabletting, adjust tablet press machine control parameter,
Control every slice weight 700mg；
(7) sheeted product in step (6) is coated；
(8) it after product after step (7) coating being carried out appearance and slice weight inspection, is dispensed with automatic packer.
Embodiment 3:
(1) negated denatured II-type collagen 4kg, Cartilage collagen 30kg, Mussel Powder 30kg, olive fruit powder 6kg, ginger
Yellow 4kg, lactose 40kg, starch 25kg, microcrystalline cellulose 10kg, magnesium stearate 3kg, egg in non denatured typeⅡ Collagen used
Bai Hanliang >=10%, protein content >=30% in Cartilage collagen, protein content >=60% in Mussel Powder, hydroxyl in olive fruit powder
Base tyrosol content >=4.5%；Curcumin In Curcuma content >=95%；Starch, microcrystalline cellulose, magnesium stearate are according to exfactory inspection
Report is checked and accepted；
(2) by non denatured typeⅡ Collagen, olive fruit powder, turmeric mix, be added 50% formulation weight part lactose into
Pedestrian's work premix, forms premix；
(3) it is sequentially added in three-dimensional mixer pre- mixed in Cartilage collagen, Mussel Powder, lactose and step (2)
Non denatured typeⅡ Collagen, olive fruit powder and turmeric premix；Control mixing machine revolving speed is 10r/min, and incorporation time is
30min；
(4) composition being uniformly mixed in step (3) is transferred to wet granulator, starch is made into 10% shallow lake with purified water
Slurry, and be granulated with 18 meshes.It is pumped into the drying of boiling granulating desiccant after granulation, selects grain with 18 meshes after drying, particle is stand-by；
(5) particle obtained by step (4) is added in three-dimensional mixer with microcrystalline cellulose and magnesium stearate and is uniformly mixed, controlled
Mixing machine revolving speed 10r/min processed, incorporation time 30min；
(6) composition being uniformly mixed in step (5) is transferred to tablet press machine and carries out tabletting, adjust tablet press machine control parameter,
Control every slice weight 700mg；
(7) sheeted product in step (6) is coated；
(8) it after product after step (7) coating being carried out appearance and slice weight inspection, is dispensed with automatic packer.
Embodiment 4:
Negated denatured II-type collagen 5kg, Cartilage collagen 20kg, Mussel Powder 20kg, olive fruit powder 8kg, turmeric
5kg, xylitol 50kg, starch 20kg, microcrystalline cellulose 8kg, magnesium stearate 2kg, the preparation method is the same as that of Example 1.
Embodiment 5:
Negated denatured II-type collagen 6kg, Cartilage collagen 10kg, Mussel Powder 10kg, olive fruit powder 10kg, turmeric
10kg, oligofructose 30kg, starch 10kg, microcrystalline cellulose 5kg, magnesium stearate 1kg, preparation method is the same as embodiment 2.
The present composition is to the clinical improvements effect observation of osteoarthritis and evaluation
1, experiment purpose: test the invention imitates human body osteoarthritis clinical improvements for improving bony articulation health composition
Fruit.
2, experimental subjects and method
2.1 experimental subjects
The diagnosis of Beijing orthopaedics section hospital determining osteoarthritis (degenerative arthritis) patient 128 is chosen, wherein
Male 60, female 68, the age 60-85 years old.Diagnostic criteria is referring to the related knee of American Society of Rheumatism revision, hand and hip joint
Osteoarthritis classification standard.All patients are divided into two groups of control group and test group, make the two groups patient age,
Gender, course of disease etc. have statistical comparativity.
2.2 experimental method
2.2.1 eating method
Test group, edible 3 composition two panels of the embodiment of the present invention, eats the course for the treatment of 6 weeks daily；Control group eats patent of invention
Application No. is the example 1 groups in 200910058056.1 to close object two panels, eats the course for the treatment of 6 weeks.
2.2.2 therapeutic evaluation
(1) cure: all symptoms completely disappear, and freely, laboratory checking index is completely normal for activity；(2) effective: all
Or cardinal symptom is eliminated, function of joint is restored substantially, can participate in normal work and labour, and laboratory checking index is normal or basic
Normally；
(3) effectively: cardinal symptom substantially eliminates, and major joint function is restored or has made marked progress substantially, and life cannot be certainly
Reason switchs to can take care of oneself, and major laboratories Index for examination makes moderate progress；(3) invalid: and before treatment relatively, various aspects are without obvious
Variation.
Total effective rate=cure rate+obvious effective rate+effective percentage
3 experimental results and conclusion
It eats after the test within 6 weeks, according to evaluation criterion, statistical results, and carries out statistical such as following table.
Table 2 is to improve osteoarthritis statistical result
| Group | Case load | Cure number | Effective number | Significant figure | Invalid number | Total effective rate |
| Control group | 64 | 12 | 16 | 12 | 24 | 62.5% |
| Test group | 64 | 30 | 22 | 9 | 3 | 95.3% |
By 2 statistical result of table it is found that edible 3 sample Human Osteoarthritis cure rate of the embodiment of the present invention and total effective rate are equal
Being significantly higher than control group to eat application number of invention patent is that the example 1 group in 200910058056.1 closes object.It is wherein total effective
Rate improves 32.8%, illustrates that 3 composition of the embodiment of the present invention improves with more significant effect, with the prior art phase osteoarthritis
Than there is significant technical advantage, the present invention is breakthrough in the obtained technological progress in its field.
The above embodiments are only used to illustrate the present invention, rather than limitation of the present invention.Although referring to embodiment to this hair
It is bright to be described in detail, those skilled in the art should understand that, to technical solution of the present invention carry out it is various combination,
Modification or equivalent replacement should all cover and want in right of the invention without departure from the spirit and scope of technical solution of the present invention
It asks in range.
Claims (4)
1. a kind of for improving the composition of bony articulation health, which is characterized in that each component including following parts by weight, it is non denatured
1~6 part of typeⅡ Collagen, 10~50 parts of Cartilage collagen, 10~50 parts of Mussel Powder, 2~10 parts of olive fruit powder, turmeric 2
~10 parts, 30~50 parts, 10~40 parts of starch, 5~20 parts of microcrystalline cellulose, 1~5 part of magnesium stearate of sugar.
2. according to claim 1 a kind of for improving the composition of bony articulation health, which is characterized in that the non-change
Property 4 parts of typeⅡ Collagen, 30 parts of Cartilage collagen, 30 parts of Mussel Powder, 6 parts of olive fruit powder, 5 parts of turmeric, sugar 40 parts, starch
25 parts, 10 parts of microcrystalline cellulose, 3 parts of magnesium stearate.
3. according to claim 1 or 2 a kind of for improving the composition of bony articulation health, which is characterized in that described
Sugar is one of lactose, isomalt, xylitol or oligofructose.
4. a kind of method for preparing the composition described in claim 1,2 or 3 for being used to improve bony articulation health, feature exist
In, comprising the following steps:
(1) each component is weighed according to the proportion of component, wherein protein content >=10% in non denatured typeⅡ Collagen used,
Protein content >=30% in Cartilage collagen, protein content >=60% in Mussel Powder, hydroxytyrosol content in olive fruit powder >=
4.5%；Curcumin In Curcuma content >=95%；
(2) non denatured typeⅡ Collagen, olive fruit powder, turmeric are mixed, the sugar that 50% formulation weight part is added carries out manually
Premix forms premix；
(3) sequentially added in three-dimensional mixer Cartilage collagen, Mussel Powder, remaining 50% formulation weight part sugar and step
Suddenly pre- mixed non denatured typeⅡ Collagen, olive fruit powder and turmeric premix in (2)；Control mixing machine revolving speed is 10r/
Min, incorporation time 30-50min；
(4) composition being uniformly mixed in step (3) is transferred to wet granulator, 10% starch slurry is added by formula rate, and
It is granulated with 18 mesh screens, Fluidbedgranulatingdrier drying is pumped into after granulation, selects grain with 18 mesh screens after drying, particle is stand-by；
(5) particle in step (4) is added to the 3d motion mixer with microcrystalline cellulose and magnesium stearate, control mixing machine turns
Speed is 10r/min, incorporation time 30-50min；
(6) composition being uniformly mixed in step (5) is transferred to tablet press machine and carries out tabletting, adjust tablet press machine control parameter, control
Every slice weight 700mg；
(7) sheeted product in step (6) is coated；
(8) it after product after step (7) coating being carried out appearance and slice weight inspection, is dispensed with automatic packer.
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| CN110250509A (en) * | 2019-06-07 | 2019-09-20 | 天津国民健康技术有限公司 | A kind of composition and preparation method thereof improving articulation health |
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| CN112219958A (en) * | 2020-07-08 | 2021-01-15 | 许昌神飞航天生物科技有限公司 | Space navigation grade solid beverage for bone joint recuperation |
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| CN114617267A (en) * | 2022-03-22 | 2022-06-14 | 意润健康产业（广州）有限公司 | Reinforced composite bone peptide and preparation method and application thereof |
| CN115282248A (en) * | 2022-08-15 | 2022-11-04 | 北京彩晔健康管理有限公司 | Composition for relieving joint pain or treating arthritis, and preparation method and application thereof |
| CN116784480A (en) * | 2023-06-07 | 2023-09-22 | 北京康比特体育科技股份有限公司 | Composition containing hydrolyzed collagen II and application thereof |
| CN117244030A (en) * | 2023-09-26 | 2023-12-19 | 广东健明生物科技有限公司 | Composition with joint maintenance effect, pressed candy and preparation method of pressed candy |
| CN117244030B (en) * | 2023-09-26 | 2024-04-09 | 广东健明生物科技有限公司 | Composition with joint maintenance effect, pressed candy and preparation method of pressed candy |
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Application publication date: 20190405 |