CN117244030B - Composition with joint maintenance effect, pressed candy and preparation method of pressed candy - Google Patents
Composition with joint maintenance effect, pressed candy and preparation method of pressed candy Download PDFInfo
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- CN117244030B CN117244030B CN202311247095.2A CN202311247095A CN117244030B CN 117244030 B CN117244030 B CN 117244030B CN 202311247095 A CN202311247095 A CN 202311247095A CN 117244030 B CN117244030 B CN 117244030B
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Abstract
The invention discloses a composition with a joint maintenance effect, a pressed candy and a preparation method thereof, and belongs to the technical field of joint maintenance products. The method comprises the following steps: the preparation method comprises the following raw materials: cartilage extract, turmeric, isomalt, sorbitol, chitosan oligosaccharide, non-denatured type II collagen, microcrystalline cellulose, magnesium stearate, lyophilized powder, stock solution; the raw materials are placed in a mixer for mixing, so as to obtain a material A; and (3) adding the material A into the stock solution, soaking, drying, adding the magnesium stearate, mixing, and grinding to obtain the composition with the effect of curing joints, which has excellent effect of curing joints and obvious effects of diminishing inflammation and relieving pain.
Description
Technical Field
The invention belongs to the technical field of joint maintenance products, and particularly relates to a composition with joint maintenance efficacy, a pressed candy and a preparation method thereof.
Background
Bones are life struts and are subject to supporting, compression, tension, torsion, bending and bending actions. Bone health problems, mainly including osteoporosis, osteoarthritis, cervical spondylosis, lumbar disc herniation, bone spurs, femoral head necrosis and the like, are the most prominent of which are osteoporosis and osteoarthritis. Arthritis generally refers to inflammatory diseases occurring in joints of the human body and surrounding tissues thereof and caused by inflammation, infection, degeneration, trauma or other factors, and can be divided into tens of kinds, mainly degenerative osteoarthritis, rheumatoid arthritis and the like. Clinically, the symptoms of red, swelling, heat, pain, dysfunction and joint deformity of joints are that the serious symptoms cause joint disability and influence the life quality of patients. Different arthritis is finally characterized by the abrasion and lesion of cartilage tissue and the formation of inflammation, so that the alleviation and treatment of arthritis are required to start from the aspects of inhibiting inflammation and repairing cartilage tissue.
Disclosure of Invention
The invention discloses a composition with a joint maintenance effect, a pressed candy and a preparation method thereof, and belongs to the technical field of joint maintenance products. The method comprises the following steps: the preparation method comprises the following raw materials in parts by mass: 55-65 parts of cartilage extract, 5-7 parts of turmeric, 17-20 parts of isomaltulose alcohol, 5-10 parts of sorbitol, 3-5 parts of chitosan oligosaccharide, 1-3 parts of non-denatured type II collagen, 2-3 parts of microcrystalline cellulose, 0.5-1 part of magnesium stearate, 2-4 parts of freeze-dried powder and 20-30 parts of stock solution; mixing cartilage extract, curcuma rhizome, isomalt, sorbitol, chitosan oligosaccharide, non-denatured type II collagen, microcrystalline cellulose, and lyophilized powder in a mixer to obtain material A; and adding the material A into the stock solution, soaking for 1-2h, drying, adding the magnesium stearate, mixing, and grinding to obtain the composition with the effect of maintaining joints.
The invention aims to solve the technical problems: the pressed candy with the effect of maintaining joints is prepared.
The aim of the invention can be achieved by the following technical scheme:
a method for preparing a composition with a joint care function, which comprises the following steps:
(1) The preparation method comprises the following raw materials in parts by mass: 55-65 parts of cartilage extract, 5-7 parts of turmeric, 17-20 parts of isomaltulose alcohol, 5-10 parts of sorbitol, 3-5 parts of chitosan oligosaccharide, 1-3 parts of non-denatured type II collagen, 2-3 parts of microcrystalline cellulose, 0.5-1 part of magnesium stearate, 2-4 parts of freeze-dried powder and 20-30 parts of stock solution;
(2) Mixing cartilage extract, curcuma rhizome, isomalt, sorbitol, chitosan oligosaccharide, non-denatured type II collagen, microcrystalline cellulose, and lyophilized powder in a mixer to obtain material A;
(3) And adding the material A into the stock solution, soaking for 1-2h, drying, adding the magnesium stearate, mixing, and grinding to obtain the composition with the effect of maintaining joints.
As a preferable technical scheme of the invention, the freeze-dried powder comprises the following components: lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bacillus bifidus lyophilized powder.
As a preferable technical scheme of the invention, the mass ratio of the lactobacillus acidophilus freeze-dried powder to the lactobacillus casei freeze-dried powder to the bifidobacterium freeze-dried powder is 2-4:3-6:1-2.
As a preferred embodiment of the present invention, the preparation of the stock solution includes the steps of: mixing Glycyrrhrizae radix, atractylodis rhizoma, radix Aconiti lateralis Preparata, ramulus Cinnamomi, pericarpium Citri Tangerinae, rhizoma Dioscoreae and Poria, soaking in distilled water for 30min, decocting with 10 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution I, decocting residue with 8 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution II, and mixing concentrated solution I and concentrated solution II to obtain the stock solution.
As a preferable technical scheme of the invention, the mass ratio of the liquorice to the bighead atractylodes rhizome to the aconite, the cassia twig to the dried orange peel to the yam to the poria cocos is 10-12:10-12:18-20:20-22:16-18:25-35:6-12.
As a preferable technical scheme of the invention, in the step (2), the mixing time is 1-2h.
As a preferable technical scheme of the invention, in the step (3), the mixing time is 25-30min.
A composition with joint caring effect prepared by the preparation method is provided.
A tabletted candy comprises a composition with the effect of maintaining joints, which is prepared by the preparation method.
As a preferable technical scheme of the invention, the preparation method of the pressed candy comprises the following steps: tabletting the composition with joint caring effect according to 450-500 mg/tablet, and bottling to obtain the tabletting candy.
The invention has the beneficial effects that:
(1) According to the composition with the effect of maintaining joints, the pressed candy and the preparation method thereof, disclosed by the invention, the cartilage extract is added to provide nutrition for cartilage cells to a certain extent, so that joint repair is promoted, further inflammation is reduced, pain is relieved, support and stability are provided for the cartilage cells, and the joint repair process is promoted;
furthermore, the cartilage extract and the non-denatured type II collagen are combined, and the cartilage extract and the non-denatured type II collagen can have a certain treatment effect on arthritis, so that the cartilage extract and the non-denatured type II collagen are combined, the cartilage extract and the non-denatured type II collagen can have a better inhibition effect on arthritis, and the arthritis symptom can be improved when a patient suffering from arthritis eats the tabletted candy; the cartilage extract has the effects of promoting cartilage cell proliferation and synthesizing cartilage matrix, and can help repair damaged cartilage tissue, the non-denatured type II collagen can maintain the structural integrity and elasticity of cartilage, regulate the function of immune system, reduce inflammatory reaction of arthritis, and the complementary effects of cartilage extract and non-denatured type II collagen can mutually enhance the efficacy of cartilage extract and non-denatured type II collagen when treating arthritis, so that arthritis can be treated more effectively. The cartilage extract promotes the activity of chondrocytes and the repair of cartilage tissues, and simultaneously, the non-denatured type II collagen regulates the immune system, reduces inflammatory reaction and plays a role in inhibiting the development of arthritis.
Further, by introducing the synergistic effect of turmeric, isomaltulose, sorbitol, chitosan oligosaccharide, microcrystalline cellulose, magnesium stearate and other components, the growth and differentiation of chondrocytes are promoted, the repairing and regenerating effects of cartilage are improved, the stability of joints is enhanced, the pain and swelling of joints are reduced, the functions of joints are improved, the self-healing capacity of joints is promoted, the friction and abrasion of joints are reduced, the flexibility of joints is improved, the stability of joints is enhanced, and the maintenance effect on joints is improved.
(2) According to the composition with the joint maintenance efficacy, the pressed candy and the preparation method thereof, probiotics such as lactobacillus acidophilus freeze-dried powder, lactobacillus casei freeze-dried powder and bifidobacterium freeze-dried powder are added to strengthen the intestinal tract immunity, prevent harmful substances from entering the blood circulation from the intestinal tract, reduce the occurrence of autoimmune reaction, reduce the permeability of intestinal mucosa, reduce local and systemic inflammatory reactions, improve the health condition of the intestinal tract, keep good intestinal health, facilitate the absorption and metabolism of medicines in the intestinal tract, increase the absorption efficiency of human bodies on nutrient substances, improve the efficacy and help to reduce the inflammatory symptoms of rheumatoid arthritis patients.
(3) The composition, the pressed candy and the preparation method thereof have good anti-inflammatory and analgesic effects by mixing and decocting liquorice, bighead atractylodes rhizome, aconite and cassia twig, and meanwhile, the dried orange peel, chinese yam and poria are added to supplement each other, so that the efficacy is enhanced, the possible side effects caused by single herbal medicine are reduced, the safety of the medicine is improved, the adaptability of individual differences is improved, the treatment success rate is improved, the overall curative effect is improved, and the better joint maintenance effect is achieved.
(4) Further, the cartilage extract contains abundant cartilage components such as collagen, chondroitin sulfate and the like, and can promote the repair and regeneration of articular cartilage; curcumin as an active ingredient in turmeric has anti-inflammatory and antioxidant effects, and can reduce joint inflammatory reaction and relieve joint pain and swelling; isomalt is a natural extract with anti-inflammatory and antioxidant effects, and can relieve joint pain and improve joint function; sorbitol has moisturizing and osmotic adjusting effects, and can improve the viscosity of joint synovial fluid and increase the joint lubrication degree; the chitosan oligosaccharide is a polysaccharide substance, can promote the proliferation of chondrocytes and enhance the synthesis of cartilage matrixes, and plays a positive role in repairing joints; the non-denatured type II collagen is a natural collagen, can promote proliferation and synthesis of articular cartilage cells, and is helpful for repairing damaged articular cartilage; microcrystalline cellulose has adsorption and toxin expelling effects, and can remove waste and metabolic products in vivo, and relieve joint burden; magnesium stearate is an organomagnesium compound with anti-inflammatory and analgesic effects, which can relieve joint pain and discomfort; the probiotics can maintain intestinal flora balance, promote nutrient absorption and immunoregulation, and are beneficial to improving joint health; the Chinese medicinal components such as liquorice, bighead atractylodes rhizome, aconite root, cassia twig and the like have the effects of warming and invigorating dampness, activating blood and dissolving stasis, relieving pain and diminishing inflammation and the like, and can improve joint circulation and relieve joint pain;
the cartilage extract, turmeric, isomaltulose, sorbitol, chitosan oligosaccharide, non-denatured type II collagen, microcrystalline cellulose, magnesium stearate, probiotics, liquorice, bighead atractylodes rhizome, aconite and cassia twig can comprehensively improve joint health, promote repair and regeneration of joint cartilage, reduce joint inflammatory reaction, relieve joint pain and swelling, and improve joint lubrication degree and function.
Detailed Description
In order to further describe the technical means and effects adopted by the present invention for achieving the intended purpose, the following detailed description is given below with reference to the embodiments, structures, features and effects according to the present invention.
Example 1
(1) The preparation method comprises the following raw materials in parts by mass: 55 parts of cartilage extract, 5 parts of turmeric, 17 parts of isomalt, 5 parts of sorbitol, 3 parts of chitosan oligosaccharide, 1 part of non-denatured type II collagen, 2 parts of microcrystalline cellulose, 0.5 part of magnesium stearate, 2 parts of freeze-dried powder and 20 parts of stock solution;
(2) 55 parts by mass of cartilage extract, 5 parts by mass of turmeric, 17 parts by mass of isomaltulose alcohol, 5 parts by mass of sorbitol, 3 parts by mass of chitosan oligosaccharide, 1 part by mass of non-denatured type II collagen, 2 parts by mass of microcrystalline cellulose and 2 parts by mass of freeze-dried powder are placed in a mixer to be mixed for 1h, so that a material A is obtained;
(3) Adding the material A into the stock solution, soaking for 1h, drying, adding the magnesium stearate, mixing for 25min, and grinding to obtain the composition with the effect of maintaining joints;
(4) And tabletting and bottling the composition with the joint maintenance effect according to 450 mg/tablet to obtain the tabletting candy.
The freeze-dried powder comprises the following components: lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bacillus bifidus lyophilized powder; the lactobacillus acidophilus freeze-dried powder, lactobacillus casei freeze-dried powder and bifidobacterium freeze-dried powder are prepared from the following components in percentage by mass: 3:1.
the preparation of the stock solution comprises the following steps: mixing Glycyrrhrizae radix, atractylodis rhizoma, radix Aconiti lateralis Preparata, ramulus Cinnamomi, pericarpium Citri Tangerinae, rhizoma Dioscoreae and Poria, soaking in distilled water for 30min, decocting with 10 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution I, decocting residue with 8 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution II, and mixing concentrated solution I and concentrated solution II to obtain the stock solution.
The mass ratio of the liquorice to the bighead atractylodes rhizome to the aconite, the cassia twig to the dried orange peel to the yam to the tuckahoe is 10:10:18:20:16:25:6.
example 2
(1) The preparation method comprises the following raw materials in parts by mass: 60 parts of cartilage extract, 6 parts of turmeric, 19 parts of isomalt, 7 parts of sorbitol, 4 parts of chitosan oligosaccharide, 2 parts of non-denatured type II collagen, 2.5 parts of microcrystalline cellulose, 0.7 part of magnesium stearate, 3 parts of freeze-dried powder and 25 parts of stock solution;
(2) Placing 60 parts by mass of cartilage extract, 6 parts by mass of turmeric, 19 parts by mass of isomaltulose alcohol, 7 parts by mass of sorbitol, 4 parts by mass of chitosan oligosaccharide, 2 parts by mass of non-denatured type II collagen, 2.5 parts by mass of microcrystalline cellulose and 3 parts by mass of freeze-dried powder into a mixer to mix for 1.5 hours to obtain a material A;
(3) Adding the material A into the stock solution, soaking for 1.5h, drying, adding the magnesium stearate, mixing for 27min, and grinding to obtain the composition with the effect of maintaining joints;
(4) And tabletting and bottling the composition with the joint maintenance effect according to 480 mg/tablet to obtain the tabletting candy.
The freeze-dried powder comprises the following components: lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bacillus bifidus lyophilized powder; the lactobacillus acidophilus freeze-dried powder, lactobacillus casei freeze-dried powder and bifidobacterium freeze-dried powder are prepared from the following components in percentage by mass: 5:1.5.
the preparation of the stock solution comprises the following steps: mixing Glycyrrhrizae radix, atractylodis rhizoma, radix Aconiti lateralis Preparata, ramulus Cinnamomi, pericarpium Citri Tangerinae, rhizoma Dioscoreae and Poria, soaking in distilled water for 30min, decocting with 10 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution I, decocting residue with 8 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution II, and mixing concentrated solution I and concentrated solution II to obtain the stock solution.
The mass ratio of the liquorice to the bighead atractylodes rhizome to the aconite, the cassia twig to the dried orange peel to the yam to the tuckahoe is 11:11:19:21:17:30:10.
example 3
(1) The preparation method comprises the following raw materials in parts by mass: 65 parts of cartilage extract, 7 parts of turmeric, 20 parts of isomalt, 10 parts of sorbitol, 5 parts of chitosan oligosaccharide, 3 parts of non-denatured type II collagen, 3 parts of microcrystalline cellulose, 1 part of magnesium stearate, 4 parts of freeze-dried powder and 30 parts of stock solution;
(2) Placing 65 parts by mass of cartilage extract, 7 parts by mass of turmeric, 20 parts by mass of isomaltulose alcohol, 10 parts by mass of sorbitol, 5 parts by mass of chitosan oligosaccharide, 3 parts by mass of non-denatured type II collagen, 3 parts by mass of microcrystalline cellulose and 4 parts by mass of freeze-dried powder into a mixer to be mixed for 2 hours to obtain a material A;
(3) Adding the material A into the stock solution, soaking for 2 hours, drying, adding the magnesium stearate, mixing for 30 minutes, and grinding to obtain the composition with the effect of maintaining joints;
(4) And tabletting and bottling the composition with the joint maintenance effect according to 500 mg/tablet to obtain the tabletting candy.
The freeze-dried powder comprises the following components: lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bacillus bifidus lyophilized powder; the lactobacillus acidophilus freeze-dried powder, lactobacillus casei freeze-dried powder and bifidobacterium freeze-dried powder are prepared from the following components in percentage by mass: 6:2.
the preparation of the stock solution comprises the following steps: the preparation of the stock solution comprises the following steps: mixing Glycyrrhrizae radix, atractylodis rhizoma, radix Aconiti lateralis Preparata, ramulus Cinnamomi, pericarpium Citri Tangerinae, rhizoma Dioscoreae and Poria, soaking in distilled water for 30min, decocting with 10 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution I, decocting residue with 8 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution II, and mixing concentrated solution I and concentrated solution II to obtain the stock solution.
The mass ratio of the liquorice to the bighead atractylodes rhizome to the aconite, the cassia twig to the dried orange peel to the yam to the tuckahoe is 12:12:20:22:18:35:12.
comparative example 1
(1) The preparation method comprises the following raw materials in parts by mass: 10 parts of turmeric, 27 parts of isomalt, 5 parts of sorbitol, 3 parts of chitosan oligosaccharide, 20 parts of non-denatured type II collagen, 2 parts of microcrystalline cellulose, 0.5 part of magnesium stearate, 3 parts of freeze-dried powder and 40 parts of stock solution;
(2) 10 parts by mass of turmeric, 27 parts by mass of isomaltulose alcohol, 5 parts by mass of sorbitol, 3 parts by mass of chitosan oligosaccharide, 20 parts by mass of non-denatured type II collagen, 2 parts by mass of microcrystalline cellulose and 3 parts by mass of freeze-dried powder are placed in a mixer to be mixed for 1h, so that a material A is obtained;
(3) Adding the material A into the stock solution, soaking for 1h, drying, adding the magnesium stearate, mixing for 25min, and grinding to obtain the composition with the effect of maintaining joints;
(4) And tabletting and bottling the composition with the joint maintenance effect according to 450 mg/tablet to obtain the tabletting candy.
The freeze-dried powder comprises the following components: lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bacillus bifidus lyophilized powder; the lactobacillus acidophilus freeze-dried powder, lactobacillus casei freeze-dried powder and bifidobacterium freeze-dried powder are prepared from the following components in percentage by mass: 3:1.
the preparation of the stock solution comprises the following steps: mixing Glycyrrhrizae radix, atractylodis rhizoma, radix Aconiti lateralis Preparata, ramulus Cinnamomi, pericarpium Citri Tangerinae, rhizoma Dioscoreae and Poria, soaking in distilled water for 30min, decocting with 10 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution I, decocting residue with 8 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution II, and mixing concentrated solution I and concentrated solution II to obtain the stock solution.
The mass ratio of the liquorice to the bighead atractylodes rhizome to the aconite, the cassia twig to the dried orange peel to the yam to the tuckahoe is 10:10:18:20:16:25:6.
comparative example 2
(1) The preparation method comprises the following raw materials in parts by mass: 57 parts of cartilage extract, 5 parts of turmeric, 17 parts of isomalt, 5 parts of sorbitol, 3 parts of chitosan oligosaccharide, 1 part of non-denatured type II collagen, 2 parts of microcrystalline cellulose, 0.5 part of magnesium stearate and 20 parts of stock solution;
(2) 55 parts by mass of cartilage extract, 5 parts by mass of turmeric, 17 parts by mass of isomaltulose alcohol, 5 parts by mass of sorbitol, 3 parts by mass of chitosan oligosaccharide, 1 part by mass of non-denatured type II collagen and 2 parts by mass of microcrystalline cellulose are placed in a mixer to be mixed for 1h, so that a material A is obtained;
(3) Adding the material A into the stock solution, soaking for 1h, drying, adding the magnesium stearate, mixing for 25min, and grinding to obtain the composition with the effect of maintaining joints;
(4) And tabletting and bottling the composition with the joint maintenance effect according to 450 mg/tablet to obtain the tabletting candy.
The preparation of the stock solution comprises the following steps: mixing Glycyrrhrizae radix, atractylodis rhizoma, radix Aconiti lateralis Preparata, ramulus Cinnamomi, pericarpium Citri Tangerinae, rhizoma Dioscoreae and Poria, soaking in distilled water for 30min, decocting with 10 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution I, decocting residue with 8 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution II, and mixing concentrated solution I and concentrated solution II to obtain the stock solution.
The mass ratio of the liquorice to the bighead atractylodes rhizome to the aconite, the cassia twig to the dried orange peel to the yam to the tuckahoe is 10:10:18:20:16:25:6.
comparative example 3
(1) The preparation method comprises the following raw materials in parts by mass: 75 parts of cartilage extract, 5 parts of turmeric, 17 parts of isomalt, 5 parts of sorbitol, 3 parts of chitosan oligosaccharide, 1 part of non-denatured type II collagen, 2 parts of microcrystalline cellulose, 0.5 part of magnesium stearate and 2 parts of freeze-dried powder;
(2) 55 parts by mass of cartilage extract, 5 parts by mass of turmeric, 17 parts by mass of isomaltulose alcohol, 5 parts by mass of sorbitol, 3 parts by mass of chitosan oligosaccharide, 1 part by mass of non-denatured type II collagen, 2 parts by mass of microcrystalline cellulose and 2 parts by mass of freeze-dried powder are placed in a mixer to be mixed for 1h, so that a material A is obtained;
(3) Adding the material A into the magnesium stearate, mixing for 25min, and grinding to obtain the composition with the effect of maintaining joints;
(4) And tabletting and bottling the composition with the joint maintenance effect according to 450 mg/tablet to obtain the tabletting candy.
The freeze-dried powder comprises the following components: lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bacillus bifidus lyophilized powder; the lactobacillus acidophilus freeze-dried powder, lactobacillus casei freeze-dried powder and bifidobacterium freeze-dried powder are prepared from the following components in percentage by mass: 3:1.
comparative examples 4 to 6
The difference compared with example 1 is that the quality of Lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bifidobacterium lyophilized powder in comparative examples 4-6 are shown in Table 1, and the other operation steps and parameters are unchanged.
TABLE 1
Comparative examples 7 to 13
Compared with example 1, the difference is that the mass of liquorice, bighead atractylodes rhizome, aconite, cassia twig, dried orange peel, chinese yam and poria cocos in comparative examples 7-13 is shown in table 2, and the rest operation steps and parameters are unchanged.
TABLE 2
Test example 1
The tabletted candies prepared in the above examples 1 to 3 and comparative examples 1 to 13 were subjected to safety tests, and oral acute toxicity tests were carried out using SD rats (refer to GB/T15193.3-2003), and whether or not the rats tested had abnormal reactions (such as the occurrence of a reaction such as the occurrence of cocking, tiredness, pallor or congestion of the eardrum, protruding eyes, stumbling of the footstep, muscle paralysis, dyspnea, coma, convulsions, fecal incontinence, etc.), death, and the cause of death were examined;
feeding test (short term oral toxicity test, subacute toxicity test, refer to GB/T23179-2008) was performed for 30 days, growth condition, weight and food utilization were observed, hematological and blood biochemical indexes were observed, pathological changes such as heart, liver, spleen, lung, kidney, stomach and intestine were observed by section examination, and visceral system values were measured for liver, kidney, spleen, testis (male) and ovary (female), and the visceral volume factor (viscera/weight×100%) was calculated.
Test results: all rats tested had good growth and development, and had normal behavioural activities, mental conditions, hair colors, feeding, drinking water and urination and defecation, revealing that the tabletted candies of each example and comparative example had no adverse effects on the general conditions of rats, on the weight gain and growth and development of rats, on the food utilization rate, on the basic indexes of hematology, on the main indexes of blood biochemistry, and on the main organs.
The tablet candy has no acute toxic or side effect, has no adverse effects on indexes such as weight increase, food utilization rate, hematology, viscera and the like after long-term feeding, and can be eaten for a long time.
Test example 2
Efficacy tests were conducted on the tabletted candies prepared in examples 1 to 3 and comparative examples 1 to 13 described above, 480 dogs having symptoms of acute arthritis onset (manifested as lameness and periarticular redness) were selected, randomly divided into 16 groups of 30 dogs each, continuously fed for 60 days (2 tablets per each dog each day, three feeds each day), and improvement of redness at 3 days, 7 days, and 14 days, and improvement of lameness at 30 days, 45 days, and 60 days, respectively, were observed, and the results are shown in table 3 below.
TABLE 3 Table 3
As can be seen from Table 3, the obtained pressed candy has excellent joint maintenance effect and obvious anti-inflammatory and analgesic effects after cartilage extract, freeze-dried powder and stock solution are added.
The present invention is not limited to the above embodiments, but is capable of modification and variation in detail, and other modifications and variations can be made by those skilled in the art without departing from the scope of the present invention.
Claims (6)
1. A method for preparing a composition with a joint care function, which is characterized by comprising the following steps:
(1) The preparation method comprises the following raw materials in parts by mass: 55-65 parts of cartilage extract, 5-7 parts of turmeric, 17-20 parts of isomaltulose alcohol, 5-10 parts of sorbitol, 3-5 parts of chitosan oligosaccharide, 1-3 parts of non-denatured type II collagen, 2-3 parts of microcrystalline cellulose, 0.5-1 part of magnesium stearate, 2-4 parts of freeze-dried powder and 20-30 parts of stock solution;
(2) Mixing cartilage extract, curcuma rhizome, isomalt, sorbitol, chitosan oligosaccharide, non-denatured type II collagen, microcrystalline cellulose, and lyophilized powder in a mixer to obtain material A;
(3) Adding the material A into the stock solution, soaking for 1-2h, drying, adding the magnesium stearate, mixing, and grinding to obtain the composition with the effect of maintaining joints;
the freeze-dried powder comprises the following components: lactobacillus acidophilus lyophilized powder, lactobacillus casei lyophilized powder, and Bacillus bifidus lyophilized powder; the mass ratio of the lactobacillus acidophilus freeze-dried powder to the lactobacillus casei freeze-dried powder to the bifidobacterium freeze-dried powder is 2-4:3-6:1-2;
the preparation of the stock solution comprises the following steps: mixing Glycyrrhrizae radix, atractylodis rhizoma, radix Aconiti lateralis Preparata, ramulus Cinnamomi, pericarpium Citri Tangerinae, rhizoma Dioscoreae and Poria, soaking in distilled water for 30min, decocting with 10 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution I, decocting residue with 8 times of water, decocting at 80deg.C for 40min, filtering, collecting filtrate to obtain concentrated solution II, and mixing concentrated solution I and concentrated solution II to obtain the stock solution; the mass ratio of the liquorice to the bighead atractylodes rhizome to the aconite, the cassia twig to the dried orange peel to the yam to the tuckahoe is 10-12:10-12:18-20:20-22:16-18:25-35:6-12.
2. The method for preparing a composition having a joint curing effect according to claim 1, wherein in the step (2), the mixing time is 1 to 2 hours.
3. The method for preparing a composition having a joint curing effect according to claim 1, wherein in the step (3), the mixing time is 25 to 30 minutes.
4. A composition having a joint care effect prepared by the preparation method of any one of claims 1 to 3.
5. A tabletted confection comprising a composition according to claim 4 having a joint care effect.
6. A tabletted confection according to claim 5, wherein the tabletted confection is prepared by the process of: tabletting the composition with joint caring effect according to 450-500 mg/tablet, and bottling to obtain the tabletting candy.
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| CN109567157A (en) * | 2018-10-23 | 2019-04-05 | 北京同仁堂健康药业股份有限公司 | A kind of composition and preparation method thereof for improving bony articulation health |
| CN115349571A (en) * | 2022-09-22 | 2022-11-18 | 广东健明生物科技有限公司 | Preparation method of cartilage collagen peptide tablet candy |
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| CN109567157A (en) * | 2018-10-23 | 2019-04-05 | 北京同仁堂健康药业股份有限公司 | A kind of composition and preparation method thereof for improving bony articulation health |
| CN115349571A (en) * | 2022-09-22 | 2022-11-18 | 广东健明生物科技有限公司 | Preparation method of cartilage collagen peptide tablet candy |
Non-Patent Citations (2)
| Title |
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| 参苓白术散新用2则;银忠甫;;广西中医药;-;第-卷(第06期);40 * |
| 国内外益生菌制品发展现状;杜鹏, 霍贵成;食品科学(第05期);194-198 * |
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