CN105725190B - A kind of functional nutrient food of joint-improving - Google Patents
A kind of functional nutrient food of joint-improving Download PDFInfo
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- CN105725190B CN105725190B CN201610086052.4A CN201610086052A CN105725190B CN 105725190 B CN105725190 B CN 105725190B CN 201610086052 A CN201610086052 A CN 201610086052A CN 105725190 B CN105725190 B CN 105725190B
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- collagen
- joint
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- seed extract
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Classifications
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention provides a kind of functional nutrient food of joint-improving, is prepared by following raw material in parts by weight：Soy meal 10 80, black bean powder 10 80, chitosan oligosaccharide 5 30, collagen protein powder 1 20, typeⅡ Collagen 1 20, grape seed extract 0.1 16, vitamin C 5 12；According to dosage form needs, the auxiliary material of following parts by weight can also be included：Maltodextrin 10 80.Product of the present invention comprehensively utilizes a variety of nutriment synergistic effects, active constituent effect is improved by specific preparation method, " rejuvenation " osteoarthrosis such as joint, tendon injury has significantly treatment and curative effect caused by being damaged for the various osteoarthrosis of the elderly and long-term motion.And also have being significantly improved to related symptoms such as back caused by women premenstrual syndrome, joint pain swelling.
Description
Technical field
The present invention relates to a kind of nutraceutical, and in particular to a kind of functional nutrient food of joint-improving.
Background technology
All kinds of bone and joint diseases, including degenerative arthritis, bursal synovitis, synovitis, cervical spondylosis, lumbar vertebra disease, scapulohumeral periarthritis, bone
The basic reason of matter hyperplasia, rheumatic arthritis, rheumatoid arthritis, caput femoris necrosis etc., illness is not bone
Lesion, modern medicine study find that old complaint is that forfeiture of the cartilage etc. " joint protection system " to joint protective capability.Respectively
The generation of class bone and joint diseases often starts from the lesions of synovium contributed, cartilage is damaged or denaturation；Take certain anti-inflammatory classes, hormone medicine
Caused cartilage damage is also one of the main reason of many bone and joint diseases.Due to synovium of joint, cartilage damage and
The missing of knuckle synovia causes joint bone to lack necessary protection so that the activity of human body one, the bone of joint due to a lack of
Necessary " cartilage protection " directly occurs violent rigid friction, and causes patient articular's pain, swelling, deformation, spur hyperplasia etc.
A variety of symptoms.It is even more important, if human synovial organ immune disorder, joint it is inevitable due to a lack of necessary " immunoprotection " and
The intrusion for causing extraneous inflammatory factor eventually leads to the generation of all kinds of bone and joint diseases.
Osteoporosis is one group of osteopathy caused by many reasons, and bone tissue has normal calcification, and calcium salt is with matrix in just
Normal ratio, the metabolic bone disease with the characteristics of the reduction of unit volume inner bone tissues amount become.In most osteoporosises, bone tissue
It reduces caused by increasing mainly due to bone absorption.By skeleton pain, be easy to fracture characterized by.
II type is mainly generated by cartilage cell, is present in the tissues such as bone, joint, tendon more.Vitamin C can promote collagen
Albumen synthesizes, and prevents its oxidation, containing having the function of that skin moisture, whitening is protected to go wrinkle.Antioxidant composition grape pip extracts
Object, vitamin E protect collagen and elastomer not to be degraded, and skin histology is rebuild in help.These superpower antioxidants are total
Same-action resists the injury of free radical and other nuisances, from many aspects effective protection collagen structure.
Main component procyanidine has stronger antioxidation in grape seed extract, is capable of providing human immunity
Power.Crease-resistant effect：The crease-resistant effect of procyanidine can safeguard the synthesis of collagen based on it；Inhibit elastoser；Assist body
It protects collagen and improves the elasticity of skin；Improve the healthy cycle of skin.To avoid or reduce the generation of wrinkle.Science
Together with practice confirmation, procyanidine and collagen binder, skin rejuvenation, health, cell can be made dynamic, it can be restored
Extensibility and elasticity, elasticity, the improvement blood circulation etc. for helping body from solar radiation damage, improving the junctions such as joint.
And there is good protective effect for the protein of fibre-bearing structure.Heart protective agent：Procyanidine not only helps to restore skin
Elasticity, and joint, artery and other tissues (such as heart) is helped to maintain normal function.Allergy inflammation：Procyanidine
Inhibit histamine to generate, thus can reduce inflammation, artery is helped to resist the impact for the mutagen that those cause cardiovascular disease, example
Such as, allergy, asthma, bronchitis, Hay Fever, rheumatoid arteritis, sports injuries, pressure ulcers etc..Sportsman appreciates flower very much
Green element because procyanidine make joint flexibly, collagen in connective tissue can be repaired, and mitigate oedema.Also report
Road, procyanidine improve the arthritis of many people.
Black soya bean, also known as black beans, include abundant protein, several mineral materials and trace element.Chinese medicine thinks, sweet in flavor,
It is mild-natured, nontoxic.There is the effect of inducing diaphoresis heat-clearing, blood-nourishing soothing the liver, Bu Shen Zhuang the moon, qi-restoratives dark hair.Li Shizhen (1518-1593 A.D.) is said：" it is more that black soya bean enters kidney function,
Therefore can harness the river, dissipate-swelling, lower gas controls wind-heat and promoting blood circulation and detoxication." protein content of black soya bean is up to 30 six to four percent
Ten, it is equivalent to two times of meat content, three times of egg, the twelvefold of milk.18 kinds of amino acid contents of black soya bean are abundant, special
It is not the necessary eight kinds of amino acid contents of human body, it is also high compared with high-grade protein standard as defined in U.S. FDA.Black soya bean contains percent
19 greases, wherein unsaturated fatty acid 80 percent, absorptivity height grows by more than 95, in addition to that can meet human body to fat
Demand outside, also reduce Blood Cholesterol effect.Cholesterol is the arch-criminal of many geriatric diseases, and black soya bean is not
Have containing only a kind of phytosterol containing cholesterol and inhibit absorption of human body cholesterol, reduce the effect of blood cholesterol level.
For the elderly, blood vessel can be softened, moisturize the skin anti-aging, especially to hypertension, heart disease, liver, artery sclerosis
Equal geriatric diseases are very beneficial.
Invention content
Purpose of the present invention is to be directed to auxotrophy of the existing technology, a variety of nutriment compatibilities are comprehensively utilized, are provided
It is a kind of to carry out effectively preventing the functional nutrient food with maintenance for all kinds of bone and joint diseases and osteoporosis.
To achieve the goals above, the present invention uses following technical scheme：
A kind of functional nutrient food of joint-improving, is prepared by following raw material in parts by weight：Soy meal 10-
80, black bean powder 10-80, chitosan oligosaccharide 5-30, collagen protein powder 1-20, typeⅡ Collagen 1-20, grape seed extract 0.1-16,
Vitamin C 5-12.
The functional nutrient food can also include the auxiliary material of following parts by weight according to dosage form needs：Maltodextrin
10-80。
Preferably, the functional nutrient food of the joint-improving, is prepared by following raw material in parts by weight：Soybean
Powder 15-40, black bean powder 25-60, chitosan oligosaccharide 10-20, collagen protein powder 5-10, typeⅡ Collagen 5-15, grape seed extract
5-12, vitamin C 6-10；According to dosage form needs, the auxiliary material of following parts by weight can also be included：Maltodextrin 15-50.
Preferably, the preparation method of the grape seed extract is as follows：Grape pip crushing is placed on equipped with 0.3-0.5%
In sodium bicarbonate solution, adjusting pH value is 7-8, is warming up to 40-50 DEG C, and the mixed enzyme of grape pip quality 2-8% is added, and stirring is equal
It is even, 40-70min is digested, high-pressure pulse electric processing, electric field strength 20-40kV/cm, burst length 400- are carried out during enzymolysis
500 μ s, pulse frequency 200-300Hz；The enzymolysis liquid of above-mentioned processing is filtered through 100-300 mesh screens, and filtrate is freeze-dried i.e.
Obtain grape seed extract；The quality group of the mixed enzyme becomes：Amylase:Pectase:Cellulase=1:5-8:5-10.
The Proanthocyanidin from Grape-seed Extracts being prepared by the above method is 97% or more.
Preferably, the preparation method of the chitosan oligosaccharide is as follows：Cellulase：Papain=3:1 is dissolved in pH5.2-5.6
Acetic acid solution, 50-55 DEG C of temperature control, mixed enzyme solution hydrolyzing chitosan 3-6h, hydrolyzate are obtained through destroy the enzyme treatment, vacuum freeze drying
To chitosan oligosaccharide.
The typeⅡ Collagen is extracted from Chick sternal cartilage and is obtained.Currently preferred extracting method is as follows：Raw material is new
Freshly-slaughtered poultry chest cartilage slices, material-water ratio 1：3-8, it is 1.8-2.5 to adjust material liquid pH with acetic acid, adds the stomach egg of raw material weight 0.5%
White enzyme, 25 DEG C of processing 2-8h of room temperature, enzyme deactivation, filtering, ethyl alcohol wash, the cartilage after being cleaned, low-temperature grinding under liquid nitrogen, addition
3-5 times of water of solid content weight adds 0.3% papain, adjusts pH 6.3-6.8,55-60 DEG C, digests 1-3h；Enzymolysis liquid
It is detached through ion-exchange chromatography, freeze-drying obtains high-purity II type collagen.
The collagen protein powder, vitamin C etc. are commercial goods raw material.The soy meal or black bean powder are commercially available quotient
Product soybean or black soya bean are obtained through crushing and screening.
Functional nutrient food of the present invention is oral preparation, and the oral preparation can be tablet, granule, ball
Agent, powder, pulvis or capsule, preferred tablet or capsule are easy to preserve, instant edible, also viable bacteria more conducively in preparation
Content and character are stablized.The tablet can be piece, buccal tablet or chewable tablets for oral administration etc..The capsule can be hard capsule or
Soft capsule.
Advantageous effect：
Product of the present invention comprehensively utilizes a variety of nutriment synergistic effects, and active constituent work(is improved by specific preparation method
Effect, " rejuvenation " Bones and joints such as joint, tendon injury caused by being damaged for the various osteoarthrosis of the elderly and long-term motion
Illness has significantly treatment and curative effect.And to correlations such as back caused by women premenstrual syndrome, joint pain swelling
Symptom also has being significantly improved.
Grape seed extract acts synergistically with vitamin C.Procyanidine protection in grape seed extract and stable dimension life
Plain c contributes to the absorption and utilization of vitamin c, procyanidine that can also enhance ascorbic effect, extends vitamin C in human body
The interior time that effect occurs.Grape seed extract and ascorbic combination accelerate the decomposition and exclusion of harmful cholesterol.Dimension
Raw element C is the biochemical synthesis necessary nutriment of collagen again, and procyanidine makes more vitamin Cs come into force, it means that dimension
Raw element C can more easily go to complete its institute's functional (including collagen generation).Grape seed extract auxiliary safeguards collagen
Together with albumen synergistic effect, procyanidine and collagen binder, improve the elasticity of the junctions such as joint, improve blood circulation etc..
Product of the present invention can effectively reduce internal low-density lipoprotein and content of triglyceride, reduce cholesterol levels.
The summary that British Journal of Sports Medicine is delivered, has looked back 17 researchs, including 2612 tendon pains or muscle-tendon structure are not
Normal patient has found that high cholesterol increases tendon complication and pain.With pain degree is minimum compares, low-density lipoprotein
Higher with triglycerides, pain is more serious.Tendon injury, inflammation and other complication increase also with the increase of cholesterol levels
Add.These Notes of Key Datas, the cholesterol levels height in blood cause cholesterol in cell to be formed, and inhibit tendon function, are similar to
Influence of the elevated cholesterol to arterial function.
Specific implementation mode
Further describe the present invention below in conjunction with specific embodiment, the advantages and features of the present invention will be with description and more
It is clear.But these examples are only exemplary, and it is not intended to limit the scope of the present invention in any way.Those skilled in the art answer
It should be appreciated that can be repaiied without departing from the spirit and scope of the invention to the details and form of technical solution of the present invention
Change or replace, but these modifications and replacement are each fallen in protection scope of the present invention.Method, ingredient involved in following embodiments
And dosage, unless otherwise specified, conventional method known to those skilled in the art.
Embodiment 1
A kind of functional nutrient food of joint-improving, is prepared by following raw material in parts by weight：Soy meal 10 is black
Bean powder 80, chitosan oligosaccharide 5, collagen protein powder 1, typeⅡ Collagen 20, grape seed extract 1, vitamin C 12；Further include following
The auxiliary material of parts by weight：Maltodextrin 80.
The preparation method of the grape seed extract is as follows：Grape pip crushing is placed on molten equipped with 0.3% sodium bicarbonate
In liquid, it is 7 to adjust pH value, is warming up to 50 DEG C, and the mixed enzyme of grape pip quality 2% is added, stirs evenly, and digests 40min, enzymolysis
Period carries out high-pressure pulse electric processing, electric field strength 20kV/cm, 500 μ s of burst length, pulse frequency 300Hz；Above-mentioned processing
Enzymolysis liquid filtered through 120 mesh screens, filtrate is freeze-dried up to grape seed extract；The quality of the mixed enzyme forms
For：Amylase:Pectase:Cellulase=1:5:5.
The preparation method of the chitosan oligosaccharide is as follows：Cellulase：Papain=3:1 is dissolved in 5.2 acetic acid solutions of pH,
50 DEG C of temperature control, mixed enzyme solution hydrolyzing chitosan 6h, hydrolyzate obtain chitosan oligosaccharide through destroy the enzyme treatment, vacuum freeze drying.
The typeⅡ Collagen is extracted from Chick sternal cartilage and is obtained.Currently preferred extracting method is as follows：Raw material is new
Freshly-slaughtered poultry chest cartilage slices, material-water ratio 1：3, it is 1.8 to adjust material liquid pH with acetic acid, adds the pepsin of raw material weight 0.5%, room
25 DEG C of processing 2h of temperature, enzyme deactivation, filtering, ethyl alcohol wash, the cartilage after being cleaned, and low-temperature grinding under liquid nitrogen adds solid content weight
3 times of water are measured, 0.3% papain is added, adjust 6.3,60 DEG C of pH, digest 1h；Enzymolysis liquid is detached through ion-exchange chromatography,
Freeze-drying obtains high-purity II type collagen.
The collagen protein powder and vitamin C are commercial goods raw material.The soy meal or black bean powder are commercially available quotient
Product soybean or black soya bean are obtained through crushing and screening.
The preparation method of above-mentioned nutraceutical is as follows：Raw soybeans and black soya bean are pulverized and sieved, then with by above method system
Chitosan oligosaccharide, typeⅡ Collagen, grape seed extract and collagen protein powder, vitamin C and the maltodextrin obtained mixes in proportion
Tablet is made in conjunction, granulation, drying, screening, tabletting, packing.
Embodiment 2
A kind of functional nutrient food of joint-improving, is prepared by following raw material in parts by weight：Soy meal 15 is black
Bean powder 60, chitosan oligosaccharide 10, collagen protein powder 10, typeⅡ Collagen 5, grape seed extract 5, vitamin C 10；Further include with
The auxiliary material of lower parts by weight：Maltodextrin 15.
The preparation method of the grape seed extract is as follows：Grape pip crushing is placed on molten equipped with 0.4% sodium bicarbonate
In liquid, it is 7.6 to adjust pH value, is warming up to 45 DEG C, and the mixed enzyme of grape pip quality 5% is added, stirs evenly, and digests 50min, enzyme
High-pressure pulse electric processing, electric field strength 40kV/cm, 500 μ s of burst length, pulse frequency 250Hz are carried out during solution；Above-mentioned place
The enzymolysis liquid of reason is filtered through 200 mesh screens, and filtrate is freeze-dried up to grape seed extract；The quality of the mixed enzyme forms
For：Amylase:Pectase:Cellulase=1:8:10.
The preparation method of the chitosan oligosaccharide is as follows：Cellulase：Papain=3:1 is dissolved in 5.4 acetic acid solutions of pH,
50 DEG C of temperature control, mixed enzyme solution hydrolyzing chitosan 4h, hydrolyzate obtain chitosan oligosaccharide through destroy the enzyme treatment, vacuum freeze drying.
The typeⅡ Collagen is extracted from Chick sternal cartilage and is obtained.Currently preferred extracting method is as follows：Raw material is new
Freshly-slaughtered poultry chest cartilage slices, material-water ratio 1：5, it is 2.2 to adjust material liquid pH with acetic acid, adds the pepsin of raw material weight 0.5%, room
25 DEG C of processing 5h of temperature, enzyme deactivation, filtering, ethyl alcohol wash, the cartilage after being cleaned, and low-temperature grinding under liquid nitrogen adds solid content weight
4 times of water are measured, 0.3% papain is added, adjust 6.5,56 DEG C of pH, digest 2h；Enzymolysis liquid is detached through ion-exchange chromatography,
Freeze-drying obtains high-purity II type collagen.
The collagen protein powder and vitamin C are commercial goods raw material.The soy meal or black bean powder are commercially available quotient
Product soybean or black soya bean are obtained through crushing and screening.
The preparation method of above-mentioned nutraceutical is as follows：Raw soybeans and black soya bean are pulverized and sieved, then with by above method system
Chitosan oligosaccharide, typeⅡ Collagen, grape seed extract and collagen protein powder, vitamin C and the maltodextrin obtained mixes in proportion
It closes, filling capsule, polishing, dispense obtained capsule product.
Embodiment 3
A kind of functional nutrient food of joint-improving, is prepared by following raw material in parts by weight：Soy meal 25 is black
Bean powder 40, chitosan oligosaccharide 15, collagen protein powder 5, typeⅡ Collagen 10, grape seed extract 10, vitamin C 8；Further include with
The auxiliary material of lower parts by weight：Maltodextrin 35.
The preparation method of the grape seed extract is as follows：Grape pip crushing is placed on molten equipped with 0.5% sodium bicarbonate
In liquid, it is 8 to adjust pH value, is warming up to 40 DEG C, and the mixed enzyme of grape pip quality 8% is added, stirs evenly, and digests 70min, enzymolysis
Period carries out high-pressure pulse electric processing, electric field strength 40kV/cm, 400 μ s of burst length, pulse frequency 200Hz；Above-mentioned processing
Enzymolysis liquid filtered through 300 mesh screens, filtrate is freeze-dried up to grape seed extract；The quality of the mixed enzyme forms
For：Amylase:Pectase:Cellulase=1:5:10.
The preparation method of the chitosan oligosaccharide is as follows：Cellulase：Papain=3:1 is dissolved in 5.6 acetic acid solutions of pH,
55 DEG C of temperature control, mixed enzyme solution hydrolyzing chitosan 3h, hydrolyzate obtain chitosan oligosaccharide through destroy the enzyme treatment, vacuum freeze drying.
The typeⅡ Collagen is extracted from Chick sternal cartilage and is obtained.Currently preferred extracting method is as follows：Raw material is new
Freshly-slaughtered poultry chest cartilage slices, material-water ratio 1：8, it is 2.5 to adjust material liquid pH with acetic acid, adds the pepsin of raw material weight 0.5%, room
25 DEG C of processing 8h of temperature, enzyme deactivation, filtering, ethyl alcohol wash, the cartilage after being cleaned, and low-temperature grinding under liquid nitrogen adds solid content weight
5 times of water are measured, 0.3% papain is added, adjust 6.8,55 DEG C of pH, digest 3h；Enzymolysis liquid is detached through ion-exchange chromatography,
Freeze-drying obtains high-purity II type collagen.
The collagen protein powder and vitamin C are commercial goods raw material.The soy meal or black bean powder are commercially available quotient
Product soybean or black soya bean are obtained through crushing and screening.
The preparation method of above-mentioned nutraceutical is as follows：Raw soybeans and black soya bean are pulverized and sieved, then with by above method system
Chitosan oligosaccharide, typeⅡ Collagen, grape seed extract and collagen protein powder, vitamin C and the maltodextrin obtained mixes in proportion
Tablet is made in conjunction, granulation, drying, screening, tabletting, packing.
Embodiment 4
A kind of functional nutrient food of joint-improving, is prepared by following raw material in parts by weight：Soy meal 40 is black
Bean powder 25, chitosan oligosaccharide 20, collagen protein powder 7, typeⅡ Collagen 15, grape seed extract 12, vitamin C 10；Further include with
The auxiliary material of lower parts by weight：Maltodextrin 50.
The chitosan oligosaccharide, grape seed extract, typeⅡ Collagen preparation method substantially with embodiment 3.The collagen
Albumen powder and vitamin C are commercial goods raw material.The soy meal or black bean powder are commercial goods soybean or black soya bean through powder
Broken screening obtains.
The preparation method of above-mentioned nutraceutical is as follows：Raw soybeans and black soya bean are pulverized and sieved, then auxiliary with other various originals
Granule product is made in mixing, granulation, dry, whole grain, packing to material in proportion.
Embodiment 5
A kind of functional nutrient food of joint-improving, is prepared by following raw material in parts by weight：Soy meal 80 is black
Bean powder 10, chitosan oligosaccharide 30, collagen protein powder 20, typeⅡ Collagen 1, grape seed extract 16, vitamin C 12；Further include with
The auxiliary material of lower parts by weight：Maltodextrin 60.
The chitosan oligosaccharide, grape seed extract, typeⅡ Collagen preparation method substantially with embodiment 3.The collagen
Albumen powder and vitamin C are commercial goods raw material.The soy meal or black bean powder are commercial goods soybean or black soya bean through powder
Broken screening obtains.
The preparation method of above-mentioned nutraceutical is as follows：Raw soybeans and black soya bean are pulverized and sieved, then with by above method system
Chitosan oligosaccharide, typeⅡ Collagen, grape seed extract and collagen protein powder, vitamin C and the maltodextrin obtained mixes in proportion
Tablet is made in conjunction, granulation, drying, screening, tabletting, packing.
Embodiment 6
It tests to the eating effect of product of the present invention, verification test is divided into four groups, collects 150 volunteers,
The amount of Products Show of the present invention is 4.21-33.8g/d, takes the embodiment of the present invention 3 by same amount and number for every group and produces
Product are continuously taken 30 days, statistical test result.
Concrete condition is as follows：
One group of subject 50 suffers from low different degrees of osteoporosis, bone density, rheumatic arthritis, gonitis
Equal bone and joint diseases, age 60-68 Sui.Product of the present invention is taken after 30 days, above-mentioned 42 people of the illness person of significantly improving,
7 people of improver, substantially without 1 people of improver.
Two groups of subjects 50, are the retired athlete of male, and arthralgia, tendon pain or muscle-tendon structure are not just
Normal patient, age 38-46 Sui.Product of the present invention is taken after 30 days, above-mentioned 36 people of the illness person of significantly improving makes moderate progress
12 people of person, substantially without 2 people of improver.
Three groups of subjects 50, age 25-35 women suffer from more serious women premenstrual syndrome, including waist for a long time
Bitterly, joint pain, swelling etc..Product of the present invention is taken after 30 days, above-mentioned 38 people of the illness person of significantly improving, the person of making moderate progress
9 people, substantially without 3 people of improver.
In addition, there are 68 to belong to high cholesterol patient in above-mentioned 150 subjects, product of the present invention is taken after 30 days,
In 56 subject's cholesterol levels significantly reduce, 12 subject's cholesterol levels decrease.
Above-mentioned alleged " improvement " situation is to take physical examination report in conjunction with the form of patient's readme, " notable " and is " " logical
According to improving, degree is opposite to be divided after crossing relatively.
Claims (8)
1. a kind of functional nutrient food of joint-improving, which is characterized in that be prepared by following raw material in parts by weight：Greatly
Bean powder 10-80, black bean powder 10-80, chitosan oligosaccharide 5-30, collagen protein powder 1-20, typeⅡ Collagen 1-20, grape seed extract
0.1-16, vitamin C 5-12；Further include the auxiliary material of following parts by weight according to dosage form needs：Maltodextrin 10-80；It is described
The preparation method of grape seed extract is as follows：Grape pip crushing is placed on equipped in 0.3-0.5% sodium bicarbonate solutions, is adjusted
PH value is 7-8, is warming up to 40-50 DEG C, and the mixed enzyme of grape pip quality 2-8% is added, stirs evenly, and digests 40-70min, enzyme
High-pressure pulse electric processing, electric field strength 20-40kV/cm, burst length 400-500 μ s, pulse frequency 200- are carried out during solution
300Hz；The enzymolysis liquid of above-mentioned processing is filtered through 100-300 mesh screens, and filtrate is freeze-dried up to grape seed extract；It is described
The quality group of mixed enzyme becomes：Amylase:Pectase:Cellulase=1:5-8:5-10.
2. a kind of functional nutrient food of joint-improving as described in claim 1, which is characterized in that by following parts by weight
Raw material be prepared：Soy meal 15-40, black bean powder 25-60, chitosan oligosaccharide 10-20, collagen protein powder 5-10, II Collagen Type VI egg
White 5-15, grape seed extract 5-12, vitamin C 6-10；Further include the auxiliary material of following parts by weight according to dosage form needs：Wheat
Bud dextrin 15-50.
3. a kind of functional nutrient food of joint-improving as described in claim 1, which is characterized in that the system of the chitosan oligosaccharide
Preparation Method is as follows：Cellulase：Papain=3:1 is dissolved in pH5.2-5.6 acetic acid solutions, and 50-55 DEG C of temperature control, mixed enzyme is molten
Liquid hydrolyzing chitosan 3-6h, hydrolyzate obtain chitosan oligosaccharide through destroy the enzyme treatment, vacuum freeze drying.
4. a kind of functional nutrient food of joint-improving as described in claim 1, which is characterized in that the II Collagen Type VI egg
It extracts and obtains from Chick sternal cartilage in vain.
5. a kind of functional nutrient food of joint-improving as claimed in claim 4, which is characterized in that the II Collagen Type VI egg
White extracting method is as follows：The fresh Chick sternal cartilage slice of raw material, material-water ratio 1：3-8, it is 1.8-2.5 to adjust material liquid pH with acetic acid,
Add the pepsin of raw material weight 0.5%, 25 DEG C of processing 2-8h of room temperature, enzyme deactivation, filtering, ethyl alcohol washing, after being cleaned
Cartilage, low-temperature grinding under liquid nitrogen add solid content 3-5 times of water of weight, add 0.3% papain, adjust pH 6.3-6.8,
55-60 DEG C, digest 1-3h；Enzymolysis liquid is detached through ion-exchange chromatography, and freeze-drying obtains high-purity II type collagen.
6. a kind of functional nutrient food of joint-improving according to any one of claims 1 to 5, which is characterized in that the function
Property nutraceutical be oral preparation.
7. a kind of functional nutrient food of joint-improving as claimed in claim 6, which is characterized in that the oral preparation is
Tablet, granule, pill, powder, pulvis or capsule.
8. a kind of functional nutrient food of joint-improving according to any one of claims 1 to 5, which is characterized in that by following heavy
The raw material of amount number is prepared：Soy meal 25, black bean powder 40, chitosan oligosaccharide 15, collagen protein powder 5, typeⅡ Collagen 10, Portugal
Grape seed extract 10, vitamin C 8；It further include the auxiliary material of following parts by weight：Maltodextrin 35；The grape seed extract
Preparation method is as follows：Grape pip crushing is placed on equipped in 0.5% sodium bicarbonate solution, it is 8 to adjust pH value, is warming up to 40
DEG C, the mixed enzyme of grape pip quality 8% is added, stirs evenly, digests 70min, high-pressure pulse electric processing is carried out during enzymolysis,
Electric field strength 40kV/cm, 400 μ s of burst length, pulse frequency 200Hz；The enzymolysis liquid of above-mentioned processing is filtered through 300 mesh screens,
Filtrate is freeze-dried up to grape seed extract；The quality group of the mixed enzyme becomes：Amylase:Pectase:Cellulase
=1:5:10；
The preparation method of the chitosan oligosaccharide is as follows：Cellulase：Papain=3:1 is dissolved in 5.6 acetic acid solutions of pH, temperature control
55 DEG C, mixed enzyme solution hydrolyzing chitosan 3h, hydrolyzate obtains chitosan oligosaccharide through destroy the enzyme treatment, vacuum freeze drying；
The typeⅡ Collagen is extracted from Chick sternal cartilage and is obtained, and extracting method is as follows：The fresh Chick sternal cartilage slice of raw material, material
Water is than 1：8, it is 2.5 to adjust material liquid pH with acetic acid, adds the pepsin of raw material weight 0.5%, and 25 DEG C of processing 8h of room temperature go out
Enzyme, filtering, ethyl alcohol wash, the cartilage after being cleaned, and low-temperature grinding under liquid nitrogen adds solid content 5 times of water of weight, addition
0.3% papain adjusts 6.8,55 DEG C of pH, digests 3h；Enzymolysis liquid is detached through ion-exchange chromatography, and freeze-drying obtains
High-purity II type collagen；
The collagen protein powder and vitamin C are commercial goods raw material, and the soy meal or black bean powder are that commercial goods are big
Beans or black soya bean are obtained through crushing and screening；
The preparation method of above-mentioned nutraceutical is as follows：Raw soybeans and black soya bean are pulverized and sieved, then with made from the above method
Chitosan oligosaccharide, typeⅡ Collagen, grape seed extract and collagen protein powder, vitamin C and maltodextrin mix in proportion,
Tablet is made in granulation, drying, screening, tabletting, packing.
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| CN106262817A (en) * | 2016-08-09 | 2017-01-04 | 江门多微生物科技有限公司 | A kind of nutraceutical being beneficial to desensitization and Mucous rehabilitation and maintenance |
| CN107348522A (en) * | 2017-08-14 | 2017-11-17 | 北京市营养源研究所 | A kind of alimentation composition for improving the elderly's kinematic system function and preparation method thereof |
| CN107691952A (en) * | 2017-08-22 | 2018-02-16 | 北京同仁堂健康药业股份有限公司 | A kind of resisting kinetic fatigue, the composition for promoting postexercise recovery and preparation method thereof |
| CN107669980A (en) * | 2017-10-10 | 2018-02-09 | 北京特食生物科技研究中心（有限合伙） | A kind of alimentation composition for improving bony articulation health and preparation method and application |
| CN108112997B (en) * | 2017-12-18 | 2021-02-26 | 北京康比特体育科技股份有限公司 | A health food composition |
| CA3106630A1 (en) * | 2018-07-16 | 2020-01-23 | Lonza Consumer Health Inc. | Collagen and cell matter supplement and method for administering same |
| CN111280447A (en) * | 2018-12-07 | 2020-06-16 | 解冰 | Composite nanometer preparation for treating and recovering bone joint function and preparation method thereof |
| CN109771444A (en) * | 2019-04-03 | 2019-05-21 | 哈尔滨北极神生物工程有限公司 | Propolis ammonia sugar panaxoside complex capsule and preparation method |
| CN110214947A (en) * | 2019-06-12 | 2019-09-10 | 宁波依萃健生物科技有限公司 | A kind of prevention and treatment osteoarthritis composition |
| CN112219958A (en) * | 2020-07-08 | 2021-01-15 | 许昌神飞航天生物科技有限公司 | Space navigation grade solid beverage for bone joint recuperation |
| CN112891518B (en) * | 2021-01-28 | 2023-07-18 | 曲词 | Composite containing non-denatured type II collagen and chitosan oligosaccharide and preparation method thereof |
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| CN109043518A (en) | 2018-12-21 |
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