CN105713011B - 一种原研制品质头孢拉定的制备方法及组合物 - Google Patents
一种原研制品质头孢拉定的制备方法及组合物 Download PDFInfo
- Publication number
- CN105713011B CN105713011B CN201610221366.0A CN201610221366A CN105713011B CN 105713011 B CN105713011 B CN 105713011B CN 201610221366 A CN201610221366 A CN 201610221366A CN 105713011 B CN105713011 B CN 105713011B
- Authority
- CN
- China
- Prior art keywords
- cefradine
- preparation
- quality
- parts
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610221366.0A CN105713011B (zh) | 2016-04-11 | 2016-04-11 | 一种原研制品质头孢拉定的制备方法及组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610221366.0A CN105713011B (zh) | 2016-04-11 | 2016-04-11 | 一种原研制品质头孢拉定的制备方法及组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105713011A CN105713011A (zh) | 2016-06-29 |
CN105713011B true CN105713011B (zh) | 2018-07-10 |
Family
ID=56160819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610221366.0A Active CN105713011B (zh) | 2016-04-11 | 2016-04-11 | 一种原研制品质头孢拉定的制备方法及组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105713011B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109836438A (zh) * | 2019-03-19 | 2019-06-04 | 河北科技大学 | 头孢氨苄杂质的合成方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106432269A (zh) * | 2016-09-07 | 2017-02-22 | 陕西顿斯制药有限公司 | 一种采用高通量药物晶型快速筛选技术制备的头孢拉定化合物及其制剂 |
CN112321608A (zh) * | 2020-11-19 | 2021-02-05 | 河北载和新材料科技有限公司 | 一种通过微反应器制备头孢拉定的工艺方法 |
CN115508464A (zh) * | 2022-06-16 | 2022-12-23 | 华北制药股份有限公司 | 一种头孢拉定合成酶活性的分析方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1813069A (zh) * | 2003-07-03 | 2006-08-02 | 帝斯曼知识产权资产管理有限公司 | 制备头孢拉定的方法 |
CN101643477A (zh) * | 2009-09-11 | 2010-02-10 | 哈药集团制药总厂 | 一种头孢拉定的合成方法 |
CN103044451A (zh) * | 2012-12-17 | 2013-04-17 | 浙江浙邦制药有限公司 | 一种头孢拉定的制备方法 |
-
2016
- 2016-04-11 CN CN201610221366.0A patent/CN105713011B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1813069A (zh) * | 2003-07-03 | 2006-08-02 | 帝斯曼知识产权资产管理有限公司 | 制备头孢拉定的方法 |
CN101643477A (zh) * | 2009-09-11 | 2010-02-10 | 哈药集团制药总厂 | 一种头孢拉定的合成方法 |
CN103044451A (zh) * | 2012-12-17 | 2013-04-17 | 浙江浙邦制药有限公司 | 一种头孢拉定的制备方法 |
Non-Patent Citations (1)
Title |
---|
头孢拉定母液回收工艺研;杨畅,等;《南昌大学学报(工科版)》;19970331;第19卷(第1期);摘要 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109836438A (zh) * | 2019-03-19 | 2019-06-04 | 河北科技大学 | 头孢氨苄杂质的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
CN105713011A (zh) | 2016-06-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105713011B (zh) | 一种原研制品质头孢拉定的制备方法及组合物 | |
CN102659818B (zh) | 一种盐酸头孢替安晶体化合物及其制备方法及含该化合物的药物组合物 | |
CN104873466B (zh) | 一种注射用头孢曲松钠粉针剂 | |
CN102924483B (zh) | 一种头孢他啶晶体化合物、其制备方法及其无菌混合粉形式的药物组合物 | |
CN102382013A (zh) | 一种卡巴匹林钙的制备方法 | |
CN102558182B (zh) | 一种厄他培南钠晶型及其制备方法 | |
CN102249977A (zh) | 4-羟基-2-氧代-1-吡咯烷乙酰胺外消旋体晶型ⅰ及其制备方法 | |
CN104530128B (zh) | 一种磷酸特地唑胺二钠盐及其制备方法 | |
CN104193765B (zh) | 一种头孢克肟的合成方法 | |
CN106632481B (zh) | 一种噁唑烷酮类抗菌药物的晶型a及其制备方法和应用 | |
CN102558394A (zh) | 羟丙基-β-环糊精的制备方法 | |
CN102358729A (zh) | 3-羟基-吲哚-2-酮衍生物,以其为有效成分的抗植物病毒病药物及其应用 | |
CN102311431A (zh) | 一种制备无水β-氨曲南的方法 | |
CN105646535A (zh) | 头孢噻肟钠的合成方法 | |
CN102303854A (zh) | 一种磷酸二氢钾的纯化方法 | |
CN107986957A (zh) | 一种山梨酸的制备方法 | |
CN101982460B (zh) | 脱氢松香基硫脲衍生物及其制备方法和应用 | |
CN103772377A (zh) | 1, 3, 4-噻二唑苯并异噻唑啉酮乙酰胺类衍生物及其合成方法 | |
CN108610347A (zh) | 一种多羰基取代六元半瓜环的化合物及其制备方法 | |
CN105646269B (zh) | 一种水杨酰胺的合成方法 | |
CN109942487A (zh) | 一种吡啶类化合物及其制备方法、用途 | |
CN109438340A (zh) | 一种2-氯-3-氰基吡啶的制备工艺 | |
CN104513237A (zh) | 一种制备n-甲基莫西沙星的新方法 | |
CN103110624A (zh) | 一种阿莫西林钠与克拉维酸钾的药物组合物 | |
CN104230984B (zh) | 一种三水合3‑氨基丙基胺乙基硫代磷酸的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 528415 Hongshan Road, Xiaolan Town, Guangdong, Zhongshan, China, No. 63 Applicant after: GUANGDONG JINCHENG JINSU PHARMACY Co.,Ltd. Applicant after: SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL Co.,Ltd. Address before: 528415 Hongshan Road, Xiaolan Town, Guangdong, Zhongshan, China, No. 63 Applicant before: ZHONGSHAN JINCHENG DOBFAR PHARMACEUTICAL CO.,LTD. Applicant before: SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL Co.,Ltd. |
|
COR | Change of bibliographic data | ||
CB02 | Change of applicant information | ||
CB02 | Change of applicant information |
Address after: 528415 Hongshan Road, Xiaolan Town, Guangdong, Zhongshan, China, No. 63 Applicant after: GUANGDONG JINCHENG JINSU PHARMACY Co.,Ltd. Applicant after: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. Address before: 528415 Hongshan Road, Xiaolan Town, Guangdong, Zhongshan, China, No. 63 Applicant before: GUANGDONG JINCHENG JINSU PHARMACY Co.,Ltd. Applicant before: SHANDONG JINCHENG PHARMACEUTICAL CO.,LTD. Address after: 528415 Hongshan Road, Xiaolan Town, Guangdong, Zhongshan, China, No. 63 Applicant after: GUANGDONG JINCHENG JINSU PHARMACY Co.,Ltd. Applicant after: SHANDONG JINCHENG PHARMACEUTICAL CO.,LTD. Address before: 528415 Hongshan Road, Xiaolan Town, Guangdong, Zhongshan, China, No. 63 Applicant before: GUANGDONG JINCHENG JINSU PHARMACY Co.,Ltd. Applicant before: SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant |