CN1813069A - 制备头孢拉定的方法 - Google Patents
制备头孢拉定的方法 Download PDFInfo
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- CN1813069A CN1813069A CNA2004800183948A CN200480018394A CN1813069A CN 1813069 A CN1813069 A CN 1813069A CN A2004800183948 A CNA2004800183948 A CN A2004800183948A CN 200480018394 A CN200480018394 A CN 200480018394A CN 1813069 A CN1813069 A CN 1813069A
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- cephradine
- adca
- enzyme
- reaction mixture
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
反应条件 | 野生型PenG酰基转移酶 | 经突变的PenG酰基转移酶Phe-24-Ala |
野生型/突变体 | 实施例1 | 实施例2 |
T=10/7℃pH=7.2-7.8/8.0-8.2 | 7-ADCA转化率74%DHMe转化率73%S/H:5.5[DH]=0.84% | 7-ADCA转化率85%DHMe转化率89%S/H:15.5[DH]=0.27% |
对照实验A | 实施例3 | |
T=20℃pH=6.9 | 7-ADCA转化率68%DHMe转化率68%S/H:1.8[DH]=2.97% | 7-ADCA转化率98.4%DHMe转化率95.6%S/H:13.8[DH]=0.56% |
通过酶制备的头孢拉定 | 通过化学方法制备的头孢拉定 | |
周 | 结晶温度T=52℃ | 结晶温度T=55℃ |
0246 | 0.0250.0430.058 | 0.0280.0650.0770.161 |
81012 | 0.0960.148 | 0.1420.211 |
实验编号 | 结晶温度(℃) | t=0时的A450 | 胁迫稳定性试验后的A450(3小时,100℃) |
4 | 65 | 0.051 | 0.301 |
5 | 50 | 0.018 | 0.056 |
6 | 30 | 0.021 | 0.291 |
7 | 20 | 0.017 | 0.330 |
Claims (32)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03077102.6 | 2003-07-03 | ||
EP03077102 | 2003-07-03 | ||
EP03104445.6 | 2003-11-28 |
Publications (2)
Publication Number | Publication Date |
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CN1813069A true CN1813069A (zh) | 2006-08-02 |
CN100507000C CN100507000C (zh) | 2009-07-01 |
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Application Number | Title | Priority Date | Filing Date |
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CNB2004800183948A Active CN100507000C (zh) | 2003-07-03 | 2004-07-01 | 制备头孢拉定的方法 |
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CN (1) | CN100507000C (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102264904A (zh) * | 2008-12-23 | 2011-11-30 | 帝斯曼知识产权资产管理有限公司 | 突变体青霉素g酰基转移酶 |
CN102656274A (zh) * | 2009-12-14 | 2012-09-05 | 中化帝斯曼制药有限公司荷兰公司 | 生产头孢拉定的方法 |
CN105713011A (zh) * | 2016-04-11 | 2016-06-29 | 中山市金城道勃法制药有限公司 | 一种原研制品质头孢拉定的制备方法及组合物 |
CN109134500A (zh) * | 2017-07-19 | 2019-01-04 | 郝志艳 | 一种1/2水头孢拉定化合物 |
CN109134501A (zh) * | 2017-07-24 | 2019-01-04 | 赵建宇 | 一种1/5水头孢拉定化合物及其药物组合物制剂 |
CN112321608A (zh) * | 2020-11-19 | 2021-02-05 | 河北载和新材料科技有限公司 | 一种通过微反应器制备头孢拉定的工艺方法 |
CN115508464A (zh) * | 2022-06-16 | 2022-12-23 | 华北制药股份有限公司 | 一种头孢拉定合成酶活性的分析方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51133488A (en) * | 1975-05-14 | 1976-11-19 | Shionogi & Co Ltd | Process for producing antibiotics enzymatically |
JP3426218B2 (ja) * | 2001-01-19 | 2003-07-14 | 松下電器産業株式会社 | 基地局装置及び符号化/変調方法 |
-
2004
- 2004-07-01 CN CNB2004800183948A patent/CN100507000C/zh active Active
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102264904A (zh) * | 2008-12-23 | 2011-11-30 | 帝斯曼知识产权资产管理有限公司 | 突变体青霉素g酰基转移酶 |
CN102264904B (zh) * | 2008-12-23 | 2013-10-23 | 中化帝斯曼制药有限公司荷兰公司 | 突变体青霉素g酰基转移酶 |
CN102656274A (zh) * | 2009-12-14 | 2012-09-05 | 中化帝斯曼制药有限公司荷兰公司 | 生产头孢拉定的方法 |
CN102656274B (zh) * | 2009-12-14 | 2014-10-15 | 中化帝斯曼制药有限公司荷兰公司 | 生产头孢拉定的方法 |
CN105713011A (zh) * | 2016-04-11 | 2016-06-29 | 中山市金城道勃法制药有限公司 | 一种原研制品质头孢拉定的制备方法及组合物 |
CN105713011B (zh) * | 2016-04-11 | 2018-07-10 | 广东金城金素制药有限公司 | 一种原研制品质头孢拉定的制备方法及组合物 |
CN109134500A (zh) * | 2017-07-19 | 2019-01-04 | 郝志艳 | 一种1/2水头孢拉定化合物 |
CN109134501A (zh) * | 2017-07-24 | 2019-01-04 | 赵建宇 | 一种1/5水头孢拉定化合物及其药物组合物制剂 |
CN112321608A (zh) * | 2020-11-19 | 2021-02-05 | 河北载和新材料科技有限公司 | 一种通过微反应器制备头孢拉定的工艺方法 |
CN115508464A (zh) * | 2022-06-16 | 2022-12-23 | 华北制药股份有限公司 | 一种头孢拉定合成酶活性的分析方法 |
Also Published As
Publication number | Publication date |
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CN100507000C (zh) | 2009-07-01 |
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Assignee: DSM Zibo Pharmaceutical Co.,Ltd. Assignor: DSM IP ASSETS B.V. Contract record no.: 2011990001128 Denomination of invention: Cefradine crystal and method for preparing cefradine Granted publication date: 20090701 License type: Exclusive License Open date: 20060802 Record date: 20111228 |
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