CN105661645B - 气雾装置和用于吸入物质的方法以及该装置的用法 - Google Patents
气雾装置和用于吸入物质的方法以及该装置的用法 Download PDFInfo
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Abstract
在此描述了气雾装置和用于吸入物质的方法以及该装置的用法。其中一种装置通过加热粘性材料而产生用于对象吸入的气雾,该气雾可在嘴或呼吸道中具有触觉响应,同时相比普通烟草香烟减少传递给使用者的霍夫曼分析物和致突变化合物。
Description
本申请是申请号为200880126977.0、国际申请日为2008年12月18日的同名的发明专利申请的分案申请。
交叉引用
本申请要求美国2008年12月16日的实用申请12/336,439的优先权,并且要求美国2007年12月18日的临时申请61/014,690的权益,上述申请通过引用并入本文。
背景技术
烟草产品的使用和吸用烟草的有害副作用在世界范围内持续获得越来越多的关注。由于更多关于在工作场所和公共场所吸烟的规定开始生效,发展可替代产品的兴趣正在显著增长。一种减少吸烟有害副作用的方法是不燃烧烟草产品,这是因为从吸烟得到的许多有害分析物,例如霍夫曼分析物,都是由于材料的燃烧而接收的。
开发和销售能释放雾化烟草产品的装置的困难是在使用时的视觉上的和身体上的吸引力方面迎合使用者。一种可多次使用以雾化多种不同物质同时为使用者提供与吸烟类似感觉(例如视觉上的雾气)的装置是值得去做的。一种可雾化烟草产品并且相比于吸烟减少传递给使用者的霍夫曼分析物和致突变的化合物的装置和产品也是值得去做的。
发明内容
本发明的一方面,公开了一种盒,该盒用在用于雾化材料的装置中,包括用于容纳粘性可汽化材料的壳体,和密封于壳体上的盖,因此形成容纳所述粘性可汽化材料的密封盒。所述盖能被刺穿,其中被刺穿的盖允许产生自加热所述粘性可汽化材料的气雾排出。所述盖也可为可热封膜,其中所述可热封膜包括基层和可热封层。所述盒的壳体或所述盒的盖可包括铝。当本发明盒的壳体包括凸缘时,盖可密封在凸缘上。
所述盒可被加热至雾化容纳在所述壳体中材料所需的温度,最好是加热至小于400°F。所述盒中的所述粘性可汽化材料可包含气雾形成介质、丙二醇和丙三醇中的至少一种。所述粘性可汽化材料可包含烟草。
所述盒可插入装置中,其中该装置能雾化所述粘性可汽化材料。所述装置可包括能加热所述盒的炉室。
为了标记本发明的盒,可在所述壳体和盖的至少一个上打印信息。
另一方面,一种填充容纳粘性可汽化材料的盒的方法,包括将所述粘性可汽化材料装填进所述盒的所述壳体,和在所述盒的所述壳体上密封盖。所述方法可自动操作,例如,在直线或旋转的移位机上完成,或者用螺旋填充器、蠕动泵或活塞泵方法装填。在装填步骤中可装填预定体积的粘性可汽化材料,其中预定体积可为大约0.1至大约0.8立方厘米,优选地体积为大约0.25立方厘米。填充所述盒的方法的密封步骤可包括加热所述盒的所述盖和所述壳体的至少一个,并且从盖上剪切掉任何多余材料。
在此提供产生可吸入气雾的装置,包括本体,本体内的加热器,该加热器可加热粘性可汽化材料以产生可吸入气雾,和包括一个或多个双金属盘的温度调节器,其中所述盘将温度变化转换为机械位移。所述可吸入气雾可包括直径小于大约2微米的微粒。可向所述装置的加热器提供气体燃料,例如丁烷,并且可通过压电点火器点燃。
温度调节器的盘可移动推杆,该推杆通过推动可变限流阀限制或停止气体燃料在所述装置本体中的流动。所述推杆也可提供对催化网元件的支撑。
另一方面,本发明提供一种模仿吸烟的装置,其中所述装置通过加热包含植物物质的粘性材料至大约150℃而产生用于对象吸入的气雾,并且其中所述气雾在口中或者呼吸道中具有触觉响应。所述粘性材料可包括气雾形成介质,该气雾形成介质科包括丙二醇和丙三醇中的至少一种,以在被加热时产生可视气雾。所述粘性材料也可包括烟草和食用香料。
所述装置也可将作为气雾一部分的活性元素传递给使用者。所述活性元素可在呼吸道被吸收。所述气雾可包括直径小于大约2微米的微粒。
在此公开的本发明的装置包括本体和加热器,其中所述装置通过加热粘性烟草材料至目标温度产生用于对象吸入的无烟气雾。所述粘性材料可包括气雾形成介质,该气雾形成介质可包括丙二醇和丙三醇的至少一种,以在被加热时产生可视气雾。所述装置可将作为气雾一部分的活性元素传递给使用者。所述活性元素可在呼吸道被吸收。所述气雾可包括直径小于大约2微米的微粒。
用于加热装置中的粘性材料的目标温度可为大约100℃至大约200℃。优选地目标温度为大约150℃。
所述装置也可由使用者用单只手操作。
本发明的另一方面,公开了一种气雾产生装置,其中所述装置在加热可点燃抽吸材料至目标温度之后产生基本上没有至少一种霍夫曼分析物的气雾。所述霍夫曼分析物可选自由氨、氨基萘、苯并芘、甲醛、乙醛、丙酮、甲基乙基酮、丁醛、氰化氢、氮氧化物、烟草特有亚硝胺(TSNAS)、吡啶、喹啉、对苯二酚、苯酚、甲酚、焦油、尼古丁、一氧化碳、1,3-丁二烯、异戊二烯、丙烯腈、苯、甲苯和苯乙烯组成的组。
用于加热所述装置中的所述粘性材料的目标温度可为大约100℃至大约200℃。优选地目标温度为大约150℃,这产生包括直径小于大约2微米微粒的气雾。
本发明也提供一种气雾产生装置,其中所述装置通过加热可点燃抽吸材料至目标温度之后产生带有至少比普通烟草香烟少70%霍夫曼分析物的气雾,并且其中霍夫曼分析物可选自由氨、氨基萘、苯并芘、甲醛、乙醛、丙酮、甲基乙基酮、丁醛、氰化氢、氮氧化物、烟草特有亚硝胺(TSNAS)、吡啶、喹啉、对苯二酚、苯酚、甲酚、焦油、尼古丁、一氧化碳、1,3-丁二烯、异戊二烯、丙烯腈、苯、甲苯和苯乙烯组成的组。所述普通香烟可包括过滤嘴。
用于加热所述装置中的所述粘性材料的目标温度可为大约100℃至大约200℃。最好是目标温度为大约150℃,并且产生包括直径小于大约2微米微粒的气雾。
一方面,本发明公开了一种给对象传递基本上没有霍夫曼分析物的气雾的方法,包括:配置包含加热器和可点燃抽吸材料的气雾产生装置,用所述装置的加热器加热所述可点燃抽吸材料至目标温度以产生气雾;和传递所述气雾至对象以用于吸入。
另一方面,公开了一种在口中或呼吸道中产生触觉响应的方法。所述方法包括:配置烟雾模仿装置,其中所述装置通过加热包含在该装置中的包含植物物质的粘性材料产生具有在口中或呼吸道中的触觉响应的无烟气雾;加热所述粘性材料至目标温度;从被加热的粘性材料产生在口中或呼吸道中的具有触觉响应的气雾;和吸入所述气雾。所述粘性材料可包括气雾形成介质,该气雾形成介质科包括丙二醇和丙三醇中的至少一种,以在被加热时产生可视气雾。所述粘性材料也可包括烟草和食用香料中的至少一种。所述装置可将作为气雾一部分的活性元素传递给使用者。所述活性元素可在呼吸道中被吸收。所述气雾可包括直径小于大约2微米微粒。
另一方面,本发明公开了一种气雾产生装置,其中所述装置从可点燃抽吸材料产生气雾,其中所述气雾包含比通过燃烧本发明提供的可点燃抽吸材料产生的物质少至少70%的霍夫曼分析物。
也公开了一种气雾产生装置,其中所述装置从可点燃抽吸材料产生气雾,该气雾通过艾姆斯试验,和一种气雾产生装置,其中所述装置从可点燃抽吸材料产生气雾,其中气雾的艾姆斯试验得分显著好于燃烧所述可点燃抽吸材料产生的物质。
本发明提供气雾产生装置,其中所述装置为使用者提供至少4个不连续小时的吸入气雾而不用补充燃料或另外保养装置。
参考结合
本说明书中提到的所有公开、专利和专利申请在相同程度上通过参考并入本文,如同每个单独的公开、专利和专利申请被具体地且单独地指明通过参考并入。
附图说明
通过参考公开了示例性实施例的下列详细描述以及附图,将获得对本发明的特征和优势的更好理解,在这些实施例中使用本发明的原理,在附图中:
图1图示了一种本发明的装置,包括吸嘴和具有加热器的本体、炉室、燃料箱和用于保持运行温度的带有控制器的点火器;
图2图示了本发明的装置,包括意欲可再填充的燃料箱和用于该目的的口;
图3图示了本发明的装置,包括可通过任何可燃燃料供能的加热器组件,和一系列双金属物体以控制流向加热器组件的可燃燃料流;
图4示出了一种装置,其中通过填充阀将燃料供应至箱中,和被压缩的液体燃料可通过燃料芯汲取使用;
图5图示了本发明的装置,包括阻止气体运动的单个弹性体止动器,其中气体燃料的流动被压缩泡沫流动限制器限制,并且仅可通过阀孔离开;
图6示出了一种装置,其中多个塑料体排出小孔定位在加热器排出小孔之上,并且流出的气体必须沿着加热器本体通过,从而与加热器本体交换更多的热,因此改善装置的效率;
图7图示了带有铰链连接吸嘴的本发明装置;
图8A示出了一种装置,其中使用者可将材料条朝装置的吸嘴端滑动以开启该装置,然后将该条向回朝向填充口滑动以将该装置关闭;
图8B从不同立体图图示了图8A装置;
图9图示了可容纳湿润的可汽化产品的盒,该盒汽化与能够汽化该产品的装置一起使用,该盒包括壳体、盖和将盖粘附至壳体的凸缘;
图10示出了带有PET基层和APET热封层的基本可热封膜;
图11显示带有PET基层和APET热封层,还有另外的金属层和金属粘附层的复合膜;
图12图示了本发明的盒,该盒容纳湿润的可汽化产品,并且包括多个小孔或通风口以允许盒中所容纳的东西接触环境;
图13A-B图示了具有两部分的盒,这两部分能组合在一起并且可具有多个小孔或通风口以释放来自盒内所容纳的东西的雾气;
图14示出了本发明的装置的示例性使用方法,该装置能通过仍然提供使用者所要求的许多期望的吸烟效果来模仿吸烟,但减少霍夫曼分析物的吸入量;
图15示出了本发明的装置的示例性使用方法,其中使用者以如下方式从本发明的装置接收吸入的烟草物质:该方式使使用者的霍夫曼分析物吸入量减少至少70%,并且使用者可吐出来自雾气形成介质的可视雾气,以提供与吸烟动作中的所吐出的烟的视觉辅助类似的视觉辅助;
图16示出了细菌突变形成试验(艾姆斯化验)的结果,该结果显示通过吸本发明装置而产生的微粒是非致突变的。
具体实施方式
本文所描述的本发明具有宽范围的应用以吸入活性物质,本领域技术人员在学习本公开之后将理解这些应用。例如,装置、盒、系统、成套工具和方法可被使用,例如,以通过嘴或鼻子吸入烟草产品。与吸烟或燃烧烟草相比,所述装置、盒、系统、成套工具和方法也可用于减少通过吸入烟草产品而提供给使用者的霍夫曼分析物。另外,所述装置、盒、系统、成套工具和方法可用于,例如,吸入任何物质,例如植物性药材、药物、保健品或任何其它向最终使用者提供益处或感觉的物质。
I.气雾产生装置
图1图示了本发明的一种示例性装置。该装置100可产生足够高的温度以雾化容纳在装置100中产品。本发明的一种装置可包括吸嘴110和具有加热器122的本体120,炉室124,燃料箱126,和用于保持运行温度的带有控制器的点火器。装置的运行温度调节器的例子包括双金属致动器。可选择地,可采用填满石蜡的部件,该部件膨胀或收缩以调节丁烷流量。可选择地,可采用一种系统以例如使用热电偶传感器测量当前温度并且例如使用微控制器并通过控制电动机械阀(例如伺服阀或电磁阀)将该温度与规定的温度比较。使用者所选择的温度,如上面的描述,该所选择的温度可用作这个系统的输入。
一种装置,可构造为没有主动调节元件。这可导致减少复杂性并且降低制造装置的总成本。例如,流向加热器122的燃料流可被设置为低水平。使用中,炉室124内部的温度增加直到平衡点,此时引入额外的热等于散失至环境的热。热由通过装置100本体的传导和随着传递至使用者的雾气而散失。该平衡点决定装置100的运行温度。通过改变燃料流率、燃烧器的尺寸和材料,以及其它因素,该系统可被标定为提供相当稳定的期望运行温度。
可使用压电点火器,其它的点火器也能使用,例如,打火石启动器或者电池供电电阻线圈。
如图2图示,本发明的装置200也可包括意欲可再填充的燃料箱226,并具有用于该目的的口230。该箱226可以是在其燃料耗尽后可丢弃的。可使用释放机构(例如销或凸轮)以允许使用者快速移除耗尽的箱226,并且代之以充满的箱。可替换的箱可包括该装置的附加零件,例如点火器和加热器。液体燃料为优选的燃料源,然而液体燃料可由电池供电的电加热器或者其它紧凑的热源补充或替换。该箱126可由如图1所示的填充阀机构128与专门的燃料源或标准商业燃料源填充。
燃料箱可装有足够的燃料以供该装置的重复使用。该装置可被使用高达10、20、30、40、50或60次。在一些实施例中,该装置可被使用多于60次。该装置也可连续或不连续的使用达1、2、3、4、5、6、7或8小时。用于与该装置一起使用的盒可在每次使用后丢弃或可多次使用。本发明的装置的长时间持续使用为使用者提供如下益处:即无需保养该装置或定期地重新填充燃料箱。多次使用的优点可优选地通过使用更大尺寸燃料箱和/或使用丁烷作为燃料而获得,这可产生必要的温度以在高效的方式下使用该装置。
通常,该装置的运行温度不超过200℃。通常所需要的雾化产品的温度在大约100至200℃之间。在一些实施例中,该需要的雾化产品的温度为大约150℃。一旦装置中的产品被雾化,通过吸嘴将已经雾化的产品提供给使用者。在很多情况下,本发明的装置设计为模仿吸烟装置,例如香烟、烟斗或雪茄烟嘴。
图3中,该装置300包括加热器组件322(其可由任何的可燃燃料供能),和一系列的双金属物体332以控制流向加热器组件322的可燃燃料流。可燃燃料的例子包括,但不限于,丙烷,丁烷,甲烷,和乙醇。当该装置300变热或该装置300的一部分变热时,该双金属物体332改变它们的形状(例如,从扁平变为凹入或凸起)以调节进入加热器组件322燃料的量。这可通过多种机构发生,包括如图3所示地抵靠着可变流量阀336推动杆334(在此称为推杆334)。
双金属物体可用于将温度变化转换成机械位移。该物体包括两种加热时具有不同膨胀率的不同金属,例如,钢和铜。该物体可为合金或固定在一起的两种金属。该双金属物体可为任意平面形状,例如正方形、长方形或带形。最好是该双金属物体为双金属盘。如果被加热,不同的膨胀力迫使平坦的物体朝一侧弯曲,如果冷却则朝相反方向弯曲。该双金属物体为双金属盘,例如商业上可获得的Truflex P675/700盘。
双金属的机械位移比两种金属中的任一种的较小纵向膨胀大很多。该效果在一系列的机械和电装置中被使用。在本发明大多数的示例装置中,双金属物体以平坦的形式被使用。其它方面,其可被缠绕成盘卷以缩小体积。
镍钛(NiTi)为形状记忆合金,也通常被称为镍钛诺。高于其变形温度,镍钛诺为超弹性的,并且当应用负载时能够承受较大量的变形和当负载移除时恢复其初始形状。低于其变形温度,其显示形状记忆效应。当它被变形时它会保持在该形状直到被加热至高于其变形温度,此时其将恢复到初始形状。镍钛诺通常由重量大约55%的镍组成。对该组成方式作微小的变化可显著地改变合金的转变温度。镍钛诺的在宽范围温度中使用的这些独特性质和可修整性,使其适于作为本发明的双金属物体的替代物。如本领域技术人员所理解的,在不脱离本发明范围的情况下也可使用其它形状记忆合金。
在本发明的装置中使用交替堆叠的双金属盘不仅是在很小的空间内实现热调节方案的简单且低成本的解决方案,而且具有相对其它热调节方法的一些关键的益处。这些盘为模块化解决方案,意味着不同数量的盘可用于调整装置的温度敏感性。用多个盘代替一个盘,对于给定(小)的盘直径允许更长的总行程。更薄或更厚的盘也可用于同样的目的,或增加额外的施加力的能力。由于这些盘的凸起形状特别地强健,燃料的压力变化对调节温度将具有最小的影响。同样,由于双金属堆叠为非离散的、连续动作系统,该装置通过使用上面提到的粗糙座设计可具有阻尼调节效果,使该装置自熄火可能性更小。这些盘也响应于最接近所述装置的炉的点处的温度,所以该炉被保持在可能的最恒定的温度。
图4图示了本发明装置400的一些部件的详细例子。图4中,燃料通过填充阀428供应至箱426,并且压缩液体燃料可使用燃料芯438汲取使用。在图5的例子中,气体燃料的流动之后受到压缩泡沫流体限制器540的限制,并且仅可通过阀孔542离开。具有阻止气体运动的单个弹性体止动器544。使用单个止动器544以用于所有气体流的调节可显著提高系统的简单性和可靠性。该止动器544在此也称为可变流量阀544。还可包括简单但独立的装置以随温度调节丁烷流,分配非常低的气体流以保持催化剂的一部分在熄灯温度之上,并且允许使用者打开和关闭装置500。可变流量阀544可允许所有这三个需求以通过单个阀来处理。
该止动器544可连接到以电绝缘部件546终止的刚性喷射组件。该喷射组件通常通过相当低弹簧常数的偏压弹簧548保持就位以允许气体离开阀口542并进入喷射组件。通过滑动密封550限制气体仅进入喷射组件。可选择地,可使用柔性膜片。使用者能够通过滑动激励滑动器而阻挠气体的正常流动,所以喷射组件被抑制以使止动器544密封阀孔542,这装置500的关闭状态。当使用者通过滑动激励滑动器至打开位置允许正常气体流动状态时,压电点火器被按下,使得在喷射座552和炉加热器522之间产生火花,因此点燃流动气体。当炉加热器522开始达到其运行温度时,一系列交替堆叠的双金属盘532改变形状(从平坦的转变到凸起的)并且作用在推杆部件534上,部件534进而压迫喷射组件,以使该止动器544限制或停止气体流。
通过使用双金属盘设计,可通过简单地改变这些盘的支撑物和阀座之间距离来将本发明的装置调整到指定的温度调节范围。在图4-5中,通过将炉加热器部件422、522螺入装置400、500的塑料本体420、520,可通过使用与炉配合的工具从外部简单地扭转炉部件422、522而改变运行温度。炉424也可设计为由使用者手动移动。这些特征也可并入到用于扭转该部件的炉424。
图5中,推杆部件534可提供多种功能。推杆534可将双金属盘532的纵向运动转移至喷射组件,该喷射组件进而将该运动转移至阀止动器544。推杆534也可以容易被组装的方式保持催化剂,例如该催化剂简单地围绕这该推杆534缠绕。推杆534在喷射座552和催化剂之间指定了固定空间,以使初始燃烧可容易发生。在一个例子中,推杆534大致具有哑铃形状,在相对端具有两个平坦的圆形表面,这两个表面用于在顶部接触双金属盘532和在底部接触绝缘部件546。推杆534的较低端具有允许气体流通过并发生初始燃烧的多个大切口。
本发明的许多装置使用温度调节方案,因为温度调节器(双金属盘)定位在非常接近(在炉上的)温度最关键的区域。相关领域通常将温度敏感部件定位在流量阀,该敏感部件可容易地受到膨胀燃料气体的较冷温度的影响,并且具有与汽化室最小的密切接触。相关的装置和方法的例子在美国专利申请11/485,168、美国专利4819665、美国专利4793365、美国专利5027836和PCT申请WO2006/082571中描述。本发明装置的调节方案可通过炉的简单扭转而调整至特定温度。
在图4-5的示例性装置中,空气通过入口小孔454、554进入喷射组件,并且在文丘里管556与丁烷流动路径混合。废气通过排出口458离开。
通过环绕隔热特征而防止使用者接触热的内部元件。本发明的装置可包括隔热部分以阻止使用者接触装置的必然热的部分。虽然更好的隔热能力是优选的以使装置以可能的最佳效率运行,但对使用者来说重要的方面是感觉到相对冷的表面温度。可采用不同的策略以满足使用者关于装置温度的感觉。该装置可缠绕在对于外部使用来说具有足够耐久性的隔热材料内。用于该目的的材料具有低的热传导性和低热容(比热)。这些性能的组合可允许少量的热传至使用者的手指。具有低热传导性和低热容的材料的例子包括一些聚合物和陶瓷。另一策略是使用隔开特征以保持使用者不直接接触高温区域。这也可最小化使用者手指与装置的接触面积,以额外地减少所感觉到的热。隔开特征的热传导性和比热应当尽可能低。
本发明装置的加热器可包括导热壳体和催化剂,其中壳体可由一种或多种材料通过焊接或压在一起而形成。加热器中的催化剂可选择为提供燃料的高效无焰燃烧。在一些情况下,为了给使用者提供视觉提示,当加热器正在加热时该催化剂或加热器可发出颜色(例如红色)以指示该装置被激活。
在一些情况中,加热器可通过侧面小孔直接向周围大气中排放。然而,如图1图示,本发明的装置100优选包括围绕加热器组件122的一系列更小的小孔158,这些小孔158更好地从被催化的气体向炉124传递热。同样,如图6显示,由于塑料本体620的排放小孔662定位在加热器排放小孔之上,流出的气体必须沿加热器本体通过并且与加热器本体交换更多的热量,改善装置600的效率。双屏障(加热器壁和本体壁)的使用,结合交错排列多个通风小孔,具有额外的改善防风性(例如,周围的风更不可能干扰内部气体流动,或者冷却催化剂至熄灭点)的益处。排放路径的特定几何形状允许这些益处而不会抑制对于启动催化活性来说所必需的气体的初始燃烧。该气体平稳地流过连续地扩大的排放区域,没有会导致气体的初始爆发而熄灭该气体的令人头疼的转向。
在燃烧催化剂的区域中,熄灯温度通常用于描述最低温度,催化剂必须被保持在该温度以催化燃料和氧的放热反应。必须使催化剂的一部分保持在此温度才能防止该反应完全熄灭。本发明装置的加热器的目标运行温度接近于大多数催化剂的熄灯温度,并可使得维持催化剂难以实现。加热器的目标运行温度可为180℃。用于本发明装置中催化剂类型的例子包括,但不限于,铂、钯、和铑。与本发明一起使用的催化剂的催化剂熄灯温度可为从大约100至200℃。
为了处理加热器温度与熄灯温度的细微差别,气体的小细流可流过催化剂和/或可将催化剂与外界因素(例如风)屏蔽开。本发明的装置可包括受保护的排放路径,即排气不直接排出至外部空气,而是改为沿盘绕路径行进,以使催化剂很难被风熄灭。
对本发明装置的可靠性的担心是保持催化剂在装置的低目标温度上运行。离散的开/关阀自身可能在该方面有困难,因为丁烷爆发之间的循环时间有时可允许催化剂冷却至太低的温度,并且由于丁烷温度较低,丁烷膨胀的迅速爆发实际上可导致催化剂熄灭。可与本发明的装置结合的简单解决方案是使阀座表面稍微变粗糙,或者使用有纹理的止动器表面,以使该装置在调节期间就在完全关闭流动之前可获得丁烷的低流动。这与针形阀的运行类似,此外实施起来更便宜和更容易。针形阀也可使用在本发明的装置中以调节燃料流。一些现有技术使用热质量以使可在调节间隔之间维持熄灯温度。当气体流动在调节间隔之间恢复时,仅仅接触热质量的区域将初始催化气体,排出合理量的未使用燃料。本发明的装置不需要这样的热质量,因为阀座可作为类似阀并且允许装置阻尼调节间隔和强度。本发明的装置可使保持催化剂在熄灯温度之上所需要的丁烷量细细地流,换句话说,不淹没催化剂。
如图3示出,本发明的装置300可用于雾化容纳在盒370中材料,该盒370可插入到装置300的炉室324中,用点火器的火花(紧接在气体流动开始后),气体点火并且热开始传导至全部加热组件322。热通过传导、对流和/或辐射转移至盒370。该盒370可为填满该室的形状,以最大化用于热传导的表面接触。当该盒370变热时,在盒370内和在该盒上并与其紧邻的空间中立刻产生雾气。当使用者吸装置300时,新鲜空气通过空气入口进入,与雾气混合,并且该混合物经过吸入通道传递给使用者。一个或多个空气入口可方向朝下,以改进从盒370中提取雾气。空气入口也可沿通过吸嘴310的对角线定向,或者在盒370之上横向地穿过壳体本身。一个或多个空气入口的直径和方向可设计为允许周围空气进入室324以搅动雾气而不影响运行温度。该空气入口小孔也可将周围空气进入并与在炉室424中产生的雾气混合的速度调节为设定速度或使用者选择的速度。例如,空气进入装置300的速率可向使用者提供如同通过香烟吸出的烟的感觉。一旦盒370用完,该装置可关闭并且通过打开装置300的炉室324移除盒370。该盒370可手动移除或通过能迅速简单地移除盒370的机械装置移除。该机械装置可包括当装置300的其它部分移动或移除时,使用销或滑动部分以推出盒370。该移除机械装置也可包括引入外部物体。
如图7显示的装置可包括吸嘴710,该吸嘴连接至装置700的本体720。该吸嘴710可为铰链连接的部件。该吸嘴710也可制造为当其关闭在装置本体720上时牢固地配合入位。也可使该装置700与在此描述的本发明的盒770一起使用。盒770可插入至本发明装置700的炉室724。如图7示出,吸嘴710可移除,或者铰链连接地打开,以提供进入炉室724的通道,并且容纳待雾化材料的盒770可插在该炉室724中。该装置700的吸嘴710也可为可移除的或者可移除的并且构造为一次使用。这样,多个使用者可使用同一装置700但具有多个可互换的吸嘴710。或者如果吸嘴710被污染,另一吸嘴710容易替换之以避免不得不将整个装置700丢弃。当装置700包括连接至装置本体的吸嘴710时,例如铰链连接的吸嘴710,该装置700可通过使用者的单手操作。
吸嘴可用高温和食用安全材料制成,例如陶瓷、玻璃或各种高温塑料,例如聚酰亚胺热塑性树脂、聚醚酰亚胺(PEI)树脂(商标)。通过使用高温材料而简化设计,但在添加隔热部件的情况下也可使用标准塑料或木材,该隔热部件防止过多热到达使用者,例如使用者嘴唇。另外,可延长吸嘴的长度,以使在使用者嘴处的温度大大低于吸嘴接近于热源端的温度。
本发明装置700的吸嘴710,例如图7中的例子可包括用于刺穿与装置700一起使用的容纳材料的密封盒的穿刺件712。例如,铰链连接的吸嘴710可被打开,盒770插入到该装置700中,并且该吸嘴710然后可关闭,吸嘴710刺穿与该装置710一起使用的盒770。该穿刺件712可为本领域技术人员显而易见的任意物体。优选地,该穿刺件712为模制在吸嘴710上的小突起712,并且该小突起以点或边缘714终止以当应用小量的力时刺穿盒770。
一些相关技术的装置需要两只手点燃,导致使用者感觉不灵活。优选地,使用本发明装置的点燃方法允许单手点燃。如图8A-8B显示,使用者可按压装置800上的按钮802以将其打开,并且然后再次按压按钮802以将其关闭。在其它的实施例中,使用者可朝装置800的吸嘴端810滑动材料条以将该装置打开,并且然后向回朝填充口滑动该条以将其关闭。如本领域技术人员显而易见的,其它部件也可结合至本发明的装置,例如开关。机械效益可提供给使用者以在无需来自使用者的过分的力的情况下就可激活点火器。机械效益的例子包括,但不限于,杠杆、四杆机构和其它本领域技术人员显而易见的装置。
本发明的装置也可提供额外的使用者友好益处。例如,双金属物体温度调节器允许该装置具有纤细、紧凑,并且因此吸引人的形式。热隔绝方法阻止使用者被高热惊吓。简单的开关机械装置允许使用者用单手开始和结束使用时间。
II.盒
图9图示了盒970,该盒可包含湿润的可汽化产品972(在此有时称为粘性可汽化材料、流体可汽化材料、湿润的可点燃抽吸的材料、流体的可点燃抽吸材料或者湿润的可汽化容纳物)以与能汽化该产品970的装置一起使用。在该图中,盒970包括用盖976密封的壳体974。在该例子中,该壳体974包括凸缘978以将该盖976粘结至壳体974。该盒970的壳体974或者整个盒970可由多种材料制造,包括但不限于,金属、硬塑料、软塑料、纸、纸板、卡纸板和蜡纸。该盒970的壳体974通常包括食用安全材料,如在很多情况中,该盒970与吸入物质的装置一起被对象使用。一些食用安全材料的例子包括铝、不锈钢、聚对苯二甲酸乙二醇酯(PET)、无定形聚对苯二甲酸乙二醇酯(APET)、高密度聚乙烯(HDPE)、聚氯乙烯(PVC)、低密度聚乙烯(LDPE)、聚丙烯、聚苯乙烯、聚碳酸酯和多种纸产品。在一些情况中,特别地当该材料为纸时,该壳体974可用材料或食用安全材料作衬里以阻止湿润的可汽化容纳物972干燥并保护湿润的可汽化容纳物972。
优选地,盒形成和成形为更容易地插入本发明装置的炉室中,并且紧密地配合在炉室的腔从而改善热传导和汽化。盒可在不产生大量有害气体的过程中形成和包装。
盒的壳体可盖上例如能热密封的盖膜,以制造完全地封闭和气密的盒。本发明的密封盒可具有如下优点:保持容纳物新鲜,并且在运输或使用者操作期间阻止盒中材料溢出。
盒的盖也可由各种材料制造。通常,该盖包括食用安全材料。该盖可在湿润的可汽化容纳物被添加到本发明的盒内后密封在盒上。在盒的壳体上密封盖的许多方法是本领域技术人员熟知的。在包括凸缘的盒壳体上密封盖的方法的一个例子是加热密封。优选地,该盒的盖在至少大约400°F被认为食用安全。该盖可为与在传统炉中烹饪的食品一起使用的商业上可获得的膜,并且经常被称为能用于双重炉(用于微波炉和传统炉应用)。该能用于双重炉的膜通常包括PET(聚对苯二甲酸乙二醇酯)基层和APET(无定形聚对苯二甲酸乙二醇酯)热封层。这样的盖膜可易于事先被金属化或贴上金属箔,优选地,用铝以改善膜对湿气、氧和其它气体的屏障性能。金属化的膜可通过本领域技术人员熟知的传统转换过程生产。
作为例子,图10显示带有PET基层1080和APET热封层1082的基本可热封膜1076。图11显示带有类似的PET基层1180和APET热封层1182的,此外还有金属层1184和金属粘附层1186的复合膜1176。在两种情况中,APET热封层1182与本发明的盒的壳体的凸缘接触。
本发明盒的材料和壳体可用于保持填充材料的新鲜度,并且增加盒的储藏寿命。金属化的盒或盖或壳体也可改进盒的视觉吸引力和感知价值。该盒的材料也可允许改进产品信息的打印和可见性,例如商标和风味说明。
本发明的容纳有湿润的可汽化产品的盒1270可在该盒1270具有多个小孔或通风口1288,如图12的盒1270的例子图示。这些小孔1288可允许盒1270中的容纳物接触环境。一些类型的容纳物可能需要接触环境或发现接触环境是有益的。
图12中示例性盒1270也可由在被放入能汽化盒1270中容纳物的装置时可被刺穿或打开的材料组成。例如,如果盒1270加热至某一温度,该容纳物汽化,并且由该装置建立的一个或多个小孔或多个开口1288允许雾气状的容纳物从被加热的盒1270逸出。在不同的方式中,该盒1270可包括就在盒1270被插入装置之前能被打开的盖或密封件1276。
盒的各部分可如图13A,盒1370带有两个可配合在一起的部分1390、1392,或具有机械装置将这两部分1390、1392密封在一起。图13B图示了放在一起的盒1370,每个部分都包含用于当盒1370被加热时释放盒1370容纳物的雾气的多个小孔或出口1388。
在很多情况中,本发明的盒设计为单次使用并且可丢弃。然而,一些类型的盒,例如那些具有将两个部分密封在一起的方法的盒,可作为可重复使用的盒使用多次。
包含单次使用湿润可汽化产品的盒可提供或卖给终端使用者。容纳在盒中产品的类型可印在或写在盒上,或者由盒的颜色、尺寸和形状指示。然而,盒可由终端使用者用湿润的可汽化产品填充。
当打算由消费者使用时,本发明的密封盒可插入本发明装置的炉室中。所述装置的吸嘴然后恢复至关闭位置,并且该点吸嘴可刺穿盒顶部的膜。然后允许加热过程产生的雾气离开该盒并且由使用者通过吸嘴吸入。
III.被雾化的材料
如本领域技术人员显而易见的,任何可被雾化并由使用者吸入的材料都可包含在本发明的装置和盒内。特别有趣的是该材料给使用者提供在呼吸道内的触觉响应方面的或关于吐出吸入材料的视觉反馈方面的体验。例如,许多材料被任务能与本发明一起使用,包括但不限于,那些包含烟草的材料、自然或人工食用香料、咖啡渣或咖啡豆、薄荷、甘菊、柠檬、蜂蜜、茶叶、可可粉和基于其它植物性药材的其它非烟草替代物。本发明的装置或盒也可与药物化合物或人工化合物的使用相容,用于医药或愉悦用途。可在相当低的温度下汽化(或挥发)且没有有害的降解产物的任何上述化合物都可适合于与本发明的盒或装置一起使用。化合物的例子包括但不限于,薄荷醇、咖啡因、牛磺酸和尼古丁。
包含在植物性药材中的活性元素在不同的温度汽化。该装置可被标定成建立单一的稳定温度,以例如汽化特定的产品。控制器也可用于选择不同的温度设置。使用者将基于所使用盒的类型选择设置。控制器也可机械地影响期望温度,例如通过阀流动速率的改变,或电子地影响期望温度,例如通过电动机械阀和微控制器媒介。例如,为了改变本发明装置的运行温度,可相对于温度调节器(例如双金属盘)移动炉室。
此处,烟草或烟草材料定义为可被汽化以用于愉悦或治疗用途的自然或合成材料的任意组合。在本发明的一个实施例中,可用加工过的烟草、丙三醇和调味料来准备盒。烟草产品制造领域的技术人员熟悉这些和其它用于香烟、雪茄和类似物的成分。该盒可通过如下方式生产:将烟草切成细片(例如小于2mm直径,优选小于1mm),加入其它成分,并且混合直到获得均匀的状态。在其它的实施例中,盒可通过将填充材料处理成均匀的类似糊状(例如,粒子尺寸少于1mm)准备,这有利于对填充该盒的处理,例如,使用螺旋填充器、蠕动泵或活塞泵。
优选地,与本发明装置一起使用的或容纳于本发明盒中的材料包括下列中的至少一种:形成雾气的介质和在使用者呼吸道中提供触觉响应介质。来自插入装置中该材料的雾化产品可为汽相气体和从汽相凝结的并保持悬浮在气体/空气混合物中的小液滴的组合(后者构成吸入物质的可视部分)。
可使用丙二醇(PG)、丙三醇或该两种物质组合作为雾气形成介质,其它的雾气形成介质也可用于本发明的盒和装置。该雾气形成介质在被加热时用于产生可视雾气,例如烟状雾气。该雾气在吸入该介质前和吐出该介质期间均可视。PG相比单独的丙三醇具有一些益处,因其在同样的温度呈现高得多的雾气压力并且允许装置在更低的温度运行。减少运行温度节约能量,并且潜在地进一步改善使用该系统的健康益处。
在一些情况中,被使用者吸入的产生自PG的雾气可在呼吸道中部分地吸收。如果发生该情况,其可能看起来好像使用者正在主要地吐出空气。这不同于传统吸烟经历,因为在吸烟的情况下,当使用者吐气时通常可看见和玩吐出的烟。因为通过加热丙三醇所产生的可视雾气能够在吐出后被看见,所以用于本发明的填充材料的一些准备可包括丙三醇和PG两者的组合。在这些实施例中,PG提供高浓度的可视雾气以及呼吸道内的触觉响应,使用者在吸入前可看见/体验该可视雾气,并且丙三醇添加物允许增加在吐出后可被看见或以其他方式体验的雾气的量。
制造用于本发明装置和盒中的材料的一种方法是在低热下将加工过的烟叶与其它成分组合,并且然后允许混合物在室温下吸收或腌泡一段延长的时间,从一天至三周那么长(依赖于所使用的特定的配方和香料)。然后可通过切成带有直径为1-2mm的粒子的均匀状态来处理该材料,并且将处理后的材料插入盒中,或直接插入装置中。可选择地,该材料可处理成更平均的、类似糊状,以改善在传统泵装置中的处理,如本文所述。
将材料填充入盒中的方法的例子包括螺旋填充方法和活塞泵方法。它们都是用于食品和药品包装工业的普通填充过程。每种方法允许将重复受控体积(例如,大约0.25立方厘米)的填充材料装载进壳体中。然后该填满的壳体可用可热封盖膜盖上。该填充和密封操作可结合在食品和药品包装领域技术人员熟知的移位机上。
IV.用法
该装置可通过提供许多使用者所需要的吸烟的期望效果而模仿吸烟。使用本发明装置和/或盒的方法的一个例子如图14图示。在此描述的雾气形成介质可与烟草材料组合并且直接或用本发明的盒插入本发明的装置1400中。该烟草材料为使用者提供物质1494(例如尼古丁)的吸入,但没有吸入许多燃烧烟草材料时产生的焦油型物质,例如许多霍夫曼分析物(参见下面)。通过将装置1400的吸嘴放置与使用者10的嘴12接触,可以以与香烟或其它吸烟物品类似的方式使用本发明的装置1400。然而,没有烟雾或烟雾的感觉,使用者可能不满意这样的体验。为了提供对烟草材料吸入的触觉响应,可添加雾气形成介质1494(例如丙二醇),该介质可在呼吸道14中被吸收。
同样,当吸烟草材料时,烟物可为使用者提供视觉辅助和/或视觉识别。为了提供同样的视觉辅助,该雾气形成介质可包含物质(例如丙三醇),该物质在吸入前和吸入期间以及吐出期间可被看见。在图15图示的使用方法的一个例子中,使用者10以减少使用者10的霍夫曼分析物吸入量至少70%的方式从本发明的装置1500接收吸入的烟草物质。吸入物质之后,使用者可通过嘴12呼出来自雾气形成介质的可视雾气1596。可视雾气1596可提供与吸烟行为中所吐出的烟雾相似的视觉辅助。
V.霍夫曼分析物
香烟的烟雾是上千种化学成分的复杂混合物。这些物质中的很多都与吸烟相关的疾病关联。关于在香烟的烟雾中发现的更有害化合物的标准参考是霍夫曼分析物列表,该列表认识到大约44种不同分析物可能出现在主流烟中。以生物化学家迪特里希.霍夫曼的名字命名,他是烟草致癌作用的第一权威。该列表包含了通常与吸烟的健康风险相关联的化学物质。这些分析物和化学物质包括,例如,氨、氨基萘、苯并芘、甲醛、乙醛、丙酮、甲基乙基酮、丁醛、氰化氢、氮氧化物、烟草特有亚硝胺(TSNAS)、吡啶、喹啉、对苯二酚、苯酚、甲酚、焦油、尼古丁、一氧化碳、1,3-丁二烯、异戊二烯、丙烯腈、苯、甲苯、苯乙烯和各种其它物质。已经确定了来自吸烟物品的主流烟中的一些霍夫曼分析物可能是有害的。如此,已经对减少霍夫曼分析物进行了广泛的研究。霍夫曼分析物也可致癌,因此用于吸烟或模仿吸烟的装置将是值得去做的。
使用本发明的装置,烟草材料可雾化而不用燃烧该材料。通过雾化该烟草,许多有害的化学物质和霍夫曼分析物不被使用者吸入。例如,本发明的装置可减少大约70%或更多的霍夫曼分析物吸入。在一些实施例中,本发明的装置可减少大约50%或更多的霍夫曼分析物吸入。在一些实施例中,本发明的装置可减少大约60%或更多的霍夫曼分析物吸入。在一些实施例中,本发明的装置可减少大约70%或更多的霍夫曼分析物吸入。在一些实施例中,本发明的装置可减少大约80%或更多的霍夫曼分析物吸入。在一些实施例中,本发明的装置可减少大约90%或更多的霍夫曼分析物吸入。
VI.艾姆斯化验
细菌回复突变试验最初由艾姆斯等发展。艾姆斯化验充当对可在人类中导致癌症作用的化合物的预报器。该方法已经广泛地被采用,并且FDA将其作对新食品添加剂和药物毒性的更全面研究的一部分。同样的试验已经广泛地用于研究烟草产品和烟草的烟雾的毒性研究。艾姆斯试验为生物化验以评估化学化合物的潜在致突变性。由于癌症通常与DNA破坏关联,该试验也作为快速化验以估计化合物的潜在致癌性。相比之下,在啮齿动物上做的致癌标准试验花费几年完成并且成本昂贵。艾姆斯试验使用包含在组氨酸合成中的携带基因突变的杆菌属鼠伤寒沙门菌的若干菌株,以使它们需要组氨酸以生长。被试验的变量为诱变剂的导致回复突变而在无组氨酸培养基中生长的能力。试验菌株被特别构造成具有为合成组氨酸所需要的基因中的移码突变和基因点突变,这允许经由不同的机械装置检测诱变剂作用。一些化合物是非常特别,仅在一个或两个菌株中产生回复突变。该试验菌株也携带用于脂多糖合成的基因中的突变,使得细菌的细胞壁更具渗透性,并且在切补修复系统中使得该试验更敏感。加入大鼠肝提取物以模拟新城代谢的作用,因为一些化合物(例如苯并芘)本身不是致突变的但他们新陈代谢的产物是致突变的。为了完成化验,细菌散布在带有少量组氨酸的琼指平皿上。这些在生长培养基中的少量组氨酸允许细菌在一段初始时间上生长并且具有变异的机会。当组氨酸耗尽时,仅有变异为获得产生组氨酸能力的细菌将存活。培养该平皿48小时。物质的诱变性与观察到的菌落数量成比例。
如下面例2所示,与许多类型的吸烟草相比,用于与包含烟草的材料一起使用的本发明装置能在艾姆斯化验结果中呈现显著的改善。因此,本发明的装置可提供很多烟草物质给使用者,例如尼古丁,而不提供一些与燃烧或抽吸烟草相关的关键致癌成分。
例1
香烟的烟雾是几千种化学成分的复杂混合物。这些成分中的很多成分都与吸烟有关的疾病关联。霍夫曼分析物列表为在香烟的烟雾中发现的更有害化合物的标准参考。将基于霍夫曼列表选择一组52种目标化合物,期望本发明装置产生的雾气将显著地减少这些目标化合物的水平(减少70%或更多)。
本发明原型装置和参考香烟(KY2R4F)的成分测试将在实验室进行。两种类型装置的样本将在自动吸烟机器中和在加拿大强烈体制下(每30秒喷出55立方厘米(cc))的现场获得。认为本方法比FTC测试(每60秒喷出35cc)更接近真实吸烟条件。Arista基于文献发展了对目标化合物的分析的大量草案。这些草案将用于测试。表1中总结了每组分析物的收集和提取方法。
表1:霍夫曼分析物分析
对于每个目标化合物,对本发明的装置和参考香烟都将进行5次重复测试。两个物品之间的平均值的差被确定为百分数。期望本发明的装置相比参考香烟减少大约70%或更多的霍夫曼分析物水平。
例2
细菌回复突变测试,或“艾姆斯化验”,作为对可导致人类癌症发生的化合物的预报器。该测试被广泛用于研究烟草产品和烟草的烟雾的毒性。在此描述的本研究的目的为利用艾姆斯化验筛去导致杆菌属鼠伤寒沙门菌的TA98菌株中突变的本发明烟凝结物。选择菌株TA98是因为其为鼠伤寒沙门菌的最敏感菌株之一,并且可检测大量的诱变剂。如果检测到剂量依赖的反应,烟凝结物被认为导致该菌株的突变。
测试设备。测试物品准备(例如,“吸烟”和提取)、化学成分分析和遗传毒性在阿里斯塔实验室实施,1941雷梅特路,弗吉尼亚州23237。
测试物品提取准备。每次重复使用连接到自动旋转吸烟机器(Borgwaldt RM-20CSR)上的本发明的吸烟装置吸三个盒,自动旋转吸烟器(Borgwaldt RM-20CSR)使用如下参数:1)喷出55ml的体积;2)喷出持续30秒和根据ISO标准的空气流。总颗粒物(TPM)相被收集到44mm剑桥过滤垫上并且提取至二甲基亚砜(DMSO)中。提取后紧接着,TPM样品被等分入单独琥珀瓶,并且在通过艾姆斯化验测试之前,在小于或等于-70℃下保存大于等于48小时。一旦解冻并且用于测试,TPM提取物不被再使用或再冷冻。
致突变性测试(艾姆斯化验)。艾姆斯化验在三个独立“吸烟”期间产生的TPM提取物上完成。该化验根据依据阿里斯塔标准操作程序#TOX001完成。被测试的TPM样品一式三份外加外生新陈代谢的激活系统(S9)。对于每个重复样品,范围从0-2000μgTPM每平皿的微粒相的十个浓度都在每个浓度下的三个平皿中的最小一个被测试。同时执行对菌株特定正控制(带有和没有S9)和KY2R4F参照香烟凝结物的单一浓度(例如,100μg)的测试。化验是根据《加拿大卫生部官方方法501》,第二版,2004-11-01,阿里斯塔标准操作程序#TOX001进行的。艾姆斯分析的结果显示在图16中。每次测试同时进行的并且与细菌菌株和培养条件有关的媒介物控制和正控制,KY2R4F和自发的回复突变都在期望的实验室控制限度内或者研究负责人认为科学上可接受。
结果。如图16显示,研究发现“吸”本发明装置所产生的总颗粒物(TPM)没有剂量依赖影响。此外,所有的TPM样品显示比控制的速率一半还少的回复突变速率。相反,根据“1R4F”Kentucky参考香烟的公布数据,具有普通烟草和过滤器组成的香烟,产生TA98测试菌株的呈正斜率趋势。参见D.W.Bombick et al.,“Chemical and Biological Studies ofa New Cigarette that Primarily Heats Tobacco.部分3.In vitro toxicity of wholesmoke,”Food and Chemical Toxicology,36:183-190(1997).
虽然在此示出和描述了本发明优选的实施例,仅仅作为例子提供的那些实施例对本领域技术人员来说是显而易见的。本领域技术人员在不脱离本发明的范围内将立刻想到很多变化、改变和替代。应当理解,在此描述的本发明实施例的各种选择可在本发明的实践中使用。随后的权利要求目的为定义本发明的范围,并且在这些权利要求范围内的方法和结构和那些等同替代在此被覆盖。
Claims (21)
1.一种气雾产生装置,包括炉室,其中所述装置:(1)在加热可点燃抽吸材料至目标温度之后在所述炉室中产生气雾;(2)产生可视气雾,其在气雾吸入前可视;(3)将所述气雾传递给使用者,其特征在于,所述气雾含有的霍夫曼分析物比普通烟草香烟少至少70%。
2.如权利要求1所述的装置,其中所述霍夫曼分析物是氨、氨基萘、苯并芘、甲醛、乙醛、丙酮、甲基乙基酮、丁醛、氰化氢、氮氧化物、烟草特有亚硝胺(TSNAs)、吡啶、喹啉、对苯二酚、苯酚、甲酚、焦油、一氧化碳、1,3-丁二烯、异戊二烯、丙烯腈、苯、甲苯和/或苯乙烯。
3.如权利要求1所述的装置,其中所述目标温度为100℃至200℃。
4.如权利要求3所述的装置,其中所述目标温度为150℃。
5.如权利要求1所述的装置,其中所述气雾包括直径小于2微米的微粒。
6.如权利要求1所述的装置,其中所述可点燃抽吸材料包括气雾形成介质。
7.如权利要求6所述的装置,其中所述气雾形成介质包括丙二醇或丙三醇。
8.如权利要求6所述的装置,其中所述气雾形成介质包括丙二醇和丙三醇。
9.如权利要求1所述的装置,其中作为所述气雾一部分的活性元素在呼吸道中被吸收。
10.如权利要求1所述的装置,其中所述可点燃抽吸材料包括食用香料。
11.如权利要求1所述的装置,其中所述装置可由使用者用单只手操作。
12.一种通过使用如权利要求1所述的装置将气雾传递给使用者的方法,所述方法包括:
(a)配置所述气雾产生装置,所述气雾产生装置包含加热器;
(b)使用所述装置的加热器加热所述炉室中的所述可点燃抽吸材料至目标温度以在所述炉室中产生气雾;和
(c)将所述气雾传递给使用者以用于吸入。
13.如权利要求12所述的方法,其中所述目标温度为100℃至200℃。
14.如权利要求12所述的方法,其中所述目标温度为150℃。
15.如权利要求12所述的方法,其中所述气雾包括直径小于2微米的微粒。
16.如权利要求12所述的方法,其中所述可点燃抽吸材料包括气雾形成介质。
17.如权利要求16所述的方法,其中所述气雾形成介质包括丙二醇或丙三醇。
18.如权利要求16所述的方法,其中所述气雾形成介质包括丙二醇和丙三醇。
19.如权利要求12所述的方法,其中作为所述气雾一部分的活性元素在呼吸道中被吸收。
20.如权利要求12所述的方法,其中所述可点燃抽吸材料包括食用香料。
21.如权利要求12所述的方法,其中所述装置可由使用者用单只手操作。
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CN200880126977.0A CN101951796B (zh) | 2007-12-18 | 2008-12-18 | 气雾装置和用于吸入物质的方法以及该装置的用法 |
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CN111280495B (zh) | 2023-09-19 |
US20090151717A1 (en) | 2009-06-18 |
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TW200944142A (en) | 2009-11-01 |
EP2234508B1 (en) | 2021-01-20 |
CN111280495A (zh) | 2020-06-16 |
CA2712469A1 (en) | 2010-06-25 |
EP2234508A4 (en) | 2013-11-13 |
US8991402B2 (en) | 2015-03-31 |
WO2009079641A3 (en) | 2009-09-03 |
CA2712469C (en) | 2016-12-13 |
JP2020072742A (ja) | 2020-05-14 |
JP2017221213A (ja) | 2017-12-21 |
CN101951796B (zh) | 2016-02-03 |
ES2854728T3 (es) | 2021-09-22 |
JP7343650B2 (ja) | 2023-09-12 |
AU2008338305A1 (en) | 2009-06-25 |
US20150157056A1 (en) | 2015-06-11 |
CN101951796A (zh) | 2011-01-19 |
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WO2009079641A2 (en) | 2009-06-25 |
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EP3536174A1 (en) | 2019-09-11 |
US11612702B2 (en) | 2023-03-28 |
TWI522051B (zh) | 2016-02-21 |
US10231484B2 (en) | 2019-03-19 |
US20190261686A1 (en) | 2019-08-29 |
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