CN105601622B - 1-氧代/酰化-14-酰化的冬凌草甲素衍生物、及其制备方法和应用 - Google Patents

1-氧代/酰化-14-酰化的冬凌草甲素衍生物、及其制备方法和应用 Download PDF

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Publication number
CN105601622B
CN105601622B CN201510997476.1A CN201510997476A CN105601622B CN 105601622 B CN105601622 B CN 105601622B CN 201510997476 A CN201510997476 A CN 201510997476A CN 105601622 B CN105601622 B CN 105601622B
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oxo
oridonin
acylated
compound
formula
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CN105601622A (zh
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徐荣臻
荣风光
谢福文
赖洪喜
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Benson Pharmaceutical Shanghai Co ltd
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Bunsen Pharmaceutical (shanghai) Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201510997476.1A 2012-01-21 2013-01-21 1-氧代/酰化-14-酰化的冬凌草甲素衍生物、及其制备方法和应用 Expired - Fee Related CN105601622B (zh)

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CNPCT/CN2012/000124 2012-01-21
CNPCT/CN2012/000124 2012-01-21
CN201510997476.1A CN105601622B (zh) 2012-01-21 2013-01-21 1-氧代/酰化-14-酰化的冬凌草甲素衍生物、及其制备方法和应用
CN201380004934.6A CN104039796B (zh) 2012-01-21 2013-01-21 1-氧代/酰化-14-酰化的冬凌草甲素衍生物、及其制备方法和应用

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CN201510997476.1A Expired - Fee Related CN105601622B (zh) 2012-01-21 2013-01-21 1-氧代/酰化-14-酰化的冬凌草甲素衍生物、及其制备方法和应用
CN201510996590.2A Pending CN105503894A (zh) 2012-01-21 2013-01-21 1-氧代/酰化-14-酰化的冬凌草甲素衍生物、及其制备方法和应用
CN201510995686.7A Expired - Fee Related CN105418627B (zh) 2012-01-21 2013-01-21 1‑氧代/酰化‑14‑酰化的冬凌草甲素衍生物、及其制备方法和应用

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CN201510995686.7A Expired - Fee Related CN105418627B (zh) 2012-01-21 2013-01-21 1‑氧代/酰化‑14‑酰化的冬凌草甲素衍生物、及其制备方法和应用

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US (1) US9902736B2 (enExample)
EP (1) EP2805955B1 (enExample)
JP (1) JP6286365B2 (enExample)
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Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
CN103467474B (zh) * 2013-09-17 2016-06-01 中国药科大学 1,6,7,14-位取代的冬凌草甲素衍生物、制备方法及用途
CN104003998B (zh) * 2014-05-12 2017-01-11 中国药科大学 冬凌草甲素14-o-取代氮芥衍生物、制备方法及用途
CN105131009A (zh) * 2014-05-30 2015-12-09 江苏恒瑞医药股份有限公司 L-丙氨酸-(14-冬凌草甲素)酯三氟乙酸盐的i型结晶及制备方法
CN105985352B (zh) * 2015-02-04 2018-05-15 中国药科大学 冬凌草甲素荧光探针、制备及其在靶细胞定位中的用途
CN105968072A (zh) * 2016-05-18 2016-09-28 沈阳药科大学 毛栲利素衍生物的制备方法及其抗菌活性的新用途
CN108017600B (zh) * 2016-10-31 2021-10-01 南开大学 六种来源于荔枝草的萜类化合物及其制备方法和用途
CN106749305B (zh) * 2016-11-16 2019-02-22 中国药科大学 A-环改造的冬凌草甲素衍生物、其制备方法及用途
CN106866695B (zh) * 2017-02-22 2018-12-21 石家庄学院 冬凌草甲素衍生物及其制备和应用
CN106883267B (zh) * 2017-02-22 2019-03-29 石家庄学院 Vbe冬凌草甲素衍生物及其制备和应用
CN108299458B (zh) * 2017-12-28 2020-10-02 青岛海洋生物医药研究院股份有限公司 冬凌草甲素衍生物及其制备方法和应用
CN113698415A (zh) * 2020-05-22 2021-11-26 中国药科大学 一种新型的冬凌草甲素类似物及衍生物、其制备方法及医药用途
WO2021237609A1 (en) * 2020-05-28 2021-12-02 Tsinghua University Novel use of oridonin or oridonin derivative
CN112979672B (zh) * 2021-03-05 2022-03-11 郑州大学 11,20-二羰基冬凌草甲素14-o酯化系列衍生物及其用途
CN114874172B (zh) * 2022-06-29 2023-09-05 庞磊 一种冬凌草甲素衍生物及其制备方法和医用用途
CN117466906A (zh) * 2023-09-19 2024-01-30 中国人民解放军海军军医大学 冬凌草甲素衍生物及其制备方法和药物组合物与应用

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CN101139350A (zh) * 2007-10-15 2008-03-12 中国药科大学 冬凌草甲素类衍生物、其制备方法及用途
CN102295649A (zh) * 2011-08-31 2011-12-28 中国药科大学 具有抗肿瘤活性的冬凌草甲素及6，7-开环冬凌草甲素含氟衍生物、制备方法及用途

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CN101723951A (zh) 2008-10-24 2010-06-09 山东靶点药物研究有限公司 冬凌草甲素衍生物及其制备方法
FR2944435B1 (fr) * 2009-04-17 2011-05-27 Sederma Sa Composition cosmetique comprenant de l'oridonine
CN102002051B (zh) 2010-10-18 2013-06-19 中国药科大学 具有抗肿瘤活性的ent-6,7-开环贝壳杉烯型冬凌草甲素衍生物、其制备方法及用途

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101139350A (zh) * 2007-10-15 2008-03-12 中国药科大学 冬凌草甲素类衍生物、其制备方法及用途
CN102295649A (zh) * 2011-08-31 2011-12-28 中国药科大学 具有抗肿瘤活性的冬凌草甲素及6，7-开环冬凌草甲素含氟衍生物、制备方法及用途

Non-Patent Citations (1)

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徐星星 等.冬凌草甲素衍生物的合成及其抗t( 8 21)白血病活性研究.《中国药物化学杂志》.2011,第21卷(第1期),第1-5页. *

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WO2013107429A1 (zh) 2013-07-25
JP2015504076A (ja) 2015-02-05
CN105418627B (zh) 2018-02-23
US20140364490A1 (en) 2014-12-11
US9902736B2 (en) 2018-02-27
CN105418627A (zh) 2016-03-23
CN105601622A (zh) 2016-05-25
CN105503894A (zh) 2016-04-20
CN104039796A (zh) 2014-09-10
EP2805955A4 (en) 2015-06-10
CN104039796B (zh) 2016-10-19
JP6286365B2 (ja) 2018-02-28
EP2805955B1 (en) 2018-10-31
EP2805955A1 (en) 2014-11-26
DK2805955T3 (en) 2019-02-18

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Effective date of registration: 20180516

Address after: Room 102, No. 131, Kai Qing Road, Pudong New Area, Shanghai

Applicant after: Benson Pharmaceutical (Shanghai) Co.,Ltd.

Address before: 310051 4 4, 6 Jiangling Road, Binjiang District, Hangzhou, Zhejiang.

Applicant before: HANGZHOU BENSHENG PHARMACEUTICAL Co.,Ltd.

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