CN105555789B - 螺氧基吲哚衍生物的制备方法 - Google Patents

螺氧基吲哚衍生物的制备方法 Download PDF

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CN105555789B
CN105555789B CN201480049022.5A CN201480049022A CN105555789B CN 105555789 B CN105555789 B CN 105555789B CN 201480049022 A CN201480049022 A CN 201480049022A CN 105555789 B CN105555789 B CN 105555789B
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CN105555789A (zh
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山内元志
中山敬司
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Sankyo Co Ltd
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CN201480049022.5A 2013-09-04 2014-09-03 螺氧基吲哚衍生物的制备方法 Active CN105555789B (zh)

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ES2712973T3 (es) * 2014-04-17 2019-05-17 Univ Michigan Regents Inhibidores de MDM2 y métodos terapéuticos que usan los mismos
TW202332444A (zh) * 2015-10-23 2023-08-16 日商第一三共股份有限公司 用於治療癌症之醫藥組成物
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US9822128B1 (en) 2017-06-01 2017-11-21 King Saud University Substituted spirooxindoles
TWI750728B (zh) * 2019-07-11 2021-12-21 大陸商蘇州亞盛藥業有限公司 2-吲哚啉螺環酮類化合物的製備方法及其中間體
GB201919219D0 (en) 2019-12-23 2020-02-05 Otsuka Pharma Co Ltd Cancer biomarkers
CA3181715A1 (en) 2020-08-27 2022-03-03 Otsuka Pharmaceutical Co., Ltd. Biomarkers for cancer therapy using mdm2 antagonists
GB202103080D0 (en) 2021-03-04 2021-04-21 Otsuka Pharma Co Ltd Cancer biomarkers
KR102548571B1 (ko) * 2021-04-02 2023-06-29 원광대학교산학협력단 스피로[인돌린-3,2'-피페리딘] 유도체 및 이의 제조 방법
CN115215872A (zh) * 2021-04-15 2022-10-21 中国科学院上海药物研究所 具有取代苯基螺[吲哚啉-3,3′-吡咯烷]结构的小分子化合物
CN113980028B (zh) * 2021-11-01 2023-03-03 浙江理工大学龙港研究院有限公司 一种手性螺环吲哚酮类化合物的制备方法

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