CN105395829A - 高效降血糖药物 - Google Patents
高效降血糖药物 Download PDFInfo
- Publication number
- CN105395829A CN105395829A CN201510899804.4A CN201510899804A CN105395829A CN 105395829 A CN105395829 A CN 105395829A CN 201510899804 A CN201510899804 A CN 201510899804A CN 105395829 A CN105395829 A CN 105395829A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- diabetes
- chinese medicine
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及高效降血糖药物,提供一种治疗糖尿病的中药,其中原料药的重量配比如下:麦冬4份,地黄9份,乌梅5份,葛根2份,苍术15份,黄芪3份,桑叶8份,杜仲6份,槐花12份,三七8份,黄连2份,芍药3份,白芝麻3份。
Description
技术领域
本发明属于医药领域,具体涉及一种高效降血糖药物。
背景技术
糖尿病是最常见的慢性病之一。随着人们生活水平的提高,人口老龄化以及肥胖发生率的增加,糖尿病的发病率呈逐年上升趋势。糖尿病在中国的发病率达到2%,据统计,中国已确诊的糖尿病患者达4000万,并以每年100万的速度递增。
糖尿病是由遗传和环境因素相互作用而引起的常见病,临床以高血糖为主要标志,常见症状有多饮、多尿、多食以及消瘦等。糖尿病若得不到有效的治疗,可引起身体多系统的损害。引起胰岛素绝对或相对分泌不足以及靶组织细胞对胰岛素敏感性降低,引起蛋白质、脂肪、水和电解质等一系列代谢紊乱综合征,其中一高血糖为主要标志。临床典型病例可出现多尿、多饮、多食、消瘦等表现,即“三多一少”症状。
糖尿病分型糖尿病和型糖尿病。其中I型糖尿病多发生于青少年,其胰岛素分泌缺乏,必须依赖胰岛素治疗维持生命。II型糖尿病多见于30岁以后中、老年人,其胰岛素的分泌量并不低甚至还偏高,病因主要是机体对胰岛素不敏感(即胰岛素抵抗)。
发明内容
本发明的目的是提供一种高效降血糖药物,其中原料药的重量配比如下:
麦冬4份,地黄9份,乌梅5份,葛根2份,苍术15份,黄芪3份,桑叶8份,杜仲6份,槐花12份,三七8份,黄连2份,芍药3份,白芝麻3份。
制备方法为取以上原料药,放入容器中,加冷水漫过药面,浸泡15~20分钟,再加水没过药面约6厘米,进行煎煮。未沸前采用武火煎煮,沸后用文火煎煮20~25分钟;第二次煎煮,水沸后文火煎煮15~20分钟。两次煎煮去渣取汁,合并。
申请人发现这种特定配方的中药能够在很大程度上降低患者的血糖浓度,可以安全有效地治疗糖尿病,具有极佳的糖尿病治疗效果。如果改变配方原料或者原料的用量都会严重降低对于糖尿病的治疗效果。
具体实施方式
实施例1:
麦冬4份,地黄9份,乌梅5份,葛根2份,苍术15份,黄芪3份,桑叶8份,杜仲6份,槐花12份,三七8份,黄连2份,芍药3份,白芝麻3份。
制备方法为取以上原料药,放入容器中,加冷水漫过药面,浸泡15~20分钟,再加水没过药面约6厘米,进行煎煮。未沸前采用武火煎煮,沸后用文火煎煮20~25分钟;第二次煎煮,水沸后文火煎煮15~20分钟。两次煎煮去渣取汁,合并。
对比实施例1
原料为黄连4份,五味子9份,生地5份,葛根2份,陈皮15份,内金3份,黄连8份,山药6份,杜仲12份,知母8份,茯苓2份,芍药3份,石斛3份。
制备方法同实施例1。
对比实施例2
原料为龙胆草8份,泽泻6份,生地13份,葛根3份,陈皮5份,黄芪4份,黄连2份,大青叶5份,杜仲10份,知母2份,茯苓2份,芍药7份,麦冬5份。
制备方法同实施例1。
对比实施例3
原料为地黄9份,乌梅5份,葛根2份,黄芪3份,杜仲6份,槐花12份,三七8份,白芝麻3份。
制备方法同实施例1。
对比实施例4
原料为麦冬8份,地黄2份,乌梅3份,葛根7份,苍术5份,黄芪13份,桑叶5份,杜仲10份,槐花7份,三七2份,黄连8份,芍药7份,白芝麻5份。
制备方法同实施例1。
注:对比实施例1-4是在实施例1原料药和用量的基础上改变原料药的成分或者用量得到的,其目的是为了证明本申请特定成分和用量的中药对于治疗糖尿病具有预料不到的优异效果。
生物活性试验:
实施例2:降血糖的活性测试
1.试验材料:动物:雄性Wistar大鼠,北京动物中心提供。试剂:实施例1,对比实施例1-4药物;链尿佐菌素(STZ)、氨基胍(AG)均为美国Sigma公司产品;羟乙基哌嗪乙磺酸(HEPES)为美国Sigma公司产品,北京京科公司分装;仪器:DV650全自动生化仪,SHIMAZU1601紫外可见分光光度计,微量移液器,电子分析天平,旋涡混匀器。
2.试验方法:
(1)糖尿病动物模型制备:180-220g雄性Wistar大鼠110只,适应性喂养三天,随机选12只大鼠作为正常对照组。余98只大鼠空腹12h后左腹腔注射STZ60mg/kg,注射后均给予正常饮食,12h后测大鼠空腹尾静脉血糖,血糖>16.7mmol/L为糖尿病造模成功。取造模成功者84只纳入试验,余弃去。
(2)动物分组及喂养:将糖尿病大鼠随机分为7组,空白对照组、AG治疗组、实施例1组,对比实施例1-4组,每组12只。空白对照组用自来水灌胃,AG治疗组用150mg/kg·d的AG灌胃,实施例1组和对比实施例1-4组分别用300mg/(kg·d)的药物进行灌胃,每日下午4时灌胃1次,各组均给予标准饲料常规喂养,自由进食及饮水,不使用胰岛素。在喂养过程中,各组大鼠均有正常死亡,试验开始时各组具有12只大鼠,试验结束时,各组均有10只大鼠。
(3)标本取材:喂养12周后,大鼠空腹6h,称体重,2%戊巴比妥钠腹腔麻醉,挖眼球取血5ml备用。取上述大鼠自凝血2ml,利用全自动生化仪测定血糖。
3.试验结果:
血清血糖:
表1各组大鼠的血糖测定结果结果显示:
组别 | 鼠数(只) | 血糖(mmol/L) |
正常对照组 | 10 | 7.58±1.21 |
空白对照组 | 10 | 33.16±1.30 |
AG治疗组 | 10 | 23.22±1.85 |
实施例1组 | 10 | 20.16±1.38 |
对比实施例1组 | 10 | 28.83±1.69 |
对比实施例2组 | 10 | 26.29±2.03 |
对比实施例3组 | 10 | 26.74±1.51 |
对比实施例4组 | 10 | 31.45±2.42 |
可见,实施例1药物具有明显的降血糖功效。而改变了用量或者成分的对比实施例1-4组不具有降血糖活性或者降血糖活性很差。
实施例3
为阐明本发明中药对糖尿病的治疗活性,用实施例1药物进行了下列临床试验以证明其疗效,但其不能对本发明的范围构成任何限制。
1资料与方法
(1)一般资料全部病例均选自四川省中医院病房患者,共计80例,将患者随机分为治疗组和对照组。治疗组40例,男20例,女20例,平均年龄为(54.17±1.54)岁,病程平均为(23.29±1.26)个月;对照组40例,男20例,女20例,平均年龄为(55.62±2.41)岁,病程平均为(25.14±2.74)个月。经统计,两组在性别、年龄、病程等方面无显著性差异(P>0.05),具有可比性。
(2)病例选择入选标准:符合《内科学》中2型糖尿病诊断标准。排除标准:(1)1型糖尿病患者;(2)伴有严重心、肝、肾功能不全及急性感染患者;(3)哺乳期、妊娠期妇女;(4)年龄不足18岁和>65岁的患者。
(3)治疗方法对照组使用格列本脲片0.25g/次,3次/日。治疗组1使用实施例1药物,2ml/kg/次,3次/日。治疗组2在对照组用量减半基础上使用用量减半的实施例1药物,1ml/kg/次,3次/日。疗程均为2个月。
(4)观察指标:治疗前后分别检查FPG(空腹血糖)、P2hPG(餐后2小时血糖)。
(5)疗效判定标准:参照卫生部1993年《中药新药临床研究指导原则》进行疗效判断。显效:治疗后症状基本消失,空腹血糖<7.2mmol/L,餐后2h血糖<8.3mmol/L;有效:空腹血糖<8.0mmol/L,餐后2h血糖<10.0mmol/L;无效:治疗后症状无改善,且空腹血糖及餐后血糖未达到上述标准者。症状疗效评定按四级评分法分级:0(无症状)、1(须经提醒时方能感觉症状存在)、2(有时有症状)、3(症状明显),并进行症状计分和积分。
(6)统计学处理采用SPSS13.0统计软件进行数据处理,计量资料以均数±标准差(x±s)表示,采用t检验,计数资料采用x2检验。
2临床疗效结果见表2。
表2两组患者临床疗效比较(%)
组别 | 例数 | 显效 | 有效 | 无效 | 总有效率 |
治疗组1 | 40 | 26 | 35 | 5 | 87.5% |
治疗组2 | 40 | 31 | 39 | 1 | 97.5% |
对照组 | 40 | 28 | 35 | 5 | 87.5% |
结论:仅使用实施例1药物的治疗效果同于格列本脲,使用实施例1药物和格列本脲组合治疗的效果明显好于单方治疗,提示二者具有协同作用。
Claims (5)
1.一种治疗糖尿病的中药,其中包括麦冬。
2.一种治疗糖尿病的中药,其中原料药的重量配比如下:
麦冬4份,地黄9份,乌梅5份,葛根2份,苍术15份,黄芪3份,桑叶8份,杜仲6份,槐花12份,三七8份,黄连2份,芍药3份,白芝麻3份。
3.如权利要求2所述一种治疗糖尿病的中药的制备方法,其特征在于:取以上原料药,放入容器中,加冷水漫过药面,浸泡15~20分钟,再加水没过药面约6厘米,进行煎煮。
4.未沸前采用武火煎煮,沸后用文火煎煮20~25分钟;第二次煎煮,水沸后文火煎煮15~20分钟。
5.两次煎煮去渣取汁,合并。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510899804.4A CN105395829A (zh) | 2015-12-08 | 2015-12-08 | 高效降血糖药物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510899804.4A CN105395829A (zh) | 2015-12-08 | 2015-12-08 | 高效降血糖药物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105395829A true CN105395829A (zh) | 2016-03-16 |
Family
ID=55461824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510899804.4A Pending CN105395829A (zh) | 2015-12-08 | 2015-12-08 | 高效降血糖药物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105395829A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105999174A (zh) * | 2016-07-06 | 2016-10-12 | 侯添有 | 一种治疗糖尿病的中药及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1424063A (zh) * | 2002-12-18 | 2003-06-18 | 成都中汇制药有限公司 | 治疗糖尿病的口服药物组合物 |
CN103656161A (zh) * | 2012-09-14 | 2014-03-26 | 宋健平 | 一种中药组合物及其制备方法和用途 |
-
2015
- 2015-12-08 CN CN201510899804.4A patent/CN105395829A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1424063A (zh) * | 2002-12-18 | 2003-06-18 | 成都中汇制药有限公司 | 治疗糖尿病的口服药物组合物 |
CN103656161A (zh) * | 2012-09-14 | 2014-03-26 | 宋健平 | 一种中药组合物及其制备方法和用途 |
Non-Patent Citations (1)
Title |
---|
潘国良等: "《降糖益肾胶囊质量控制方法的研究》" * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105999174A (zh) * | 2016-07-06 | 2016-10-12 | 侯添有 | 一种治疗糖尿病的中药及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106421633B (zh) | 一种治疗桥本氏甲状腺炎的药物组合物及其制备方法 | |
CN105079089A (zh) | 一种辅助降血糖的葛根苦瓜保健食品制备方法 | |
CN101879278B (zh) | 一种具有降血糖作用的药物组合物及制备方法和用途 | |
CN103405655A (zh) | 一种降糖的中药组合物及其制备方法 | |
CN102631595B (zh) | 治疗2型糖尿病的药物及其制备方法 | |
CN100493572C (zh) | 一种治疗糖尿病的药物组合物 | |
CN106265531A (zh) | 一种汤方鲜药浓缩成颗粒型的药剂及其制备方法 | |
CN103816278B (zh) | 一种用于降低血糖的组合物及其应用 | |
CN103417846A (zh) | 一种降糖的中药组合物及其制备方法 | |
CN102836333A (zh) | 治疗不明原因发热的药物组合物及其制备方法和用途 | |
CN103705796B (zh) | 一种治疗腹泻的药物组合物及其制备方法 | |
CN104001072A (zh) | 一种用于预防和治疗糖尿病的药物组合物 | |
CN105456734A (zh) | 一种治疗糖尿病的中药 | |
CN106420955A (zh) | 具有辅助降血糖功效的中药组合物及其制备方法和产品 | |
CN102488202B (zh) | 用于糖尿病治疗的药用组合物和制备方法 | |
CN1315499C (zh) | 治疗糖尿病及并发症的药物及其制备方法 | |
CN105395829A (zh) | 高效降血糖药物 | |
CN104173734B (zh) | 一种治疗糖调节受损的药物组合物及其制备方法 | |
CN100428951C (zh) | 一种降血糖的保健食品 | |
CN106562415A (zh) | 一种保健食品及其制备方法 | |
CN102266428A (zh) | 抗衰老中药组合物及其制备方法和应用 | |
CN101564511A (zh) | 一种治疗糖尿病的天然蛋白制品及制作方法 | |
CN104958615A (zh) | 一种预防和治疗ii糖尿病的中药组合物及其制备方法 | |
CN104069384A (zh) | 一种治疗气虚血瘀型2型糖尿病的中药散剂 | |
CN104352748A (zh) | 一种治疗糖尿病肾病的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160316 |