CN105377835B - 酪氨酸蛋白激酶调节剂及其应用方法 - Google Patents

酪氨酸蛋白激酶调节剂及其应用方法 Download PDF

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CN105377835B
CN105377835B CN201480039578.6A CN201480039578A CN105377835B CN 105377835 B CN105377835 B CN 105377835B CN 201480039578 A CN201480039578 A CN 201480039578A CN 105377835 B CN105377835 B CN 105377835B
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amino
pyrimidin
chloro
phenyl
dimethylamino
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CN105377835A (zh
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胡邵京
刘湘永
白金龙
龙伟
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Betta Pharmaceuticals Co Ltd
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201480039578.6A 2013-07-11 2014-07-11 酪氨酸蛋白激酶调节剂及其应用方法 Expired - Fee Related CN105377835B (zh)

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CN2013079232 2013-07-11
CNPCT/CN2013/079232 2013-07-11
PCT/CN2014/082084 WO2015003658A1 (en) 2013-07-11 2014-07-11 Protein tyrosine kinase modulators and methods of use
CN201480039578.6A CN105377835B (zh) 2013-07-11 2014-07-11 酪氨酸蛋白激酶调节剂及其应用方法

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WO2015003658A1 (en) 2015-01-15
US20160145237A1 (en) 2016-05-26
AU2014289762B2 (en) 2017-02-16
CA2917735C (en) 2017-04-18
RU2656591C2 (ru) 2018-06-06
HK1221953A1 (zh) 2017-06-16
TW201512176A (zh) 2015-04-01
EP3019489A4 (en) 2016-12-28
TWI610923B (zh) 2018-01-11
SG11201600055PA (en) 2016-02-26
JP2016525509A (ja) 2016-08-25
CN105377835A (zh) 2016-03-02
US9783524B2 (en) 2017-10-10
RU2016103938A (ru) 2017-08-16
US20180009782A1 (en) 2018-01-11
CA2917735A1 (en) 2015-01-15
JP6510510B2 (ja) 2019-05-08
EP3019489A1 (en) 2016-05-18
AU2014289762A1 (en) 2016-02-18
US10059688B2 (en) 2018-08-28

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