SG11201600055PA - Protein tyrosine kinase modulators and methods of use - Google Patents
Protein tyrosine kinase modulators and methods of useInfo
- Publication number
- SG11201600055PA SG11201600055PA SG11201600055PA SG11201600055PA SG11201600055PA SG 11201600055P A SG11201600055P A SG 11201600055PA SG 11201600055P A SG11201600055P A SG 11201600055PA SG 11201600055P A SG11201600055P A SG 11201600055PA SG 11201600055P A SG11201600055P A SG 11201600055PA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- tyrosine kinase
- protein tyrosine
- kinase modulators
- modulators
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013079232 | 2013-07-11 | ||
| PCT/CN2014/082084 WO2015003658A1 (en) | 2013-07-11 | 2014-07-11 | Protein tyrosine kinase modulators and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201600055PA true SG11201600055PA (en) | 2016-02-26 |
Family
ID=52279364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201600055PA SG11201600055PA (en) | 2013-07-11 | 2014-07-11 | Protein tyrosine kinase modulators and methods of use |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9783524B2 (en) |
| EP (1) | EP3019489A4 (en) |
| JP (1) | JP6510510B2 (en) |
| AU (1) | AU2014289762B2 (en) |
| CA (1) | CA2917735C (en) |
| HK (1) | HK1221953A1 (en) |
| RU (1) | RU2656591C2 (en) |
| SG (1) | SG11201600055PA (en) |
| TW (1) | TWI610923B (en) |
| WO (1) | WO2015003658A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS53350B (en) | 2008-09-22 | 2014-10-31 | Array Biopharma, Inc. | Substituted imidazo[1,2b] pyridazine compounds as trk kinase inhibitors |
| TWI577680B (en) | 2008-10-22 | 2017-04-11 | 亞雷生物製藥股份有限公司 | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| AR077468A1 (en) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS |
| ES2534335T3 (en) | 2010-05-20 | 2015-04-21 | Array Biopharma, Inc. | Macrocyclic compounds as Trk kinase inhibitors |
| FI3699181T3 (en) | 2014-11-16 | 2023-03-28 | Array Biopharma Inc | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| CN106146525B (en) * | 2015-04-10 | 2018-11-02 | 山东轩竹医药科技有限公司 | Three and ring class anaplastic lymphoma kinase inhibitor |
| CN104803925B (en) * | 2015-04-16 | 2018-01-12 | 温州医科大学 | A kind of 2,4,5 trisubstituted pyrimidine class compounds using FGFR as target spot and its production and use |
| KR102604425B1 (en) * | 2015-04-29 | 2023-11-22 | 난징 산홈 팔마세우티칼 컴퍼니 리미티드 | Fused ring or tricycloarylpyrimidine compounds used as kinase inhibitors |
| CN106187915A (en) * | 2015-05-27 | 2016-12-07 | 上海翰森生物医药科技有限公司 | There is inhibitor of ALK Yu EGFR double activity and its preparation method and application |
| CN105017160B (en) * | 2015-06-24 | 2017-12-29 | 温州医科大学 | A kind of miazines EGFRT790MInhibitor and its synthetic method and application |
| MX2018005087A (en) | 2015-10-26 | 2019-05-16 | Loxo Oncology Inc | Point mutations in trk inhibitor-resistant cancer and methods relating to the same. |
| CN106749267B (en) * | 2015-11-23 | 2020-08-21 | 南京圣和药业股份有限公司 | Novel epidermal growth factor receptor inhibitors and uses thereof |
| CN106883213B (en) * | 2015-12-15 | 2021-04-20 | 合肥中科普瑞昇生物医药科技有限公司 | Dual inhibitor of EGFR (epidermal growth factor receptor) and ALK (anaplastic lymphoma kinase) |
| CN106928150B (en) * | 2015-12-31 | 2020-07-31 | 恩瑞生物医药科技（上海）有限公司 | Acrylamide aniline derivative and pharmaceutical application thereof |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| JP7061602B2 (en) | 2016-04-04 | 2022-04-28 | ロクソ オンコロジー， インコーポレイテッド | (S) -N- (5-((R) -2- (2,5-difluorophenyl) -pyrrolidin-1-yl) -pyrazolo [1,5-a] pyrimidin-3-yl) -3-hydroxy Liquid formulation of pyrrolidine-1-carboxamide |
| DK3458456T3 (en) | 2016-05-18 | 2020-12-14 | Array Biopharma Inc | PREPARATION OF (S) -N- (5 - ((R) -2- (2,5-DIFLUOROPHENYL) PYRROLIDIN-1-YL) PYRAZOLE [1,5-A] PYRIMIDIN-3-YL) -3-HYDROXYPYRROLIDIN- 1-CARBOXAMID |
| WO2018019252A1 (en) * | 2016-07-26 | 2018-02-01 | Jacobio Pharmaceuticals Co., Ltd. | Novel fused pyridine derivatives useful as fak/aurora kinase inhibitors |
| JOP20190092A1 (en) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF |
| JOP20190213A1 (en) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | Macrocyclic compounds as ros1 kinase inhibitors |
| TWI798334B (en) * | 2018-01-31 | 2023-04-11 | 大陸商迪哲（江蘇）醫藥股份有限公司 | Erbb/btk inhibitors |
| CN110372664A (en) * | 2018-04-13 | 2019-10-25 | 华东理工大学 | Selective JAK2 inhibitor and its application |
| US10644385B1 (en) * | 2019-03-14 | 2020-05-05 | L3Harris Technologies, Inc. | Wideband antenna system components in rotary aircraft rotors |
| KR20220016049A (en) * | 2019-05-31 | 2022-02-08 | 스촨 하이스코 파마수티컬 씨오., 엘티디 | BTK inhibitor ring derivatives, methods for their preparation, and pharmaceutical applications thereof |
| JP2023540491A (en) * | 2020-08-28 | 2023-09-25 | イースト チャイナ ユニバーシティ オブ サイエンス アンド テクノロジー | Mutant EGFR inhibitory compounds and their applications |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| DK1660458T3 (en) * | 2003-08-15 | 2012-05-07 | Irm Llc | 2,4-Pyrimidine diamines useful in the treatment of neoplastic diseases, inflammatory disorders and disorders of the immune system. |
| AU2007333394C1 (en) * | 2006-12-08 | 2011-08-18 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| WO2008118823A2 (en) * | 2007-03-26 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US7989465B2 (en) * | 2007-10-19 | 2011-08-02 | Avila Therapeutics, Inc. | 4,6-disubstituted pyrimidines useful as kinase inhibitors |
| CA2986640C (en) * | 2008-06-27 | 2019-03-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| TW201024281A (en) * | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| US20130137709A1 (en) * | 2010-05-05 | 2013-05-30 | Nathanael S. Gray | Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith |
| ME02200B (en) * | 2011-02-02 | 2016-02-20 | Novartis Ag | Methods of using alk inhibitors |
-
2014
- 2014-07-11 RU RU2016103938A patent/RU2656591C2/en active
- 2014-07-11 TW TW103124057A patent/TWI610923B/en not_active IP Right Cessation
- 2014-07-11 CA CA2917735A patent/CA2917735C/en not_active Expired - Fee Related
- 2014-07-11 JP JP2016524675A patent/JP6510510B2/en not_active Expired - Fee Related
- 2014-07-11 SG SG11201600055PA patent/SG11201600055PA/en unknown
- 2014-07-11 WO PCT/CN2014/082084 patent/WO2015003658A1/en active Application Filing
- 2014-07-11 EP EP14822363.9A patent/EP3019489A4/en not_active Withdrawn
- 2014-07-11 US US14/903,369 patent/US9783524B2/en not_active Expired - Fee Related
- 2014-07-11 AU AU2014289762A patent/AU2014289762B2/en not_active Ceased
-
2016
- 2016-08-25 HK HK16110131.1A patent/HK1221953A1/en not_active IP Right Cessation
-
2017
- 2017-09-01 US US15/694,620 patent/US10059688B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015003658A1 (en) | 2015-01-15 |
| TWI610923B (en) | 2018-01-11 |
| EP3019489A4 (en) | 2016-12-28 |
| RU2016103938A (en) | 2017-08-16 |
| US9783524B2 (en) | 2017-10-10 |
| JP2016525509A (en) | 2016-08-25 |
| JP6510510B2 (en) | 2019-05-08 |
| AU2014289762A1 (en) | 2016-02-18 |
| US10059688B2 (en) | 2018-08-28 |
| EP3019489A1 (en) | 2016-05-18 |
| HK1221953A1 (en) | 2017-06-16 |
| TW201512176A (en) | 2015-04-01 |
| US20160145237A1 (en) | 2016-05-26 |
| CA2917735A1 (en) | 2015-01-15 |
| RU2656591C2 (en) | 2018-06-06 |
| US20180009782A1 (en) | 2018-01-11 |
| AU2014289762B2 (en) | 2017-02-16 |
| CA2917735C (en) | 2017-04-18 |
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