CN105326651B - A kind of mouthwash and preparation method thereof - Google Patents
A kind of mouthwash and preparation method thereof Download PDFInfo
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- CN105326651B CN105326651B CN201510815638.5A CN201510815638A CN105326651B CN 105326651 B CN105326651 B CN 105326651B CN 201510815638 A CN201510815638 A CN 201510815638A CN 105326651 B CN105326651 B CN 105326651B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Abstract
The invention discloses a kind of mouthwashes, are made of by weight following component：WS‑23：0.01~10 parts by weight, menthol：0.01~50 parts by weight, dispersant：1~300 parts by weight, surfactant：0.01~10 parts by weight, sweetener：0.01~300 parts by weight, preservative：0.5~1 parts by weight, essence：0.5~1 parts by weight, pure water：800~1000 parts by weight；Preparation method：By menthol low-temperature grinding, grain size D90 values are less than 380um；By menthol powder, WS 23, polysorbate are added in glycerine, stir oil-phase solution processed；Sweetener, preservative, essence are added to the water stirring, aqueous phase solution processed；Oil-phase solution is added in aqueous phase solution, stirs to obtain mouthwash.It is an advantage of the invention that the refrigerant sense sustainable time is long, cool feeling is enriched；More pure and fresh, lasting fragrance can be generated；The mouthwash is edible.
Description
【Technical field】
The present invention relates to food daily chemicals fields, concretely relate to a kind of mouthwash and preparation method thereof.
【Background technology】
It is previous it is believed that brushing teeth sooner or later just can reach sanitary standard, can be for oral hygiene new concept but far from
It is enough.Expert proposes：It is required as washing one's hands to clean oral cavity.It is the easy method of oral health most convenient to gargle, it can remove mouth
The soft dirt of the swill of intracavitary and part, moreover it is possible to temporarily reduce the quantity of oral cavity bacterium.With people's oral health consciousness
Enhancing, can the mouthwash that takes care of one's teeth of fresh breath favored by more and more people.Mouthwash is divided into health and treatment
Two major class of property.The general mouthfeel of health mouthwash is relatively preferable, and main component is oral cleansing lotion, for removing halitosis, therefore
It is also unlimited using crowd without special guidance.But therapeutic mouthwash contain the anti-inflammatory such as chlorohexidene, compound iodine preparation, sterilization
Drug ingedient cannot be used at will.Such mouthwash can prevent and control periodontium inflammation, so meeting
For periodontosis, the auxiliary therapy of oral mucosal disease.
Whether health or therapeutic type mouthwash, mouthfeel are all extremely important.Health mouthwash mainly plays clear
The effect of new implication, the requirement higher to mouthfeel；If therapeutic mouthwash mouthfeel is bad, the use of user can be caused to support
It touches, and then repels and use.And the complicated component for the mouthwash sold currently on the market, typically just suggest spuing after gargling,
It is it is not recommended that edible；In order to achieve the effect that the fresh implication of mouthwash, increased by adding the composition of a variety of fresheners
Refrigerant sense, has in freshener water-soluble, also has fat-soluble, adds in freshener generally for better, add in mouthwash
Enter ethyl alcohol, but the mouthwash containing ethyl alcohol is not suitable for children and driver uses.The situation of ethyl alcohol is not used in mouthwash
Under, ensure stability of the composition of a variety of fresheners in mouthwash and freshener persistence is new the problem of.
【Invention content】
To ensure stability and freshener of the composition of a variety of fresheners in mouthwash in persistence, the present invention
A kind of mouthwash is provided, which can significantly improve refrigerant mouthfeel, oral cavity be made to have lasting salubrious sense, and this is gargled
Water is respectively provided with good stability in a variety of contexts.
The present invention is to achieve the goal by the following technical programs：
A kind of mouthwash is made of by weight following component：WS-23：0.01~10 parts by weight, menthol：0.01~
50 parts by weight, dispersant：1~300 parts by weight, surfactant：0.01~10 parts by weight, sweetener：0.01~300 weight
Part, preservative：0.5~1 parts by weight, essence：0.5~1 parts by weight, pure water：800~1000 parts by weight
Preferably, a kind of mouthwash is made of by weight following component：WS-23：0.1~10 parts by weight, menthol：
0.1~20 parts by weight, glycerine：10~100 parts by weight, polysorbate：0.1~10 parts by weight, sweetener：0.1~50 parts by weight,
Preservative：0.5~1 parts by weight, essence：0.5~1 parts by weight, pure water：800~1000 parts by weight.
The mouthwash also contains following parts by weight ingredient：10~40 parts by weight of chitosan.
WS-23, that is, n,2,3-trimethyl-2-isopropylbutanamide is a kind of good coolant agent of quality, is had higher cool
Taste activity has been put into Food Additives Used in China standard GB-2760 without side effects such as calcination, numbness and stimulations, can be with
Safe handling.
Preferably, the mouthwash is made of by weight following component：WS-23：5 parts by weight, menthol：10 weight
Part, glycerine：50 parts by weight, polysorbate：8 parts by weight, sweetener：30 parts by weight, preservative：0.6 parts by weight, essence：0.8 weight
Measure part, pure water：850 parts by weight.
Preferably, dispersant is grape seed oil in the water constituent of gargling.
Preferably, following parts by weight ingredient is also contained in the water constituent of gargling：10 parts by weight of chitosan.
Preferably, the polysorbate in the water constituent of gargling can also be sucrose monolaurate, sorbitan ester, poly- sweet
Oleostearin acid esters, polyoxyethylene sorbitan fatty acid ester, apricot glue sell any of pool.
Preferably, the chitosan in the water constituent of gargling can also be hydroxypropyl methylcellulose.
A kind of preparation method of mouthwash, includes the following steps：
Step 1：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, menthol is crushed to grain size D90 values and is less than
380um；
Step 2：Menthol powder prepared by step 1 is added in glycerine under conditions of WS-23, polysorbate stirring, is filled
Divide stirring that oil-phase solution is made；
Step 3：Sweetener, preservative, essence are added in, stirring is dissolved in pure water, aqueous phase solution is made；
Step 4：The oil-phase solution prepared is added to the linear velocity of 0.4~1.0m/s in aqueous phase solution, with 600~
The speed of 800 turns/min stirs 30~50min, obtains mouthwash.
Preferably, the step 3：Pure water is heated to 50~60 DEG C, adds in chitosan, stirring is cold to being completely dissolved
But to room temperature, sweetener, preservative, essence is added in dissolve in pure water and stirred, aqueous phase solution is made.
It is an advantage of the invention that：
(1) mouthwash of the invention, using WS-23 and menthol combination as freshener, refrigerant sense is sustainable longer, cool
Ganfeng is rich；More pure and fresh, lasting fragrance can be generated by acting on whole oral cavity mucous membrane and throat；
(2) mouthwash of the invention, menthol powder, WS-23, polysorbate add in glycerine and stir, make oil phase,
It is then added in water phase, stirring can obtain the mouthwash of stiff stability, and can enable answering for menthol and WS-23
The soft irritation of refrigerant sense for closing freshener is small, effectively prevent the volatilization of WS-23 and menthol, is more suitable for public mouthfeel, especially
It is that children is suitble to use.
(3) raw material of mouthwash of the invention is food-grade, and consumer can eat in use in the case of recommended amounts
With being safe from harm to health.
(4) in mouthwash of the invention, chitosan is added in ingredient, can not only further enhance the stabilization of mouthwash
Property, the effect of freshener sustained release is may also reach up, extends mouthwash refrigerant sense time in the oral cavity.
(5) in mouthwash of the invention, grape seed oil is used in ingredient as dispersant, grape seed oil contain it is abundant not
Saturated fatty acid, mainly oleic acid and linoleic acid, wherein linoleic content is up to 72%~76%.Grape seed oil gives birth to rich in dimension
Plain E has stronger inoxidizability, can effectively extend the shelf shelf-life, be not easy to cause due to illumination, heat radiation and with sky
The oxidative rancidity phenomenon that gas is contacted and generated；Penetration is strong, salubrious non-greasy, easily by buccal absorption.
【Specific embodiment】
Below in conjunction with specific embodiment, the invention will be further described：
The investigation of polysorbate, glycerine input in mouthwash：
WS-23：5 parts by weight, menthol：10 parts by weight, sweetener：30 parts by weight, preservative：0.6 parts by weight, essence：
0.8 parts by weight, pure water：1000 parts by weight；
By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, and menthol is crushed to grain size D90 values less than 380um；It will
The menthol powder of preparation, sweetener, preservative, essence, which add in, dissolves stirring in pure water, with the speed of 600~800 turns/min
Degree 30~50min of stirring, obtains base mouthrinse.
Take base mouthrinse obtained, 6 parts of the amount of grading, add respectively glycerine to a concentration of 0,5,10,20,50,
100mg/100ml is tested and is recorded the coolant agent duration；
Glycerine dosage and coolant agent duration relation list
Take base mouthrinse obtained, 7 parts of the amount of grading, add respectively polysorbate to a concentration of 0,0.1,5,10,50,
100th, 150mg/100ml is tested and is recorded the coolant agent duration；
Polysorbate dosage and coolant agent duration relation list
The research of mouthwash formula
Weigh WS-23, menthol, polysorbate, glycerine, sweetener, preservative, essence, pure water；It makes by the following method
It is standby：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, and menthol is crushed to grain size D90 values less than 380um；It will prepare
Menthol powder, under conditions of WS-23, polysorbate, stirring add in glycerine in, be sufficiently stirred obtained oil-phase solution；
Sweetener, preservative, essence are added in, stirring is dissolved in pure water, aqueous phase solution is made；
The oil-phase solution prepared is slowly added into the aqueous phase solution in stirring, controls 0.4~1.0m/s of linear velocity, with
The speed of 600~800 turns/min stirs 30~50min, obtains mouthwash.
By adjusting WS-23, polysorbate, glycerine concentration, carry out orthogonal design, to investigate the coolant agent duration：
The orthogonal and experimental result of three kinds of components influence factors
By experimental result it is found that each factor primary and secondary is arranged as, glycerine>Polysorbate>WS-23, the optimal level group of experiment
It is combined into glycerine：50th, polysorbate：10、WS-23：6.
Embodiment one：
Weigh WS-23：0.1 parts by weight, menthol：0.1 parts by weight, polysorbate：0.1 parts by weight, glycerine：10 weight
Part, sweetener：100 parts by weight, preservative：0.5 parts by weight, essence：1 parts by weight, pure water：800 parts by weight；
It prepares：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, menthol is crushed to grain size D90 values and is less than
380um；By the menthol powder of preparation, added in glycerine under conditions of WS-23, polysorbate stirring, be sufficiently stirred and oil is made
Phase solution；
Sweetener, preservative, essence are added in, stirring is dissolved in pure water, aqueous phase solution is made；
The oil-phase solution prepared is slowly added into the aqueous phase solution in stirring, controls 0.4~1.0m/s of linear velocity, with
The speed of 600~800 turns/min stirs 30~50min, obtains mouthwash.
Embodiment two：
Weigh WS-23：1 parts by weight, menthol：1 parts by weight, polysorbate：1 parts by weight, glycerine：10 parts by weight, sweet taste
Agent：100 parts by weight, preservative：0.5 parts by weight, essence：1 parts by weight, pure water：800 parts by weight；
It prepares：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, menthol is crushed to grain size D90 values and is less than
380um；By the menthol powder of preparation, added in glycerine under conditions of WS-23, polysorbate stirring, be sufficiently stirred and oil is made
Phase solution；
Sweetener, preservative, essence are added in, stirring is dissolved in pure water, aqueous phase solution is made；
The oil-phase solution prepared is slowly added into the aqueous phase solution in stirring, controls 0.4~1.0m/s of linear velocity, with
The speed of 600~800 turns/min stirs 30~50min, obtains mouthwash.
Embodiment three：
WS-23：5 parts by weight, menthol：10 parts by weight, polysorbate：8 parts by weight, glycerine：50 parts by weight, sweetener：
30 parts by weight, preservative：0.6 parts by weight, essence：0.8 parts by weight, pure water：850 parts by weight；
It prepares：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, menthol is crushed to grain size D90 values and is less than
380um；By the menthol powder of preparation, added in glycerine under conditions of WS-23, polysorbate stirring, be sufficiently stirred and oil is made
Phase solution；
Sweetener, preservative, essence are added in, stirring is dissolved in pure water, aqueous phase solution is made；
The oil-phase solution prepared is slowly added into the aqueous phase solution in stirring, controls 0.4~1.0m/s of linear velocity, with
The speed of 600~800 turns/min stirs 30~50min, obtains mouthwash.
Example IV：
Weigh WS-23：10 parts by weight, menthol：20 parts by weight, polysorbate：10 parts by weight, glycerine：100 parts by weight,
Sweetener：300 parts by weight, preservative：1 parts by weight, essence：0.5 parts by weight, pure water：1000 parts by weight；
It prepares：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, menthol is crushed to grain size D90 values and is less than
380um；By the menthol powder of preparation, added in glycerine under conditions of WS-23, polysorbate stirring, be sufficiently stirred and oil is made
Phase solution；
Sweetener, preservative, essence are added in, stirring is dissolved in pure water, aqueous phase solution is made；
The oil-phase solution prepared is slowly added into the aqueous phase solution in stirring, controls 0.4~1.0m/s of linear velocity, with
The speed of 600~800 turns/min stirs 30~50min, obtains mouthwash.
Embodiment five：
WS-23：5 parts by weight, menthol：10 parts by weight, polysorbate：8 parts by weight, glycerine：50 parts by weight, chitosan：
15 parts by weight, sweetener：30 parts by weight, preservative：0.6 parts by weight, essence：0.8 parts by weight, pure water：850 parts by weight；
It prepares：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, menthol is crushed to grain size D90 values and is less than
380um；By the menthol powder of preparation, added in glycerine under conditions of WS-23, polysorbate stirring, be sufficiently stirred and oil is made
Phase solution；
Pure water is heated to 50~60 DEG C, adds in chitosan, stirs to being completely dissolved, is cooled to room temperature, by sweetener,
Preservative, essence, which add in, dissolves stirring in pure water, aqueous phase solution is made；
The oil-phase solution prepared is slowly added into the aqueous phase solution in stirring, controls 0.4~1.0m/s of linear velocity, with
The speed of 600~800 turns/min stirs 30~50min, obtains mouthwash.
Embodiment six：
WS-23：5 parts by weight, menthol：10 parts by weight, sweetener：30 parts by weight, preservative：0.6 parts by weight, essence：
0.8 parts by weight, pure water：850 parts by weight；
WS-23, menthol, fructose, preservative, essence are added in pure water, stirred evenly.
Embodiment seven：
WS-23：5 parts by weight, menthol：10 parts by weight, polysorbate：8 parts by weight, grape seed oil：50 parts by weight, shell gather
Sugar：15 parts by weight, sweetener：30 parts by weight, preservative：0.6 parts by weight, essence：0.8 parts by weight, pure water：850 parts by weight；
It prepares：By menthol low-temperature grinding, temperature is crushed not higher than 35 DEG C, menthol is crushed to grain size D90 values and is less than
380um；By the menthol powder of preparation, added in grape seed oil under conditions of WS-23, polysorbate stirring, be sufficiently stirred system
Obtain oil-phase solution；
Pure water is heated to 50~60 DEG C, adds in chitosan, stirs to being completely dissolved, is cooled to room temperature, by sweetener,
Preservative, essence, which add in, dissolves stirring in pure water, aqueous phase solution is made；
The oil-phase solution prepared is slowly added into the aqueous phase solution in stirring, controls 0.4~1.0m/s of linear velocity, with
The speed of 600~800 turns/min stirs 30~50min, obtains mouthwash.
Refrigerant mouthfeel duration test experiments：
Seven kinds of mouthwashes in above-mentioned seven embodiments are taken respectively, and number is 1. number -7. number mouthwash respectively, at random please
100 consumers try out four kinds of mouthwashes, according to the experience of consumer, record the duration of refrigerant mouthfeel, wherein 1. number flat
Equal duration 3.1min, 2. number 3.5min, 3. number 27.3min, 4. number 28.5min, 5. number 29.6min, 6. number 3.1min, 7.
Number 29.1min；By contrasting, the three kinds of mouthwashes that can be obtained in embodiment two, three, four add in glycerine, polysorbate can be shown
Writing increases the duration of refrigerant mouthfeel；Embodiment five is adding in glycerine, on the basis of polysorbate, and adding chitosan can be with
Further increase the duration of refrigerant mouthfeel；Embodiment five is compared with embodiment seven, and glycerine is replaced using grape seed oil, refrigerant
The duration of mouthfeel is long, and the refrigerant sense of subject's experience is stronger.
Refrigerant sensory test experiment：
Take above-described embodiment one, two, three, four respectively, five kinds of mouthwashes in five, respectively reference numeral for 1. number, 2. number,
3. number, 4. number, 5. number, 100 consumers is asked to try out three kinds of mouthwashes, a kind of best mouthwash of ballot selection mouthfeel at random；
3. number and 5. number mouthfeel evaluation is recorded, wherein 1. number 15 tickets, 2. number 21 tickets, 3. number 52 tickets, 4. number 27 tickets, 5. number 58 tickets, can be obtained
The mouthfeel of mouthwash is liked for more consumers.
Stability experiment：
Seven kinds of mouthwashes in above-mentioned seven embodiments are taken respectively, and number is 1. number -7. number mouthwash respectively, each is gargled
Five parts of water sampling, the sealing of four parts of samples be placed on 4 DEG C, room temperature, 40 DEG C, keep sample 1 week under 60 DEG C of temperature condition, a sample opens
Mouth is placed to keep sample one week at ambient temperature, and the stability of mouthwash is investigated by seeing whether layering；
As a result it records as follows：
It is to be noted that all embodiments were done in multiple repetition experiment, with using sugarcane respectively in repeating to test
Sugared monolaurate, sorbitan ester, polyglycerol stearate, polyoxyethylene sorbitan fatty acid ester, apricot glue sell pool
It is any come etc. parts by weight replace polysorbate, same method prepares mouthwash, and the mouthwash of preparation is in refrigerant mouthfeel
As duration, the basic mouthwash with using polysorbate of sensory test effect, it is existing that stability experiment does not occur layering
As.
Chitosan is usually replaced with hypromellose, prepares mouthwash by embodiment five, the mouthwash of preparation is in refrigerant mouth
The duration of sense, sensory test effect are basic as the mouthwash for using chitosan, and stability experiment is not layered
Phenomenon.
Claims (3)
1. a kind of mouthwash, it is characterised in that：The mouthwash is made of by weight following component：
N, 2,3- trimethyl -2- butanamides：5 parts by weight, menthol：10 parts by weight, polysorbate：8 parts by weight, grape
Seed oil：50 parts by weight, chitosan：15 parts by weight, sweetener：30 parts by weight, preservative：0.6 parts by weight, essence：0.8 weight
Part, pure water：850 parts by weight.
2. mouthwash as described in claim 1, it is characterised in that：The chitosan is replaced with hydroxypropyl methylcellulose.
3. a kind of preparation method of mouthwash as described in claim 1-, it is characterised in that：Include the following steps：
Step 1：By 10 parts by weight menthol low-temperature grindings, temperature is crushed not higher than 35 DEG C, it is small that menthol is crushed to grain size D90 values
In 380 μm；
Step 2：Menthol powder prepared by step 1,5 parts by weight n,2,3-trimethyl-2-isopropylbutanamide, 8 parts by weight
Polysorbate is added under conditions of stirring in 50 parts by weight grape seed oils, is sufficiently stirred obtained oil-phase solution；
Step 3：850 parts by weight pure water are heated to 50~60 DEG C, add in 15 parts by weight chitosans, stirring to being completely dissolved,
It is cooled to room temperature, 30 parts by weight sweeteners, 0.6 parts by weight preservative, 0.8 parts by weight essence is added in into 850 parts by weight pure water
Middle dissolving stirring, is made aqueous phase solution；
Step 4：The oil-phase solution prepared is added to the linear velocity of 0.4~1.0m/s in aqueous phase solution, with 600~800
Turn/speed of min stirs 30~50min, obtain mouthwash.
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|---|---|---|---|---|
| CN104983595A (en) * | 2015-06-27 | 2015-10-21 | 合肥九研医药科技开发有限公司 | Mouth wash and preparation method thereof |
| WO2017187421A1 (en) * | 2016-04-28 | 2017-11-02 | The Regents Of The University Of California | Compositions for managing plaque formation |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN106726691A (en) * | 2016-12-30 | 2017-05-31 | 泉州亚林新材料科技有限公司 | A kind of shitosan mouthwash and preparation method thereof |
| CN107449856A (en) * | 2017-09-12 | 2017-12-08 | 国网天津市电力公司电力科学研究院 | The titration method of dodecyl benzyl dimethyl ammonium chloride content in a kind of water |
| CN107648130A (en) * | 2017-11-17 | 2018-02-02 | 蚌埠崇迪生物科技有限公司 | A kind of anti-inflammation gargle water and preparation method thereof |
| CN110638672A (en) * | 2019-09-16 | 2020-01-03 | 陈秋迎 | Mouthwash for oral examination or treatment |
| CN111166711A (en) * | 2020-03-05 | 2020-05-19 | 珠海市尼诺生物科技有限公司 | Sterilizing mouthwash |
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| AU4016095A (en) * | 1994-11-18 | 1996-06-17 | Procter & Gamble Company, The | Oral compositions |
| US6696047B2 (en) * | 2001-09-13 | 2004-02-24 | The Procter & Gamble Company | Stable oral care compositions comprising chlorite |
| US8664261B2 (en) * | 2009-05-05 | 2014-03-04 | Givaudan S.A. | Organic compounds having cooling properties |
| CN101627965B (en) * | 2009-07-21 | 2011-03-30 | 清华大学 | Multifunctional pure natural mouthwash and preparation method thereof |
| CN102940066B (en) * | 2012-10-27 | 2014-02-12 | 安徽丰乐香料有限责任公司 | Preparation method for ice black tea drink containing coolant agent |
| CN103462847A (en) * | 2013-09-18 | 2013-12-25 | 韩秀英 | Oral care mouthwash |
| CN104146194A (en) * | 2014-08-11 | 2014-11-19 | 安徽丰乐香料有限责任公司 | Preparation method for powdery compound cooling agent |
| CN104983595A (en) * | 2015-06-27 | 2015-10-21 | 合肥九研医药科技开发有限公司 | Mouth wash and preparation method thereof |
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| CN105326651A (en) | 2016-02-17 |
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