CN101627965B - Multifunctional pure natural mouthwash and preparation method thereof - Google Patents
Multifunctional pure natural mouthwash and preparation method thereof Download PDFInfo
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Abstract
The invention provides a mouthwash and a preparation method thereof. The mouthwash contains sweetening agent, acidity agent, wetting agent, essence, alcohol, 0.5-1% of active constituent stabilizing agent, 0.01-0.3% of active constituent modifier and 0.05-0.1% of the active constituent deionized water, wherein the active constituents are at least two of tea polyphenol, propolis and Magnolia officinalis. The preparation method comprises the following steps of: dissolving the sweetening agent and the acidity agent into water, and adding with the wetting agent to form water-soluble cleaning liquid; and dissolving the active constituents into the alcohol, adding with the active constituent stabilizing agent, the essence and the active constituent modifier, and stirring to form oily solution; slowly adding the oily solution into the cleaning liquid, evenly mixing, statically putting for a night, filtering, and aseptically processing to obtain final products. Because of the combined action of the active constituents, the mouthwash has an effect for multiply preventing and curing oral problems, such as decayed tooth, and has the functions of diminish inflammation and sterilization, desensitization, hemostasis, breath freshening, etc.
Description
Technical field
The present invention relates to a kind of collutory, more particularly, relate to a kind of collutory with active ingredient of Chinese herbs.
Background technology
Along with the raising of people's living standard, to the continuous pursuit of U.S., oral hygiene has become one of focus of modern's concern.Nursing for oral hygiene no longer is confined to twice brush teeth sooner or later, and carrying collutory has become a kind of fashion, and collutory is played the part of more and more important role in daily life.Collutory can be divided into beauty treatment property (spatter property) and therapeutic (functional) two big classes as a kind of oral health care product.The main effect of beauty treatment property collutory is to remove halitosis, and the therapeutic collutory is that the oral cavity commonly encountered diseases is carried out auxiliary treatment.
At oral problem, two kinds of methods of general employing in the prior art, a kind of is pharmaceutical preparation, to add broad-spectrum antibiotic and chemical synthetic drug, life-time service can cause oral microorganism balance and other potential safety hazard.Another kind is to use biologically active agents.In recent years, many scientists and medical personnel add in the oral care product with multiple biologically active agents, have obtained good effect for the oral cavity.
Propolis is the resin of Apis from plant spore and trunk collection, sneaks into a kind of gluey solid content of viscosity with fragranced of formation such as Apis mandibular gland secretions and Cera Flava, has stronger enriching blood, hemostasis, effect such as nourshing Yin and drynsessmoistening prescription grade; Propolis is to staphylococcus aureus in the oral cavity, and Candida albicans, Streptococcus mutans etc. have stronger inhibition effect, also has the effect of anti-inflammatory and antalgic simultaneously.Cortex Magnoliae Officinalis is the comparatively precious Chinese crude drug of China, the chain timbers orchid.Studies show that magnolol and honokiol in the Cortex Magnoliae Officinalis bark have the obvious suppression effect to causing dental caries pathogen Streptococcus mutans, minimum inhibitory concentration (MIC) is 6.3 μ g/ml.Tea polyphenols is the general name of catechin in the Folium Camelliae sinensis, flavonoid, phenolic acids and anthocyan chemical compound, its antibacterial in addition, bactericidal action, to staphylococcus aureus, escherichia coli, Streptococcus mutans etc. all have effect, and tea polyphenols has very strong antioxidation simultaneously, and its oxidation resistance is synthetic antioxidant BHT, BHA 4-6 a times, be VE 6-7 doubly, the 5-10 of VC is doubly.Along with the wind of " healthy harmonious; back to nature " in vogue on the current global consumption market is in vogue, natural environmental-protective, the little bioactive substance of side effect has met people and has pursued nature and healthy consumption concept, so propolis, Cortex Magnoliae Officinalis, tea polyphenols instead of chemical medicine is used at toothpaste, not only can avoid the side effect of chemical substance, and the cooperation of multiple natural component can reach the effect in comprehensive health care oral cavity.
Patent 200710032149.8, patent 200310101961.3 is announced the collutory that propolis-containing is relevant respectively with 01107701.8, be mainly used in antibacterial, antiinflammatory, the treatment oral ulcer, but the interpolation of its Chinese herbal medicine there is no corresponding test, because of there is evident difference in the property of medicine of the Chinese herbal medicine of separate sources, only determines the randomness that addition causes Chinese herbal medicine to add probably with in the past research or experience; Patent 99816880.7 has been announced a kind of oral cleaning detergent component that contains tea polyphenols, is used to dispel halitosis, cleans implication, but exists adding ingredient single, act on limitedly, so is difficult to give the collutory multi-efficiency.
Summary of the invention
The object of the invention provides a kind of collutory and preparation method thereof, determine the propolis that adds, effect and its addition in toothpaste of tea polyphenols magnolia obovata composition by test on the one hand, and in conjunction with the effect of propolis, tea polyphenols magnolia obovata active component, make collutory sterilize, anti-inflammatory, the treatment oral ulcer, multi-efficiencies such as caries prevention; Adjust other matrix components and its compatibility in the toothpaste on the other hand, to guarantee that active component is in the effect of collutory and the stability of collutory self.
A kind of collutory provided by the invention, it is characterized in that, the composition and the mass percentage content of described collutory are as follows: 0.01%～0.1% sweeting agent, 0.02～0.1% acidic flavoring agent, 2～10% wetting agents, 0.5-1% active component stabilizing agent, 0.05～0.6% essence, 0.01～0.3% active component regulator, 0.05～1% active component, 5～10% ethanol, the deionized water surplus;
Described active component is at least two kinds in tea polyphenols, the propolis magnolia obovata;
Described active component stabilizing agent adopts a kind of in polysorbas20, Tween 80, polyoxyethylene ether (40) castor oil hydrogenated and the sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride or their mixture;
Described active component regulator adopts one or both of sodium lauryl sulphate and lauryl creatine acid.
Described sweeting agent adopts a kind of in saccharin sodium, xylitol, Sorbitol, aspartame and the cyclamate or wherein two kinds.Described acidic flavoring agent adopts citric acid, malic acid or tartaric acid.Described wetting agent adopts glycerol or sorbitol.Described essence adopts Herba Menthae Rotundifoliae essence, Herba Menthae essence or green tea essence.
The preparation method of a kind of collutory provided by the invention, this method comprises the steps:
1) being that 0.01～0.1% sweeting agent and 0.02～0.1% acidic flavoring agent are stirred to dissolving with mass percent in water, is that 2～10% wetting agents add in the aqueous solution again with mass percent, stirs and forms finely dispersed water miscible clear liquor;
2) be that 0.05～1% active component is dissolved in 5～10% ethanol with mass percent, add 0.5～1% active component stabilizing agent again, 0.05～0.6% essence and 0.01～0.3% active component regulator stir and form uniform oily solution;
3) under the state that stirs, oily solution is slowly joined in the water miscible clear liquor, behind the mix homogeneously, stops to stir, spend the night leave standstill after, filter, after the aseptic process finished product.
The present invention compared with prior art, prepared collutory has the following advantages: the present invention is in conjunction with each active component propolis, tea polyphenols, the functional trial of Cortex Magnoliae Officinalis, determine active component in the collutory (propolis, tea polyphenols, Cortex Magnoliae Officinalis) to the bacteriostasis of oral cavity pathogen and the effective addition in collutory thereof, the stabilizing agent of the compatibility experiment sieving active component by collutory matrix components and each active component is to guarantee that indissoluble composition propolis magnolia obovata is at the water stability of gargling; Filter out the active component regulator simultaneously, in the collutory use, can bring into play effect well to guarantee active component.Various active composition combined effect in the collutory makes collutory have multiple effect of preventing and treating oral problem again, as prevents and treats dental caries, anti-inflammation and sterilization, desensitization, hemostasis, functions such as fresh breath.
The specific embodiment
A kind of collutory provided by the invention, containing mass percent is 0.01%～0.1% sweeting agent, 0.02～0.1% acidic flavoring agent, 2～10% wetting agents, 0.5-1% active component stabilizing agent, 0.05～0.6% essence, 0.01～0.3% active component regulator, 0.05～1% active component and 5～10% ethanol, surplus are deionized water.
Described active component is at least two kinds in tea polyphenols, the propolis magnolia obovata; Described active component stabilizing agent adopts a kind of in polysorbas20, Tween 80, polyoxyethylene ether (40) castor oil hydrogenated and the sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride or their mixture; Described active component regulator adopts one or both of sodium lauryl sulphate and lauryl creatine acid.
Described sweeting agent adopts a kind of in saccharin sodium, xylitol, Sorbitol, aspartame and the cyclamate or wherein two kinds; Described acidic flavoring agent adopts citric acid, malic acid or tartaric acid.Described wetting agent adopts glycerol or sorbitol.Described essence adopts Herba Menthae Rotundifoliae essence, Herba Menthae essence or green tea essence.
The preparation method of a kind of collutory of the present invention, its concrete preparation process is as follows:
1) with 0.01～0.1% sweeting agent (one or both in employing saccharin sodium, xylitol, Sorbitol, aspartame, the cyclamate), 0.02～0.1% acidic flavoring agent (adopt in citric acid, tartaric acid, the malic acid a kind of) is stirred to dissolving in water, again 2-10% wetting agent (adopt glycerol or sorbitol) is added in the aqueous solution, stir and form finely dispersed clear liquor;
2) the 0.05-1% active component (is adopted tea polyphenols, propolis, in the Cortex Magnoliae Officinalis at least two kinds or two or more) be dissolved in the 5-10% ethanol, add 0.5-1% active component stabilizing agent again and (adopt polyoxyethylene ether (40) castor oil hydrogenated, polysorbas20, Tween 80, in the sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride one or more), 0.05～0.6% essence (adopting Herba Menthae essence or Herba Menthae Rotundifoliae essence or green tea essence) and 0.01-0.3% active component regulator (one or both in employing sodium lauryl sulphate or the lauryl creatine acid) stir and form even oily solution.
3) under the state that stirs, oily solution is slowly added in the water miscible clear liquor.
4) behind all material mix homogeneously, after stopping to stir, spend the night and leave standstill.
5) filter with filter membrane (0.8 micron), get finished product after the aseptic process
In order to determine active component (Cortex Magnoliae Officinalis in the toothpaste, propolis and tea polyphenols) to oral inflammation, dental caries, the effect of oral problem such as oral ulcer and useful effect concentration, the functional experiment that Cortex Magnoliae Officinalis, propolis and tea polyphenols have been carried out respectively, to investigate it to causing several pathogenic bacterium of these oral problem, as the effect of staphylococcus aureus, Candida albicans, escherichia coli and Streptococcus mutans.Result of the test shows: propolis all has inhibitory action to staphylococcus aureus, Candida albicans, escherichia coli and four kinds of bacterium of Streptococcus mutans, and minimum Mlc is respectively 10ug/ml, 20mg/ml, 15ug/ml and 25ug/ml; Tea polyphenols is to staphylococcus aureus, escherichia coli, three kinds of bacterium of Streptococcus mutans all have inhibitory action, minimal inhibitory concentration is respectively 15ug/ml, 20ug/ml, 20ug/ml, and Cortex Magnoliae Officinalis is to staphylococcus aureus, escherichia coli, Streptococcus mutans has inhibitory action, minimal inhibitory concentration is respectively 10mg/ml, 15mg/ml, and 15.6ug/ml. is according to above result of the test, and we determine that two or three addition at collutory in propolis, the tea polyphenols magnolia obovata is 0.05～1%.
Studies show that: propolis, Cortex Magnoliae Officinalis is a water-insoluble materials, add in the collutory and can separate out, cause the muddiness of collutory, thereby influence the stability and the texture of collutory, therefore we are to propolis, the compatibility of Cortex Magnoliae Officinalis and collutory substrate is tested, and the alcoholic content in the discovery collutory has certain solubilization to the propolis magnolia obovata of trace, and along with propolis magnolia obovata addition increases, the propolis magnolia obovata can be separated out rapidly, causes the muddiness of collutory.Obtain screening by the active component stabilizing agent, find polysorbas20, Tween 80, polyoxyethylene ether (40) castor oil hydrogenated, sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride all can promote the dissolubility of propolis magnolia obovata in collutory to guarantee indissoluble active component (propolis magnolia obovata) stable existence in collutory substrate, so our preferred polysorbas20, Tween 80, in polyoxyethylene ether (40) castor oil hydrogenated, the sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride one or more are as the active component stabilizing agent, and addition is 0.5-1%.
The active component stabilizing agent is surfactant, its role is to make the slightly solubility active matter emulsified to a certain extent, thereby increase its dissolving in collutory, but the function test of collutory is found, contain active component (Cortex Magnoliae Officinalis, propolis and tea polyphenols) collutory in four kinds of pathogenic bacterium are not all had fungistatic effect, infer the performance that has influenced its function after active component is wrapped thus, therefore we have carried out experiment with screening active component regulator to the stripping property of active component, find dodecyl sodium sulfate and sarcosyl all can with active component stable existence in collutory, and can promote the stripping of active component in the collutory use, guaranteed active component performance bacteriostasis, so one or both in we are preferred sodium lauryl sulphate and the sarcosyl are as the active component regulator, addition is 0.01-0.3%
Further specify the present invention below by several specific embodiments.
Embodiment 1:
Collutory contains composition and mass percentage content is as follows: saccharin sodium 0.05%, ethanol 6%, Herba Menthae essence 0.2%, tween 20 0.8% in this enforcement, sorbitol 5%, citric acid 0.03%, Cortex Magnoliae Officinalis 0.06%, tea polyphenols 0.5%, sarcosyl 0.2%, deionized water surplus.
With 0.05% saccharin sodium, 0.03% citric acid is stirred to dissolving in water, 5% sorbitol is added in the aqueous solution again, stirs and forms finely dispersed clear liquor; 0.06% Cortex Magnoliae Officinalis and 0.5% tea polyphenols are dissolved in 6% ethanol, add 0.8% polysorbas20 again, and 0.2% Herba Menthae essence and 0.2% sodium lauryl sulphate stir and form even oily solution; Under the state that stirs, slowly add oily solution in the water miscible clear liquor; Behind all material mix homogeneously, after stopping to stir, spend the night and leave standstill; Filter with filter membrane (0.8 micron), get finished product after the aseptic process.
Embodiment 2
Contain described in this enforcement that the active matter collutory contains composition and mass percentage content is as follows: aspartame 0.04%, cyclamate 0.02%, ethanol 8%, Herba Menthae Rotundifoliae essence 0.3%, tween 80 0.3%, polyoxyethylene ether (40) castor oil hydrogenated 0.4%, glycerol 6%, malic acid 0.05%, propolis 0.4%, Cortex Magnoliae Officinalis 0.02%, sodium lauryl sulphate 0.25%, deionized water surplus.Its preparation method is with embodiment 1.
Embodiment 3
Collutory contains composition and mass percentage content is as follows: xylitol 0.03%, Sorbitol 0.05%, ethanol 7% in this enforcement, green tea essence 0.25%, polyoxyethylene ether (40) castor oil hydrogenated 0.5%, tartaric acid 0.04%, sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride 0.1%, propolis 0.8%, tea polyphenols 0.1%, Cortex Magnoliae Officinalis 0.05%, sodium lauryl sulphate 0.15%, sarcosyl 0.15%, sorbitol 9%, deionized water surplus.Its preparation method is with embodiment 1.
Embodiment 4:
In this example collutory contain be divided into and hundred li ratio contents of quality as follows: xylitol 0.1%, ethanol 5%, glycerol 2%, tartaric acid 0.1%, Cortex Magnoliae Officinalis 0.02%, propolis 0.03%, sodium lauryl sulphate 0.01%, Tween 80 0.5%, Herba Menthae essence 0.05% deionized water surplus.Its preparation method is with embodiment 1.
Embodiment 5:
Collutory contains composition and mass percentage content is as follows: Sorbitol 0.01%, sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride 1%, malic acid 0.02% in this example, sorbitol 10%, propolis 0.8%, tea polyphenols 0.2%, lauryl creatine sodium 0.3%, ethanol 10%, green tea essence 0.6%.Its preparation method is with embodiment 1.
Claims (3)
1. collutory, it is characterized in that, the composition and the mass percentage content of described collutory are as follows: 0.01%～0.1% sweeting agent, 0.02～0.1% acidic flavoring agent, 2～10% wetting agents, 0.5-1% active component stabilizing agent, 0.05～0.6% essence, 0.01～0.3% active component regulator, 0.05～1% active component, 5～10% ethanol, the deionized water surplus;
Described active component is at least two kinds in tea polyphenols, the propolis magnolia obovata;
Described active component stabilizing agent adopts a kind of in polysorbas20, Tween 80, polyoxyethylene ether (40) castor oil hydrogenated and the sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride or their mixture;
Described active component regulator adopts one or both of sodium lauryl sulphate and lauryl creatine acid;
Described sweeting agent adopts a kind of in saccharin sodium, xylitol, Sorbitol, aspartame and the cyclamate or wherein two kinds;
Described acidic flavoring agent adopts citric acid, malic acid or tartaric acid;
Described wetting agent adopts glycerol or sorbitol.
2. according to the described a kind of collutory of claim 1, it is characterized in that: described essence adopts Herba Menthae Rotundifoliae essence, Herba Menthae essence or green tea essence.
3. the preparation method of a collutory as claimed in claim 1, this method comprises the steps:
1) being that 0.01～0.1% sweeting agent and 0.02～0.1% acidic flavoring agent are stirred to dissolving with mass percent in water, is that 2～10% wetting agents add in the aqueous solution again with mass percent, stirs and forms finely dispersed water miscible clear liquor;
2) be that 0.05～1% active component is dissolved in 5～10% ethanol with mass percent, add 0.5～1% active component stabilizing agent again, 0.05～0.6% essence and 0.01～0.3% active component regulator stir and form uniform oily solution;
3) under the state that stirs, oily solution is slowly joined in the water miscible clear liquor, behind the mix homogeneously, stops to stir, spend the night leave standstill after, filter, after the aseptic process finished product.
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