CN105324397B - 胰岛素-肠促胰岛素缀合物 - Google Patents

胰岛素-肠促胰岛素缀合物 Download PDF

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Publication number
CN105324397B
CN105324397B CN201480027381.0A CN201480027381A CN105324397B CN 105324397 B CN105324397 B CN 105324397B CN 201480027381 A CN201480027381 A CN 201480027381A CN 105324397 B CN105324397 B CN 105324397B
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amino acid
seq
glucagon
insulin
peptide
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CN105324397A (zh
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R.D.迪马基
T.帕罗迪
J.韩
P.李
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Indiana University Research and Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480027381.0A 2013-03-14 2014-03-05 胰岛素-肠促胰岛素缀合物 Expired - Fee Related CN105324397B (zh)

Applications Claiming Priority (3)

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US201361783491P 2013-03-14 2013-03-14
US61/783,491 2013-03-14
PCT/US2014/020801 WO2014158900A1 (en) 2013-03-14 2014-03-05 Insulin-incretin conjugates

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CN105324397A CN105324397A (zh) 2016-02-10
CN105324397B true CN105324397B (zh) 2020-01-14

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US (2) US20160024169A1 (https=)
EP (1) EP2970511B1 (https=)
JP (1) JP6538645B2 (https=)
KR (1) KR20150131213A (https=)
CN (1) CN105324397B (https=)
AU (1) AU2014241743B2 (https=)
BR (1) BR112015023071A2 (https=)
CA (1) CA2904332A1 (https=)
RU (1) RU2678134C2 (https=)
WO (1) WO2014158900A1 (https=)

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TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
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EP3448417B1 (en) * 2016-04-26 2025-11-12 Merck Sharp & Dohme LLC Insulin dimer-incretin conjugates
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CN110446496A (zh) * 2017-02-03 2019-11-12 范德比尔特大学 用于治疗糖尿病的系统、组合物和方法
WO2018213151A1 (en) 2017-05-18 2018-11-22 Merck Sharp & Dohme Corp. Pharmaceutical formulation comprising incretin-insulin conjugates
SG11202000775SA (en) 2017-07-28 2020-02-27 Univ Princeton Fusion tags for recombinant protein expression
CN111032685A (zh) 2017-08-17 2020-04-17 诺沃挪第克公司 新型酰化胰岛素类似物及其用途
KR102379958B1 (ko) 2018-05-04 2022-04-01 노보 노르디스크 에이/에스 Gip 유도체 및 이의 용도
JP7589049B2 (ja) * 2018-06-21 2024-11-25 ノヴォ ノルディスク アー／エス 肥満を治療するための新規化合物
SG11202106167XA (en) 2018-12-11 2021-07-29 Sanofi Sa Insulin conjugates
US12435116B2 (en) 2019-10-16 2025-10-07 Clarence Hurt Compounds, compositions, methods, and uses for treating insulin resistance, type 2 diabetes and metabolic syndrome
EP4480492A3 (en) 2019-12-11 2025-03-19 Novo Nordisk A/S Novel insulin analogues and uses thereof
EP4230216A4 (en) * 2020-07-24 2025-02-19 Jiangsu Gensciences Inc. Insulin-fc fusion protein and application thereof
WO2022094146A1 (en) 2020-10-28 2022-05-05 The Trustees Of Princeton University Methods of converting precursor proteins to mature proteins using kex2 proteases
US20240116999A1 (en) * 2021-02-09 2024-04-11 The Trustees Of Indiana University Conformationally constrained glucagon analogues and their use in glucagon-single chain insulin fusion proteins

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US20160024169A1 (en) 2016-01-28
CN105324397A (zh) 2016-02-10
US20180194827A1 (en) 2018-07-12
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