CN1052725C - 三环加压素拮抗剂 - Google Patents

三环加压素拮抗剂 Download PDF

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Publication number
CN1052725C
CN1052725C CN96192570A CN96192570A CN1052725C CN 1052725 C CN1052725 C CN 1052725C CN 96192570 A CN96192570 A CN 96192570A CN 96192570 A CN96192570 A CN 96192570A CN 1052725 C CN1052725 C CN 1052725C
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CN
China
Prior art keywords
compound
alkyl group
low alkyl
dihydro
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96192570A
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English (en)
Chinese (zh)
Other versions
CN1178532A (zh
Inventor
A·M·文卡特桑
J·D·阿尔布赖特
G·T·格罗苏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
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American Cyanamid Co
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Publication of CN1178532A publication Critical patent/CN1178532A/zh
Application granted granted Critical
Publication of CN1052725C publication Critical patent/CN1052725C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN96192570A 1995-01-17 1996-01-16 三环加压素拮抗剂 Expired - Fee Related CN1052725C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/373,125 US5521173A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists
US08/373,125 1995-01-17

Publications (2)

Publication Number Publication Date
CN1178532A CN1178532A (zh) 1998-04-08
CN1052725C true CN1052725C (zh) 2000-05-24

Family

ID=23471074

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96192570A Expired - Fee Related CN1052725C (zh) 1995-01-17 1996-01-16 三环加压素拮抗剂

Country Status (24)

Country Link
US (2) US5521173A (ja)
EP (1) EP0805813B1 (ja)
JP (2) JP4156664B2 (ja)
CN (1) CN1052725C (ja)
AR (1) AR002021A1 (ja)
AT (1) ATE217625T1 (ja)
AU (1) AU707881B2 (ja)
BR (1) BR9607177A (ja)
CA (1) CA2210708C (ja)
CZ (1) CZ224797A3 (ja)
DE (1) DE69621225T2 (ja)
DK (1) DK0805813T3 (ja)
EA (1) EA000056B1 (ja)
ES (1) ES2175066T3 (ja)
HK (1) HK1003891A1 (ja)
HU (1) HUP9702459A3 (ja)
IL (1) IL116774A (ja)
MX (1) MX9705414A (ja)
NZ (1) NZ301198A (ja)
PT (1) PT805813E (ja)
TW (1) TW472056B (ja)
UA (1) UA48960C2 (ja)
WO (1) WO1996022292A1 (ja)
ZA (1) ZA96303B (ja)

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US5736540A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
CA2285343A1 (en) 1997-03-31 1998-10-08 Wakamoto Pharmaceutical Co., Ltd. Biphenyl derivatives and medicinal compositions
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
PT1000062E (pt) * 1997-07-30 2004-12-31 Wyeth Corp Agonistas triciclicos de vasopressina
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
BRPI9917086B8 (pt) * 1999-01-19 2016-05-24 Ortho Mcneil Pharm Inc benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en) * 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
WO2000046227A1 (en) * 1999-02-04 2000-08-10 American Home Products Corporation Thienylbenzoylbenzazepines as vasopressin agonists
US6620807B1 (en) 1999-02-04 2003-09-16 Wyeth Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
US6344451B1 (en) 1999-02-04 2002-02-05 American Home Products Pyrrolobenzodiazepine carboxyamide vasopressin agonists
AU7615200A (en) * 1999-09-27 2001-04-30 American Cyanamid Company Vasopressin agonist formulation and process
CA2440002A1 (en) * 2001-03-20 2002-09-26 Applied Research Systems Ars Holding N.V. Pyrrolidine ester derivatives with oxytocin modulating activity
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US6903087B2 (en) * 2001-04-12 2005-06-07 Wyeth Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
EP1381370B1 (en) * 2001-04-12 2007-03-07 Wyeth N-biphenylcarbonyl- and n-phenylpyridylcarbonyl substituted bi- and tricyclic azepines and diazepines as vasopressing agonists
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
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US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
ES2287326T3 (es) * 2001-10-29 2007-12-16 Ortho-Mcneil Pharmaceutical, Inc. Antagonistas del receptor de vasopresina de (,4) benzodiazepina biciclica enlazada.
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CN102216305B (zh) 2008-11-13 2013-12-18 弗·哈夫曼-拉罗切有限公司 螺-5,6-二氢-4H-2,3,5,10b-四氮杂-苯并[e]薁类
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Also Published As

Publication number Publication date
EA000056B1 (ru) 1998-04-30
US5780471A (en) 1998-07-14
WO1996022292A1 (en) 1996-07-25
EP0805813A1 (en) 1997-11-12
JPH11500424A (ja) 1999-01-12
CZ224797A3 (cs) 1998-03-18
US5521173A (en) 1996-05-28
AU707881B2 (en) 1999-07-22
ATE217625T1 (de) 2002-06-15
AR002021A1 (es) 1998-01-07
UA48960C2 (uk) 2002-09-16
IL116774A (en) 2000-12-06
BR9607177A (pt) 1997-11-11
DK0805813T3 (da) 2002-08-05
TW472056B (en) 2002-01-11
CN1178532A (zh) 1998-04-08
CA2210708A1 (en) 1996-07-25
MX9705414A (es) 1997-11-29
ES2175066T3 (es) 2002-11-16
CA2210708C (en) 2005-05-24
ZA96303B (en) 1997-07-15
JP2008069176A (ja) 2008-03-27
JP4156664B2 (ja) 2008-09-24
HK1003891A1 (en) 1998-11-13
HUP9702459A3 (en) 2000-08-28
AU4656696A (en) 1996-08-07
PT805813E (pt) 2002-10-31
HUP9702459A2 (hu) 1998-05-28
EA199700118A1 (ru) 1997-12-30
EP0805813B1 (en) 2002-05-15
DE69621225T2 (de) 2002-11-14
IL116774A0 (en) 1996-05-14
DE69621225D1 (de) 2002-06-20
NZ301198A (en) 1999-08-30

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