CN105232726A - Medicine for preventing and treating duck cholera and preparation method thereof - Google Patents
Medicine for preventing and treating duck cholera and preparation method thereof Download PDFInfo
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Abstract
The invention discloses medicine for preventing and treating duck cholera. The medicine is prepared from, by mass, 190-215 parts of agastache rugosus, 170-195 parts of coptis chinensis, 190-215 parts of rheum officinale, 280-320 parts of rhizoma atractylodis, 140-165 parts of milkvetch roots, 350-380 parts of smoked plums, 180-215 parts of mangnolia officinalis, 190-215 parts of golden cypress and 290-320 parts of isatis roots. The compatibility of all raw materials in the medicine is free of incompatibility, the occurrence rate of duck cholera can be obviously lowered, the good preventing and treating function on duck cholera is achieved, toxic and side effects are avoided, use is safe, and no harmful medicine residue exists.
Description
Technical field
The present invention relates to medicine of a kind of duck epidemic diseases control and preparation method thereof, particularly a kind of have medicine of obvious preventive and therapeutic action and preparation method thereof to dfuck cholera.
Background technology
Dfuck cholera is also called duck poultry and loses, and is the contagious disease caused by pasteurella multocida.The brevibacterium that eggs crack detection is a kind of Gram-negative, do not move, have pod membrane, do not form brood cell.The culture medium of adding blood or serum forms dew and drips sample petite.The equal easy infection primary disease of duck of the various age in days of dfuck cholera susceptible, various kind, laying ducks is susceptible the most.Route of infection is mainly through digestive tract and respiratory tract infection.Many one-tenth septic processes after virulent isolates infects, acute onset, case fatality rate is high, and comparatively slow compared with the course of disease after the strain infection of weak virulence, mortality rate is also not high, normal in sporadic.Precipitating factor is mainly because cut off the water supply fracture, flip-flop feedstuff, and the excessive environmental stress factor that waits of the sudden change stocking density of air all can make the susceptibility of dfuck cholera improve.Acute performance body temperature risings of dfuck cholera, poor appetite, mouth, nasal secretions and cause dyspnea, attempt of shaking the head throws away larynx mucus, suffers from diarrhoea.Chronic type often shows as chronic arthritis, pneumonia, airsacculitis etc.
Western medicine antibiotics, sulfa drugs, olaquindox etc. all have certain effect to control primary disease, but also problem served by band, as treatment is not thorough, often recur after drug withdrawal; Abuse of antibiotics makes bacterial resistance occurred, scope of medication is caused to reduce, dosage increases, production cost increases, and heavy dose of medication produces certain side effect to body, and cause duck product drug residue excessively high, find the emphasis that the medicine preventing and treating dfuck cholera that is safer, efficient, that have no side effect becomes people's research.
Western medicine focuses on Eradicates except pathogenic factor, eliminates the cause of disease; Entirety emphasized by Chinese medicine, focuses on the resistance against diseases improving body, the various functions of adjustment, balance body, and application safety is reliable, adopts Chinese medicine to replace western medicine disease, can overcome the many disadvantages that Western medicine exists.Therefore research and develop and a kind ofly treat the drug residue free of dfuck cholera, the generation that has no drug resistance, clinical effectiveness significant specially good effect Chinese herb medicine are one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome the above-mentioned deficiency of prior art and a kind of medicine preventing and treating dfuck cholera is provided, in medicine of the present invention there is not incompatibility in each material combination, obviously can reduce the incidence rate of dfuck cholera, good preventive and therapeutic action is had to dfuck cholera, and have no side effect, use safety, remains without hazardous drugs.
Another object of the present invention is to provide a kind of preparation method of said medicine, and its technique is simple, and its crude drug is common, cheap.
Technical scheme of the present invention is: a kind of medicine preventing and treating dfuck cholera, and it is made up of the crude drug of following masses part proportioning: Herba Pogostemonis 190-215 part, Rhizoma Coptidis 170-200 part, Radix Et Rhizoma Rhei 190-215 part, Rhizoma Atractylodis 280-320 part, Radix Astragali 140-165 part, Fructus Mume 350-380 part, Cortex Magnoliae Officinalis 180-215 part, Cortex Phellodendri 190-215 part, Radix Isatidis 290-320 part.
Its further preferred mass part proportioning is: Herba Pogostemonis 190-210 part, Rhizoma Coptidis 170-195 part, Radix Et Rhizoma Rhei 190-210 part, Rhizoma Atractylodis 280-315 part, Radix Astragali 140-160 part, Fructus Mume 350-375 part, Cortex Magnoliae Officinalis 180-210 part, Cortex Phellodendri 190-210 part, Radix Isatidis 290-315 part.
Its further preferred mass part proportioning is: Herba Pogostemonis 190-205 part, Rhizoma Coptidis 170-190 part, Radix Et Rhizoma Rhei 190-205 part, Rhizoma Atractylodis 290-315 part, Radix Astragali 140-155 part, Fructus Mume 350-370 part, Cortex Magnoliae Officinalis 190-210 part, Cortex Phellodendri 190-205 part, Radix Isatidis 290-310 part.
Its further preferred mass part proportioning is: Herba Pogostemonis 190-200 part, Rhizoma Coptidis 170-190 part, Radix Et Rhizoma Rhei 190-200 part, Rhizoma Atractylodis 290-310 part, Radix Astragali 145-155 part, Fructus Mume 350-365 part, Cortex Magnoliae Officinalis 195-210 part, Cortex Phellodendri 195-205 part, Radix Isatidis 290-305 part.
Its further preferred mass part proportioning is: Herba Pogostemonis 195-200 part, Rhizoma Coptidis 180-190 part, Radix Et Rhizoma Rhei 195-200 part, Rhizoma Atractylodis 300-310 part, Radix Astragali 145-150 part, Fructus Mume 350-360 part, Cortex Magnoliae Officinalis 200-210 part, Cortex Phellodendri 195-200 part, Radix Isatidis 300-305 part.
Its further preferred mass part proportioning is: Herba Pogostemonis 200 parts, Rhizoma Coptidis 180 parts, Radix Et Rhizoma Rhei 200 parts, Rhizoma Atractylodis 300 parts, the Radix Astragali 150 parts, Fructus Mume 360 parts, Cortex Magnoliae Officinalis 200 parts, Cortex Phellodendri 200 parts, Radix Isatidis 300 parts.
Another technical scheme of the present invention is: a kind of preparation method of preventing and treating the medicine of dfuck cholera, it mainly comprises the steps:
One, by formula weighting raw materials;
Two, pulverized by the crude drug claimed, mix homogeneously, obtains the medicine preventing and treating dfuck cholera.
The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 100-300 mesh sieve.
The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 150-300 mesh sieve.
The primary symbols that the present invention uses and name resolving as follows:
-: numerical range, such as 1-5 represents 1 to 5.
The primary raw material medicine that the present invention uses is described as follows:
Herba Pogostemonis: have another name called: blending, grey announcement, mountain Fructus Foeniculi etc., belongs to tubular flower order, and [function with cure mainly] eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly do not relax, cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
Rhizoma Coptidis: another name: taste company, Rhizoma Coptidis, Rhizoma Coptidis, belongs to Ranunculaceae, Coptis herbaceos perennial, heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Radix Et Rhizoma Rhei: States Pharmacopoeia specifications medicine Radix Et Rhizoma Rhei should from the dry root welding technology of sorrel, Rheum officinale, Rheum tanguticum.Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing, and removing radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.[nature and flavor with return through] are bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.[function with cure mainly] heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.To stagnate constipation for excess-heat, heat in blood tells nosebleed, conjunctival congestion pharyngeal swelling, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema; Externally treating burns and scalds.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.
Rhizoma Atractylodis: perennial herb.Stem list is raw or cluster, and stem branch is dredged by arachnoid hair.Rhizoma Atractylodis root stock is used as medicine, and has dampness, changes effect that is turbid, pain relieving.
The Radix Astragali: in Compendium of Material Medica also known as wearing crushed grain, wear mulberry, grass, hundred, Rhizoma Paridis tetraphyllae, (" stilbene " original work are " over sixty years of age "); Abnormal smells from the patient (root) is sweet, tepor, nontoxic; Cure mainly: the yellow disease of urinary obstruction, alcoholic jaundice, nebulousurine, sallow terribly thirsty, old people constipation, stranguria with blood, drench less, spit blood, cough pus hemoptysis, lung abscess, frequent fetal movement, polyhidrosis around the external genitals pruritus due to damp pathogen.There is invigorating the spleen and replenishing QI arresting sweating, control chronic nephritis, the albumen that disappears, removing toxic substances and promoting granulation, the effect such as strengthen the spleen and stomach.The Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting; The Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper; Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Fructus Mume: be the dry almost ripe fruit of rose department plant plum.For chronic cough of deficiency lung, chronic diarrhea chronic dysentery, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache.
Cortex Magnoliae Officinalis: calling ZIPU, purple oil Piao, Wen Piao etc. within the scope of botany, is Magnoliaceae, magnolia.Cortex Magnoliae Officinalis decoct has inhibitory action to dermatophytess such as trichophyton, Trichophyton concentricunm, trichophyton. to cariogenic pathogen---and the test of Streptococcus mutans shows, Cortex Magnoliae Officinalis oral toxicity is both little, and has efficient quick sterilization effect.
Cortex Phellodendri: be the dry bark of rutaceae wampee.Practise and claim " Cortex Phellodendri ".After stripping bark, removing rough bark, dries.For damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, beriberi flaccidity is knitted, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Radix Isatidis: another name: indigo-blue, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) root, Radix Clerodenri Cyrtophylli, be a kind of Chinese crude drug.For the dry root of cruciferae isatis, usually excavate in the fall, can be used as medicine after the process of preparing Chinese medicine.It is cold in nature, and taste is micro-sweet rear bitterness first, has effect of heat-clearing and toxic substances removing, preventing cold, sore-throat relieving.Be mainly used in the diseases such as treatment maculae caused by violent heat pathogen, crimson tongue are purple dark, scarlet fever.
In medicine of the present invention there is not incompatibility in each material combination, obviously can reduce the incidence rate of dfuck cholera, have good preventive and therapeutic action, and have no side effect, use safety to dfuck cholera, remains without hazardous drugs.
Drug use method of the present invention: during nursing, every 500 kg diet, take the medicine that 2000-2200 gram is prevented and treated dfuck cholera, again by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day is sooner or later each feeds once, within 10 days, is a course for the treatment of, can feed a course for the treatment of of this medicine every 20 days.
In order to be illustrated more clearly in the present invention, enumerate following examples, but it is without any restrictions to scope of invention.
Detailed description of the invention
embodiment 1
Take Herba Pogostemonis 200g, Rhizoma Coptidis 180g, Radix Et Rhizoma Rhei 200g, Rhizoma Atractylodis 300g, Radix Astragali 150g, Fructus Mume 360g, Cortex Magnoliae Officinalis 200g, Cortex Phellodendri 200g, Radix Isatidis 300g, these material compositions are the quality after drying, 150-300 order is ground into super micron mill, mix homogeneously, then packs with plastic bag sealing, the obtained medicine preventing and treating dfuck cholera.
using method:during each nursing, every 500 kilograms of feedstuffs mixed up, take the medicine of 2090 grams of the present embodiment control duckling typhoid fever, again by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day is sooner or later each feeds once, within 10 days, is a course for the treatment of, can feed a course for the treatment of of this medicine every 20 days.
embodiment 2-14, comparative example 1-2
Embodiment 2-12 is except raw material mass mixture ratio is different from embodiment 1, its raw material type and step of preparation process and using method identical with embodiment 1, comparative example 1 eliminates Cortex Magnoliae Officinalis on the basis of embodiment 1, comparative example 2 eliminates Rhizoma Atractylodis on the basis of embodiment 1, the raw material that embodiment 1-12, comparative example 1-2 use and quality as shown in Table 1 below, table 1 below illustrates embodiment 1-12, raw material that comparative example 1-2 uses and quality.
Table 1
Clinical practice one:
Hengyang duckery, 95 age in days sheldrake morbidities of raising, spirit is depressed, and tail fin is sagging, and close one's eyes slow-witted vertical, feather is fluffy and disorderly unglazed; Poor appetite or absolutely useless, drink is for increasing; Body temperature 42-43 DEG C; Mouth and nose flow out mucus, and mouth breathing, shakes the head; Violent dysentery, row's green or white loose stool; Duck hat and wattle blue, be judged to be dfuck cholera by clinical with laboratory diagnosis.Select 600 sick ducks, sick duck is divided into 15 groups at random, often organize 40, treat with embodiment 1-12, comparative example 1-2 institute's pharmacy and oxytetracycline treatment (matched group) respectively, medication is after 10 days, use the duck group more than 95% of the made Drug therapy of the present invention to get well, the duck group 70% of oxytetracycline treatment group treatment gets well, and result is as table 2:
Table 2
As can be seen from Table 2, medicine of the present invention has significant therapeutic effect to dfuck cholera, and cure rate is higher than oxytetracycline treatment group.
Clinical practice two:
In order to prove the feeding effect of the present invention to duck, feeding experiment is repeatedly tried in the duck field occurred in epidemic situation, and choose large-scale duckery 600 ducklings, body weight size, health status are basically identical, are divided into 15 groups at random, often organizes 40.Wherein 14 groups is experimental group, the feedstuff that described in embodiment 1-12, comparative example 1-2, medicine is made into of feeding respectively, twice daily, continuous 10 days, feeds a course for the treatment of every 20 days.Another group is for matched group, and feeding does not add the identical feedstuff of medicine, and the nursing number of times of 15 groups of ducklings, feeding volume, nursing time are all identical.Contrast the various performance indications of 15 groups of ducklings, meansigma methods is as table 3.
After 40 days, 15 groups of duckling situations are as table 3:
Table 3
Can it is evident that from table, experimental group duckling is after continuous feeding feedstuff provided by the invention, and the comparatively matched group that increases weight increases obviously, and experimental group duckling comparatively matched group honey stomach, energetic, state is good, occurs without dfuck cholera disease.
So the present invention is not limited to the protective agents as dfuck cholera, as long as the composition of raw materials medicine identical or equivalent with the present invention just drops within protection scope of the present invention.Also drop on making any one Chinese medicine preparation with the raw material preventing and treating the protective agents same recipe of dfuck cholera of the present invention within protection scope of the present invention, as long as the medicine that namely composition of raw materials is identical with the present invention just drops within protection scope of the present invention.
Claims (9)
1. prevent and treat a medicine for dfuck cholera, it is characterized in that it is made up of the crude drug of following masses part proportioning: Herba Pogostemonis 190-215 part, Rhizoma Coptidis 170-200 part, Radix Et Rhizoma Rhei 190-215 part, Rhizoma Atractylodis 280-320 part, Radix Astragali 140-165 part, Fructus Mume 350-380 part, Cortex Magnoliae Officinalis 180-215 part, Cortex Phellodendri 190-215 part, Radix Isatidis 290-320 part.
2. the medicine preventing and treating dfuck cholera according to claim 1, is characterized in that Herba Pogostemonis 190-210 part, Rhizoma Coptidis 170-195 part, Radix Et Rhizoma Rhei 190-210 part, Rhizoma Atractylodis 280-315 part, Radix Astragali 140-160 part, Fructus Mume 350-375 part, Cortex Magnoliae Officinalis 180-210 part, Cortex Phellodendri 190-210 part, Radix Isatidis 290-315 part.
3. the medicine preventing and treating dfuck cholera according to claim 1, is characterized in that Herba Pogostemonis 190-205 part, Rhizoma Coptidis 170-190 part, Radix Et Rhizoma Rhei 190-205 part, Rhizoma Atractylodis 290-315 part, Radix Astragali 140-155 part, Fructus Mume 350-370 part, Cortex Magnoliae Officinalis 190-210 part, Cortex Phellodendri 190-205 part, Radix Isatidis 290-310 part.
4. the medicine preventing and treating dfuck cholera according to claim 1, is characterized in that Herba Pogostemonis 190-200 part, Rhizoma Coptidis 170-190 part, Radix Et Rhizoma Rhei 190-200 part, Rhizoma Atractylodis 290-310 part, Radix Astragali 145-155 part, Fructus Mume 350-365 part, Cortex Magnoliae Officinalis 195-210 part, Cortex Phellodendri 195-205 part, Radix Isatidis 290-305 part.
5. the medicine preventing and treating dfuck cholera according to claim 1, is characterized in that Herba Pogostemonis 195-200 part, Rhizoma Coptidis 180-190 part, Radix Et Rhizoma Rhei 195-200 part, Rhizoma Atractylodis 300-310 part, Radix Astragali 145-150 part, Fructus Mume 350-360 part, Cortex Magnoliae Officinalis 200-210 part, Cortex Phellodendri 195-200 part, Radix Isatidis 300-305 part.
6. the medicine preventing and treating dfuck cholera according to claim 1, is characterized in that Herba Pogostemonis 200 parts, Rhizoma Coptidis 180 parts, Radix Et Rhizoma Rhei 200 parts, Rhizoma Atractylodis 300 parts, the Radix Astragali 150 parts, Fructus Mume 360 parts, Cortex Magnoliae Officinalis 200 parts, Cortex Phellodendri 200 parts, Radix Isatidis 300 parts.
7. prevent and treat the preparation method of the medicine of dfuck cholera according to claim 1, it is characterized in that: it mainly comprises the steps:
One, weighting raw materials;
Two, pulverized by the crude drug claimed, mix homogeneously, obtains the medicine preventing and treating dfuck cholera.
8. prevent and treat the preparation method of the medicine of dfuck cholera according to claim 7, it is characterized in that: after step 2 raw material pulverizing, cross 100-300 mesh sieve.
9. preparation method of preventing and treating the medicine of dfuck cholera according to claim 7, is characterized in that: after step 2 raw material pulverizing, crosses 150-300 mesh sieve.
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| CN104173605A (en) * | 2014-07-22 | 2014-12-03 | 刘学勤 | Traditional Chinese medicine prescription for treating duck cholera |
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| CN104173605A (en) * | 2014-07-22 | 2014-12-03 | 刘学勤 | Traditional Chinese medicine prescription for treating duck cholera |
Non-Patent Citations (3)
| Title |
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| 姚彩兰等: "黄芪在养禽业中的应用", 《上海畜牧兽医通讯》 * |
| 李秀艳等: "防治禽霍乱的土法良方", 《养殖技术顾问》 * |
| 田玉民等: "《家禽饲养技术》", 31 March 2013, 中国农业出版社 * |
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Application publication date: 20160113 |