CN105189517A - 含多环取代的吡唑类激酶活性抑制剂及其用途 - Google Patents

含多环取代的吡唑类激酶活性抑制剂及其用途 Download PDF

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CN105189517A
CN105189517A CN201480004085.9A CN201480004085A CN105189517A CN 105189517 A CN105189517 A CN 105189517A CN 201480004085 A CN201480004085 A CN 201480004085A CN 105189517 A CN105189517 A CN 105189517A
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methyl
phenyl
pyrazolecarboxamides
another
amino
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CN105189517B (zh
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陆涛
王越
陈亚东
陆旖
王占伟
金乔梅
杨涛涛
林国武
郭青龙
赵丽
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Shanghai Fosun Pharmaceutical Development Co Ltd
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

本发明涉及药物化学领域，具体涉及4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类衍生物、它们的制备方法、含有这些化合物的药用组合物以及它们的医疗用途，特别是作为蛋白激酶抑制剂的抗肿瘤用途。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201480004085.9A 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途 Active CN105189517B (zh)

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CN201480004085.9A CN105189517B (zh) 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途
CN201710450213.8A CN107098903B (zh) 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途

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CN2013100052586 2013-01-08
CN2013100052586A CN103012428A (zh) 2013-01-08 2013-01-08 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
CN201480004085.9A CN105189517B (zh) 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途
PCT/CN2014/070195 WO2014108053A1 (zh) 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途

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CN201710450213.8A Active CN107098903B (zh) 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途
CN201480004085.9A Active CN105189517B (zh) 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途

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CN201710450213.8A Active CN107098903B (zh) 2013-01-08 2014-01-07 含多环取代的吡唑类激酶活性抑制剂及其用途

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US (1) US9550792B2 (zh)
EP (1) EP2955185B1 (zh)
JP (1) JP6322848B2 (zh)
KR (1) KR102136628B1 (zh)
CN (3) CN103012428A (zh)
AU (1) AU2014204633B2 (zh)
BR (1) BR112015016327A8 (zh)
CA (1) CA2897366C (zh)
DK (1) DK2955185T3 (zh)
ES (1) ES2863175T3 (zh)
PT (1) PT2955185T (zh)
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CN110835334A (zh) * 2018-08-16 2020-02-25 中国药科大学 吲哚取代唑类化合物及其用途

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CN103012428A (zh) * 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
CN103435606A (zh) * 2013-08-22 2013-12-11 中国药科大学 CDK2与GSK3β双重抑制剂及用途
CN104592251B (zh) * 2015-01-23 2019-10-01 上海复星医药产业发展有限公司 4-(稠杂环取代氨基)-1h-吡唑-3-甲酰胺类化合物及其用途
CN107235906B (zh) * 2017-06-28 2020-05-01 郑州大学第一附属医院 一组吡唑酰胺类衍生物及其应用
CN107245073B (zh) * 2017-07-11 2020-04-17 中国药科大学 4-(芳杂环取代)氨基-1h-3-吡唑甲酰胺类flt3抑制剂及其用途
IL272838B2 (en) 2017-10-06 2023-09-01 Forma Therapeutics Inc Peptidase-specific ubiquitin inhibition 30
CN109970717B (zh) * 2017-12-28 2022-10-18 中国药科大学 4-(脂肪环并嘧啶/吡啶取代)氨基-1h-3-吡唑甲酰胺类flt3抑制剂及其用途
SG11202011299PA (en) 2018-05-17 2020-12-30 Forma Therapeutics Inc Fused bicyclic compounds useful as ubiquitin-specific peptidase 30 inhibitors
PE20211053A1 (es) 2018-10-05 2021-06-07 Forma Therapeutics Inc Inhibicion de la proteasa 30 especifica de la ubiquitina (usp30)
CN111171044B (zh) * 2018-11-13 2022-06-24 沈阳化工研究院有限公司 一种噻吩并嘧啶类化合物及其医药用途
WO2020132384A1 (en) 2018-12-21 2020-06-25 Celgene Corporation Thienopyridine inhibitors of ripk2
CN113677341B (zh) * 2019-02-01 2024-07-05 南卡罗莱纳大学 双环吡啶组合物及其用于癌症治疗的方法
KR20200100429A (ko) * 2019-02-18 2020-08-26 한국과학기술연구원 단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물
CN110183464B (zh) * 2019-05-31 2021-08-31 淮阴工学院 一种抗癌化合物艾斯替尼及其合成方法和应用
CN112794855B (zh) * 2019-11-13 2023-07-28 中国药科大学 N-芳基嘧啶-4-胺类衍生物的制备方法与应用
CN112043710A (zh) * 2020-09-28 2020-12-08 广州智睿医药科技有限公司 一种治疗或预防与lrrk2激酶或异常lrrk2突变激酶活性相关疾病的药物
WO2023168246A2 (en) * 2022-03-01 2023-09-07 Purdue Research Foundation Selective g protein-coupled receptor kinase 5 inhibitors, compositions, and methods of use
CN114685371A (zh) * 2022-03-08 2022-07-01 四川大学 吡唑甲酰胺衍生物及其制备方法和用途
CN115746002B (zh) * 2022-11-13 2023-12-08 药康众拓(江苏)医药科技有限公司 一种氘代氮杂吲哚氨基-吡唑甲酰胺类化合物及其用途

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