CN105188701A - 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 - Google Patents

3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 Download PDF

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Publication number
CN105188701A
CN105188701A CN201380072027.5A CN201380072027A CN105188701A CN 105188701 A CN105188701 A CN 105188701A CN 201380072027 A CN201380072027 A CN 201380072027A CN 105188701 A CN105188701 A CN 105188701A
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CN
China
Prior art keywords
methyl
imidazo
trifluoromethyl
phenyl
ylethynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201380072027.5A
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English (en)
Chinese (zh)
Inventor
C.K.默里
L.W.罗扎马斯
J.J.沙伯
P.夏尔马
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Ariad Pharmaceuticals Inc
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Ariad Pharmaceuticals Inc
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50929140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN105188701(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ariad Pharmaceuticals Inc filed Critical Ariad Pharmaceuticals Inc
Priority to CN202210369530.8A priority Critical patent/CN115043843A/zh
Publication of CN105188701A publication Critical patent/CN105188701A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380072027.5A 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 Pending CN105188701A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210369530.8A CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US61/736,543 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US61/737,007 2012-12-13
US201361788208P 2013-03-15 2013-03-15
US61/788,208 2013-03-15
PCT/US2013/074571 WO2014093579A2 (en) 2012-12-12 2013-12-12 Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210369530.8A Division CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Publications (1)

Publication Number Publication Date
CN105188701A true CN105188701A (zh) 2015-12-23

Family

ID=50929140

Family Applications (2)

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CN201380072027.5A Pending CN105188701A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形
CN202210369530.8A Pending CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202210369530.8A Pending CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Country Status (9)

Country Link
US (9) US9493470B2 (enExample)
JP (5) JP6447508B2 (enExample)
CN (2) CN105188701A (enExample)
CA (3) CA2815506C (enExample)
CL (1) CL2015001643A1 (enExample)
HK (1) HK1218878A1 (enExample)
MX (11) MX391445B (enExample)
NZ (1) NZ709648A (enExample)
WO (2) WO2014093579A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104496994A (zh) * 2014-01-06 2015-04-08 广东东阳光药业有限公司 一种炔类杂芳基化合物的新晶型
CN111004240A (zh) * 2019-12-13 2020-04-14 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法
CN112292388A (zh) * 2018-04-02 2021-01-29 隐形生物治疗公司 用于合成elamipretide的结晶二肽

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5200939B2 (ja) 2005-12-23 2013-06-05 アリアド・ファーマシューティカルズ・インコーポレイテッド 二環式ヘテロアリール化合物
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CA2815506C (en) 2012-12-12 2018-12-11 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
US9725454B2 (en) 2013-07-04 2017-08-08 Sandoz Ag Crystalline forms of ponatinib hydrochloride
CN110291081B (zh) * 2016-12-15 2023-01-31 阿瑞雅德制药公司 作为c-kit抑制剂的苯并咪唑化合物
US10221184B2 (en) 2017-01-20 2019-03-05 Apicore Us Llc Polymorphs of ponatinib hydrochloride
US11072620B2 (en) 2017-06-20 2021-07-27 Apotex Inc. Crystalline forms of Ponatinib hydrochloride
WO2019246479A1 (en) 2018-06-22 2019-12-26 Johnson Matthey Public Limited Company Form of ponatinib
AU2019374142A1 (en) 2018-11-01 2021-05-27 Syros Pharmaceuticals, Inc. Methods of treating cancer in biomarker-identified patients with non-covalent inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2020223235A1 (en) 2019-04-29 2020-11-05 Incyte Corporation Mini-tablet dosage forms of ponatinib

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101389338A (zh) * 2005-12-23 2009-03-18 阿里亚德医药股份有限公司 双环杂芳基化合物
US8114874B2 (en) * 2005-12-23 2012-02-14 Ariad Pharmaceuticals, Inc. Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
CN102770129A (zh) * 2009-10-30 2012-11-07 阿里亚德医药股份有限公司 治疗癌症的方法和组合物

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099067A (en) * 1988-08-05 1992-03-24 Northwestern University Use of ammonium formate as a hydrogen transfer reagent for reduction of chiral nitro compounds with retention of configuration
AU1465301A (en) * 1999-11-08 2001-06-06 Schering Corporation Process for preparing n-(4-hydroxy-phenyl)-n'-(4'-aminophenyl)-piperazine
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
DE10021246A1 (de) 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
IL159811A0 (en) 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
AR041992A1 (es) 2002-11-06 2005-06-08 Smithkline Beecham Corp Compuesto de piridinil benzoheterociclico, composicion farmaceutica que lo comprende y su uso para prepararla
GB0230089D0 (en) 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
WO2005051366A2 (en) 2003-11-28 2005-06-09 Novartis Ag Diaryl urea derivatives in the treatment of protein kinase dependent diseases
NZ546782A (en) * 2003-12-05 2010-04-30 Biovitrum Ab Improved synthesis of 2-substituted adenosines such as spongosine
JP2007517007A (ja) 2003-12-24 2007-06-28 アストラゼネカ アクチボラグ Ｔｉｅ２（ＴＥＫ）活性を持つピリミジン
DE602004015509D1 (de) 2003-12-24 2008-09-11 Astrazeneca Ab Pyrimidine mit tie2 (tek) aktivität
CA2560648C (en) 2004-04-07 2013-01-22 Applied Research Systems Ars Holding N.V. 1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors
JP2008506702A (ja) 2004-07-14 2008-03-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するための方法
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
GB0502418D0 (en) 2005-02-05 2005-03-16 Astrazeneca Ab Compounds
JP2008534565A (ja) 2005-03-31 2008-08-28 アストラゼネカ アクチボラグ Ｔｉｅ２阻害活性のあるアミノピリミジン誘導体
EP1910369A1 (en) 2005-07-29 2008-04-16 Astellas Pharma Inc. Fused heterocycles as lck inhibitors
WO2007021937A2 (en) 2005-08-11 2007-02-22 Ariad Pharmaceuticals, Inc. Unsaturated heterocyclic derivatives
EP2024366B1 (en) 2006-05-08 2015-09-16 Ariad Pharmaceuticals, Inc. Monocyclic heteroaryl compounds
KR20090018104A (ko) 2006-05-08 2009-02-19 어리어드 파마슈티칼스, 인코포레이티드 아세틸렌계 헤테로아릴 화합물
EP2107054A1 (en) 2008-04-01 2009-10-07 Università Degli Studi Di Milano - Bicocca Antiproliferative compounds and therapeutic uses thereof
WO2010124047A1 (en) 2009-04-23 2010-10-28 Wyeth Llc Bisaryl alkynylamides as negative allosteric modulators of metabotropic glutamate receptor 5 (mglur5)
US8329724B2 (en) * 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
BR112013024169A2 (pt) 2011-04-07 2016-12-06 Ariad Pharma Inc método para o tratamento e prevenção da doença de parkinson
CN103582478A (zh) * 2011-04-07 2014-02-12 阿里亚德医药股份有限公司 治疗神经退行性疾病的方法和组合物
JP2015514802A (ja) 2012-04-25 2015-05-21 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｒａｆキナーゼ媒介疾患用の方法及び組成物
CA2815506C (en) * 2012-12-12 2018-12-11 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101389338A (zh) * 2005-12-23 2009-03-18 阿里亚德医药股份有限公司 双环杂芳基化合物
US8114874B2 (en) * 2005-12-23 2012-02-14 Ariad Pharmaceuticals, Inc. Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
CN102770129A (zh) * 2009-10-30 2012-11-07 阿里亚德医药股份有限公司 治疗癌症的方法和组合物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104496994A (zh) * 2014-01-06 2015-04-08 广东东阳光药业有限公司 一种炔类杂芳基化合物的新晶型
CN112292388A (zh) * 2018-04-02 2021-01-29 隐形生物治疗公司 用于合成elamipretide的结晶二肽
CN112292388B (zh) * 2018-04-02 2024-04-19 隐形生物治疗公司 用于合成elamipretide的结晶二肽
CN111004240A (zh) * 2019-12-13 2020-04-14 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法

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US20240083902A1 (en) 2024-03-14
US9493470B2 (en) 2016-11-15
CA3022250A1 (en) 2014-06-12
US20210277012A1 (en) 2021-09-09
CL2015001643A1 (es) 2015-10-02
CA3167093A1 (en) 2014-06-12
MX391445B (es) 2025-03-21
US20210024527A1 (en) 2021-01-28
MX2021002253A (es) 2021-05-27
JP2016503010A (ja) 2016-02-01
CA2815506A1 (en) 2014-06-12
US10125136B2 (en) 2018-11-13
US10662197B2 (en) 2020-05-26
MX2021002261A (es) 2021-05-27
US11192895B2 (en) 2021-12-07
CN115043843A (zh) 2022-09-13
US11192896B2 (en) 2021-12-07
MX2021002258A (es) 2021-05-27
US20210340149A1 (en) 2021-11-04
JP2026010061A (ja) 2026-01-21
US11279705B2 (en) 2022-03-22
US20190169196A1 (en) 2019-06-06
MX2021002254A (es) 2021-05-27
US20210277011A1 (en) 2021-09-09
WO2014093583A3 (en) 2014-08-07
JP7042175B2 (ja) 2022-03-25
US11384086B2 (en) 2022-07-12
MX359147B (es) 2018-09-17
US20150315194A1 (en) 2015-11-05
JP2023179498A (ja) 2023-12-19
US20210277010A1 (en) 2021-09-09
MX2015007578A (es) 2016-03-21
US11192897B2 (en) 2021-12-07
JP2018168191A (ja) 2018-11-01
MX2021002255A (es) 2021-05-27
JP6447508B2 (ja) 2019-01-09
MX2021002259A (es) 2021-05-27
WO2014093583A2 (en) 2014-06-19
WO2014093579A3 (en) 2014-07-10
US20170190707A1 (en) 2017-07-06
NZ709648A (en) 2020-05-29
MX2021002256A (es) 2021-05-27
JP7352841B2 (ja) 2023-09-29
MX2021002264A (es) 2021-05-27
MX2021002257A (es) 2021-05-27
CA2815506C (en) 2018-12-11
JP2022037122A (ja) 2022-03-08
WO2014093579A2 (en) 2014-06-19
HK1218878A1 (zh) 2017-03-17

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