CA2815506C - Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride - Google Patents

Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride Download PDF

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Publication number
CA2815506C
CA2815506C CA2815506A CA2815506A CA2815506C CA 2815506 C CA2815506 C CA 2815506C CA 2815506 A CA2815506 A CA 2815506A CA 2815506 A CA2815506 A CA 2815506A CA 2815506 C CA2815506 C CA 2815506C
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Prior art keywords
ponatinib
ponatinib hydrochloride
solvent
hydrochloride
xrpd
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CA2815506A
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English (en)
French (fr)
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CA2815506A1 (en
Inventor
Christopher K. Murray
Leonard W. Rozamus
John J. Chaber
Pradeep Sharma
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Ariad Pharmaceuticals Inc
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Ariad Pharmaceuticals Inc
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Application filed by Ariad Pharmaceuticals Inc filed Critical Ariad Pharmaceuticals Inc
Priority to CA3022250A priority Critical patent/CA3022250A1/en
Publication of CA2815506A1 publication Critical patent/CA2815506A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2815506A 2012-12-12 2013-05-09 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride Active CA2815506C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3022250A CA3022250A1 (en) 2012-12-12 2013-05-09 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US61/736,543 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US61/737,007 2012-12-13
US201361788208P 2013-03-15 2013-03-15
US61/788,208 2013-03-15

Related Child Applications (1)

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CA3022250A Division CA3022250A1 (en) 2012-12-12 2013-05-09 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride

Publications (2)

Publication Number Publication Date
CA2815506A1 CA2815506A1 (en) 2014-06-12
CA2815506C true CA2815506C (en) 2018-12-11

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ID=50929140

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2815506A Active CA2815506C (en) 2012-12-12 2013-05-09 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
CA3022250A Abandoned CA3022250A1 (en) 2012-12-12 2013-05-09 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
CA3167093A Pending CA3167093A1 (en) 2012-12-12 2013-05-09 Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3022250A Abandoned CA3022250A1 (en) 2012-12-12 2013-05-09 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
CA3167093A Pending CA3167093A1 (en) 2012-12-12 2013-05-09 Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride

Country Status (9)

Country Link
US (9) US9493470B2 (enExample)
JP (5) JP6447508B2 (enExample)
CN (2) CN115043843A (enExample)
CA (3) CA2815506C (enExample)
CL (1) CL2015001643A1 (enExample)
HK (1) HK1218878A1 (enExample)
MX (11) MX359147B (enExample)
NZ (1) NZ709648A (enExample)
WO (2) WO2014093583A2 (enExample)

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CN115043843A (zh) 2022-09-13
US20210024527A1 (en) 2021-01-28
MX2021002253A (es) 2021-05-27
JP2018168191A (ja) 2018-11-01
CL2015001643A1 (es) 2015-10-02
MX2021002256A (es) 2021-05-27
US11384086B2 (en) 2022-07-12
US20210277010A1 (en) 2021-09-09
CA3167093A1 (en) 2014-06-12
US11279705B2 (en) 2022-03-22
JP7352841B2 (ja) 2023-09-29
MX2021002261A (es) 2021-05-27
MX2021002255A (es) 2021-05-27
JP2016503010A (ja) 2016-02-01
HK1218878A1 (zh) 2017-03-17
JP7042175B2 (ja) 2022-03-25
CA2815506A1 (en) 2014-06-12
US20190169196A1 (en) 2019-06-06
MX2021002257A (es) 2021-05-27
MX2021002258A (es) 2021-05-27
US20210277011A1 (en) 2021-09-09
US10662197B2 (en) 2020-05-26
JP2022037122A (ja) 2022-03-08
US20150315194A1 (en) 2015-11-05
US11192895B2 (en) 2021-12-07
WO2014093583A3 (en) 2014-08-07
US9493470B2 (en) 2016-11-15
US20240083902A1 (en) 2024-03-14
WO2014093583A2 (en) 2014-06-19
MX2021002259A (es) 2021-05-27
MX2015007578A (es) 2016-03-21
MX391445B (es) 2025-03-21
MX2021002264A (es) 2021-05-27
US11192897B2 (en) 2021-12-07
MX359147B (es) 2018-09-17
WO2014093579A3 (en) 2014-07-10
US10125136B2 (en) 2018-11-13
US20210340149A1 (en) 2021-11-04
MX2021002254A (es) 2021-05-27
NZ709648A (en) 2020-05-29
US11192896B2 (en) 2021-12-07
CA3022250A1 (en) 2014-06-12
WO2014093579A2 (en) 2014-06-19
CN105188701A (zh) 2015-12-23
US20210277012A1 (en) 2021-09-09
JP2026010061A (ja) 2026-01-21
JP2023179498A (ja) 2023-12-19
JP6447508B2 (ja) 2019-01-09
US20170190707A1 (en) 2017-07-06

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