CN105164270B8 - 由甜菊苷制备莱苞迪甙a的方法 - Google Patents

由甜菊苷制备莱苞迪甙a的方法 Download PDF

Info

Publication number
CN105164270B8
CN105164270B8 CN201380073982.0A CN201380073982A CN105164270B8 CN 105164270 B8 CN105164270 B8 CN 105164270B8 CN 201380073982 A CN201380073982 A CN 201380073982A CN 105164270 B8 CN105164270 B8 CN 105164270B8
Authority
CN
China
Prior art keywords
stevioside
preparing rebaudioside
rebaudioside
preparing
sucrose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380073982.0A
Other languages
English (en)
Other versions
CN105164270A (zh
CN105164270B (zh
Inventor
朴晟喜
金贞银
尹烂*
尹烂
洪暎镐
金成俌
朴承源
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ CheilJedang Corp filed Critical CJ CheilJedang Corp
Publication of CN105164270A publication Critical patent/CN105164270A/zh
Application granted granted Critical
Publication of CN105164270B publication Critical patent/CN105164270B/zh
Publication of CN105164270B8 publication Critical patent/CN105164270B8/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

本发明涉及由蔗糖和甜菊苷通过蔗糖合成酶和糖基转移酶来制备莱苞迪甙A的原位方法。
CN201380073982.0A 2013-02-28 2013-12-09 由甜菊苷制备莱苞迪甙a的方法 Active CN105164270B8 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2013-0022176 2013-02-28
KR1020130022176A KR101404728B1 (ko) 2013-02-28 2013-02-28 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
PCT/KR2013/011330 WO2014133248A1 (ko) 2013-02-28 2013-12-09 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법

Publications (3)

Publication Number Publication Date
CN105164270A CN105164270A (zh) 2015-12-16
CN105164270B CN105164270B (zh) 2019-07-09
CN105164270B8 true CN105164270B8 (zh) 2019-12-06

Family

ID=51132132

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380073982.0A Active CN105164270B8 (zh) 2013-02-28 2013-12-09 由甜菊苷制备莱苞迪甙a的方法

Country Status (7)

Country Link
US (1) US10472660B2 (zh)
EP (1) EP2963122B1 (zh)
JP (2) JP6147370B2 (zh)
KR (1) KR101404728B1 (zh)
CN (1) CN105164270B8 (zh)
ES (1) ES2674480T3 (zh)
WO (1) WO2014133248A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
EP3862426A3 (en) 2015-03-16 2021-11-17 DSM IP Assets B.V. Udp-glycosyltransferases
JP6793957B2 (ja) * 2015-04-14 2020-12-02 コナゲン インコーポレイテッド 改変された全細胞触媒を用いたノンカロリー甘味料の生成
US20170266524A1 (en) * 2016-03-18 2017-09-21 James C. Van Loon, III Method of using lacrosse mesh
WO2017207484A1 (en) 2016-05-31 2017-12-07 Universiteit Gent Mutant sucrose synthases and their uses
EA201990034A1 (ru) * 2016-06-15 2019-06-28 Кодексис, Инк. Ферментативное гликозилирование стевиолгликозидов и других соединений с глюкозо-1-фосфатом
SG11201810998WA (en) 2016-06-15 2019-01-30 Codexis Inc Engineered beta-glucosidases and glucosylation methods
ES2906310T3 (es) 2016-08-12 2022-04-18 Amyris Inc Glicosiltransferasa dependiente de UDP para la producción de alta eficiencia de rebaudiósidos
CA3175070A1 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
CN108315394A (zh) * 2018-04-23 2018-07-24 沈阳师范大学 甜高粱蔗糖合成酶基因的表达检测方法及扩增引物
CN109196110A (zh) * 2018-07-19 2019-01-11 邦泰生物工程(深圳)有限公司 莱苞迪甙a的制备方法、莱苞迪甙a制备用酶及应用
CN111344399B (zh) * 2018-11-16 2023-03-03 邦泰生物工程(深圳)有限公司 一种udp-葡萄糖基转移酶突变体、其应用及其制备莱鲍迪苷d的方法
KR102303415B1 (ko) * 2019-06-14 2021-09-23 씨제이제일제당 (주) 감미 소재 조성물 및 이의 제조 방법
CN111593062A (zh) * 2020-05-25 2020-08-28 安徽金禾实业股份有限公司 一种利用枯草芽孢杆菌发酵催化制备莱鲍迪苷a的方法
CN111621456A (zh) * 2020-05-25 2020-09-04 安徽金禾实业股份有限公司 一种液态发酵制备莱鲍迪苷a的方法
KR102628374B1 (ko) 2021-10-19 2024-01-24 씨제이제일제당 주식회사 신규한 당전이효소 및 이의 용도
AU2022373017A1 (en) 2021-10-19 2024-05-30 Cj Cheiljedang Corporation Method for producing rebaudioside d and rebaudioside m

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100099857A1 (en) * 2007-01-22 2010-04-22 Cargill, Incorporated Method of producing purified rebaudioside a compositions using solvent/antisolvent crystallization
US20110087011A1 (en) * 2008-05-13 2011-04-14 Cargill, Incorporated Separation of rebaudioside a from stevia glycosides using chromatography
WO2011153378A1 (en) * 2010-06-02 2011-12-08 Abunda Nutrition, Inc. Recombinant Production of Steviol Glycosides
CN102766667A (zh) * 2012-08-14 2012-11-07 成都南诺格生物科技有限责任公司 甜菊苷转化为莱鲍迪苷e的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219571A (en) * 1978-06-15 1980-08-26 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for producing a sweetener
JPS58149697A (ja) * 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−１，３グリコシルステビオシドの製造方法
JPH11290075A (ja) * 1998-02-26 1999-10-26 Univ Kyoto 組み換えミュータントシュクロース合成酵素によるシュクロースからのセルロースの合成
JP2000245279A (ja) * 1999-03-01 2000-09-12 Mitsui Chemicals Inc 植物の耐冷性の増強方法
US6469947B2 (en) 1999-06-29 2002-10-22 Hyundai Electronics Co., Ltd. Semiconductor memory device having regions with independent word lines alternately selected for refresh operation
KR20040026747A (ko) 2002-09-26 2004-04-01 바이오스펙트럼 주식회사 미생물을 이용한 리보디오사이드 에이의 제조방법
MX2007010819A (es) * 2005-03-04 2008-01-14 Morita Kagaku Kogyo Edulcorante de stevia.
FR2887253A1 (fr) 2005-06-20 2006-12-22 Phosphoenix Sarl Nouvelles arylphosphines p chirales ortho-fonctionnalisees et derives: leur preparation et utilisation en catalyse asymetrique
JP2007330112A (ja) * 2006-06-12 2007-12-27 Sanei Gen Ffi Inc フェノール性化合物のグルコース配糖体の製造方法
KR101598935B1 (ko) * 2010-04-16 2016-03-03 씨제이제일제당(주) 레바우디오사이드 ａ의 생산 공정에서 발생하는 부산물을 재활용하여 고수득율의 레바우디오사이드 ａ를 제조하는 방법
WO2013022989A2 (en) * 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100099857A1 (en) * 2007-01-22 2010-04-22 Cargill, Incorporated Method of producing purified rebaudioside a compositions using solvent/antisolvent crystallization
US20110087011A1 (en) * 2008-05-13 2011-04-14 Cargill, Incorporated Separation of rebaudioside a from stevia glycosides using chromatography
WO2011153378A1 (en) * 2010-06-02 2011-12-08 Abunda Nutrition, Inc. Recombinant Production of Steviol Glycosides
CN102766667A (zh) * 2012-08-14 2012-11-07 成都南诺格生物科技有限责任公司 甜菊苷转化为莱鲍迪苷e的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
生物法合成尿苷二磷酸葡萄糖的研究进展;陈圣等;《中国生物工程杂志》;20121231;125-130 *

Also Published As

Publication number Publication date
US20160010133A1 (en) 2016-01-14
KR101404728B1 (ko) 2014-06-09
EP2963122B1 (en) 2018-05-30
CN105164270A (zh) 2015-12-16
JP2017148050A (ja) 2017-08-31
ES2674480T3 (es) 2018-07-02
WO2014133248A1 (ko) 2014-09-04
EP2963122A1 (en) 2016-01-06
JP2016508378A (ja) 2016-03-22
EP2963122A4 (en) 2016-10-12
JP6147370B2 (ja) 2017-06-21
US10472660B2 (en) 2019-11-12
CN105164270B (zh) 2019-07-09

Similar Documents

Publication Publication Date Title
CN105164270B8 (zh) 由甜菊苷制备莱苞迪甙a的方法
HK1226103A1 (zh) 一種酶法製備瑞鮑迪甙m的方法
CN106536536A8 (zh) 无热量甜味剂
EP3303553A4 (en) Fermentation methods for producing steviol glycosides using high ph and compositions obtained therefrom
WO2014122227A3 (en) Methods for improved production of rebaudioside d and rebaudioside m
EP3331373A4 (en) FERMENTATION PROCESS FOR THE PREPARATION OF STEVIOL GLYCOSIDES
EP3019198A4 (en) Compositions and methods for improving rebaudioside m solubility
MY179680A (en) Non-caloric sweeteners and methods for synthesizing
EP3468385A4 (en) STEVIOL GLYCOSIDE COMPOSITIONS, PRODUCTION METHODS AND USES
EP3019197A4 (en) Rebaudioside x to provide sweetness enhancement
EP3166981A4 (en) Oligosaccharide compositions and methods for producing thereof
EP3303782A4 (en) ELECTRICALLY ROTATING ROCKER ARM ASSEMBLY WITH BUILT-IN OBD FUNCTIONALITY
WO2014172055A3 (en) Novel glucosyl steviol glycosides, their compositions and their purification
EP3052638A4 (en) Glucosyl stevia composition
EP3569707A4 (en) HIGH-REBAUDIOSIDE C STEVIA PLANT
PL2990483T3 (pl) Mutant epimerazy psikozy i sposób wytwarzania psikozy przy jego użyciu
EP3384322A4 (en) GEOMECHANICAL DISPLACEMENT LIMIT CONDITIONS
EP3303552A4 (en) FERMENTATION PROCESSES FOR THE PRODUCTION OF STEVIOL GLYCOSIDES WITH MULTI-PHASE FEEDING
HUE040000T2 (hu) Glikozilált szteviol-glikozidokat tartalmazó készítmény
EP3046427A4 (en) Glucosylated steviol glycoside as a flavor modifier
EP3153468A4 (en) Method for producing polycrystalline silicon rod, polycrystalline silicon rod, and polycrystalline silicon mass
EP3598461A4 (en) DISPERSION, METHOD OF MANUFACTURING A STRUCTURE WITH CONDUCTIVE PATTERNS USING THE DISPERSION AND STRUCTURE WITH CONDUCTIVE PATTERNS
MX358829B (es) Vacunas conjugadas de salmonela.
EP3530745A4 (en) PROCESS FOR PREPARING REBAUDIOSIDE N USING AN ENZYMATIC PROCESS
EP2952371A4 (en) CONNECTOR, BOLT ASSEMBLY AND VEHICLE WITH BOLTING DEVICE

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CI03 Correction of invention patent

Correction item: Inventor

Correct: Pu Chengxi|Jin Zhenyin|Yin Lun *|Hong Yinggao|Jin Chengfu|Pu Chengyuan

False: Pu Chengxi|Jin Zhenyin|Yin Lan|Hong Yinggao|Jin Chengfu|Pu Chengyuan

Number: 28-01

Page: The title page

Volume: 35

Correction item: Inventor

Correct: Pu Chengxi|Jin Zhenyin|Yin Lun *|Hong Yinggao|Jin Chengfu|Pu Chengyuan

False: Pu Chengxi|Jin Zhenyin|Yin Lan|Hong Yinggao|Jin Chengfu|Pu Chengyuan

Number: 28-01

Volume: 35

CI03 Correction of invention patent