CN105164162B - 用二羧酸酯化的纤维素醚 - Google Patents

用二羧酸酯化的纤维素醚 Download PDF

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Publication number
CN105164162B
CN105164162B CN201480024334.0A CN201480024334A CN105164162B CN 105164162 B CN105164162 B CN 105164162B CN 201480024334 A CN201480024334 A CN 201480024334A CN 105164162 B CN105164162 B CN 105164162B
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CN
China
Prior art keywords
esterified
group
chr
hydroxy groups
hpmc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480024334.0A
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English (en)
Chinese (zh)
Other versions
CN105164162A (zh
Inventor
L·阴
M·A·希尔玛雅
S·J·吉尔劳德
R·L·斯密特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Global Technologies LLC
University of Minnesota System
Original Assignee
Dow Global Technologies LLC
University of Minnesota System
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Publication date
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Publication of CN105164162A publication Critical patent/CN105164162A/zh
Application granted granted Critical
Publication of CN105164162B publication Critical patent/CN105164162B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480024334.0A 2013-05-14 2014-05-07 用二羧酸酯化的纤维素醚 Expired - Fee Related CN105164162B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361822977P 2013-05-14 2013-05-14
US61/822977 2013-05-14
PCT/US2014/037070 WO2014186185A1 (en) 2013-05-14 2014-05-07 Cellulose ethers esterified with dicarboxylic acids

Publications (2)

Publication Number Publication Date
CN105164162A CN105164162A (zh) 2015-12-16
CN105164162B true CN105164162B (zh) 2017-11-28

Family

ID=50977076

Family Applications (1)

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CN201480024334.0A Expired - Fee Related CN105164162B (zh) 2013-05-14 2014-05-07 用二羧酸酯化的纤维素醚

Country Status (7)

Country Link
US (1) US9890221B2 (enExample)
EP (1) EP2997046B1 (enExample)
JP (1) JP6306691B2 (enExample)
KR (1) KR20160006788A (enExample)
CN (1) CN105164162B (enExample)
BR (1) BR112015024522A8 (enExample)
WO (1) WO2014186185A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6683561B2 (ja) * 2016-07-12 2020-04-22 信越化学工業株式会社 腸溶性硬カプセル用組成物及び腸溶性硬カプセルの製造方法
CN112704671B (zh) * 2020-12-28 2022-04-19 普洛药业股份有限公司 一种阿莫西林克拉维酸钾胶囊及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906744A (en) * 1986-06-23 1990-03-06 Henkel Corporation Water-soluble ethers substituted with alkenyl or alkyl succinic acid esters
CN102807625A (zh) * 2012-08-23 2012-12-05 浙江中维药业有限公司 一种醋酸羟丙甲纤维素琥珀酸酯的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226981A (en) 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
DE2917104A1 (de) 1979-04-27 1980-11-06 Hoechst Ag Verfahren zur viskositaetserniedrigung von celluloseethern durch ozon und seine verwendung
JPS607492B2 (ja) * 1979-04-28 1985-02-25 信越化学工業株式会社 腸溶性カプセル
JPS5632424A (en) * 1979-08-27 1981-04-01 Shin Etsu Chem Co Ltd Preparation of formed enteric product
US4365060A (en) * 1979-04-28 1982-12-21 Shin-Etsu Chemical Co. Ltd. Enterosoluble capsules
JPS6225101A (ja) 1985-07-24 1987-02-03 Shin Etsu Chem Co Ltd 低重合度セルロ−スエ−テルの製造方法
JPS6281402A (ja) 1985-10-07 1987-04-14 Shin Etsu Chem Co Ltd セルロ−スエ−テル酸性ジカルボン酸エステルの製造方法
DE4404840A1 (de) * 1994-02-16 1995-08-17 Wolff Walsrode Ag Thermoplastische biologisch abbaubare Polysaccharidderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19529409A1 (de) 1995-08-10 1997-02-13 Wolff Walsrode Ag Maleinsäureadditionsproduktgruppen enthaltende, thermoplastische und biologisch abbaubare Polysaccharidester/-etherester
EP0872233A1 (en) 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Antiretroviral compositions with improved bioavailability
US6261218B1 (en) 1998-12-01 2001-07-17 The Dow Chemical Company Process and apparatus for making low molecular weight cellulose ethers
WO2000078285A1 (en) * 1999-06-18 2000-12-28 University Of Medicine And Dentistry Of New Jersey Controlled release of therapeutics by in-situ entrapment by matrix cross-linking
US20020076443A1 (en) * 2000-06-19 2002-06-20 Stanley Stein Multiple phase cross-linked compositions and uses thereof
DE10141680B4 (de) 2001-08-25 2004-02-26 Clariant Gmbh Verfahren zur Herstellung niederviskoser Celluloseether durch sauer-oxidativen Abbau von gemahlenen und getrockneten Celluloseethern
JP2003073443A (ja) * 2001-08-31 2003-03-12 Hiroshi Takimoto 生分解性高吸水性樹脂
JP2003160694A (ja) * 2001-11-28 2003-06-03 Hiroshi Takimoto 生分解性組成物
MXPA06013891A (es) 2004-05-28 2007-01-26 Pfizer Prod Inc Composiciones farmaceuticas con comportamiento potenciado.
EP2325247B1 (en) 2007-11-09 2014-10-08 Dow Global Technologies LLC Cellulose ether coating compositions and method
CN101855247B (zh) 2007-11-09 2013-03-20 联合碳化化学品及塑料技术公司 制备非常低粘度的纤维素醚的方法和产品
CN102933615B (zh) * 2010-06-08 2015-08-12 陶氏环球技术有限责任公司 制备粒状可逆交联的聚合物材料的方法
JP5792807B2 (ja) 2010-06-14 2015-10-14 ダウ グローバル テクノロジーズ エルエルシー アセテートおよびサクシネートの置換が向上されたヒドロキシプロピルメチルセルロースアセテートサクシネート
WO2013154607A1 (en) * 2012-04-11 2013-10-17 Dow Global Technologies Llc Esterified cellulose ethers having a specific substituent distribution

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906744A (en) * 1986-06-23 1990-03-06 Henkel Corporation Water-soluble ethers substituted with alkenyl or alkyl succinic acid esters
CN102807625A (zh) * 2012-08-23 2012-12-05 浙江中维药业有限公司 一种醋酸羟丙甲纤维素琥珀酸酯的制备方法

Also Published As

Publication number Publication date
EP2997046A1 (en) 2016-03-23
US9890221B2 (en) 2018-02-13
US20160289344A1 (en) 2016-10-06
BR112015024522A8 (pt) 2019-12-10
JP6306691B2 (ja) 2018-04-04
CN105164162A (zh) 2015-12-16
JP2016519198A (ja) 2016-06-30
WO2014186185A1 (en) 2014-11-20
KR20160006788A (ko) 2016-01-19
EP2997046B1 (en) 2019-09-25
BR112015024522A2 (enExample) 2017-08-22

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Granted publication date: 20171128

Termination date: 20200507