CN105122034B - 用于尿样中粒子分析的自动对焦系统以及方法 - Google Patents

用于尿样中粒子分析的自动对焦系统以及方法 Download PDF

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CN105122034B
CN105122034B CN201480012475.0A CN201480012475A CN105122034B CN 105122034 B CN105122034 B CN 105122034B CN 201480012475 A CN201480012475 A CN 201480012475A CN 105122034 B CN105122034 B CN 105122034B
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sample
fluid
cell
flow
particle
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CN105122034A (zh
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巴特·J·万德斯
埃里克·沙普洛
布雷特·乔丹
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Iris International Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1452—Adjustment of focus; Alignment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N2021/8557—Special shaping of flow, e.g. using a by-pass line, jet flow, curtain flow

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201480012475.0A 2013-03-15 2014-03-18 用于尿样中粒子分析的自动对焦系统以及方法 Active CN105122034B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361799014P 2013-03-15 2013-03-15
US61/799,014 2013-03-15
US14/217,228 2014-03-17
US14/217,228 US9857361B2 (en) 2013-03-15 2014-03-17 Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples
PCT/US2014/030940 WO2014146062A2 (en) 2013-03-15 2014-03-18 Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples

Publications (2)

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CN105122034A CN105122034A (zh) 2015-12-02
CN105122034B true CN105122034B (zh) 2019-03-29

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US (2) US9857361B2 (enExample)
EP (1) EP2972215B1 (enExample)
JP (1) JP6521940B2 (enExample)
KR (1) KR102083051B1 (enExample)
CN (1) CN105122034B (enExample)
BR (1) BR112015020255B1 (enExample)
WO (1) WO2014146062A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2747790C1 (ru) * 2020-01-30 2021-05-14 Сергей Анатольевич Жданов Проточный микроскоп для измерения распределения по размерам взвешенных в жидкости частиц

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015021902B1 (pt) * 2013-03-15 2021-06-15 Iris International, Inc Líquido para alinhamento de partícula e organela intracelular
WO2014145984A1 (en) 2013-03-15 2014-09-18 Iris International Inc. Method and composition for staining and sample processing
US9429524B2 (en) * 2014-10-17 2016-08-30 Iris International, Inc. Systems and methods for imaging fluid samples
US11291931B2 (en) 2014-12-15 2022-04-05 Akadeum Life Sciences, Inc. Method and system for buoyant separation
JP6762938B2 (ja) 2014-12-22 2020-09-30 レナル センス リミテッド 検尿のための装置、システム及び方法
WO2016136801A1 (ja) 2015-02-24 2016-09-01 国立大学法人東京大学 動的高速高感度イメージング装置及びイメージング方法
CN105067488A (zh) * 2015-08-11 2015-11-18 长春瑞克医疗科技有限公司 一种粒子成像室
EP4589550A3 (en) 2015-10-28 2025-10-15 The University of Tokyo Analysis device
CN105671123B (zh) * 2016-01-19 2018-11-20 西南交通大学 一种液体中细菌的计数方法
CN105572020B (zh) * 2016-01-19 2018-05-22 西南交通大学 一种纳米粒子计数方法
WO2017141063A1 (en) 2016-02-17 2017-08-24 Waterscope International Zrt. Digital holographic automatic microscope with through flowing cell
KR102478639B1 (ko) 2016-02-23 2022-12-19 노을 주식회사 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치
US10371610B2 (en) 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
KR20170099739A (ko) * 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법
ES2944957T3 (es) * 2016-03-16 2023-06-27 Siemens Healthcare Gmbh Diferencial de 5 partes de alta exactitud con microscopía holográfica digital y leucocitos intactos de sangre periférica
CN113406004A (zh) 2016-08-15 2021-09-17 国立大学法人大阪大学 电磁波相位振幅生成装置、方法和非临时记录介质
US10705011B2 (en) 2016-10-06 2020-07-07 Beckman Coulter, Inc. Dynamic focus system and methods
CN106501256A (zh) * 2016-10-25 2017-03-15 许静 一种流体介质自动识别装置
JP6875930B2 (ja) * 2017-05-31 2021-05-26 シスメックス株式会社 尿分析装置および尿分析方法
CN107091800A (zh) * 2017-06-06 2017-08-25 深圳小孚医疗科技有限公司 用于显微成像粒子分析的聚焦系统和聚焦方法
JP6875944B2 (ja) * 2017-06-27 2021-05-26 アークレイ株式会社 フローセル及び測定装置
CN107402212A (zh) * 2017-08-28 2017-11-28 深圳小孚医疗科技有限公司 一种粪便应用液检测装置
CN109596619B (zh) * 2017-10-02 2023-11-21 爱科来株式会社 尿中有形成分的分析装置
US10585028B2 (en) 2017-10-20 2020-03-10 Charted Scientific, Inc. Method and apparatus for optical analysis
WO2019118929A1 (en) * 2017-12-15 2019-06-20 Gastroklenz Inc. Sensor monitoring system for in-dwelling catheter based treatments
JP7073805B2 (ja) * 2018-03-14 2022-05-24 株式会社リコー 液滴形成ヘッド、液滴形成装置、及び液滴形成方法
US10761007B2 (en) * 2018-05-31 2020-09-01 Yokogawa Fluid Imaging Technologies, Inc. System and method for light obscuration enhanced imaging flow cytometry
JP7369385B2 (ja) 2018-06-13 2023-10-26 シンクサイト株式会社 サイトメトリーのための方法及びシステム
EP3820588A4 (en) 2018-07-09 2022-04-06 Akadeum Life Sciences, Inc. SYSTEM AND PROCESS FOR PROCESSING FLOATABLE PARTICLES
JP7270907B2 (ja) * 2019-02-27 2023-05-11 国立大学法人浜松医科大学 細胞観察システムおよび細胞観察方法
CN110118717A (zh) * 2019-05-28 2019-08-13 北京唯公医疗技术有限公司 流式细胞仪的液路系统及其使用方法与流式细胞仪
CN110118718A (zh) * 2019-05-28 2019-08-13 深圳唯公生物科技有限公司 液流系统、测试方法、负压装置的调控方法及流式细胞仪
TWI808435B (zh) * 2019-06-17 2023-07-11 邦睿生技股份有限公司 複數視角分析的自動測試裝置
USD903126S1 (en) 2019-06-26 2020-11-24 Gastroklenz Inc. Monitoring device
USD984637S1 (en) 2019-06-26 2023-04-25 Gastroklenz Inc. Measurement vessel
JP7668237B2 (ja) 2019-06-26 2025-04-24 ガストロクレンツ インコーポレイテッド 流体モニタリングシステム、装置及び方法
JP7549647B2 (ja) * 2019-08-19 2024-09-11 ザルトリウス バイオアナリティカル インストゥルメンツ， インコーポレイテッド サンプル間の分離ガス検出のためのシステムおよび方法
US10620104B1 (en) * 2019-10-17 2020-04-14 Horiba Instruments Incorporated Apparatus and method for observation of microscopic movements and counting of particles in colloids
CN112986104B (zh) * 2019-12-17 2025-05-13 爱科来株式会社 测定装置和测定方法
CN114930150A (zh) 2019-12-27 2022-08-19 新克赛特株式会社 评估流式细胞仪性能的方法和标准粒子悬浮液
WO2021200911A1 (ja) 2020-04-01 2021-10-07 シンクサイト株式会社 フローサイトメーター
JPWO2021200960A1 (enExample) 2020-04-01 2021-10-07
JP6874888B1 (ja) * 2020-05-26 2021-05-19 東洋紡株式会社 尿沈渣用染色液
WO2021247918A1 (en) * 2020-06-03 2021-12-09 Kinetic River Corp. Configurable particle analyzer apparatuses and methods
EP4377669A1 (en) * 2021-07-29 2024-06-05 Technische Universität München Detection of molecular biological objects, cellular biological objects and cell aggregates using quantitative phase-contrast microscopy
EP4124846A1 (en) * 2021-07-29 2023-02-01 Technische Universität München Detection of cell aggregates using quantitative phase-contrast microscopy
FR3126043A1 (fr) * 2021-08-04 2023-02-10 Univers 2020 Installation de cytométrie en flux comportant un système de détection optique, notamment pour le traitement de cellules du type spermatozoïde
EP4392158A4 (en) 2021-08-26 2025-09-03 Akadeum Life Sciences Inc METHOD AND SYSTEM FOR FLOATING SEPARATION
CN114441421A (zh) * 2022-02-10 2022-05-06 长春市布拉泽医疗科技有限公司 一种用于细胞成像分析仪的细胞流动室及其调节方法
WO2023191984A1 (en) 2022-04-01 2023-10-05 Akadeum Life Sciences, Inc. Method and system for buoyant-particle-assisted cell therapy
US11506588B1 (en) 2022-05-06 2022-11-22 HavaTell Inc. Air quality meter
US20240027310A1 (en) 2022-07-22 2024-01-25 Beckman Coulter, Inc. Biological sample staining module and biological analysis systems and methods
FR3138211A1 (fr) * 2022-07-25 2024-01-26 Horiba Abx Sas Dispositif pour le comptage et la différenciation de particules d’un flux d’échantillon
JP2025527255A (ja) 2022-08-05 2025-08-20 ベックマン コールター， インコーポレイテッド 撮像を利用した未成熟細胞タイプの識別
EP4630784A1 (en) 2022-12-05 2025-10-15 Beckman Coulter, Inc. Multi-channel hematology flow system
CN120380512A (zh) 2022-12-22 2025-07-25 贝克曼库尔特有限公司 用于血细胞图像的多级图像分类器
WO2024138139A1 (en) 2022-12-22 2024-06-27 Beckman Coulter, Inc. Population based cell classification
US12099050B2 (en) 2023-02-14 2024-09-24 Akadeum Life Sciences, Inc. Method and system for partially or fully automated buoyancy-assisted separation
CN116448990A (zh) * 2023-05-09 2023-07-18 中夏医学科技(青岛)有限公司 一种尿沉渣分析用鞘液
WO2025014621A1 (en) 2023-07-12 2025-01-16 Beckman Coulter, Inc. Biological sample analysis techniques
WO2025059446A1 (en) 2023-09-13 2025-03-20 Beckman Coulter, Inc. Imaging techniques to determine blood cell characteristics
WO2025059453A1 (en) 2023-09-13 2025-03-20 Beckman Coulter, Inc. Using trained machine learning models to determine alignment characteristics
WO2025144829A1 (en) 2023-12-27 2025-07-03 Qbeckman Coulter, Inc. Systems and methods of for integrating stained and unstained sample processing
WO2025144690A1 (en) 2023-12-27 2025-07-03 Beckman Coulter, Inc. Systems and methods of processing samples comprising immature granulocytes
WO2025145095A1 (en) 2023-12-29 2025-07-03 Beckman Coulter, Inc. Customized sample handling in biological analysis
WO2025244904A1 (en) 2024-05-21 2025-11-27 Beckman Coulter, Inc. Systems and methods of field of observation filtering
WO2025245511A1 (en) 2024-05-24 2025-11-27 Beckman Coulter, Inc. Control particles for volumetric assessment
WO2025245510A1 (en) 2024-05-24 2025-11-27 Beckman Coulter, Inc. Patient and control sample based analyzer evaluation
WO2025245513A1 (en) 2024-05-24 2025-11-27 Beckman Coulter, Inc. Assessing and enhancing biological analyzer functionality through particle staining

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486747A2 (en) * 1990-11-22 1992-05-27 Toa Medical Electronics Co., Ltd. Flow cell mechanism in flow imaging cytometer
US5891733A (en) * 1994-10-20 1999-04-06 Toa Medical Electronics Co., Ltd. Reagent for analyzing solid components in urine and method for analyzing solid components by employing the same
EP0949498A2 (en) * 1998-04-08 1999-10-13 Sysmex Corporation Apparatus and method for differentiating erythrocytes in urine
WO2000046590A1 (en) * 1999-02-05 2000-08-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
WO2001048455A2 (en) * 1999-12-29 2001-07-05 Union Biometrica, Inc. High viscosity sheath reagent for flow cytometry

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822095A (en) 1972-08-14 1974-07-02 Block Engineering System for differentiating particles
US3894845A (en) 1973-05-24 1975-07-15 Bernard Mcdonald Urine collection and analysis device
US3988209A (en) 1973-05-24 1976-10-26 Mcdonald Bernard Microorganism analysis device
GB1471976A (en) * 1974-09-20 1977-04-27 Coulter Electronics Particle sensing apparatus including a device for orienting generally flat particles
US4338024A (en) 1980-05-02 1982-07-06 International Remote Imaging Systems, Inc. Flow analyzer and system for analysis of fluids with particles
US4393466A (en) 1980-09-12 1983-07-12 International Remote Imaging Systems Method of analyzing particles in a dilute fluid sample
US4612614A (en) 1980-09-12 1986-09-16 International Remote Imaging Systems, Inc. Method of analyzing particles in a fluid sample
US4473530A (en) 1980-09-24 1984-09-25 Villa Real Antony Euclid C Compact sanitary urinalysis unit
DE3315195A1 (de) 1982-04-29 1983-11-03 International Remote Imaging Systems Inc., 91311 Chatsworth, Calif. Verfahren zum ausrichten von teilchen in einer fluidprobe
US4622298A (en) 1984-08-09 1986-11-11 Becton, Dickinson And Company Detection and quantitation of microorganisms, leukocytes and squamous epithelial cells in urine
AU563260B2 (en) 1984-11-29 1987-07-02 International Remote Imaging Systems Inc. Method of operating a microscopic instrument
US5132232A (en) 1985-07-30 1992-07-21 V-Tech, Inc. Method and apparatus for preparation of liquids for examination
DE3719302C1 (de) 1987-06-10 1988-12-29 Hoyer Gmbh & Co Vorrichtung zur Harnuntersuchung
US5123055A (en) 1989-08-10 1992-06-16 International Remote Imaging Systems, Inc. Method and an apparatus for differentiating a sample of biological cells
JP2939647B2 (ja) 1990-07-24 1999-08-25 シスメックス株式会社 フローイメージングサイトメータにおける自動焦点調整方法
JP3111706B2 (ja) * 1992-02-18 2000-11-27 株式会社日立製作所 粒子分析装置及び粒子分析方法
JP3215175B2 (ja) 1992-08-10 2001-10-02 シスメックス株式会社 粒子分析装置
JP3052665B2 (ja) * 1993-01-26 2000-06-19 株式会社日立製作所 フローセル装置
JP3290786B2 (ja) 1993-11-26 2002-06-10 シスメックス株式会社 粒子分析装置
US5457523A (en) 1994-05-27 1995-10-10 Xerox Corporation Ferrofluid media charging of photoreceptors
US5876697A (en) 1994-08-04 1999-03-02 Gakko Houjin Toin Gakuen Method for the production of microbubble-type ultrasonic contrast agent using fatty acid surfactants
WO1996020456A1 (en) 1994-12-23 1996-07-04 International Remote Imaging Systems, Inc. Method and apparatus of analyzing particles in a fluid sample and displaying same
US5619032A (en) 1995-01-18 1997-04-08 International Remote Imaging Systems, Inc. Method and apparatus for automatically selecting the best focal position from a plurality of focal positions for a focusing apparatus
JPH08320285A (ja) * 1995-05-25 1996-12-03 Hitachi Ltd 粒子分析装置
JPH0989753A (ja) * 1995-09-25 1997-04-04 Hitachi Ltd 粒子分析装置
US6184978B1 (en) 1996-05-15 2001-02-06 International Remote Imaging Systems, Inc. Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide
US6632676B1 (en) 1999-09-24 2003-10-14 Clinical Diagnostic Solutions Multi-purpose reagent system and method for enumeration of red blood cells, white blood cells and thrombocytes and differential determination of white blood cells
US6974938B1 (en) 2000-03-08 2005-12-13 Tibotec Bvba Microscope having a stable autofocusing apparatus
PT1301894E (pt) 2000-04-24 2009-08-21 Iris Int Inc Aparelho e método de imagiologia por redes neuronais múltiplas
US7236623B2 (en) 2000-04-24 2007-06-26 International Remote Imaging Systems, Inc. Analyte recognition for urinalysis diagnostic system
US6809804B1 (en) * 2000-05-11 2004-10-26 Becton, Dickinson And Company System and method for providing improved event reading and data processing capabilities in a flow cytometer
CA2349995A1 (en) 2000-06-14 2001-12-14 Lianne Ing Viewing particles in a relatively translucent medium
JP2003005088A (ja) 2001-06-22 2003-01-08 Nikon Corp 顕微鏡用焦点合わせ装置およびそれを備えた顕微鏡
IL161357A0 (en) 2001-10-26 2004-09-27 Immunivest Corp Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample
JP4021183B2 (ja) 2001-11-29 2007-12-12 オリンパス株式会社 合焦状態信号出力装置
JP4370554B2 (ja) 2002-06-14 2009-11-25 株式会社ニコン オートフォーカス装置およびオートフォーカス付き顕微鏡
AU2003261795A1 (en) * 2002-09-05 2004-03-29 Fuji Electric Systems Co., Ltd. Method for detecting microbe or cell
EP1565795B1 (en) 2002-11-18 2008-11-12 International Remote Imaging Systems, Inc. A multi-level controller system
US6825926B2 (en) 2002-11-19 2004-11-30 International Remote Imaging Systems, Inc. Flow cell for urinalysis diagnostic system and method of making same
GB0228301D0 (en) 2002-12-04 2003-01-08 Imp College Innovations Ltd Engineering redox proteins
DE10308171A1 (de) 2003-02-27 2004-09-09 Leica Microsystems Jena Gmbh Verfahren zur automatischen Fokussierung
EP2194379B1 (en) * 2003-03-28 2014-09-03 Inguran, LLC Apparatus and methods for providing sex-sorted animal sperm
US7324694B2 (en) 2003-05-23 2008-01-29 International Remote Imaging Systems, Inc. Fluid sample analysis using class weights
US20070292346A1 (en) 2004-03-25 2007-12-20 Rong Fan Lng105 Antibody Composition and Methods of Use, and Use of Lng105 to Assess Lung Cancer Risk
US7394943B2 (en) 2004-06-30 2008-07-01 Applera Corporation Methods, software, and apparatus for focusing an optical system using computer image analysis
JP2006039315A (ja) 2004-07-28 2006-02-09 Hamamatsu Photonics Kk 自動焦点装置及びそれを用いた顕微鏡装置
DE102005034441A1 (de) 2005-07-22 2007-02-22 Carl Zeiss Microimaging Gmbh Mikroskopobjektiv
JP5289768B2 (ja) 2005-09-29 2013-09-11 オリンパス株式会社 焦点位置決定方法、焦点位置決定装置、微弱光検出装置及び微弱光検出方法
JPWO2007145091A1 (ja) 2006-06-15 2009-10-29 株式会社ニコン 細胞培養装置
DE102006027836B4 (de) 2006-06-16 2020-02-20 Carl Zeiss Microscopy Gmbh Mikroskop mit Autofokuseinrichtung
SE531041C2 (sv) 2006-07-17 2008-11-25 Hemocue Ab Räkning av trombocyter
US7799575B2 (en) * 2006-11-07 2010-09-21 Genetix Limited Flow cytometers
JP2008276070A (ja) 2007-05-02 2008-11-13 Olympus Corp 拡大撮像装置
US9602777B2 (en) 2008-04-25 2017-03-21 Roche Diagnostics Hematology, Inc. Systems and methods for analyzing body fluids
DE102008050347B4 (de) 2008-10-02 2011-01-20 Siemens Aktiengesellschaft Verfahren, Magnetresonanzanlage und Datenträger zur Bestimmung eines Nierenfunktionsparameters
JP2010151566A (ja) 2008-12-25 2010-07-08 Hitachi High-Technologies Corp 粒子画像解析方法及び装置
JP2010213598A (ja) 2009-03-16 2010-09-30 Kyokuto Seiyaku Kogyo Kk 抗菌薬の微生物に対する有効性の検査方法
US8362409B2 (en) 2009-10-29 2013-01-29 Applied Precision, Inc. System and method for continuous, asynchronous autofocus of optical instruments
US9404160B2 (en) 2009-12-22 2016-08-02 Becton, Dickinson And Company Methods for the detection of microorganisms
JP5872569B2 (ja) 2010-10-27 2016-03-01 キャピタルバイオ コーポレーションＣａｐｉｔａｌＢｉｏ Ｃｏｒｐｏｒａｔｉｏｎ マイクロアレイに基づくアッセイのための粒子と結合させた発光団で標識された分子
US8445284B2 (en) 2011-06-17 2013-05-21 Constitution Medical, Inc. Fixative and staining solutions
KR101849974B1 (ko) 2011-09-16 2018-04-19 삼성전자주식회사 개구수 제어 유닛, 이를 채용한 가변형 광 프로브 및 깊이 스캐닝 방법
BR112015021902B1 (pt) 2013-03-15 2021-06-15 Iris International, Inc Líquido para alinhamento de partícula e organela intracelular
BR112015023425B1 (pt) 2013-03-15 2021-01-12 Iris International, Inc. método e composição para coloração e processamento de uma amostra de urina
WO2014145984A1 (en) 2013-03-15 2014-09-18 Iris International Inc. Method and composition for staining and sample processing
JP6112066B2 (ja) 2014-05-27 2017-04-12 横河電機株式会社 モジュール式電子機器連結用収納部材

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486747A2 (en) * 1990-11-22 1992-05-27 Toa Medical Electronics Co., Ltd. Flow cell mechanism in flow imaging cytometer
US5891733A (en) * 1994-10-20 1999-04-06 Toa Medical Electronics Co., Ltd. Reagent for analyzing solid components in urine and method for analyzing solid components by employing the same
EP0949498A2 (en) * 1998-04-08 1999-10-13 Sysmex Corporation Apparatus and method for differentiating erythrocytes in urine
CN1237707A (zh) * 1998-04-08 1999-12-08 希森美康株式会社 尿中红细胞的鉴定装置及其方法
WO2000046590A1 (en) * 1999-02-05 2000-08-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
WO2001048455A2 (en) * 1999-12-29 2001-07-05 Union Biometrica, Inc. High viscosity sheath reagent for flow cytometry

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2747790C1 (ru) * 2020-01-30 2021-05-14 Сергей Анатольевич Жданов Проточный микроскоп для измерения распределения по размерам взвешенных в жидкости частиц

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