CN105106719A - Pharmaceutic preparation for treating chronic pharyngolaryngitis - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a pharmaceutic preparation for treating chronic pharyngolaryngitis. The pharmaceutic preparation is prepared from the following raw materials: 28 parts of whole herb of potamogeton pectinatus, 25 parts of whole herb of lygodium flexuosum, 20 parts of whole herb of oberonia iridifolia, 18 parts of whole herb of sporobolus fertilis, 25 parts of bark of sorbus pohuashanensis, 15 parts of radix scrophulariae, 20 parts of lonicera japonica, 20 parts of platycodon grandiflorum, 25 parts of houttuynia cordata, 25 parts of radix achyranthis bidentatae, 20 parts of chrysanthemum, 15 parts of dandelion, 18 parts of Japanese milkwort herb, 15 parts of pericarpium citri reticulatae, 20 parts of divaricate saposhnikovia root, 15 parts of aster tataricus and 5 parts of liquorice. The pharmaceutic preparation is used for treating chronic pharyngolaryngitis.

Description

A kind of pharmaceutical preparation being used for the treatment of chronic pharyngolaryngitis

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic pharyngolaryngitis and its preparation method and application.

Background technology

Chronic pharyngolaryngitis refers to pathological changes mainly at mucous layer, shows as pharyngeal mucosa chronic congestion, has infiltration of more lymphocytes around its blood vessel, also show leukocyte and plasmocyte infiltrating.Connective tissue proliferation under mucosa and mucosa.Mucous gland can be loose, and secretory function is hyperfunction, and mucilage secretion increases.Common adult, the course of disease is long, easily recurs.Chronic pharyngitis General Symptoms is all not obvious, and based on local symptom.Various chronic pharyngitis symptom is roughly similar, and varied, as pharyngeal sense of discomfort, foreign body sensation, gargalesthesia, burning sensation, dry sensation or excitement, and also can by hypodynia etc.Caused by stimulating primarily of the lymph follicle of its secretions and hypertrophy.Cough can be had, accompany and feel sick.For this reason, be bursting to and develop the needs that more medicines for the treatment of chronic pharyngolaryngitis safely and effectively meet clinical treatment.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic pharyngolaryngitis disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic pharyngolaryngitis, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: dragon must potamogeton grass 28 parts, Herba Lygodii Flexuosi 25 parts, Herba Oberoniae iridifoliae 20 parts, Mus tail chestnut 18 parts, flower seize 25 parts, Radix Scrophulariae 15 parts, Flos Lonicerae 20 parts, Radix Platycodonis 20 parts, Herba Houttuyniae 25 parts, Radix Achyranthis Bidentatae 25 parts, Flos Chrysanthemi 20 parts, Herba Taraxaci 15 parts, Herba Polygalae Japonicae 18 parts, Pericarpium Citri Reticulatae 15 parts, Radix Saposhnikoviae 20 parts, Radix Asteris 15 parts, 5 parts, Radix Glycyrrhizae.

The described pharmaceutical preparation being used for the treatment of chronic pharyngolaryngitis, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of chronic pharyngolaryngitis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described application of pharmaceutical preparation in preparation treatment chronic pharyngolaryngitis medicine being used for the treatment of chronic pharyngolaryngitis.

Dragon palpus potamogeton grass is the herb of Potamogetonaceae plant Herba Potamogetonis Pectinati.Micro-hardship, cool.Heat-clearing and toxic substances removing.Control pneumonia, furuncle.

Herba Lygodii Flexuosi is the herb of Lygodiaceae plant bent axle Spora Lygodii.Latin name: Lygodiumflexuosum (L.) Sw. is sweet; Micro-hardship; Cold, relaxing muscles and tendons and activating QI and blood in the collateral; Clearing away heat-damp and promoting diuresis; Hemostasis.Main rheumatic numbness; Traumatic injury; Urinary tract infection; Urinary system calculus; Edema; Dysentery; Sore and toxic; Oral aphthae in children; Acute catarrhal conjunctivitis; Tinea disease; Traumatic hemorrhage.

Herba Oberoniae iridifoliae is the orchid family cowherb white orchid platymiscium Rhizoma Iridis Tectori Rhizoma Tupistrae Wattii OberoniairidifoliaLindl., with all herbal medicine.The four seasons can adopt, and boiled water dries after scalding.Regulate the flow of vital energy and help digestion, clearing away heat and promoting diuresis, cough-relieving pain relieving.For dyspepsia, stomachache, enteritis, urinary tract infection, cough, bronchitis, asthma, traumatic injury, fracture, venom.

Mus tail chestnut, formal name used at school: Sporobolusfertilis (Steud.) W.D.Clayt., belongs to Poales, grass family perennial plant.Produce the provinces and regions such as East China, Central China, southwest, Shaanxi, Gansu, Tibet; Be born in the roadside, field of height above sea level 120-2600 rice, patana and mountain valley to wet place and sylvan life.Be distributed in the ground such as India, Burma, Sri Lanka, Thailand, Vietnam, Malaysia, Indonesia, Philippine, Japan, the Soviet Union.Nature and flavor: sweet light are flat.Function cures mainly: heat clearing away, removing heat from blood, removing toxic substances, diuresis.Control epidemic encephalitis, encephalitis b unconsciousness due to high fever, infectious hepatitis, dysentery, pyretic stranguria, hematuria.The present invention is with all herbal medicine.

Flower is seized as flower seizes tree, and machaka or dungarunga tree, Classification system is Sorbuspohuashanensis (Hance) Hedl, fruit stomach invigorating tonify deficiency.For gastritis, Vitamin A, the third deficiency disease.Stem, peel of stem clearing away lung-heat to relieve cough.For pulmonary tuberculosis, asthma, cough.The present invention adopts peel of stem to be used as medicine.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science thinks that depletion fire syndrome going up that the chronic pharyngolaryngitis cause of disease causes based on YIN-deficiency of the lung and kidney, throat lose and support.The present invention dragon must potamogeton grass, Herba Lygodii Flexuosi, Herba Oberoniae iridifoliae, Mus tail chestnut, flower be seized, Radix Scrophulariae, Flos Lonicerae heat-clearing and toxic substances removing, nourishing the lung and kidney, clearing throat be monarch drug, Radix Platycodonis, Herba Houttuyniae, Radix Achyranthis Bidentatae, Flos Chrysanthemi, Herba Taraxaci, Herba Polygalae Japonicae, Pericarpium Citri Reticulatae, Radix Saposhnikoviae, Radix Asteris anti-inflammation are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment chronic pharyngolaryngitis successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get dragon palpus potamogeton grass 28g, Herba Lygodii Flexuosi 25g, Herba Oberoniae iridifoliae 20g, Mus tail chestnut 18g, flower seizes 25g, Radix Scrophulariae 15g, Flos Lonicerae 20g, Radix Platycodonis 20g, Herba Houttuyniae 25g, Radix Achyranthis Bidentatae 25g, Flos Chrysanthemi 20g, Herba Taraxaci 15g, Herba Polygalae Japonicae 18g, Pericarpium Citri Reticulatae 15g, Radix Saposhnikoviae 20g, Radix Asteris 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get dragon palpus potamogeton grass 28g, Herba Lygodii Flexuosi 25g, Herba Oberoniae iridifoliae 20g, Mus tail chestnut 18g, flower seizes 25g, Radix Scrophulariae 15g, Flos Lonicerae 20g, Radix Platycodonis 20g, Herba Houttuyniae 25g, Radix Achyranthis Bidentatae 25g, Flos Chrysanthemi 20g, Herba Taraxaci 15g, Herba Polygalae Japonicae 18g, Pericarpium Citri Reticulatae 15g, Radix Saposhnikoviae 20g, Radix Asteris 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get dragon palpus potamogeton grass 28g, Herba Lygodii Flexuosi 25g, Herba Oberoniae iridifoliae 20g, Mus tail chestnut 18g, flower seizes 25g, Radix Scrophulariae 15g, Flos Lonicerae 20g, Radix Platycodonis 20g, Herba Houttuyniae 25g, Radix Achyranthis Bidentatae 25g, Flos Chrysanthemi 20g, Herba Taraxaci 15g, Herba Polygalae Japonicae 18g, Pericarpium Citri Reticulatae 15g, Radix Saposhnikoviae 20g, Radix Asteris 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation treatment chronic pharyngolaryngitis of the present invention clinical research

4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic pharyngolaryngitis case 60 example, 25 ~ 48 years old age.The shortest person of the course of disease 3 months, most elder reaches 3 years.

4.2 diagnostic criteria: one, medical history: patient has the medical history of acute pharyngitis recurrent exerbation, or there is the situation of long-term mouth breathing; In addition, there are long-term tobacco and wine excessive; To treat for a long time in the environment of dry, many, the irritant gas of dust etc.Two, clinical symptoms: the classical symptom of chronic pharyngitis: pharyngeal discomfort, or pain or itch or dry sensation, burning sensation, sootiness sense, foreign body sensation etc.; Irritable cough, plays firmly expectoration secretions morning, even feel sick.The course of disease more than 2 months, the reasons such as Chang Yin suffers from cold, catch a cold, fatigue, polylogia are caused a disease.Three, inspect by instrument: if patient is through this inspect by instrument, visible pharyngeal chronic congestion, increases the weight of.In kermesinus, or dendroid is congested; Retropharyneal folliculosis, or lateral pharyngeal band enlargement; Pharynx mucosa hypertrophy is plump, or drying, atrophy, thinning, and have secretions to adhere to, that just can be diagnosed as chronic pharyngitis substantially.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: recovery from illness: symptom all disappears, throat recovers as before; Effective: symptom obviously alleviates, pharyngitis, pain disappear substantially, successful; Invalid: without significant change or deterioration before and after treatment.。

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Effectively	Invalid	Total effective rate (%)
						Treatment group	30	16	11	3	90
Blank group	30	1	1	28	6.67

Visible, the medicine that the present invention obtains can safe and effective treatment chronic pharyngolaryngitis, and has no side effect.

Claims (4)

1. one kind is used for the treatment of the pharmaceutical preparation of chronic pharyngolaryngitis, it is characterized in that, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: dragon must potamogeton grass 28 parts, Herba Lygodii Flexuosi 25 parts, Herba Oberoniae iridifoliae 20 parts, Mus tail chestnut 18 parts, flower seize 25 parts, Radix Scrophulariae 15 parts, Flos Lonicerae 20 parts, Radix Platycodonis 20 parts, Herba Houttuyniae 25 parts, Radix Achyranthis Bidentatae 25 parts, Flos Chrysanthemi 20 parts, Herba Taraxaci 15 parts, Herba Polygalae Japonicae 18 parts, Pericarpium Citri Reticulatae 15 parts, Radix Saposhnikoviae 20 parts, Radix Asteris 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of the pharmaceutical preparation of chronic pharyngolaryngitis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the pharmaceutical preparation of chronic pharyngolaryngitis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic pharyngolaryngitis medicine of chronic pharyngolaryngitis according to claim 1.