CN104840522A

CN104840522A - Granule for treating phthisis

Info

Publication number: CN104840522A
Application number: CN201510290192.9A
Authority: CN
Inventors: 陈爱华
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-30
Filing date: 2015-05-30
Publication date: 2015-08-19

Abstract

The invention belongs to the field of traditional Chinese medicines, and provides granules for treating phthisis. The granules are prepared from the following raw materials: 18 parts of panax japonicas, 12 parts of roots or stems of dalbergia hupeana, 20 parts of stephania sinica, 15 parts of thesium chinense and 12 parts of lysimachia fortune. The granules can be used for treating phthisis.

Description

One is used for the treatment of phthisical granule

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of phthisical granule and its preparation method and application.

Background technology

Pulmonary tuberculosis is the chronic infectious disease caused by mycobacterium tuberculosis, and excreter is its important source of infection.Not necessarily fall ill after human infection tulase, when resistance reduces or cell-mediated allergy increases, just may cause clinical onset.Visible cough, spitting of blood, hectic fever, night sweat, the primary symptom such as to become thin, for this reason, be bursting to develop and manyly treat the needs that phthisical medicine meets clinical treatment safely and effectively.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of pulmonary tuberculosis disease.In order to reach this object, adopt following technical scheme:

Technical scheme: one is used for the treatment of phthisical granule, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma Panacis Japonici 18 parts, Caulis Dalbergiae Hancei 12 parts, Radix Stephaniae Japonicae 20 parts, Herba Thesii 15 parts, large Herba Hyperici Japonici 12 parts.

Describedly be used for the treatment of phthisical granule, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make granule.

Described be used for the treatment of phthisical granule preparation treatment tuberculosis drugs in application.

Above-mentioned Chinese medicine Rhizoma Panacis Japonici is the dry rhizome of Araliaceae Rhizoma Panacis Japonici PanaxjaponicusC.A.Mey..Autumn excavates, removing main root and crust, dry.Strengthening by means of tonics, eliminating stasis to stop pain, hemostasis is eliminated the phlegm.For weak after being ill, chronic cough is spat blood, cough with copious phlegm, injury from falling down.

Caulis Dalbergiae Hancei is stem or the root of leguminous plant Resina garciniae wingceltis.Mainly become as alkaloid, flavonoid glycoside, phenols, saccharide etc., control heart peratodynia, for a long time the long-pending pain of wound, the effects such as asthma epistaxis.The present invention is used as medicine with stem.

Radix Stephaniae Japonicae is Menispermaceae stephania plant Radix Stephaniae Japonicae StephaniasinicaDiels, is used as medicine with tuber.Heat-clearing and toxic substances removing, eliminating stasis to stop pain.For upper respiratory tract infection, pharyngolaryngitis, stomachache, acute gastroenteritis, bacillary dysentery, malaria, rheumatalgia, trauma pain; Traumatic injury is controlled in external, venom, sore swollen toxin.

Herba Thesii is the herb of Santalaceae Thesium plant Herba Thesii Thesium chinense Turcz..Xia Qiu gathers, and cleans and dries.Heat-clearing and toxic substances removing, expelling summer-heat.For enteritis, lung abscess, tonsillitis, heatstroke, acute mastitis, tuberculous lymphadenitis, acute cystitis.

Large Herba Hyperici Japonici is Primulaceae Lysimachia plant Arisaema balansae Engl. Herba lysimachiae capillipedis Lysimachia fortunei Maxim., with all herbal medicine.Summer, autumn gather, clean, dry, cutting or binding for subsequent use.Clearing away heat-damp and promoting diuresis, promoting blood flow to regulate menstruation.For flu, cough spitting of blood, enteritis, dysentery, hepatitis, infantile malnutrition, malaria, rheumatic arthritis, dysmenorrhea, amenorrhea, leucorrhea; Mastitis, conjunctivitis, venom, traumatic injury.

Beneficial effect: Rhizoma Panacis Japonici of the present invention, Caulis Dalbergiae Hancei strengthening by means of tonics, eliminating stasis to stop pain, hemostasis is eliminated the phlegm as monarch drug, Radix Stephaniae Japonicae, Herba Thesii heat-clearing and toxic substances removing, and eliminating stasis to stop pain is ministerial drug, large Herba Hyperici Japonici clearing away heat-damp and promoting diuresis, and promoting blood flow to regulate menstruation is adjuvant, treatment pulmonary tuberculosis successful.The present invention actively can prevent and treat phthisical generation and development effectively, and this is for improving existence and the quality of life of broad masses, protecting the health of broad masses, and then raising productivity, significant and higher practical value.Because primary disease sickness rate is high, estimate, once marketing application, good Social benefit and economic benefit will be produced.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Rhizoma Panacis Japonici 18g, Caulis Dalbergiae Hancei 12g, Radix Stephaniae Japonicae 20g, Herba Thesii 15g, large Herba Hyperici Japonici 12g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, Granules in Treating tuberculosis research of the present invention

2.1 general data: this granule is applied to clinical observation tuberculosis cases 60 example, the shortest person of the course of disease 0.5 year, and most elder reaches 3 years, average 1.2 years.

2.2 diagnostic criterias:

2.2.1 the initial stage only feels tired weak, dry cough, inappetence, and body is become thin gradually, and sick severe one can occur coughing (coughing up) blood, hectic fever, flushed cheeks, night sweat, and body such as obviously to be become thin the disease.

2.2.2 often have and pulmonary tuberculosis person's close contact history.

2.2.3 lesions position diminished breath sound, or hear and bronchial breathing sound and moist rale.

2.2.4 sputum smear, concentrated or cultivation, tulase is positive more.

2.2.5 erythrocyte sedimentation rate speeds

2.2.6 tuberculin skin test is strong positive.

2.2.7X the visible tuberculose focus of Xian Shepianshi pulmonary.Sheet can be taken the photograph if desired as x-ray tomography.

2.3 syndrome-classification

2.3.1 lung yin virtual loss: dry cough, expectorant is sticky white less, or the band blood streak, dry mouth and throat.Red tongue, thin fur, thready pulse band number.

2.3.2 hyperactivity of fire caused by deficiency of YIN: cough and choke is out of breath, spitting of blood, expectorant is sticky white or yellow less, dry mouth and throat, afternoon flushed cheeks, hectic fever, hectic fever due to YIN-deficiency, night sweat.Red tongue or deep red, yellow and thin fur or stripping, stringy,thready and rapid pulse.

2.3.3 deficiency of both QI and YIN: cough is breathed hard, coughing up thin sputum, occasionally has spitting of blood, spiritlessness and weakness, spontaneous sweating, or lack of appetite abdominal distention, loose stool.Red tongue is tender, thin fur, weak pulse and counting.

2.3.4 deficiency of both YIN and YANG: cough with dyspnea is panted, expectorant show bubble or folder blood, cold physique spontaneous perspiration, hoarseness hoarseness, emaciated physique.Or with the disease such as edema, diarrhoea.Pale tongue and few Tianjin, tongue light is shelled, and faint and rapid pulse or void are unable greatly.

2.4 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within one month, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule, a month sky is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

2.5 criterions of therapeutical effect: clinical recovery: transference cure, pulmonary lesions absorbs calcification, and Sputum inspection is turned out cloudy.Take a turn for the better: symptom is improved, and pulmonary lesions partially absorbs.Invalid: symptom and focus unchanged.

2.6 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	30	9	15	6	80
Blank group	30	1	1	28	6.67

Visible, the medicine that the present invention obtains can safe and effective treatment pulmonary tuberculosis.

Claims

1. be used for the treatment of a phthisical granule, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma Panacis Japonici 18 parts, Caulis Dalbergiae Hancei 12 parts, Radix Stephaniae Japonicae 20 parts, Herba Thesii 15 parts, large Herba Hyperici Japonici 12 parts.

2. be used for the treatment of phthisical granule as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make granule.

3. be used for the treatment of the application of phthisical granule in treatment tuberculosis drugs according to claim 1.