CN103655715A - Traditional Chinese medicine for treating pityriasis rubra pilaris - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating pityriasis rubra pilaris. The traditional Chinese medicine is prepared from the following medicine materials in parts by weight: 15 parts of nothapodytes pittosporoides, 9 parts of patrinia heterophylla, 6 parts of heraeleum apaense, 12 parts of tripterospermum, 9 parts of membrane of hen egg, 9 parts of stephania hainanensis, 12 parts of scutellaria indica, 10 parts of phyllagathis elattandra diels, 12 parts of quassic root, 9 parts of teucrium pilosum, 15 parts of narrow leaf radix bupleuri herb and 9 parts of pogostemen nigrescens. Clinical trials prove that the traditional Chinese medicine is capable of treating the pityriasis rubra pilaris safely and effectively.

Description

A kind of Chinese medicine for the treatment of pityriasis rubra pilaris

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of pityriasis rubra pilaris.

Background technology

Pityriasis rubra pilaris is a kind of agnogenic rare chronic inflammatory disease dermatoses.Show as the hard pointed little pimple of hair follicle, there is black keratotic plug in central authorities, normal intensive in blocks, surface companion's bran shape squama.Though this disease symptoms is light, course of disease delay; Adult sends out patient period may be with dimension methanol in conjunction with relevant (acquisition sexual types) such as albumen defect, low blood plasma vitamin A or dysthyreosises, and morbidity is very fast, can develop into erythroderma.The most remarkable histopathologic characteristics be keratinization of epidermis excessively and hair follicle horn plug, in bolt, have a hair.Near follicular orifice, have point-like parakeratosis, granular layer slightly thickens, and the irregular plumpness of spinous layer can have liquefaction of basal cell to change.

For pityriasis rubra pilaris, still lack at present satisfied medicine.

The present Research of the related medical material of Chinese medicine of the present invention is as follows:

Cortex Nothapodytis Radicis [source] is Icacinaceae plant Cortex Nothapodytis Radicis Nothapodytes pittosporoids (Oliv.) Sleum.[Mappia pittosporoides Oliv.] root bark.All can adopt the whole year, takes root, cleans, and strips root bark, dries.[function cures mainly] expelling wind and removing dampness; The cold expelling of regulating the flow of vital energy.Main anemofrigid-damp arthralgia; Edema; Hernia.

Radix Patriniae heterophyllae [source] is Valerianaceae plant Radix Patriniae Scabrae or a little beans Patrinia of different leaf rupestris (Pall.) Juss.subsp.scabra (Bunge) H. J. Wang[Patriniascabra Bunge] root.Excavate autumn, removes stem and leaf, and impurity is cleaned, using fresh herb or dry.[function cures mainly] dampness leukorrhagia stopping; Astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main leucorrhea with red and white discharge; Metrorrhagia; Dysentery; Jaundice; Malaria; Intestinal carbuncle; Sore swollen toxin; Traumatic injury; Cervical cancer; Gastric cancer.

Heracleum apaense [source] is samphire Aba Radix Angelicae Sinensis Anglica apaensis Shan et Yuan[Heracleum apaensis (Shan et Yuan) Shan et T. S. Wang] root.When autumn Mo, winter adornment leaf are withered, gather, take root, remove the sheath residue that stem and leaf or reservation are about 1cm, remove earth, dry.[function cures mainly] regulating QI to relieve pain; Relieving cough and asthma.Main breast side of body epigastric pain; Headache; Cough with asthma.

Herba Tripterospermi [source] is gentianaceae plant Tripterospermum affine Tripterospermum chinense(Migo) H.Smith ［ Crawfurdia chinensis Migo; C.coerulea Hand.-Mazz.; C.Fasciculata auct.non Wall.; Tripterosperm affine auct.Non(Wall.) H.Smith " the tender herb of children.Summer, autumn gather, and dry or using fresh herb.[function cures mainly] clearing away lung-heat to relieve cough; Cooling blood for hemostasis; Diuresis removing toxic substances.Main cough due to lung-heat; Pulmonary tuberculosis spitting of blood; Lung abscess; Nephritis; Acute mastitis; Carbuncle sore furuncle is swollen; Wound hemorrhage; Venom.

Membrana Follicularis ovi [source] is incubated after chicken the egg membrane of Gallus gallus domesticus Brisson in eggshell for Phasianidae animal man ovum gallinaceum.The eggshell staying after chicken is incubated in collection, and the egg membrane of getting interior side is standby.[function cures mainly] nourishing YIN and clearing away lung-heat; Sore; Removing nebula; Synthetism.The main outer asthma of coughing; Pharyngalgia aphonia; Lymphoid tuberculosis; Ulcer being unable to heal; The raw cataracta of order; The vertigo; Trauma fracture.

Hainan Radix Stephaniae Epigaeae [source] is the tuber of menispermaceous plants Hainan Radix Stephaniae Epigaeae Stephania hainanensis H.S.Loet Y.Tsoong.Autumn, winter excavate, and remove fibrous root, clean, and section, dries.[function cures mainly] pain relieving; Subduing swelling and detoxicating.Main stomachache; Wound pain; Furuncle carbuncle.

Herba Scutellariae indicae [source] is the herb of labiate Herba Scutellariae indicae Scutellaria indica L..Spring, summer gather, and clean using fresh herb or dry.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Hemostasia and detumescence.Main carbuncle furunculosis; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Lung-heat cough with asthma; Toothache; Sore throat; Pharyngalgia; Bones and muscles pain; Spit blood; Spitting of blood; Have blood in stool; Traumatic injury; Wound hemorrhage; Skin pruritus.

Red send out [source] is red Phyllagathis elattandra Diels[Stap-fiophyton elattandra (Didls) H.L.Li that sends out of Melastomateae plants depositedly depositedly] herb.Spring, summer gather, using fresh herb or dry.[function cures mainly] clearing and antitussive; Subduing swelling and detoxicating.Main lung-heat cough with asthma; Chronic cough; Treating swelling and pain by traumatic injury; Furuncle; Scald; Scabies.

Ramulus Et Folium Picrasmae root [source] is quassia Ramulus Et Folium Picrasmae Picrasmaquassioides(D.Don) root or the root bark of Benn..All can excavate the whole year, cleans, and section, looks into dry; Or stripping root bark, cutting is dried.[function cures mainly] heat-clearing and toxic substances removing; Removing dampness and killing parasites.Main cold, fever; Acute gastroenteritis; Dysentery; Biliary tract infection; Ascariasis; Furuncle; Scabies; Eczema; Scald; Venom.

Tucrium Pilosum [source] is labiate Tucrium Pilosum Teucrium pilosum (Pamp.) C.Y.Wu et S.Chow[T.japonicum Willd. Var.pilosum Pamp.] herb.The 7-9 month gathers, and cleans using fresh herb or dry.[function cures mainly] dispeled the wind and delivered; Heat-clearing and toxic substances removing; Antipruritic.Main anemopyretic cold; Laryngopharynx swelling and pain; Mumps; Dysentery; Dermatitis rhus; Eczema; Scabies; Rubella.

Herba Bupleuri candollei [source] is the herb of Yunnan, samphire river Radix Bupleuri Bupleurum candollei Wall.ex DC..Gather autumn, and cutting is dried.The heat radiation of [function cures mainly] wind dispelling; Removing toxic substances.Main anemopyretic cold; Pertussis; Hypochondriac pain due to stagnation of liverQI; Rubella; Sore furuncle and phyma.

Pale reddish brown YIZHUXIANG [source] is labiate Pogostemen nigrescens Dunn. Pogostemon nigrescens Dunn[P.fraternus Miq.var.nigrescens (Dunn) Kudo] herb.Summer, autumn gather, using fresh herb or dry.[function cures mainly] heat-clearing and toxic substances removing; Regulating QI to relieve pain.Main anemopyretic cold; Aphtha; Abdominal distention.

Summary of the invention

The present invention aims to provide a kind of Chinese medicine for the treatment of pityriasis rubra pilaris, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing pityriasis rubra pilaris.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of Chinese medicine for the treatment of pityriasis rubra pilaris, it is characterized in that, by the medical material of following weight proportion, be prepared from: 15 parts of Cortex Nothapodytis Radiciss, 9 parts of Radix Patriniae heterophyllaes, 6 parts of Heracleum apaense, 12 parts of Herba Tripterospermis, 9 parts of Membrana Follicularis ovis, 9 parts of Hainan Radix Stephaniae Epigaeae, 12 parts of Herba Scutellariae indicae, redly send out 10 parts, 12 parts of Ramulus Et Folium Picrasmae roots, 9 parts of Tucrium Pilosums, 15 parts of Herba Bupleuri candolleis, 9 parts of pale reddish brown YIZHUXIANG depositedly.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

1, physical data

Inventor in March, 2008-2011 collects the out-patient of 51 routine pityriasis rubra pilaris, age 18-61 year, the course of disease 4 months-5 years altogether between year October.By random table, be divided at random: treatment group 26 examples, blank group 25 examples.The data there was no significant differences such as two groups of ages, the state of an illness, have comparability.

2, test method

The capsule that the oral the present invention of 2.1 treatment group makes according to specific embodiment 1, sooner or later respectively once.The January course for the treatment of.

2.2 blank group oral placebo capsules, sooner or later respectively once.The January course for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

Recovery from illness: deflorescence is more than 90%, and subjective symptoms disappears.Effective: deflorescence >=60%, subjective symptoms disappears substantially.Taking a turn for the better: clinical symptoms disappears >=and 30%, subjective symptoms disappears.Invalid: the pustule <30% or unchanged that disappears, clinical symptoms is not improved even and increases the weight of.

3.2 treatment statistical results are in Table 1.

Table 1 liang group curative effect comparison

Group

n

Recovery from illness

Effective

Take a turn for the better

Invalid

Untoward reaction example

Total effective rate (%)

Treatment group

26

2（7.7%）

8（30.8%)

10(38.5%)

6（23.1%）

0

77.0%

Blank group

25

0

0

3（12.0%）

22（88.0%）

0

12.0%

Visible, the medicine that the present invention makes can safe and effective treatment pityriasis rubra pilaris.

The specific embodiment

In order to understand better and to implement the present invention, below in conjunction with specific embodiment, further illustrate the present invention.

specific embodiment 1

Take: 15 grams of Cortex Nothapodytis Radiciss, 9 grams of Radix Patriniae heterophyllaes, 6 grams of Heracleum apaense, 12 grams of Herba Tripterospermis, 9 grams of Membrana Follicularis ovis, 9 grams of Hainan Radix Stephaniae Epigaeae, 12 grams of Herba Scutellariae indicae, redly send out 10 grams, 12 grams of Ramulus Et Folium Picrasmae roots, 9 grams of Tucrium Pilosums, 15 grams of Herba Bupleuri candolleis, 9 grams of pale reddish brown YIZHUXIANG depositedly, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, must meet the capsule of 1 day consumption of normal adult.

Be used for the treatment of pityriasis rubra pilaris.Oral, every bu is taken for twice sooner or later.

specific embodiment 2

Take: 15 grams of Cortex Nothapodytis Radiciss, 9 grams of Radix Patriniae heterophyllaes, 6 grams of Heracleum apaense, 12 grams of Herba Tripterospermis, 9 grams of Membrana Follicularis ovis, 9 grams of Hainan Radix Stephaniae Epigaeae, 12 grams of Herba Scutellariae indicae, redly send out 10 grams, 12 grams of Ramulus Et Folium Picrasmae roots, 9 grams of Tucrium Pilosums, 15 grams of Herba Bupleuri candolleis, 9 grams of pale reddish brown YIZHUXIANG depositedly, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, pulverize, must meet the powder of 1 day consumption of normal adult.

Be used for the treatment of pityriasis rubra pilaris.Oral, every bu is taken for twice sooner or later.

specific embodiment 3

Take: 15 grams of Cortex Nothapodytis Radiciss, 9 grams of Radix Patriniae heterophyllaes, 6 grams of Heracleum apaense, 12 grams of Herba Tripterospermis, 9 grams of Membrana Follicularis ovis, 9 grams of Hainan Radix Stephaniae Epigaeae, 12 grams of Herba Scutellariae indicae, redly send out 10 grams, 12 grams of Ramulus Et Folium Picrasmae roots, 9 grams of Tucrium Pilosums, 15 grams of Herba Bupleuri candolleis, 9 grams of pale reddish brown YIZHUXIANG depositedly, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, then add appropriate dextrin and correctives, and according to this area common process, to granulate, packing, can make the granule that meets 1 day consumption of normal adult.

Be used for the treatment of pityriasis rubra pilaris.Oral, every bu is taken for twice sooner or later.

Claims (1)

1. a Chinese medicine for the treatment of pityriasis rubra pilaris, it is characterized in that, by the medical material of following weight proportion, be prepared from: 15 parts of Cortex Nothapodytis Radiciss, 9 parts of Radix Patriniae heterophyllaes, 6 parts of Heracleum apaense, 12 parts of Herba Tripterospermis, 9 parts of Membrana Follicularis ovis, 9 parts of Hainan Radix Stephaniae Epigaeae, 12 parts of Herba Scutellariae indicae, redly send out 10 parts, 12 parts of Ramulus Et Folium Picrasmae roots, 9 parts of Tucrium Pilosums, 15 parts of Herba Bupleuri candolleis, 9 parts of pale reddish brown YIZHUXIANG depositedly.