CN105102967B - 雷帕霉素衍生物的纯化 - Google Patents

雷帕霉素衍生物的纯化 Download PDF

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Publication number
CN105102967B
CN105102967B CN201480013252.6A CN201480013252A CN105102967B CN 105102967 B CN105102967 B CN 105102967B CN 201480013252 A CN201480013252 A CN 201480013252A CN 105102967 B CN105102967 B CN 105102967B
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compound
mixture
solvent
formula
solid
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Chinese (zh)
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CN105102967A (zh
Inventor
M·W·卡约
R·S·福尼科拉
I·科瓦奇克
L·康达维提
A·辛格
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Xtent Inc
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Biosensors International Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480013252.6A 2013-03-15 2014-03-17 雷帕霉素衍生物的纯化 Active CN105102967B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811056060.XA CN108864149B (zh) 2013-03-15 2014-03-17 雷帕霉素衍生物的纯化

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361799857P 2013-03-15 2013-03-15
US61/799,857 2013-03-15
PCT/US2014/030602 WO2014145780A1 (en) 2013-03-15 2014-03-17 Purification of rapamycin derivatives

Related Child Applications (1)

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CN201811056060.XA Division CN108864149B (zh) 2013-03-15 2014-03-17 雷帕霉素衍生物的纯化

Publications (2)

Publication Number Publication Date
CN105102967A CN105102967A (zh) 2015-11-25
CN105102967B true CN105102967B (zh) 2018-10-12

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CN201811056060.XA Active CN108864149B (zh) 2013-03-15 2014-03-17 雷帕霉素衍生物的纯化

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Country Status (8)

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US (5) US9598439B2 (enExample)
EP (1) EP2972258B1 (enExample)
JP (4) JP2016519086A (enExample)
CN (2) CN105102967B (enExample)
CA (1) CA2901162C (enExample)
ES (1) ES2897473T3 (enExample)
SG (3) SG10202112135VA (enExample)
WO (1) WO2014145780A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2777841C (en) 2009-11-02 2017-01-17 Francis M. Creighton Magnetomotive stator system and methods for wireless control of magnetic rotors
CA2901162C (en) 2013-03-15 2021-06-01 Biosensors International Group, Ltd. Purification of rapamycin derivatives
CN109851626B (zh) * 2019-01-08 2021-11-02 扬子江药业集团四川海蓉药业有限公司 一种替西罗莫司的分离纯化方法
CN116102576B (zh) * 2021-11-09 2025-08-29 上海博畅医疗科技有限公司 一种优美莫司晶体的制造方法及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101133065A (zh) * 2005-03-02 2008-02-27 惠氏公司 雷帕霉素的纯化
CN101351702A (zh) * 2005-12-07 2009-01-21 惠氏公司 结晶雷帕霉素的制备方法以及使用差示扫描量热法测量雷帕霉素化合物结晶度的方法
CN101522691A (zh) * 2006-11-27 2009-09-02 泰尔茂株式会社 O-烷基化雷帕霉素衍生物的制备方法及o-烷基化雷帕霉素衍生物
US20130035483A1 (en) * 2011-08-05 2013-02-07 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US20130053947A1 (en) * 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical Device with Crystalline Drug Coating

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GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US20060198867A1 (en) * 1997-09-25 2006-09-07 Abbott Laboratories, Inc. Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
TW200504079A (en) * 2003-03-31 2005-02-01 Biogal Gyogyszergyar Crystallization and purification of macrolides
US7220755B2 (en) * 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
EP1697383B1 (en) * 2003-12-05 2014-04-23 Biocon Limited Process for the purification of tacrolimus
JP4716280B2 (ja) * 2004-03-01 2011-07-06 テルモ株式会社 Ｏ−アルキル化ラパマイシン誘導体の製造法
CN1942476A (zh) * 2004-04-14 2007-04-04 惠氏公司 纳巴霉素42－酯衍生物的区位特异合成
EP1817314A1 (en) 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Non-hygroscopic and powdery amorphous pimecrolimus
US20060222627A1 (en) * 2005-03-30 2006-10-05 Andrew Carter Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue
US7700614B2 (en) * 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
EP1993610A2 (en) 2006-03-07 2008-11-26 Wyeth Process for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
US7812032B2 (en) * 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
US7820812B2 (en) * 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
JP2010509317A (ja) * 2006-11-10 2010-03-25 バイオコン リミテッド 純粋な形態のラパマイシンならびにこの回収方法および精製方法
US20080287675A1 (en) * 2007-05-18 2008-11-20 Abbott Laboratories Cascade system
CN101077334A (zh) * 2007-06-29 2007-11-28 济南康泉医药科技有限公司 含酪氨酸激酶抑制剂的抗癌组合物
TW200948361A (en) * 2008-05-26 2009-12-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Method for synthesizing Biolimus A9 and the like and method for improving stability of the same
US20100055145A1 (en) * 2008-08-29 2010-03-04 Biosensors International Group Stent coatings for reducing late stent thrombosis
US20100272773A1 (en) 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of Drug Polymorphs to Achieve Controlled Drug Delivery From a Coated Medical Device
CN102464669B (zh) * 2010-11-17 2014-04-16 浙江海正药业股份有限公司 无定形依维莫司及其制备方法
CN102786534A (zh) * 2012-05-25 2012-11-21 上海现代制药股份有限公司 一种依维莫司的制备方法
CA2901162C (en) 2013-03-15 2021-06-01 Biosensors International Group, Ltd. Purification of rapamycin derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101133065A (zh) * 2005-03-02 2008-02-27 惠氏公司 雷帕霉素的纯化
CN101351702A (zh) * 2005-12-07 2009-01-21 惠氏公司 结晶雷帕霉素的制备方法以及使用差示扫描量热法测量雷帕霉素化合物结晶度的方法
CN101522691A (zh) * 2006-11-27 2009-09-02 泰尔茂株式会社 O-烷基化雷帕霉素衍生物的制备方法及o-烷基化雷帕霉素衍生物
US20130035483A1 (en) * 2011-08-05 2013-02-07 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US20130053947A1 (en) * 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical Device with Crystalline Drug Coating

Also Published As

Publication number Publication date
CN105102967A (zh) 2015-11-25
JP2021121601A (ja) 2021-08-26
EP2972258A1 (en) 2016-01-20
JP2023164476A (ja) 2023-11-10
US10597406B2 (en) 2020-03-24
CA2901162A1 (en) 2014-09-18
WO2014145780A1 (en) 2014-09-18
US11780850B2 (en) 2023-10-10
CN108864149A (zh) 2018-11-23
US11046711B2 (en) 2021-06-29
US20170334928A1 (en) 2017-11-23
US10202402B2 (en) 2019-02-12
CN108864149B (zh) 2022-04-05
SG10201707632PA (en) 2017-11-29
EP2972258A4 (en) 2016-12-21
WO2014145780A4 (en) 2014-11-20
US20200270272A1 (en) 2020-08-27
US20220024947A1 (en) 2022-01-27
CA2901162C (en) 2021-06-01
SG11201507406YA (en) 2015-10-29
SG10202112135VA (en) 2021-12-30
JP2019089848A (ja) 2019-06-13
EP2972258B1 (en) 2021-08-04
JP2016519086A (ja) 2016-06-30
US20190256527A1 (en) 2019-08-22
HK1218959A1 (zh) 2017-03-17
ES2897473T3 (es) 2022-03-01
US20160002262A1 (en) 2016-01-07
US9598439B2 (en) 2017-03-21

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