JP2016519086A - ラパマイシン誘導体の精製 - Google Patents

ラパマイシン誘導体の精製 Download PDF

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Publication number
JP2016519086A
JP2016519086A JP2016503426A JP2016503426A JP2016519086A JP 2016519086 A JP2016519086 A JP 2016519086A JP 2016503426 A JP2016503426 A JP 2016503426A JP 2016503426 A JP2016503426 A JP 2016503426A JP 2016519086 A JP2016519086 A JP 2016519086A
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Japan
Prior art keywords
compound
mixture
alkyl
organic solvent
solid
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JP2016503426A
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English (en)
Japanese (ja)
Inventor
ダブリュ． ケイヨー、マーガレット
ダブリュ． ケイヨー、マーガレット
エス． フォーニコラ、リチャード
エス． フォーニコラ、リチャード
コヴァチク、イヴァン
コンダヴェティ、リーラクリシュナ
シン、アニルッダー
Original Assignee
バイオセンサーズ インターナショナル グループ、リミテッド
バイオセンサーズ インターナショナル グループ、リミテッド
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Publication of JP2016519086A publication Critical patent/JP2016519086A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016503426A 2013-03-15 2014-03-17 ラパマイシン誘導体の精製 Withdrawn JP2016519086A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361799857P 2013-03-15 2013-03-15
US61/799,857 2013-03-15
PCT/US2014/030602 WO2014145780A1 (en) 2013-03-15 2014-03-17 Purification of rapamycin derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019041615A Division JP2019089848A (ja) 2013-03-15 2019-03-07 ラパマイシン誘導体の精製

Publications (1)

Publication Number Publication Date
JP2016519086A true JP2016519086A (ja) 2016-06-30

Family

ID=51538094

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016503426A Withdrawn JP2016519086A (ja) 2013-03-15 2014-03-17 ラパマイシン誘導体の精製
JP2019041615A Pending JP2019089848A (ja) 2013-03-15 2019-03-07 ラパマイシン誘導体の精製
JP2021078418A Pending JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A Pending JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019041615A Pending JP2019089848A (ja) 2013-03-15 2019-03-07 ラパマイシン誘導体の精製
JP2021078418A Pending JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A Pending JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Country Status (8)

Country Link
US (5) US9598439B2 (enExample)
EP (1) EP2972258B1 (enExample)
JP (4) JP2016519086A (enExample)
CN (2) CN105102967B (enExample)
CA (1) CA2901162C (enExample)
ES (1) ES2897473T3 (enExample)
SG (3) SG10202112135VA (enExample)
WO (1) WO2014145780A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2777841C (en) 2009-11-02 2017-01-17 Francis M. Creighton Magnetomotive stator system and methods for wireless control of magnetic rotors
CA2901162C (en) 2013-03-15 2021-06-01 Biosensors International Group, Ltd. Purification of rapamycin derivatives
CN109851626B (zh) * 2019-01-08 2021-11-02 扬子江药业集团四川海蓉药业有限公司 一种替西罗莫司的分离纯化方法
CN116102576B (zh) * 2021-11-09 2025-08-29 上海博畅医疗科技有限公司 一种优美莫司晶体的制造方法及其应用

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2007532134A (ja) * 2004-04-14 2007-11-15 ワイス ラパマイシン４２−エステル誘導体の位置特異的合成
WO2008065887A1 (en) * 2006-11-27 2008-06-05 Terumo Kabushiki Kaisha Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
US20130035483A1 (en) * 2011-08-05 2013-02-07 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form

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GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US20060198867A1 (en) * 1997-09-25 2006-09-07 Abbott Laboratories, Inc. Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
TW200504079A (en) * 2003-03-31 2005-02-01 Biogal Gyogyszergyar Crystallization and purification of macrolides
US7220755B2 (en) * 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
EP1697383B1 (en) * 2003-12-05 2014-04-23 Biocon Limited Process for the purification of tacrolimus
JP4716280B2 (ja) * 2004-03-01 2011-07-06 テルモ株式会社 Ｏ−アルキル化ラパマイシン誘導体の製造法
EP1817314A1 (en) 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Non-hygroscopic and powdery amorphous pimecrolimus
KR20070107087A (ko) * 2005-03-02 2007-11-06 와이어쓰 라파마이신의 정제
US20060222627A1 (en) * 2005-03-30 2006-10-05 Andrew Carter Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue
TW200736603A (en) * 2005-12-07 2007-10-01 Wyeth Corp Methods for preparing crystalline rapamycin and measuring crystallinity of rapamycin compounds using differential scanning calorimetry
US7700614B2 (en) * 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
EP1993610A2 (en) 2006-03-07 2008-11-26 Wyeth Process for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
US7812032B2 (en) * 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
US7820812B2 (en) * 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
JP2010509317A (ja) * 2006-11-10 2010-03-25 バイオコン リミテッド 純粋な形態のラパマイシンならびにこの回収方法および精製方法
US20080287675A1 (en) * 2007-05-18 2008-11-20 Abbott Laboratories Cascade system
CN101077334A (zh) * 2007-06-29 2007-11-28 济南康泉医药科技有限公司 含酪氨酸激酶抑制剂的抗癌组合物
TW200948361A (en) * 2008-05-26 2009-12-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Method for synthesizing Biolimus A9 and the like and method for improving stability of the same
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CN102464669B (zh) * 2010-11-17 2014-04-16 浙江海正药业股份有限公司 无定形依维莫司及其制备方法
WO2013028208A1 (en) * 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN102786534A (zh) * 2012-05-25 2012-11-21 上海现代制药股份有限公司 一种依维莫司的制备方法
CA2901162C (en) 2013-03-15 2021-06-01 Biosensors International Group, Ltd. Purification of rapamycin derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532134A (ja) * 2004-04-14 2007-11-15 ワイス ラパマイシン４２−エステル誘導体の位置特異的合成
WO2008065887A1 (en) * 2006-11-27 2008-06-05 Terumo Kabushiki Kaisha Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
US20130035483A1 (en) * 2011-08-05 2013-02-07 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form

Non-Patent Citations (2)

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芦澤 一英、他, 医薬品の多形現象と晶析の科学, JPN7015003233, 20 September 2002 (2002-09-20), pages 305 - 317, ISSN: 0004057833 *

Also Published As

Publication number Publication date
CN105102967A (zh) 2015-11-25
JP2021121601A (ja) 2021-08-26
EP2972258A1 (en) 2016-01-20
JP2023164476A (ja) 2023-11-10
US10597406B2 (en) 2020-03-24
CA2901162A1 (en) 2014-09-18
WO2014145780A1 (en) 2014-09-18
US11780850B2 (en) 2023-10-10
CN108864149A (zh) 2018-11-23
US11046711B2 (en) 2021-06-29
US20170334928A1 (en) 2017-11-23
US10202402B2 (en) 2019-02-12
CN108864149B (zh) 2022-04-05
SG10201707632PA (en) 2017-11-29
EP2972258A4 (en) 2016-12-21
WO2014145780A4 (en) 2014-11-20
US20200270272A1 (en) 2020-08-27
US20220024947A1 (en) 2022-01-27
CA2901162C (en) 2021-06-01
SG11201507406YA (en) 2015-10-29
SG10202112135VA (en) 2021-12-30
JP2019089848A (ja) 2019-06-13
EP2972258B1 (en) 2021-08-04
US20190256527A1 (en) 2019-08-22
HK1218959A1 (zh) 2017-03-17
ES2897473T3 (es) 2022-03-01
US20160002262A1 (en) 2016-01-07
CN105102967B (zh) 2018-10-12
US9598439B2 (en) 2017-03-21

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