SG10201707632PA - Purification of rapamycin derivatives - Google Patents

Purification of rapamycin derivatives

Info

Publication number
SG10201707632PA
SG10201707632PA SG10201707632PA SG10201707632PA SG10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA
Authority
SG
Singapore
Prior art keywords
purification
rapamycin derivatives
rapamycin
derivatives
Prior art date
Application number
SG10201707632PA
Inventor
Richard S Fornicola
Ivan Kovacik
Leelakrishna Kondaveti
Aniruddh Singh
Margaret W Kayo
Original Assignee
Biosensors Int Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosensors Int Group Ltd filed Critical Biosensors Int Group Ltd
Publication of SG10201707632PA publication Critical patent/SG10201707632PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
SG10201707632PA 2013-03-15 2014-03-17 Purification of rapamycin derivatives SG10201707632PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361799857P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
SG10201707632PA true SG10201707632PA (en) 2017-11-29

Family

ID=51538094

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201507406YA SG11201507406YA (en) 2013-03-15 2014-03-17 Purification of rapamycin derivatives
SG10202112135VA SG10202112135VA (en) 2013-03-15 2014-03-17 Purification of rapamycin derivatives
SG10201707632PA SG10201707632PA (en) 2013-03-15 2014-03-17 Purification of rapamycin derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG11201507406YA SG11201507406YA (en) 2013-03-15 2014-03-17 Purification of rapamycin derivatives
SG10202112135VA SG10202112135VA (en) 2013-03-15 2014-03-17 Purification of rapamycin derivatives

Country Status (9)

Country Link
US (5) US9598439B2 (en)
EP (1) EP2972258B1 (en)
JP (4) JP2016519086A (en)
CN (2) CN105102967B (en)
CA (1) CA2901162C (en)
ES (1) ES2897473T3 (en)
HK (1) HK1218959A1 (en)
SG (3) SG11201507406YA (en)
WO (1) WO2014145780A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102695542B (en) 2009-11-02 2015-08-12 脉冲治疗公司 For magnetic potential stator system and the method for controlled in wireless magnet rotor
JP2016519086A (en) 2013-03-15 2016-06-30 バイオセンサーズ インターナショナル グループ、リミテッド Purification of rapamycin derivatives
CN109851626B (en) * 2019-01-08 2021-11-02 扬子江药业集团四川海蓉药业有限公司 Method for separating and purifying temsirolimus

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GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US20060198867A1 (en) * 1997-09-25 2006-09-07 Abbott Laboratories, Inc. Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
ES2229975T1 (en) * 2003-03-31 2005-05-01 Teva Gyogyszergyar Reszvenytarsasag CRYSTALLIZATION AND PURIFICATION OF MACROLIDS.
US7220755B2 (en) * 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
RU2317991C1 (en) * 2003-12-05 2008-02-27 Байокон Лимитид Method for isolation and purification of macrolides
JP4716280B2 (en) * 2004-03-01 2011-07-06 テルモ株式会社 Process for producing O-alkylated rapamycin derivatives
RU2387657C2 (en) * 2004-04-14 2010-04-27 Вайет Regiospecific synthesis of rapamycin 42-ester derivatives
CA2584358A1 (en) 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag Non-hygroscopic and powdery amorphous pimecrolimus
MX2007010716A (en) * 2005-03-02 2008-01-16 Wyeth Corp Purification of rapamycin.
US20060222627A1 (en) * 2005-03-30 2006-10-05 Andrew Carter Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue
BRPI0619592A2 (en) * 2005-12-07 2016-09-06 Wyeth Corp methods for measuring particle quality of a rapamycin compound, for determining the average particle size of a sample and the crystallinity of a rapamycin compound, and for rapamycin purification
US7700614B2 (en) * 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
EP1993610A2 (en) 2006-03-07 2008-11-26 Wyeth Process for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
US7820812B2 (en) * 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
US7812032B2 (en) * 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
AU2006350684B2 (en) * 2006-11-10 2012-07-05 Biocon Limited A pure form of rapamycin and a process for recovery and purification thereof
WO2008065887A1 (en) 2006-11-27 2008-06-05 Terumo Kabushiki Kaisha Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
US20080287675A1 (en) * 2007-05-18 2008-11-20 Abbott Laboratories Cascade system
CN101077334A (en) * 2007-06-29 2007-11-28 济南康泉医药科技有限公司 Anticancer composition containing tyrosine kinase inhibitor
TW200948361A (en) * 2008-05-26 2009-12-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Method for synthesizing Biolimus A9 and the like and method for improving stability of the same
US20100055145A1 (en) * 2008-08-29 2010-03-04 Biosensors International Group Stent coatings for reducing late stent thrombosis
US20100272773A1 (en) 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of Drug Polymorphs to Achieve Controlled Drug Delivery From a Coated Medical Device
CN102464669B (en) * 2010-11-17 2014-04-16 浙江海正药业股份有限公司 Amorphous everolimus and preparation method thereof
US8669360B2 (en) * 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN102786534A (en) * 2012-05-25 2012-11-21 上海现代制药股份有限公司 Preparation method of everolimus
JP2016519086A (en) 2013-03-15 2016-06-30 バイオセンサーズ インターナショナル グループ、リミテッド Purification of rapamycin derivatives

Also Published As

Publication number Publication date
JP2023164476A (en) 2023-11-10
US11780850B2 (en) 2023-10-10
JP2021121601A (en) 2021-08-26
HK1218959A1 (en) 2017-03-17
US20170334928A1 (en) 2017-11-23
US9598439B2 (en) 2017-03-21
CA2901162C (en) 2021-06-01
CA2901162A1 (en) 2014-09-18
JP2019089848A (en) 2019-06-13
EP2972258A4 (en) 2016-12-21
WO2014145780A1 (en) 2014-09-18
ES2897473T3 (en) 2022-03-01
US10202402B2 (en) 2019-02-12
US20190256527A1 (en) 2019-08-22
SG10202112135VA (en) 2021-12-30
US20200270272A1 (en) 2020-08-27
US20220024947A1 (en) 2022-01-27
EP2972258B1 (en) 2021-08-04
CN108864149B (en) 2022-04-05
WO2014145780A4 (en) 2014-11-20
US20160002262A1 (en) 2016-01-07
CN105102967A (en) 2015-11-25
SG11201507406YA (en) 2015-10-29
JP2016519086A (en) 2016-06-30
US11046711B2 (en) 2021-06-29
CN105102967B (en) 2018-10-12
US10597406B2 (en) 2020-03-24
EP2972258A1 (en) 2016-01-20
CN108864149A (en) 2018-11-23

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